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The map label for this gene is hrcA

Identifier: 108800426

GI number: 108800426

Start: 3670070

End: 3671113

Strand: Reverse

Name: hrcA

Synonym: Mmcs_3460

Alternate gene names: 108800426

Gene position: 3671113-3670070 (Counterclockwise)

Preceding gene: 108800429

Following gene: 108800425

Centisome position: 64.34

GC content: 68.3

Gene sequence:

>1044_bases
ATGGGTAGTGCCGACGACCGCCGCTTCGAGGTGCTGCGCGCCATCGTCGCCGACTTCGTCGCCACCAAGGAGCCGATCGG
CTCCAAGACCCTGGTGGAGCGACACAACCTCGGGGTGTCCAGCGCGACCGTCCGCAACGACATGGCCGTCCTGGAGGCCG
AGGGGTACATCACCCAGCCGCACACCAGTTCCGGGCGCGTCCCCACGGAGAAGGGCTACCGCGAGTTCGTCGACCGCCTC
GACGACGTCAAACCGCTGTCGTCGGCCGAACGTCGGGCGATCCTCAAATTCCTCGAGACCGGCGTCGACCTCGACGACGT
GCTGCGCCGGGCGGTGCGCCTGCTGGCGCAGTTGACCCGTCAGGTCGCGATCGTGCAGTACCCGACCCTGTCCACCTCGT
CGGTCCGCCACCTGGAGGTGGTTGCGCTCACGCCGGCACGCCTGCTGCTGGTCGTCATCACCGACACCGGCCGCGTCGAT
CAGCGCATCGTCGAACTCGGCGATGCAATCGACGAGCACGAACTCGCGACCCTGCGCGATCTGCTGGGCCAGGCACTGGA
GGGTAAGCGGCTCTCCGCCGCGTCGGTGGCGGTCTCGGACCTCGCCACCCATCTGAGCGGCAGTCCCGGGATGTCGCACC
GGCTGGCCGACGCTGTCGGCCGCTCGGCGACCGTGCTGGTCGAGACCCTGGTCGAGCACACCGAGGAGCGGCTGCTGCTC
GGCGGCACCGCGAACCTCACCCGCAACACCGCCGATTTTGGCGGCTCGCTGCGGTCGGTTCTCGAAGCGCTCGAGGAGCA
GGTGGTGGTGCTGCGGTTGCTCGCCGCGCAGCAGGAGGCGGGCAAGGTCACCGTGCGGATCGGTCACGAGACCGAGGCCG
AGCAGATGGCGGGCACGTCGGTGGTCACCACCGCGTACGGCAGTTCGGGCAAGGTCTACGGCGGCATGGGTGTGGTGGGT
CCCACACGGATGGACTATCCGGGAACTATCGCTAATGTCGCTGCGGTTGCTTTGTACATAGGTGAGGTCCTGGGCACGCG
ATGA

Upstream 100 bases:

>100_bases
GGTGGGTAGTACGCGTACCGCGCACGATGCGTAACACGGCTGCTGAGCACCGTAAACTGGACCCCGAACAGCGCTGGGAC
TCGAGAGGTGGGTGAACACG

Downstream 100 bases:

>100_bases
CCGCGGCGCAGGGAGAGTCTCAACAGCCGGTACACCGGCACTGAAAGGTCAAGCGTGGCACGCGATTATTACGGCCTGCT
CGGAGTGAGCAAGGGCGCCA

Product: heat-inducible transcription repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 347; Mature: 346

Protein sequence:

>347_residues
MGSADDRRFEVLRAIVADFVATKEPIGSKTLVERHNLGVSSATVRNDMAVLEAEGYITQPHTSSGRVPTEKGYREFVDRL
DDVKPLSSAERRAILKFLETGVDLDDVLRRAVRLLAQLTRQVAIVQYPTLSTSSVRHLEVVALTPARLLLVVITDTGRVD
QRIVELGDAIDEHELATLRDLLGQALEGKRLSAASVAVSDLATHLSGSPGMSHRLADAVGRSATVLVETLVEHTEERLLL
GGTANLTRNTADFGGSLRSVLEALEEQVVVLRLLAAQQEAGKVTVRIGHETEAEQMAGTSVVTTAYGSSGKVYGGMGVVG
PTRMDYPGTIANVAAVALYIGEVLGTR

Sequences:

>Translated_347_residues
MGSADDRRFEVLRAIVADFVATKEPIGSKTLVERHNLGVSSATVRNDMAVLEAEGYITQPHTSSGRVPTEKGYREFVDRL
DDVKPLSSAERRAILKFLETGVDLDDVLRRAVRLLAQLTRQVAIVQYPTLSTSSVRHLEVVALTPARLLLVVITDTGRVD
QRIVELGDAIDEHELATLRDLLGQALEGKRLSAASVAVSDLATHLSGSPGMSHRLADAVGRSATVLVETLVEHTEERLLL
GGTANLTRNTADFGGSLRSVLEALEEQVVVLRLLAAQQEAGKVTVRIGHETEAEQMAGTSVVTTAYGSSGKVYGGMGVVG
PTRMDYPGTIANVAAVALYIGEVLGTR
>Mature_346_residues
GSADDRRFEVLRAIVADFVATKEPIGSKTLVERHNLGVSSATVRNDMAVLEAEGYITQPHTSSGRVPTEKGYREFVDRLD
DVKPLSSAERRAILKFLETGVDLDDVLRRAVRLLAQLTRQVAIVQYPTLSTSSVRHLEVVALTPARLLLVVITDTGRVDQ
RIVELGDAIDEHELATLRDLLGQALEGKRLSAASVAVSDLATHLSGSPGMSHRLADAVGRSATVLVETLVEHTEERLLLG
GTANLTRNTADFGGSLRSVLEALEEQVVVLRLLAAQQEAGKVTVRIGHETEAEQMAGTSVVTTAYGSSGKVYGGMGVVGP
TRMDYPGTIANVAAVALYIGEVLGTR

Specific function: Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons

COG id: COG1420

COG function: function code K; Transcriptional regulator of heat shock gene

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hrcA family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HRCA_MYCSJ (A3Q272)

Other databases:

- EMBL:   CP000580
- RefSeq:   YP_001071740.1
- ProteinModelPortal:   A3Q272
- SMR:   A3Q272
- STRING:   A3Q272
- EnsemblBacteria:   EBMYCT00000050770
- GeneID:   4879183
- GenomeReviews:   CP000580_GR
- KEGG:   mjl:Mjls_3471
- eggNOG:   COG1420
- GeneTree:   EBGT00050000016264
- HOGENOM:   HBG729878
- OMA:   RYLTAFL
- ProtClustDB:   PRK00082
- BioCyc:   MSP164757:MJLS_3471-MONOMER
- GO:   GO:0006350
- HAMAP:   MF_00081
- InterPro:   IPR002571
- InterPro:   IPR021153
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PIRSF:   PIRSF005485
- TIGRFAMs:   TIGR00331

Pfam domain/function: PF01628 HrcA

EC number: NA

Molecular weight: Translated: 37156; Mature: 37025

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSADDRRFEVLRAIVADFVATKEPIGSKTLVERHNLGVSSATVRNDMAVLEAEGYITQP
CCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCHHHHHCCCEEEECCCCEECC
HTSSGRVPTEKGYREFVDRLDDVKPLSSAERRAILKFLETGVDLDDVLRRAVRLLAQLTR
CCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
QVAIVQYPTLSTSSVRHLEVVALTPARLLLVVITDTGRVDQRIVELGDAIDEHELATLRD
HHHHEECCCCCCCCCCEEEEEEECCCCEEEEEEECCCHHHHHHHHHHCCCCHHHHHHHHH
LLGQALEGKRLSAASVAVSDLATHLSGSPGMSHRLADAVGRSATVLVETLVEHTEERLLL
HHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHEEE
GGTANLTRNTADFGGSLRSVLEALEEQVVVLRLLAAQQEAGKVTVRIGHETEAEQMAGTS
CCCCCCCCCCHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHCCCE
VVTTAYGSSGKVYGGMGVVGPTRMDYPGTIANVAAVALYIGEVLGTR
EEEEEECCCCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GSADDRRFEVLRAIVADFVATKEPIGSKTLVERHNLGVSSATVRNDMAVLEAEGYITQP
CCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCHHHHHCCCEEEECCCCEECC
HTSSGRVPTEKGYREFVDRLDDVKPLSSAERRAILKFLETGVDLDDVLRRAVRLLAQLTR
CCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
QVAIVQYPTLSTSSVRHLEVVALTPARLLLVVITDTGRVDQRIVELGDAIDEHELATLRD
HHHHEECCCCCCCCCCEEEEEEECCCCEEEEEEECCCHHHHHHHHHHCCCCHHHHHHHHH
LLGQALEGKRLSAASVAVSDLATHLSGSPGMSHRLADAVGRSATVLVETLVEHTEERLLL
HHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHEEE
GGTANLTRNTADFGGSLRSVLEALEEQVVVLRLLAAQQEAGKVTVRIGHETEAEQMAGTS
CCCCCCCCCCHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHCCCE
VVTTAYGSSGKVYGGMGVVGPTRMDYPGTIANVAAVALYIGEVLGTR
EEEEEECCCCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA