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The map label for this gene is gcvT [H]

Identifier: 108800275

GI number: 108800275

Start: 3505153

End: 3506247

Strand: Reverse

Name: gcvT [H]

Synonym: Mmcs_3309

Alternate gene names: 108800275

Gene position: 3506247-3505153 (Counterclockwise)

Preceding gene: 108800277

Following gene: 108800274

Centisome position: 61.45

GC content: 71.42

Gene sequence:

>1095_bases
GTGAGTGAACCCCTGCACGGCCCTCTGGAAGACCGCCACCGCGAGCTGGGAGCGACGTTCGCCGAGTTCGGCGGCTGGCT
GATGCCGGTGTCCTACGCGGGCACGGTCACCGAGCACACCGCGACCCGCACGACGGTCGGGCTGTTCGACGTCAGCCACC
TCGGCAAGGCACTGGTGCGGGGCCCCGGCGCGGCGGCCTACGTCAACTCCGCGCTGACCAACGACCTCAACCGCATCGGC
CCCGGCAAGGCGCAATACACGTTGTGCTGCAACGACTCCGGCGGGGTGATCGACGATCTGATCGCCTACTACGTCTCCGA
CGACGAGATCTTCCTGGTGCCCAACGCCGCGAACACCGCTGCCGTGGTGGCCGCACTCGCCGAACGGGCGCCCGACGGGG
TGACGGTCACCGACGAGCACCGCTCGTACGCGGTGCTGGCGGTGCAGGGACCCAAGTCCGCGGAGGTGCTCGGCGGGCTG
GGTCTGCCCACCGACATGGACTACATGGGATACGTCGACGCGGAACTGAACGGCACCGCGGTGCGGGTCTGCCGCACCGG
CTACACCGGGGAGCAGGGCTACGAGCTGCTGCCGGCCTGGGACGACGCGCCCGCCGTCTTCGACGCGCTGGTGTCGGCGG
TGCGTGACGCCGCCGGTGAGCTGGCCGGGCTCGGCGCGCGCGACACCCTGCGCACCGAGATGGGATACCCGCTGCACGGT
CACGAACTTTCGCCGGAGATCTCCCCGCTGCAAGCCCGCTGCGGGTGGGCGGTCGGCTGGCGCAAGGACGCCTTCTGGGG
CCGCGACGCGCTGCTGGCCGAGAAGGAGGCCGGTCCGAAGCGGCTGCTGCGCGGGCTGCGCGCGGTCGGCCGCGGGGTGC
TGCGGCCGGATCTGACGGTGTTCGACGGCGACACCGCGGTCGGTGTGACGACGTCGGGGACCTTCTCGCCGAGCCTGAAG
GTCGGTATCGCGCTGGCGCTCGTCGACACGGCCCATGACATCGCCGACGGCAGCCGCGTGGAGGTCGACGTGCGTGGCCG
GCGCATCGAGTGCGAGGTCGTGCCTCCGCCGTTTGTCACCGCGAAAACCCGCTAG

Upstream 100 bases:

>100_bases
GTCACCCACTCCGCGGCGCGGGATGGAGGAACTGACGGTGACGACGGGGGCCTGATAGCCGGGATCGGAACTCACGAGAA
TCCACCATAAGGTGTCAGAC

Downstream 100 bases:

>100_bases
CCACCGGAGATACAATTTCTTCCATGACTGACGGCCCCCTCGAGTTCACCGTTCACCGCAACGCGGAGCCGGCGACCGAC
GAGGTACGCGCCGAGATCCT

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 364; Mature: 363

Protein sequence:

>364_residues
MSEPLHGPLEDRHRELGATFAEFGGWLMPVSYAGTVTEHTATRTTVGLFDVSHLGKALVRGPGAAAYVNSALTNDLNRIG
PGKAQYTLCCNDSGGVIDDLIAYYVSDDEIFLVPNAANTAAVVAALAERAPDGVTVTDEHRSYAVLAVQGPKSAEVLGGL
GLPTDMDYMGYVDAELNGTAVRVCRTGYTGEQGYELLPAWDDAPAVFDALVSAVRDAAGELAGLGARDTLRTEMGYPLHG
HELSPEISPLQARCGWAVGWRKDAFWGRDALLAEKEAGPKRLLRGLRAVGRGVLRPDLTVFDGDTAVGVTTSGTFSPSLK
VGIALALVDTAHDIADGSRVEVDVRGRRIECEVVPPPFVTAKTR

Sequences:

>Translated_364_residues
MSEPLHGPLEDRHRELGATFAEFGGWLMPVSYAGTVTEHTATRTTVGLFDVSHLGKALVRGPGAAAYVNSALTNDLNRIG
PGKAQYTLCCNDSGGVIDDLIAYYVSDDEIFLVPNAANTAAVVAALAERAPDGVTVTDEHRSYAVLAVQGPKSAEVLGGL
GLPTDMDYMGYVDAELNGTAVRVCRTGYTGEQGYELLPAWDDAPAVFDALVSAVRDAAGELAGLGARDTLRTEMGYPLHG
HELSPEISPLQARCGWAVGWRKDAFWGRDALLAEKEAGPKRLLRGLRAVGRGVLRPDLTVFDGDTAVGVTTSGTFSPSLK
VGIALALVDTAHDIADGSRVEVDVRGRRIECEVVPPPFVTAKTR
>Mature_363_residues
SEPLHGPLEDRHRELGATFAEFGGWLMPVSYAGTVTEHTATRTTVGLFDVSHLGKALVRGPGAAAYVNSALTNDLNRIGP
GKAQYTLCCNDSGGVIDDLIAYYVSDDEIFLVPNAANTAAVVAALAERAPDGVTVTDEHRSYAVLAVQGPKSAEVLGGLG
LPTDMDYMGYVDAELNGTAVRVCRTGYTGEQGYELLPAWDDAPAVFDALVSAVRDAAGELAGLGARDTLRTEMGYPLHGH
ELSPEISPLQARCGWAVGWRKDAFWGRDALLAEKEAGPKRLLRGLRAVGRGVLRPDLTVFDGDTAVGVTTSGTFSPSLKV
GIALALVDTAHDIADGSRVEVDVRGRRIECEVVPPPFVTAKTR

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=366, Percent_Identity=31.4207650273224, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI257796258, Length=334, Percent_Identity=31.7365269461078, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI257796254, Length=361, Percent_Identity=28.2548476454294, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI257796256, Length=313, Percent_Identity=29.7124600638978, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI24797151, Length=350, Percent_Identity=26.2857142857143, Blast_Score=92, Evalue=6e-19,
Organism=Escherichia coli, GI1789272, Length=363, Percent_Identity=37.1900826446281, Blast_Score=195, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI17560118, Length=369, Percent_Identity=32.2493224932249, Blast_Score=147, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI71994045, Length=386, Percent_Identity=26.1658031088083, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71994052, Length=386, Percent_Identity=26.1658031088083, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI32563613, Length=390, Percent_Identity=22.3076923076923, Blast_Score=82, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6320222, Length=377, Percent_Identity=30.5039787798408, Blast_Score=150, Evalue=4e-37,
Organism=Drosophila melanogaster, GI20129441, Length=373, Percent_Identity=32.9758713136729, Blast_Score=165, Evalue=4e-41,
Organism=Drosophila melanogaster, GI20130091, Length=348, Percent_Identity=23.8505747126437, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI28571104, Length=294, Percent_Identity=24.4897959183673, Blast_Score=75, Evalue=9e-14,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 38545; Mature: 38414

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEPLHGPLEDRHRELGATFAEFGGWLMPVSYAGTVTEHTATRTTVGLFDVSHLGKALVR
CCCCCCCCHHHHHHHHCCHHHHHCCEEEEEECCCCCCCCCCCCEEEEEHHHHHHHHHHHC
GPGAAAYVNSALTNDLNRIGPGKAQYTLCCNDSGGVIDDLIAYYVSDDEIFLVPNAANTA
CCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHEECCCEEEEEECCCCHH
AVVAALAERAPDGVTVTDEHRSYAVLAVQGPKSAEVLGGLGLPTDMDYMGYVDAELNGTA
HHHHHHHHHCCCCCEEEECCCCEEEEEEECCCCHHHHCCCCCCCCCCCCEEEECCCCCCE
VRVCRTGYTGEQGYELLPAWDDAPAVFDALVSAVRDAAGELAGLGARDTLRTEMGYPLHG
EEEEECCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCC
HELSPEISPLQARCGWAVGWRKDAFWGRDALLAEKEAGPKRLLRGLRAVGRGVLRPDLTV
CCCCCCCCCHHHHCCEEECCCCCCCCCCCHHHCCCCCCHHHHHHHHHHHCCCCCCCCCEE
FDGDTAVGVTTSGTFSPSLKVGIALALVDTAHDIADGSRVEVDVRGRRIECEVVPPPFVT
ECCCEEEEEEECCCCCCCCEEEEEEEEEHHHHHHCCCCEEEEEECCCEEEEEECCCCCEE
AKTR
CCCC
>Mature Secondary Structure 
SEPLHGPLEDRHRELGATFAEFGGWLMPVSYAGTVTEHTATRTTVGLFDVSHLGKALVR
CCCCCCCHHHHHHHHCCHHHHHCCEEEEEECCCCCCCCCCCCEEEEEHHHHHHHHHHHC
GPGAAAYVNSALTNDLNRIGPGKAQYTLCCNDSGGVIDDLIAYYVSDDEIFLVPNAANTA
CCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHEECCCEEEEEECCCCHH
AVVAALAERAPDGVTVTDEHRSYAVLAVQGPKSAEVLGGLGLPTDMDYMGYVDAELNGTA
HHHHHHHHHCCCCCEEEECCCCEEEEEEECCCCHHHHCCCCCCCCCCCCEEEECCCCCCE
VRVCRTGYTGEQGYELLPAWDDAPAVFDALVSAVRDAAGELAGLGARDTLRTEMGYPLHG
EEEEECCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCC
HELSPEISPLQARCGWAVGWRKDAFWGRDALLAEKEAGPKRLLRGLRAVGRGVLRPDLTV
CCCCCCCCCHHHHCCEEECCCCCCCCCCCHHHCCCCCCHHHHHHHHHHHCCCCCCCCCEE
FDGDTAVGVTTSGTFSPSLKVGIALALVDTAHDIADGSRVEVDVRGRRIECEVVPPPFVT
ECCCEEEEEEECCCCCCCCEEEEEEEEEHHHHHHCCCCEEEEEECCCEEEEEECCCCCEE
AKTR
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA