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The map label for this gene is penA [H]

Identifier: 108800228

GI number: 108800228

Start: 3458888

End: 3460816

Strand: Reverse

Name: penA [H]

Synonym: Mmcs_3262

Alternate gene names: 108800228

Gene position: 3460816-3458888 (Counterclockwise)

Preceding gene: 108800229

Following gene: 108800227

Centisome position: 60.66

GC content: 69.36

Gene sequence:

>1929_bases
GTGAGCCCCCGCCGCGATCCGCGGGGTGGTGCTCCCCGGCGCGCCCGCGGCCCGAAGGCGGCCTCCGCCCAGGGCCGCCC
GGCCAAGGCCCGCCGCACCCGCAAGGCGGTGGCCGGCGAATCCGGCCTGCGCAGTTCGTCGTTCGTGTTCCGGCACCGCG
CCGGAACCGCGGTGATGCTGGTACTGCTGTTGGTCGCCGCCGCTCAGCTGTTCAACCTCCAGGTGCCGCGCGCAGAGGGG
TTGCGCGCGGAGGCGGCCGGACAGCTCAAGGTCACCGATGTGCAGAAGGCGGTGCGCGGCAGCATCGTCGACCGCAACGA
CGACAAGCTGGCCTTCACCATCGAGGCGCGGGCGTTGACGTTCCAGCCGGTCAAGGTCCGCAAACAACTCGAGGAGGCGC
GCGCGAAGTCGGAGGAGGCGCCCGATCCCAAGCGCCGCCTGGTCGAGATCGCCGACGAGGTCGCCGCGCGGCTGAACAAC
AAACCGGATGCGAAAACCGTTCTGCGCAAACTGAACAGCAACGAGACGTTCGTCTACCTGGCGCGCGCGGTCGATCCGGT
GATCTCCGATGCGATCACCGAGAAGTTCCCCGAGGTCGGTTCGGAACGCCAGGACATCCGGCAGTACCCGGGTGGCTCGC
TGGCGGCCAACATCGTCGGCGGCATCGACTGGGACGGCCACGGCCTGCTGGGCCTGGAGGATTCGCTCGACGCCGTCCTG
GCCGGCACCGACGGCTCGGTCACCTACGACCGGGGTTCCGACGGTGTGGTGATCCCCGGCAGCTACCGCAACCGCCACGA
CGCGGTCGACGGTTCCACCGTGCAGCTGACCATCGACGACGACATCCAGTTCTACGTCCAGCAGCAGGTGCAGATGGCCA
AGGACGCCTCCGGCGCCAAGAACGTCTCGGCCGTCGTGCTGGACGCGAAAACCTCTGAGGTGCTCGCGATGTCGAACGAC
AACACGTTCGACCCCAGCCAGGACATCGGCAAGCAGGACAACCGCCAGATCGGCAACCTCCCGGTGTCCTCGCCGTTCGA
GCCGGGTTCGGTGAACAAGATCGTCACCGCGGCCGCGGCGATCGAGTACGGGCTGACCAACCCCGACGAGGTGCTGCAGG
TGCCCGGTTCGATCAACATGGGCGGCGTCACGGTGGGCGACGCGTGGAAGCACGGCACGATGCCGTACACCACCACCGGC
GTGTTCGGGAAGTCGTCCAACGTCGGCACGCTGATGCTCGCCGACCGGATCGGGCCGGAGCGCTACGCCGAGATGCTCAA
GAAGTTCGGCCTGGGCCAGCGCACCGGCGTCGGCCTGCCGGGCGAGAGCGCCGGCCTGGTGCCGCCCATCCACCAGTGGT
CGGGCAGCACGTTCTCCAACCTGCCCATCGGACAGGGTCTTTCGATGACGTTGCTGCAGATGGCCGGGATGTACCAGGCG
ATCGCCAACGACGGCGTGCGCATCCCGCCGCGGGTCCTCAAGGCGACCATCGCCCCCGACGGCACCCGCACCGAAGAGGA
GCGGCCCGAGGGCGTGCGCGTGGTGTCGCCGCAGACGGCGCAGACCGTGCGCAACATGTTCCGCTCGGTGGTACAGCGCG
ATCCGATGGGGGAGCAGCAGGGCACCGGGCCGGCGGCGGCGGTCGAGGGCTACCAGATCGCGGGCAAGACCGGCACCGCG
CAGCAGATCAACCCCGCCTGCGGCTGCTACTACAGCGACGTCTACTGGATCACCTTCGCCGGTATGGCCACCGTCGACGA
TCCGCGCTACGTCATCGGCATCATGATGGACGCCCCGCACCGCGCCGCCGACGGTTCCCCGGGCTCGTCGGCCGCCCCGC
TGTTCCACAACATCGCCTCGTGGCTGCTGCAGCGGCAGAACGTGCCGCTGTCACCGCCCGGCGCTCCGCTGACACTGCAG
GCGACCTGA

Upstream 100 bases:

>100_bases
CGGTCGACCCGGCGCTGGCCCCAGTGCCCCCGCCGCTTCCGGCTCCCGCCCCGGACCACCTCGCCGCGCCGCAGGCGCCC
GTGCCGGCAGGACCGCCGGC

Downstream 100 bases:

>100_bases
CCGACGCGTCGGGCCGACCGAGGCTCGGTACTGTGTCATGGCCATGAAGCTGCGCCCCAGCCATCCCGTCGGACACGCGC
TCGGTGCCCTTGCCGAGCAG

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 642; Mature: 641

Protein sequence:

>642_residues
MSPRRDPRGGAPRRARGPKAASAQGRPAKARRTRKAVAGESGLRSSSFVFRHRAGTAVMLVLLLVAAAQLFNLQVPRAEG
LRAEAAGQLKVTDVQKAVRGSIVDRNDDKLAFTIEARALTFQPVKVRKQLEEARAKSEEAPDPKRRLVEIADEVAARLNN
KPDAKTVLRKLNSNETFVYLARAVDPVISDAITEKFPEVGSERQDIRQYPGGSLAANIVGGIDWDGHGLLGLEDSLDAVL
AGTDGSVTYDRGSDGVVIPGSYRNRHDAVDGSTVQLTIDDDIQFYVQQQVQMAKDASGAKNVSAVVLDAKTSEVLAMSND
NTFDPSQDIGKQDNRQIGNLPVSSPFEPGSVNKIVTAAAAIEYGLTNPDEVLQVPGSINMGGVTVGDAWKHGTMPYTTTG
VFGKSSNVGTLMLADRIGPERYAEMLKKFGLGQRTGVGLPGESAGLVPPIHQWSGSTFSNLPIGQGLSMTLLQMAGMYQA
IANDGVRIPPRVLKATIAPDGTRTEEERPEGVRVVSPQTAQTVRNMFRSVVQRDPMGEQQGTGPAAAVEGYQIAGKTGTA
QQINPACGCYYSDVYWITFAGMATVDDPRYVIGIMMDAPHRAADGSPGSSAAPLFHNIASWLLQRQNVPLSPPGAPLTLQ
AT

Sequences:

>Translated_642_residues
MSPRRDPRGGAPRRARGPKAASAQGRPAKARRTRKAVAGESGLRSSSFVFRHRAGTAVMLVLLLVAAAQLFNLQVPRAEG
LRAEAAGQLKVTDVQKAVRGSIVDRNDDKLAFTIEARALTFQPVKVRKQLEEARAKSEEAPDPKRRLVEIADEVAARLNN
KPDAKTVLRKLNSNETFVYLARAVDPVISDAITEKFPEVGSERQDIRQYPGGSLAANIVGGIDWDGHGLLGLEDSLDAVL
AGTDGSVTYDRGSDGVVIPGSYRNRHDAVDGSTVQLTIDDDIQFYVQQQVQMAKDASGAKNVSAVVLDAKTSEVLAMSND
NTFDPSQDIGKQDNRQIGNLPVSSPFEPGSVNKIVTAAAAIEYGLTNPDEVLQVPGSINMGGVTVGDAWKHGTMPYTTTG
VFGKSSNVGTLMLADRIGPERYAEMLKKFGLGQRTGVGLPGESAGLVPPIHQWSGSTFSNLPIGQGLSMTLLQMAGMYQA
IANDGVRIPPRVLKATIAPDGTRTEEERPEGVRVVSPQTAQTVRNMFRSVVQRDPMGEQQGTGPAAAVEGYQIAGKTGTA
QQINPACGCYYSDVYWITFAGMATVDDPRYVIGIMMDAPHRAADGSPGSSAAPLFHNIASWLLQRQNVPLSPPGAPLTLQ
AT
>Mature_641_residues
SPRRDPRGGAPRRARGPKAASAQGRPAKARRTRKAVAGESGLRSSSFVFRHRAGTAVMLVLLLVAAAQLFNLQVPRAEGL
RAEAAGQLKVTDVQKAVRGSIVDRNDDKLAFTIEARALTFQPVKVRKQLEEARAKSEEAPDPKRRLVEIADEVAARLNNK
PDAKTVLRKLNSNETFVYLARAVDPVISDAITEKFPEVGSERQDIRQYPGGSLAANIVGGIDWDGHGLLGLEDSLDAVLA
GTDGSVTYDRGSDGVVIPGSYRNRHDAVDGSTVQLTIDDDIQFYVQQQVQMAKDASGAKNVSAVVLDAKTSEVLAMSNDN
TFDPSQDIGKQDNRQIGNLPVSSPFEPGSVNKIVTAAAAIEYGLTNPDEVLQVPGSINMGGVTVGDAWKHGTMPYTTTGV
FGKSSNVGTLMLADRIGPERYAEMLKKFGLGQRTGVGLPGESAGLVPPIHQWSGSTFSNLPIGQGLSMTLLQMAGMYQAI
ANDGVRIPPRVLKATIAPDGTRTEEERPEGVRVVSPQTAQTVRNMFRSVVQRDPMGEQQGTGPAAAVEGYQIAGKTGTAQ
QINPACGCYYSDVYWITFAGMATVDDPRYVIGIMMDAPHRAADGSPGSSAAPLFHNIASWLLQRQNVPLSPPGAPLTLQA
T

Specific function: Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=584, Percent_Identity=29.7945205479452, Blast_Score=197, Evalue=2e-51,
Organism=Escherichia coli, GI1786854, Length=574, Percent_Identity=25.2613240418118, Blast_Score=95, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 68513; Mature: 68382

Theoretical pI: Translated: 8.55; Mature: 8.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPRRDPRGGAPRRARGPKAASAQGRPAKARRTRKAVAGESGLRSSSFVFRHRAGTAVML
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEECCCCHHHHH
VLLLVAAAQLFNLQVPRAEGLRAEAAGQLKVTDVQKAVRGSIVDRNDDKLAFTIEARALT
HHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEHHHHHHHHCCCCCCCCCEEEEEEEECEEE
FQPVKVRKQLEEARAKSEEAPDPKRRLVEIADEVAARLNNKPDAKTVLRKLNSNETFVYL
ECHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEEE
ARAVDPVISDAITEKFPEVGSERQDIRQYPGGSLAANIVGGIDWDGHGLLGLEDSLDAVL
HHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCEEEHHCCCCCCCCCCEECCCCCCCEEE
AGTDGSVTYDRGSDGVVIPGSYRNRHDAVDGSTVQLTIDDDIQFYVQQQVQMAKDASGAK
ECCCCCEEEECCCCCEEECCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCC
NVSAVVLDAKTSEVLAMSNDNTFDPSQDIGKQDNRQIGNLPVSSPFEPGSVNKIVTAAAA
CCEEEEEECCCCEEEEECCCCCCCCCHHCCCCCCCEECCCCCCCCCCCCCCHHHHHHHHH
IEYGLTNPDEVLQVPGSINMGGVTVGDAWKHGTMPYTTTGVFGKSSNVGTLMLADRIGPE
HHHCCCCHHHHEECCCCCCCCCEEECCCCCCCCCCEEECCCCCCCCCCEEEEEECCCCHH
RYAEMLKKFGLGQRTGVGLPGESAGLVPPIHQWSGSTFSNLPIGQGLSMTLLQMAGMYQA
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHH
IANDGVRIPPRVLKATIAPDGTRTEEERPEGVRVVSPQTAQTVRNMFRSVVQRDPMGEQQ
HHCCCCCCCHHHHEEEECCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHCCCCCCCC
GTGPAAAVEGYQIAGKTGTAQQINPACGCYYSDVYWITFAGMATVDDPRYVIGIMMDAPH
CCCCHHHCCCEEEECCCCCCHHCCCHHCCEECCEEEEEEECEEECCCCCEEEEEEECCCC
RAADGSPGSSAAPLFHNIASWLLQRQNVPLSPPGAPLTLQAT
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEC
>Mature Secondary Structure 
SPRRDPRGGAPRRARGPKAASAQGRPAKARRTRKAVAGESGLRSSSFVFRHRAGTAVML
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEECCCCHHHHH
VLLLVAAAQLFNLQVPRAEGLRAEAAGQLKVTDVQKAVRGSIVDRNDDKLAFTIEARALT
HHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEHHHHHHHHCCCCCCCCCEEEEEEEECEEE
FQPVKVRKQLEEARAKSEEAPDPKRRLVEIADEVAARLNNKPDAKTVLRKLNSNETFVYL
ECHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEEE
ARAVDPVISDAITEKFPEVGSERQDIRQYPGGSLAANIVGGIDWDGHGLLGLEDSLDAVL
HHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCEEEHHCCCCCCCCCCEECCCCCCCEEE
AGTDGSVTYDRGSDGVVIPGSYRNRHDAVDGSTVQLTIDDDIQFYVQQQVQMAKDASGAK
ECCCCCEEEECCCCCEEECCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCC
NVSAVVLDAKTSEVLAMSNDNTFDPSQDIGKQDNRQIGNLPVSSPFEPGSVNKIVTAAAA
CCEEEEEECCCCEEEEECCCCCCCCCHHCCCCCCCEECCCCCCCCCCCCCCHHHHHHHHH
IEYGLTNPDEVLQVPGSINMGGVTVGDAWKHGTMPYTTTGVFGKSSNVGTLMLADRIGPE
HHHCCCCHHHHEECCCCCCCCCEEECCCCCCCCCCEEECCCCCCCCCCEEEEEECCCCHH
RYAEMLKKFGLGQRTGVGLPGESAGLVPPIHQWSGSTFSNLPIGQGLSMTLLQMAGMYQA
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHH
IANDGVRIPPRVLKATIAPDGTRTEEERPEGVRVVSPQTAQTVRNMFRSVVQRDPMGEQQ
HHCCCCCCCHHHHEEEECCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHCCCCCCCC
GTGPAAAVEGYQIAGKTGTAQQINPACGCYYSDVYWITFAGMATVDDPRYVIGIMMDAPH
CCCCHHHCCCEEEECCCCCCHHCCCHHCCEECCEEEEEEECEEECCCCCEEEEEEECCCC
RAADGSPGSSAAPLFHNIASWLLQRQNVPLSPPGAPLTLQAT
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3126399 [H]