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The map label for this gene is mutA [H]

Identifier: 108800089

GI number: 108800089

Start: 3315661

End: 3317508

Strand: Reverse

Name: mutA [H]

Synonym: Mmcs_3123

Alternate gene names: 108800089

Gene position: 3317508-3315661 (Counterclockwise)

Preceding gene: 108800091

Following gene: 108800088

Centisome position: 58.15

GC content: 72.19

Gene sequence:

>1848_bases
GTGTCTGTGCAGGGGGCCAGTGCTGTCGAGTCCGGTCTGGAGCAGTGGCGCTCCGCAGTGGCGGGGGTGTTGGCGAAAAG
CACCCGCAAGGACCCCGCCGACCTGCCCGCCGAACCCGACCGGCTGCTCGATTCGCCGACCTACGAGGGTTTCGCGATCC
GCCCTCTCTACACCAGCCTCGACGAGTTGCCCGAGCCGCCGCTGCCGGGCCAGTGGCCGTACGTGCGCGGCGGTGACGCC
CTGCGTGACGTCAAGTCCGGGTGGAAGGTGGCCGAGACCTTCCCGGCCGTGCCGAGCAGCGCCGACGAGGCCAACGGCGC
GATACTGCTCGGCCTCACCGAAGGCGTCAGCGCACTGGTACTGCGCGTCGGCGCCGACGGCGTCGCCCCGTCCGACCTGG
GACGGCTCCTCGAATCGGTGTTCCTCGACCTGGTCCCGGTCCAACTCGACGCCGGCACCGAATACGCCGCGGCCGCCGCA
GCCCTCCTGCCGCTGCTGACCGATCTGGACGCCGAACAGCGCGAACGACTTTCGGTGGACCTGGGCGCCGACCCCCTCAC
CGCACCGTTCAGCGACCGGCCCGCACCCGAGGTGGCCGACGTGGTGTCCATCGCGGCCGGGGTCACCGGACACGGCGGGC
ATGTGCGCGCCATCACCGTCGACGGGCCCGCGCTGCACAACCGCGGGGCGAGCGCCTCCTGGGAGTTGGCGGGTGCCGTC
GCGGCCGGGGTGTCGTATCTGCGGCTGCTCGACCAGGGCGGCCTCGACATCGTCGACGCCGTGCGCCAGATCAGCTTCCG
CTTCGCCGCCGACGACGACCAGTTCATGACCATCGCCAAGCTGCGGGCCGCCCGGCTGCTGTGGGCCCGCGTCTGCGAGG
TCGTCGGCGCCGCGGATGCGGGTGCGGCCACGGTCCACGCGGTGTCGTCGCTGCCGATGATGGCCCAGCGCGATCCGTGG
GTGAACATGCTGCGCACGACACTCGCGGCGTTCTCCGCGGGTGTCGGAGGCGCCGACACCGTGCTGGTGCACCCCTTCGA
CGTGGCGATCCCGAACGGATTCCCCGGCACCTCGAGCACGTTCGCACGCCGCATCGCCCGCAACACCCAGCTGTTGCTGC
TCGAGGAGTCCCACATCGGCCGGGTACTCGACCCGGCCGGTGGGTCCTGGTTCGTCGAGGACCTGACCGCGCAGCTGGCC
GAGCGGGCATGGAAACACTTCCAGGACATCGAGTCGCGCGGCGGGTTCGTCGCCGCACACGACCACATCGCCGAGCAGAT
CGCCGACGTCGCCGCCCGCCGCGCCGACGACATCGCGCACCGGCGCACCGCGCTGACCGGCGTCAACGAGTACCCGAACC
TTGACGAACCCGCGCTTCCGCCCGGCGAGGCGTTCACCGCGGTCGCCCGCTACGCGGCCGGGTTCGAAGCGCTGCGCGAC
CGCTCCGATGCGGTTCTGGAGAGCACCGGCGCGCGCCCGAAGGTGCTGCTGCTGCCGCTGGGGCCGCTGGCCGAACACAA
CATCCGCGCGACGTTCGCCACCAACCTGCTCGCCTCCGGTGGGATCGAGGCCGTCAACCCGGGCTCTGTCGGTGCCGCCG
ATGTGGCCCGGGCGGTGTCGGCCGCGGGCAACCCGTCGGTCGCCGTCATCTGCGGCACCGACACCCGCTACGGCACCGAC
GCCGCCGCCGTGGTCGCGGCCGCCCGCGAGGCGGGTGTCACCCGCGTCTATCTGGCCGGCCCGGAAAAGGCCGTCGCAGA
AGCGGATCCCAAGCCGGACGACTACCTGACCGCCAAGATCGACGCGGTCGCGGCCCTGTCGAACCTCCTCACCCGATTGG
GGGCCTGA

Upstream 100 bases:

>100_bases
GGTCCGGCACGTCGGCCGACCGGCGGGCAGCGCGGTGACCGCCATCATTTAGCCTGATGGCGGATACGTCAGTCACACGC
TGCGACAACAGGAGATGCCG

Downstream 100 bases:

>100_bases
CTGCTATGACGGTCAACGATGTCGCCGGCAAGCCGGCTCCGGAAACCACCGGCATCGGCAGCTTCGCCGACGTACCGCTG
CACGGTGAAGGCGCCGGCGC

Product: methylmalonyl-CoA mutase, small subunit

Products: NA

Alternate protein names: MCM [H]

Number of amino acids: Translated: 615; Mature: 614

Protein sequence:

>615_residues
MSVQGASAVESGLEQWRSAVAGVLAKSTRKDPADLPAEPDRLLDSPTYEGFAIRPLYTSLDELPEPPLPGQWPYVRGGDA
LRDVKSGWKVAETFPAVPSSADEANGAILLGLTEGVSALVLRVGADGVAPSDLGRLLESVFLDLVPVQLDAGTEYAAAAA
ALLPLLTDLDAEQRERLSVDLGADPLTAPFSDRPAPEVADVVSIAAGVTGHGGHVRAITVDGPALHNRGASASWELAGAV
AAGVSYLRLLDQGGLDIVDAVRQISFRFAADDDQFMTIAKLRAARLLWARVCEVVGAADAGAATVHAVSSLPMMAQRDPW
VNMLRTTLAAFSAGVGGADTVLVHPFDVAIPNGFPGTSSTFARRIARNTQLLLLEESHIGRVLDPAGGSWFVEDLTAQLA
ERAWKHFQDIESRGGFVAAHDHIAEQIADVAARRADDIAHRRTALTGVNEYPNLDEPALPPGEAFTAVARYAAGFEALRD
RSDAVLESTGARPKVLLLPLGPLAEHNIRATFATNLLASGGIEAVNPGSVGAADVARAVSAAGNPSVAVICGTDTRYGTD
AAAVVAAAREAGVTRVYLAGPEKAVAEADPKPDDYLTAKIDAVAALSNLLTRLGA

Sequences:

>Translated_615_residues
MSVQGASAVESGLEQWRSAVAGVLAKSTRKDPADLPAEPDRLLDSPTYEGFAIRPLYTSLDELPEPPLPGQWPYVRGGDA
LRDVKSGWKVAETFPAVPSSADEANGAILLGLTEGVSALVLRVGADGVAPSDLGRLLESVFLDLVPVQLDAGTEYAAAAA
ALLPLLTDLDAEQRERLSVDLGADPLTAPFSDRPAPEVADVVSIAAGVTGHGGHVRAITVDGPALHNRGASASWELAGAV
AAGVSYLRLLDQGGLDIVDAVRQISFRFAADDDQFMTIAKLRAARLLWARVCEVVGAADAGAATVHAVSSLPMMAQRDPW
VNMLRTTLAAFSAGVGGADTVLVHPFDVAIPNGFPGTSSTFARRIARNTQLLLLEESHIGRVLDPAGGSWFVEDLTAQLA
ERAWKHFQDIESRGGFVAAHDHIAEQIADVAARRADDIAHRRTALTGVNEYPNLDEPALPPGEAFTAVARYAAGFEALRD
RSDAVLESTGARPKVLLLPLGPLAEHNIRATFATNLLASGGIEAVNPGSVGAADVARAVSAAGNPSVAVICGTDTRYGTD
AAAVVAAAREAGVTRVYLAGPEKAVAEADPKPDDYLTAKIDAVAALSNLLTRLGA
>Mature_614_residues
SVQGASAVESGLEQWRSAVAGVLAKSTRKDPADLPAEPDRLLDSPTYEGFAIRPLYTSLDELPEPPLPGQWPYVRGGDAL
RDVKSGWKVAETFPAVPSSADEANGAILLGLTEGVSALVLRVGADGVAPSDLGRLLESVFLDLVPVQLDAGTEYAAAAAA
LLPLLTDLDAEQRERLSVDLGADPLTAPFSDRPAPEVADVVSIAAGVTGHGGHVRAITVDGPALHNRGASASWELAGAVA
AGVSYLRLLDQGGLDIVDAVRQISFRFAADDDQFMTIAKLRAARLLWARVCEVVGAADAGAATVHAVSSLPMMAQRDPWV
NMLRTTLAAFSAGVGGADTVLVHPFDVAIPNGFPGTSSTFARRIARNTQLLLLEESHIGRVLDPAGGSWFVEDLTAQLAE
RAWKHFQDIESRGGFVAAHDHIAEQIADVAARRADDIAHRRTALTGVNEYPNLDEPALPPGEAFTAVARYAAGFEALRDR
SDAVLESTGARPKVLLLPLGPLAEHNIRATFATNLLASGGIEAVNPGSVGAADVARAVSAAGNPSVAVICGTDTRYGTDA
AAVVAAAREAGVTRVYLAGPEKAVAEADPKPDDYLTAKIDAVAALSNLLTRLGA

Specific function: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates [H]

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methylmalonyl-CoA mutase family [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=458, Percent_Identity=30.1310043668122, Blast_Score=142, Evalue=9e-34,
Organism=Escherichia coli, GI1789284, Length=442, Percent_Identity=30.5429864253394, Blast_Score=159, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI25144500, Length=448, Percent_Identity=27.4553571428571, Blast_Score=132, Evalue=4e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR004608 [H]

Pfam domain/function: PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 64044; Mature: 63912

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS00544 METMALONYL_COA_MUTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVQGASAVESGLEQWRSAVAGVLAKSTRKDPADLPAEPDRLLDSPTYEGFAIRPLYTSL
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCCCCCEEECHHHHHH
DELPEPPLPGQWPYVRGGDALRDVKSGWKVAETFPAVPSSADEANGAILLGLTEGVSALV
HHCCCCCCCCCCCCCCCCHHHHHHHCCCEEHHHCCCCCCCCCCCCCEEEEEEHHCHHHHH
LRVGADGVAPSDLGRLLESVFLDLVPVQLDAGTEYAAAAAALLPLLTDLDAEQRERLSVD
HHHCCCCCCHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHCCCHHHHHHEEEE
LGADPLTAPFSDRPAPEVADVVSIAAGVTGHGGHVRAITVDGPALHNRGASASWELAGAV
CCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCHHHCCCCCCCCHHHHHHH
AAGVSYLRLLDQGGLDIVDAVRQISFRFAADDDQFMTIAKLRAARLLWARVCEVVGAADA
HHHHHHHHHHHCCCCHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
GAATVHAVSSLPMMAQRDPWVNMLRTTLAAFSAGVGGADTVLVHPFDVAIPNGFPGTSST
CHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHCCCCCCCEEEEECEEEECCCCCCCCHHH
FARRIARNTQLLLLEESHIGRVLDPAGGSWFVEDLTAQLAERAWKHFQDIESRGGFVAAH
HHHHHHCCCEEEEEECCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEH
DHIAEQIADVAARRADDIAHRRTALTGVNEYPNLDEPALPPGEAFTAVARYAAGFEALRD
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
RSDAVLESTGARPKVLLLPLGPLAEHNIRATFATNLLASGGIEAVNPGSVGAADVARAVS
HHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
AAGNPSVAVICGTDTRYGTDAAAVVAAAREAGVTRVYLAGPEKAVAEADPKPDDYLTAKI
CCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCEEEEEECCCHHHHCCCCCCCCCEEHHH
DAVAALSNLLTRLGA
HHHHHHHHHHHHHCC
>Mature Secondary Structure 
SVQGASAVESGLEQWRSAVAGVLAKSTRKDPADLPAEPDRLLDSPTYEGFAIRPLYTSL
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCCCCCEEECHHHHHH
DELPEPPLPGQWPYVRGGDALRDVKSGWKVAETFPAVPSSADEANGAILLGLTEGVSALV
HHCCCCCCCCCCCCCCCCHHHHHHHCCCEEHHHCCCCCCCCCCCCCEEEEEEHHCHHHHH
LRVGADGVAPSDLGRLLESVFLDLVPVQLDAGTEYAAAAAALLPLLTDLDAEQRERLSVD
HHHCCCCCCHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHCCCHHHHHHEEEE
LGADPLTAPFSDRPAPEVADVVSIAAGVTGHGGHVRAITVDGPALHNRGASASWELAGAV
CCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCHHHCCCCCCCCHHHHHHH
AAGVSYLRLLDQGGLDIVDAVRQISFRFAADDDQFMTIAKLRAARLLWARVCEVVGAADA
HHHHHHHHHHHCCCCHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
GAATVHAVSSLPMMAQRDPWVNMLRTTLAAFSAGVGGADTVLVHPFDVAIPNGFPGTSST
CHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHCCCCCCCEEEEECEEEECCCCCCCCHHH
FARRIARNTQLLLLEESHIGRVLDPAGGSWFVEDLTAQLAERAWKHFQDIESRGGFVAAH
HHHHHHCCCEEEEEECCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEH
DHIAEQIADVAARRADDIAHRRTALTGVNEYPNLDEPALPPGEAFTAVARYAAGFEALRD
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
RSDAVLESTGARPKVLLLPLGPLAEHNIRATFATNLLASGGIEAVNPGSVGAADVARAVS
HHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
AAGNPSVAVICGTDTRYGTDAAAVVAAAREAGVTRVYLAGPEKAVAEADPKPDDYLTAKI
CCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCEEEEEECCCHHHHCCCCCCCCCEEHHH
DAVAALSNLLTRLGA
HHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]