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The map label for this gene is mutB [H]

Identifier: 108800088

GI number: 108800088

Start: 3313373

End: 3315655

Strand: Reverse

Name: mutB [H]

Synonym: Mmcs_3122

Alternate gene names: 108800088

Gene position: 3315655-3313373 (Counterclockwise)

Preceding gene: 108800089

Following gene: 108800087

Centisome position: 58.11

GC content: 68.94

Gene sequence:

>2283_bases
ATGACGGTCAACGATGTCGCCGGCAAGCCGGCTCCGGAAACCACCGGCATCGGCAGCTTCGCCGACGTACCGCTGCACGG
TGAAGGCGCCGGCGCACCCGCGACCGAGGCCGCCGTCGCCGCACACATCGAGGCCGCGGCCGCCGCGCACGGGTACACCC
CCGAGCAACTCGACTGGGTGACGCCGGAGGGCATCGACGTCAAACCGGTCTACGTCGCCGCCGACCGCGCCGCCGCCGCC
TCGGCCGGATACCCGCTCGACTCGTTCCCTGGCGCACCGCCGTTCCTGCGCGGGCCGTACCCGACGATGTACGTCAACCA
GCCCTGGACCATCCGCCAGTACGCCGGCTTCTCGACCGCCGCGGAGTCCAACGCGTTCTACCGCCGCAACCTGGCCGCGG
GCCAGAAGGGCCTCTCGGTGGCCTTCGACCTGGCCACCCACCGCGGCTACGACTCCGACCACCCGCGGGTGCAGGGCGAT
GTGGGCATGGCCGGGGTGGCCATCGACTCCATCCTCGACATGCGCCAGCTCTTCGACGGCATCGACCTGTCGACGGTGTC
GGTGTCGATGACCATGAACGGCGCGGTGCTGCCGATCCTGGCGCTCTACGTCGTGGCCGCCGAGGAGCAGAGGGTGCCGC
CGGAGAAGCTGGCGGGGACCATCCAGAACGACATCCTCAAAGAGTTCATGGTCCGCAACACCTACATCTATCCGCCCAAG
GCGTCGATGCGGATCATCAGCGACATCTTCGGTTACACCAGCACCAAGATGCCGAAGTTCAACTCGATCTCGATCTCCGG
CTACCACATCCAGGAGGCCGGGGCGACGGCCGATCTGGAGCTGGCCTACACGCTGGCCGACGGCGTCGAGTACATCAAGG
CCGGCCTGGACGCCGGGCTCTCGATCGACAAGTTCGCGCCGCGACTGTCCTTCTTCTGGGGCATCGGGATGAACTTCTTC
ATGGAGGTCGCCAAGCTGCGCGCCGGCCGACTGCTGTGGAGCGAACTGGTCGCCGAGTTCGACCCGAAGAACGAGAAGTC
GCTGTCGCTGCGCACCCACTCGCAGACCTCGGGCTGGTCGCTGACCGCACAGGACGTGTTCAACAACGTCGCCCGCACCT
GCATCGAGGCGATGGCCGCCACCCAGGGGCACACGCAGTCGCTGCACACAAACGCCCTCGATGAGGCGCTCGCGCTGCCG
ACCGACTTCTCGGCCCGCATCGCGCGCAACACCCAGCTGCTGCTGCAGCAGGAGTCCGGAACCACCAGGCCGATCGACCC
ATGGGGTGGGTCGTACTACGTCGAGTGGCTGACCCACCAGCTGGCCACCGCCGCTCGGATGCACATCGGTGAGGTCGTCG
CCCACGGCGGAATGGCGCAGGCGATCAGCGAGGGCATCCCGAAGCTGCGCATCGAGGAGGCCGCGGCCCGCACCCAGGCC
CGTATCGACTCCGGCGCGCAGACCGTCATCGGCGTCAACAAGTACCAGGTGACCGAGGACCACGAGATCGAGGTGCTCAA
GGTCGAGAACAGCCGGGTGCGCGCCGAGCAGCTCGCCAAGCTGCAGCAGTTGCGCGCCGACCGTGACGAGGACGCGACCC
GCGCCGCGCTCGACGAGCTGACCCGGGCGGCCGGTGCGCAGGGGTCAGCCGGGGAGGACGGGCTGGGCAACAATCTGTTG
GCGCTCGCGATCAACGCCGCCCGCGCCAAGGCGACCGTGGGGGAGATCTCCGACGCACTGGAGAAGGTCTACGGCCGCCA
CGTCGCCGAGATCCGCACGATCTCCGGCGTCTACCGCGACGAAGCCGGGAAGGCCACCAACATCTCTTCCGCAACCGAAC
TCGTGGAGAAGTTCGCCGAGGCCGACGGCCGCCGACCCCGCATCCTGGTCGCCAAGATGGGGCAGGACGGCCACGACCGC
GGCCAGAAGGTCATCGCGACGGCCTTCGCCGACATCGGTTTCGACGTCGATGTGGGTTCGTTGTTCTCCACGCCCGACGA
GGTCGCCCAGCAGGCCGCCGACAACGACGTGCACGTCGTCGGTGTCTCGTCGCTGGCCGCCGGTCACCTCACGCTGGTGC
CCGCGCTGCGCGACGCGCTGGCCGCGGTCGGCAGGCCCGACATCATGGTGGTGGTCGGCGGGGTCATCCCGCCCGGCGAC
TTCGACGAGCTCTACGCCGCAGGGGCCGCCGCCATCTTCCCGCCGGGCACCGTGATCGCCGACGCCGCGACCGGGCTGCT
GCACAAACTCGCCGAACGGCTCGGCTACGACCTGAACGCCTGA

Upstream 100 bases:

>100_bases
TCGCAGAAGCGGATCCCAAGCCGGACGACTACCTGACCGCCAAGATCGACGCGGTCGCGGCCCTGTCGAACCTCCTCACC
CGATTGGGGGCCTGACTGCT

Downstream 100 bases:

>100_bases
CATGGCGGCCCCGACCGTCGCCGAGCTGTCCGCAGCGATCCGCAGCGGTGACCGGTCGGCGCTGGCGAAGGCGATCACCC
TGGTCGAGTCGACGCGCGCC

Product: methylmalonyl-CoA mutase

Products: NA

Alternate protein names: MCM [H]

Number of amino acids: Translated: 760; Mature: 759

Protein sequence:

>760_residues
MTVNDVAGKPAPETTGIGSFADVPLHGEGAGAPATEAAVAAHIEAAAAAHGYTPEQLDWVTPEGIDVKPVYVAADRAAAA
SAGYPLDSFPGAPPFLRGPYPTMYVNQPWTIRQYAGFSTAAESNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVQGD
VGMAGVAIDSILDMRQLFDGIDLSTVSVSMTMNGAVLPILALYVVAAEEQRVPPEKLAGTIQNDILKEFMVRNTYIYPPK
ASMRIISDIFGYTSTKMPKFNSISISGYHIQEAGATADLELAYTLADGVEYIKAGLDAGLSIDKFAPRLSFFWGIGMNFF
MEVAKLRAGRLLWSELVAEFDPKNEKSLSLRTHSQTSGWSLTAQDVFNNVARTCIEAMAATQGHTQSLHTNALDEALALP
TDFSARIARNTQLLLQQESGTTRPIDPWGGSYYVEWLTHQLATAARMHIGEVVAHGGMAQAISEGIPKLRIEEAAARTQA
RIDSGAQTVIGVNKYQVTEDHEIEVLKVENSRVRAEQLAKLQQLRADRDEDATRAALDELTRAAGAQGSAGEDGLGNNLL
ALAINAARAKATVGEISDALEKVYGRHVAEIRTISGVYRDEAGKATNISSATELVEKFAEADGRRPRILVAKMGQDGHDR
GQKVIATAFADIGFDVDVGSLFSTPDEVAQQAADNDVHVVGVSSLAAGHLTLVPALRDALAAVGRPDIMVVVGGVIPPGD
FDELYAAGAAAIFPPGTVIADAATGLLHKLAERLGYDLNA

Sequences:

>Translated_760_residues
MTVNDVAGKPAPETTGIGSFADVPLHGEGAGAPATEAAVAAHIEAAAAAHGYTPEQLDWVTPEGIDVKPVYVAADRAAAA
SAGYPLDSFPGAPPFLRGPYPTMYVNQPWTIRQYAGFSTAAESNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVQGD
VGMAGVAIDSILDMRQLFDGIDLSTVSVSMTMNGAVLPILALYVVAAEEQRVPPEKLAGTIQNDILKEFMVRNTYIYPPK
ASMRIISDIFGYTSTKMPKFNSISISGYHIQEAGATADLELAYTLADGVEYIKAGLDAGLSIDKFAPRLSFFWGIGMNFF
MEVAKLRAGRLLWSELVAEFDPKNEKSLSLRTHSQTSGWSLTAQDVFNNVARTCIEAMAATQGHTQSLHTNALDEALALP
TDFSARIARNTQLLLQQESGTTRPIDPWGGSYYVEWLTHQLATAARMHIGEVVAHGGMAQAISEGIPKLRIEEAAARTQA
RIDSGAQTVIGVNKYQVTEDHEIEVLKVENSRVRAEQLAKLQQLRADRDEDATRAALDELTRAAGAQGSAGEDGLGNNLL
ALAINAARAKATVGEISDALEKVYGRHVAEIRTISGVYRDEAGKATNISSATELVEKFAEADGRRPRILVAKMGQDGHDR
GQKVIATAFADIGFDVDVGSLFSTPDEVAQQAADNDVHVVGVSSLAAGHLTLVPALRDALAAVGRPDIMVVVGGVIPPGD
FDELYAAGAAAIFPPGTVIADAATGLLHKLAERLGYDLNA
>Mature_759_residues
TVNDVAGKPAPETTGIGSFADVPLHGEGAGAPATEAAVAAHIEAAAAAHGYTPEQLDWVTPEGIDVKPVYVAADRAAAAS
AGYPLDSFPGAPPFLRGPYPTMYVNQPWTIRQYAGFSTAAESNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVQGDV
GMAGVAIDSILDMRQLFDGIDLSTVSVSMTMNGAVLPILALYVVAAEEQRVPPEKLAGTIQNDILKEFMVRNTYIYPPKA
SMRIISDIFGYTSTKMPKFNSISISGYHIQEAGATADLELAYTLADGVEYIKAGLDAGLSIDKFAPRLSFFWGIGMNFFM
EVAKLRAGRLLWSELVAEFDPKNEKSLSLRTHSQTSGWSLTAQDVFNNVARTCIEAMAATQGHTQSLHTNALDEALALPT
DFSARIARNTQLLLQQESGTTRPIDPWGGSYYVEWLTHQLATAARMHIGEVVAHGGMAQAISEGIPKLRIEEAAARTQAR
IDSGAQTVIGVNKYQVTEDHEIEVLKVENSRVRAEQLAKLQQLRADRDEDATRAALDELTRAAGAQGSAGEDGLGNNLLA
LAINAARAKATVGEISDALEKVYGRHVAEIRTISGVYRDEAGKATNISSATELVEKFAEADGRRPRILVAKMGQDGHDRG
QKVIATAFADIGFDVDVGSLFSTPDEVAQQAADNDVHVVGVSSLAAGHLTLVPALRDALAAVGRPDIMVVVGGVIPPGDF
DELYAAGAAAIFPPGTVIADAATGLLHKLAERLGYDLNA

Specific function: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates [H]

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=718, Percent_Identity=62.2562674094708, Blast_Score=910, Evalue=0.0,
Organism=Escherichia coli, GI1789284, Length=696, Percent_Identity=60.0574712643678, Blast_Score=815, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25144500, Length=711, Percent_Identity=62.8691983122363, Blast_Score=921, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 80920; Mature: 80789

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00544 METMALONYL_COA_MUTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVNDVAGKPAPETTGIGSFADVPLHGEGAGAPATEAAVAAHIEAAAAAHGYTPEQLDWV
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCC
TPEGIDVKPVYVAADRAAAASAGYPLDSFPGAPPFLRGPYPTMYVNQPWTIRQYAGFSTA
CCCCCCCEEEEEECCCHHHCCCCCCCCCCCCCCCCCCCCCCEEEECCCEEEHHHCCCCCH
AESNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVQGDVGMAGVAIDSILDMRQLFDG
HCCCCHHHHHHHCCCCCCEEEEEHHHHCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHCC
IDLSTVSVSMTMNGAVLPILALYVVAAEEQRVPPEKLAGTIQNDILKEFMVRNTYIYPPK
CCEEEEEEEEEECCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCEECCCC
ASMRIISDIFGYTSTKMPKFNSISISGYHIQEAGATADLELAYTLADGVEYIKAGLDAGL
CHHHHHHHHHCCCCCCCCCCCEEEEECEEECCCCCCCCEEEEEHHHHHHHHHHHHHCCCC
SIDKFAPRLSFFWGIGMNFFMEVAKLRAGRLLWSELVAEFDPKNEKSLSLRTHSQTSGWS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCE
LTAQDVFNNVARTCIEAMAATQGHTQSLHTNALDEALALPTDFSARIARNTQLLLQQESG
EEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHCCCEEEEEECCC
TTRPIDPWGGSYYVEWLTHQLATAARMHIGEVVAHGGMAQAISEGIPKLRIEEAAARTQA
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCEEHHHHHHHHHH
RIDSGAQTVIGVNKYQVTEDHEIEVLKVENSRVRAEQLAKLQQLRADRDEDATRAALDEL
HHCCCCCEEEECCEEEECCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
TRAAGAQGSAGEDGLGNNLLALAINAARAKATVGEISDALEKVYGRHVAEIRTISGVYRD
HHHHCCCCCCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EAGKATNISSATELVEKFAEADGRRPRILVAKMGQDGHDRGQKVIATAFADIGFDVDVGS
CCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCHH
LFSTPDEVAQQAADNDVHVVGVSSLAAGHLTLVPALRDALAAVGRPDIMVVVGGVIPPGD
HHCCHHHHHHHHCCCCEEEEEEHHHCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCC
FDELYAAGAAAIFPPGTVIADAATGLLHKLAERLGYDLNA
HHHHHHCCCCEECCCCHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TVNDVAGKPAPETTGIGSFADVPLHGEGAGAPATEAAVAAHIEAAAAAHGYTPEQLDWV
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCC
TPEGIDVKPVYVAADRAAAASAGYPLDSFPGAPPFLRGPYPTMYVNQPWTIRQYAGFSTA
CCCCCCCEEEEEECCCHHHCCCCCCCCCCCCCCCCCCCCCCEEEECCCEEEHHHCCCCCH
AESNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVQGDVGMAGVAIDSILDMRQLFDG
HCCCCHHHHHHHCCCCCCEEEEEHHHHCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHCC
IDLSTVSVSMTMNGAVLPILALYVVAAEEQRVPPEKLAGTIQNDILKEFMVRNTYIYPPK
CCEEEEEEEEEECCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCEECCCC
ASMRIISDIFGYTSTKMPKFNSISISGYHIQEAGATADLELAYTLADGVEYIKAGLDAGL
CHHHHHHHHHCCCCCCCCCCCEEEEECEEECCCCCCCCEEEEEHHHHHHHHHHHHHCCCC
SIDKFAPRLSFFWGIGMNFFMEVAKLRAGRLLWSELVAEFDPKNEKSLSLRTHSQTSGWS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCE
LTAQDVFNNVARTCIEAMAATQGHTQSLHTNALDEALALPTDFSARIARNTQLLLQQESG
EEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHCCCEEEEEECCC
TTRPIDPWGGSYYVEWLTHQLATAARMHIGEVVAHGGMAQAISEGIPKLRIEEAAARTQA
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCEEHHHHHHHHHH
RIDSGAQTVIGVNKYQVTEDHEIEVLKVENSRVRAEQLAKLQQLRADRDEDATRAALDEL
HHCCCCCEEEECCEEEECCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
TRAAGAQGSAGEDGLGNNLLALAINAARAKATVGEISDALEKVYGRHVAEIRTISGVYRD
HHHHCCCCCCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EAGKATNISSATELVEKFAEADGRRPRILVAKMGQDGHDRGQKVIATAFADIGFDVDVGS
CCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCHH
LFSTPDEVAQQAADNDVHVVGVSSLAAGHLTLVPALRDALAAVGRPDIMVVVGGVIPPGD
HHCCHHHHHHHHCCCCEEEEEEHHHCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCC
FDELYAAGAAAIFPPGTVIADAATGLLHKLAERLGYDLNA
HHHHHHCCCCEECCCCHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]