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The map label for this gene is degU [H]

Identifier: 108799996

GI number: 108799996

Start: 3201602

End: 3202258

Strand: Reverse

Name: degU [H]

Synonym: Mmcs_3030

Alternate gene names: 108799996

Gene position: 3202258-3201602 (Counterclockwise)

Preceding gene: 108799997

Following gene: 108799995

Centisome position: 56.13

GC content: 71.23

Gene sequence:

>657_bases
GTGGCTGACGACCAGCCGACCACCGTGATGGTGGTCGACGATCACCCCATCTGGCGGGACGCGGTGGCCCGCGACCTTGC
CGACGAAGGCTTCTCCGTGGTCGCGACCGCCGACGGGGTGGCGGCAGCGCGCCGCCGTGCCGCGGTGGTCAAACCGGCCG
TCGTGGTGATGGACATGCGGTTGACCGACGGCGGCGGCGCCCAGGCCACCGCCGAGGTACTGGCCGTCTCACCGGCGTCC
CGGGTGCTGGTGCTGTCGGCGTCCGATGAGCGCGACGACGTCCTGGAGGCGGTGAAGGCCGGCGCCACCGGCTATCTGGT
CAAGAGCGCCTCCAAGGCCGAACTGAGCGCGGCGGTGCGGGCCACCGCCGACGGCCGTGCCGTCTTCACACCGGGCCTCG
CCGGACTCGTGCTGGGGGAGTACCGCCGGATCGCGCAGCGCCCGGACACCGGCGACTCGGCGCCGACCCTCACCGAACGC
GAGACCGAGGTGCTGCGCCATGTGGCGAAGGGGTTGACGGCCAAACAGATCGCCGCGCGGCTGTCGCTGAGTCACCGCAC
CGTCGAGAACCACGTACAGGCCACCTTTCGCAAGCTGCAGGTGGCCAACCGGGTCGAACTGGCGCGTTACGCGATCGAAC
ACGGCCTCGACGAATAG

Upstream 100 bases:

>100_bases
CGGATCGATTCCCTCGGTGGCACGGCCGAGTTGTACACCGAGCCGGGACGCGGCACGGAATGGGAGCTGACGGTGCCCCG
CAGACGGCAGGATGGTGGCC

Downstream 100 bases:

>100_bases
CGAAGTCGGGTAGTCCTACTCATCCGCACCGGGTGCCCTCGCGCCCACGATGAGTGCATGACCGAATCCCCCCATGCCGT
CATCGCCCGGCTGTCGGCCG

Product: two component LuxR family transcriptional regulator

Products: NA

Alternate protein names: Protease production enhancer protein [H]

Number of amino acids: Translated: 218; Mature: 217

Protein sequence:

>218_residues
MADDQPTTVMVVDDHPIWRDAVARDLADEGFSVVATADGVAAARRRAAVVKPAVVVMDMRLTDGGGAQATAEVLAVSPAS
RVLVLSASDERDDVLEAVKAGATGYLVKSASKAELSAAVRATADGRAVFTPGLAGLVLGEYRRIAQRPDTGDSAPTLTER
ETEVLRHVAKGLTAKQIAARLSLSHRTVENHVQATFRKLQVANRVELARYAIEHGLDE

Sequences:

>Translated_218_residues
MADDQPTTVMVVDDHPIWRDAVARDLADEGFSVVATADGVAAARRRAAVVKPAVVVMDMRLTDGGGAQATAEVLAVSPAS
RVLVLSASDERDDVLEAVKAGATGYLVKSASKAELSAAVRATADGRAVFTPGLAGLVLGEYRRIAQRPDTGDSAPTLTER
ETEVLRHVAKGLTAKQIAARLSLSHRTVENHVQATFRKLQVANRVELARYAIEHGLDE
>Mature_217_residues
ADDQPTTVMVVDDHPIWRDAVARDLADEGFSVVATADGVAAARRRAAVVKPAVVVMDMRLTDGGGAQATAEVLAVSPASR
VLVLSASDERDDVLEAVKAGATGYLVKSASKAELSAAVRATADGRAVFTPGLAGLVLGEYRRIAQRPDTGDSAPTLTERE
TEVLRHVAKGLTAKQIAARLSLSHRTVENHVQATFRKLQVANRVELARYAIEHGLDE

Specific function: Regulating factor for the production of extracellular proteases. The N-terminal region acts as an inhibitor, whereas the C-terminal region carries enhancing activity [H]

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788521, Length=209, Percent_Identity=35.4066985645933, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1788222, Length=216, Percent_Identity=31.0185185185185, Blast_Score=91, Evalue=5e-20,
Organism=Escherichia coli, GI1787473, Length=211, Percent_Identity=29.8578199052133, Blast_Score=84, Evalue=8e-18,
Organism=Escherichia coli, GI1790102, Length=208, Percent_Identity=35.5769230769231, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1786747, Length=213, Percent_Identity=27.2300469483568, Blast_Score=78, Evalue=4e-16,
Organism=Escherichia coli, GI1788712, Length=202, Percent_Identity=22.7722772277228, Blast_Score=68, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 23102; Mature: 22971

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADDQPTTVMVVDDHPIWRDAVARDLADEGFSVVATADGVAAARRRAAVVKPAVVVMDMR
CCCCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHCCEEEEEEEE
LTDGGGAQATAEVLAVSPASRVLVLSASDERDDVLEAVKAGATGYLVKSASKAELSAAVR
ECCCCCCHHHHHHEEECCCCEEEEEECCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHHH
ATADGRAVFTPGLAGLVLGEYRRIAQRPDTGDSAPTLTERETEVLRHVAKGLTAKQIAAR
CCCCCCEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHH
LSLSHRTVENHVQATFRKLQVANRVELARYAIEHGLDE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
ADDQPTTVMVVDDHPIWRDAVARDLADEGFSVVATADGVAAARRRAAVVKPAVVVMDMR
CCCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHCCEEEEEEEE
LTDGGGAQATAEVLAVSPASRVLVLSASDERDDVLEAVKAGATGYLVKSASKAELSAAVR
ECCCCCCHHHHHHEEECCCCEEEEEECCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHHH
ATADGRAVFTPGLAGLVLGEYRRIAQRPDTGDSAPTLTERETEVLRHVAKGLTAKQIAAR
CCCCCCEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHH
LSLSHRTVENHVQATFRKLQVANRVELARYAIEHGLDE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3136143; 3141378; 3141377; 9384377 [H]