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The map label for this gene is argH [H]

Identifier: 108799931

GI number: 108799931

Start: 3129498

End: 3130910

Strand: Reverse

Name: argH [H]

Synonym: Mmcs_2965

Alternate gene names: 108799931

Gene position: 3130910-3129498 (Counterclockwise)

Preceding gene: 108799932

Following gene: 108799930

Centisome position: 54.88

GC content: 71.27

Gene sequence:

>1413_bases
GTGAGCACCAACGAAGGCTCACTGTGGGGCGGCCGGTTCGCCGACGGACCCGCCGACGCGCTGGCGGCGCTGAGCAAGTC
GACGCATTTCGACTGGGTGCTGGCGCCCTACGACATCGCGGCGTCCAAAGCCCATGCCCGCGTGTTGTTCTCGGCCGGAC
TGCTGACCGAAGACCAGCGTGACGGTCTGCTCGCCGGTCTCGACAGCCTGGCCTCCGACGTCGCCGACGGCTCCTTCGCG
CCGCTGGTCACCGACGAGGACGTGCACGGGGCGCTCGAACGTGGCCTGATCGACCGGGTCGGGGCCGAACTCGGCGGCCG
GCTGCGGGCTGGGCGCTCGCGCAACGACCAGGTGGCCACCCTGTTCCGGGCGTGGCTGCGCGACGCGATCCGCCGCGTCG
CCGACGGGGTGCTCGGCGTGGTGAGCGCCCTGGCGACCCAGGCCGCCGCCCACCCGACCGCGATCATGCCCGGCAAGACG
CACCTGCAGTCGGCGCAGCCCGTGCTGCTGGCCCACCATCTGCTCGCCCACGCCCACCCGCTGCTGCGCGACGTCGACCG
GCTCGCCGATTTCGACAAACGGGCGGCGGTGTCGCCCTATGGCGCCGGTGCGCTGGCCGGCTCGTCGCTGGGGCTCGACC
CCGACGCGATCGCCGCGGAACTGGGCTTCGACTCCGCGGCCGACAATTCGATCGACGCGACCGCCGCCCGCGACTTCGCC
GCCGAGGCGGCGTTCGTGCTGGCGATGATCGGGGTGGACCTGTCCCGGCTCGCCGAGGACATCATCCTCTGGAGCACAAC
CGAATTCGGCTACGTCACGCTGCACGACGCCTGGTCGACGGGCAGCTCGATCATGCCGCAGAAGAAGAACCCCGACATCG
CCGAGCTGGCGCGCGGCAAATCCGGCCGGCTGATCGGCAACCTCACCGGGCTGCTGGCCACGCTCAAGGCGCAGCCGCTG
GCCTACAACCGCGATCTGCAGGAGGACAAGGAGCCGGTCTTCGACTCGGTGGCGCAGCTGGAACTGCTGCTGCCCGCCGT
CGCCGGCCTGGTGTCCACACTGAGTTTCGACGTCGACCGGATGGCCGAACTCGCGCCCCTGGGATACACGCTCGCCACCG
ATGTCGCGGAATGGCTGGTGCGGCGCGGGGTTCCGTTCCGCGTCGCGCACGAGGCCGCAGGCGCGGCGGTGCGCGCGGCA
GAAGCCCGCGGTGTCGGACTCGAGGACCTCGAGGACGCCGAGCTGACCGGCATCCACCCGGAACTGACCGGGGACGTCCG
CGAAGTGCTGACCATCGAGGGCTCGGTCAACTCCCGCGATGCGCGCGGCGGCACCGCGCCGGTGCAGGTGGCCAAACAGC
TCAACGTCGTTCGCGACACCGCCGACCGGTTACGGCTACGTTTGAGGACGTGA

Upstream 100 bases:

>100_bases
GACACCTTCGACCAGTCCTCGGCCAAGGGCTTCGTGCACGTGCACGGCCTGAGCTCGAGCATCTCCGCGCGCCGCGACCT
CGGCATCAAGTGAGCGATCG

Downstream 100 bases:

>100_bases
CCGAGCGGGTCGAGTTCGCCGTCGACGGGACGTCCGCGGTCGGGTACCTGTCGGGTGTCGGCAGGGGCGGCCCACGGCCG
TGTGTGGTGATGTGCCCGGG

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 470; Mature: 469

Protein sequence:

>470_residues
MSTNEGSLWGGRFADGPADALAALSKSTHFDWVLAPYDIAASKAHARVLFSAGLLTEDQRDGLLAGLDSLASDVADGSFA
PLVTDEDVHGALERGLIDRVGAELGGRLRAGRSRNDQVATLFRAWLRDAIRRVADGVLGVVSALATQAAAHPTAIMPGKT
HLQSAQPVLLAHHLLAHAHPLLRDVDRLADFDKRAAVSPYGAGALAGSSLGLDPDAIAAELGFDSAADNSIDATAARDFA
AEAAFVLAMIGVDLSRLAEDIILWSTTEFGYVTLHDAWSTGSSIMPQKKNPDIAELARGKSGRLIGNLTGLLATLKAQPL
AYNRDLQEDKEPVFDSVAQLELLLPAVAGLVSTLSFDVDRMAELAPLGYTLATDVAEWLVRRGVPFRVAHEAAGAAVRAA
EARGVGLEDLEDAELTGIHPELTGDVREVLTIEGSVNSRDARGGTAPVQVAKQLNVVRDTADRLRLRLRT

Sequences:

>Translated_470_residues
MSTNEGSLWGGRFADGPADALAALSKSTHFDWVLAPYDIAASKAHARVLFSAGLLTEDQRDGLLAGLDSLASDVADGSFA
PLVTDEDVHGALERGLIDRVGAELGGRLRAGRSRNDQVATLFRAWLRDAIRRVADGVLGVVSALATQAAAHPTAIMPGKT
HLQSAQPVLLAHHLLAHAHPLLRDVDRLADFDKRAAVSPYGAGALAGSSLGLDPDAIAAELGFDSAADNSIDATAARDFA
AEAAFVLAMIGVDLSRLAEDIILWSTTEFGYVTLHDAWSTGSSIMPQKKNPDIAELARGKSGRLIGNLTGLLATLKAQPL
AYNRDLQEDKEPVFDSVAQLELLLPAVAGLVSTLSFDVDRMAELAPLGYTLATDVAEWLVRRGVPFRVAHEAAGAAVRAA
EARGVGLEDLEDAELTGIHPELTGDVREVLTIEGSVNSRDARGGTAPVQVAKQLNVVRDTADRLRLRLRT
>Mature_469_residues
STNEGSLWGGRFADGPADALAALSKSTHFDWVLAPYDIAASKAHARVLFSAGLLTEDQRDGLLAGLDSLASDVADGSFAP
LVTDEDVHGALERGLIDRVGAELGGRLRAGRSRNDQVATLFRAWLRDAIRRVADGVLGVVSALATQAAAHPTAIMPGKTH
LQSAQPVLLAHHLLAHAHPLLRDVDRLADFDKRAAVSPYGAGALAGSSLGLDPDAIAAELGFDSAADNSIDATAARDFAA
EAAFVLAMIGVDLSRLAEDIILWSTTEFGYVTLHDAWSTGSSIMPQKKNPDIAELARGKSGRLIGNLTGLLATLKAQPLA
YNRDLQEDKEPVFDSVAQLELLLPAVAGLVSTLSFDVDRMAELAPLGYTLATDVAEWLVRRGVPFRVAHEAAGAAVRAAE
ARGVGLEDLEDAELTGIHPELTGDVREVLTIEGSVNSRDARGGTAPVQVAKQLNVVRDTADRLRLRLRT

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=459, Percent_Identity=45.0980392156863, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI68303542, Length=459, Percent_Identity=45.0980392156863, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI68303549, Length=459, Percent_Identity=42.483660130719, Blast_Score=334, Evalue=1e-91,
Organism=Homo sapiens, GI68303547, Length=459, Percent_Identity=42.483660130719, Blast_Score=333, Evalue=2e-91,
Organism=Escherichia coli, GI1790398, Length=447, Percent_Identity=43.4004474272931, Blast_Score=332, Evalue=2e-92,
Organism=Saccharomyces cerevisiae, GI6321806, Length=461, Percent_Identity=40.997830802603, Blast_Score=327, Evalue=3e-90,
Organism=Drosophila melanogaster, GI221473854, Length=455, Percent_Identity=42.8571428571429, Blast_Score=350, Evalue=1e-96,
Organism=Drosophila melanogaster, GI78706858, Length=455, Percent_Identity=42.8571428571429, Blast_Score=350, Evalue=1e-96,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 49661; Mature: 49529

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTNEGSLWGGRFADGPADALAALSKSTHFDWVLAPYDIAASKAHARVLFSAGLLTEDQR
CCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHHCCCCCCCCC
DGLLAGLDSLASDVADGSFAPLVTDEDVHGALERGLIDRVGAELGGRLRAGRSRNDQVAT
CHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHCCCCCCHHHHH
LFRAWLRDAIRRVADGVLGVVSALATQAAAHPTAIMPGKTHLQSAQPVLLAHHLLAHAHP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCHHHCCCCHHHHHHHHHHHHHH
LLRDVDRLADFDKRAAVSPYGAGALAGSSLGLDPDAIAAELGFDSAADNSIDATAARDFA
HHHHHHHHHCHHHHCCCCCCCCCHHCCCCCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHH
AEAAFVLAMIGVDLSRLAEDIILWSTTEFGYVTLHDAWSTGSSIMPQKKNPDIAELARGK
HHHHHHHHHHHCCHHHHHHHHEEEECCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHCCC
SGRLIGNLTGLLATLKAQPLAYNRDLQEDKEPVFDSVAQLELLLPAVAGLVSTLSFDVDR
CCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHH
MAELAPLGYTLATDVAEWLVRRGVPFRVAHEAAGAAVRAAEARGVGLEDLEDAELTGIHP
HHHHHCCCHHHHHHHHHHHHHCCCCEEEHHHHHCHHHHHHHHCCCCCCCCCCCCCCCCCC
ELTGDVREVLTIEGSVNSRDARGGTAPVQVAKQLNVVRDTADRLRLRLRT
HHHHHHHHHEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEECCC
>Mature Secondary Structure 
STNEGSLWGGRFADGPADALAALSKSTHFDWVLAPYDIAASKAHARVLFSAGLLTEDQR
CCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHHCCCCCCCCC
DGLLAGLDSLASDVADGSFAPLVTDEDVHGALERGLIDRVGAELGGRLRAGRSRNDQVAT
CHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHCCCCCCHHHHH
LFRAWLRDAIRRVADGVLGVVSALATQAAAHPTAIMPGKTHLQSAQPVLLAHHLLAHAHP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCHHHCCCCHHHHHHHHHHHHHH
LLRDVDRLADFDKRAAVSPYGAGALAGSSLGLDPDAIAAELGFDSAADNSIDATAARDFA
HHHHHHHHHCHHHHCCCCCCCCCHHCCCCCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHH
AEAAFVLAMIGVDLSRLAEDIILWSTTEFGYVTLHDAWSTGSSIMPQKKNPDIAELARGK
HHHHHHHHHHHCCHHHHHHHHEEEECCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHCCC
SGRLIGNLTGLLATLKAQPLAYNRDLQEDKEPVFDSVAQLELLLPAVAGLVSTLSFDVDR
CCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHH
MAELAPLGYTLATDVAEWLVRRGVPFRVAHEAAGAAVRAAEARGVGLEDLEDAELTGIHP
HHHHHCCCHHHHHHHHHHHHHCCCCEEEHHHHHCHHHHHHHHCCCCCCCCCCCCCCCCCC
ELTGDVREVLTIEGSVNSRDARGGTAPVQVAKQLNVVRDTADRLRLRLRT
HHHHHHHHHEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA