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The map label for this gene is pks2 [H]

Identifier: 108799798

GI number: 108799798

Start: 2982416

End: 2986834

Strand: Reverse

Name: pks2 [H]

Synonym: Mmcs_2832

Alternate gene names: 108799798

Gene position: 2986834-2982416 (Counterclockwise)

Preceding gene: 108799799

Following gene: 108799797

Centisome position: 52.35

GC content: 68.97

Gene sequence:

>4419_bases
GTGAACGCTCCTGCGACACCGGGCGACGTGCCACCCAACGCGGTCGCCGTCATCGGGATGGCGGCACGACTCCCGGGTGC
GAACTCGGTGTCGGCATTCTGGGACAACCTGCGCCGTGGCGAGGAATCGATCGTCACCCTGTCCGAGGAAGAACTCCTGG
CCGCCGGGATCAGCGAGCAGACACTGGCCAACCCGTTCTACATCCGGCGGGCCCCCATCGTCGACGGCATCGACGAATTC
GACAACGACTTCTTCGGGTTCCCGCCGCAGATGGCGCGCATGATGGACCCGCAGCACCGGCTGTTCCTCCAAACCGCCTG
GCACGCCATGGAAGACGCCGGATGCGACCCGGCCGGATTCGACGGCTCGATCGGTGTCTACGCCACCAGTGGGTCGAGCA
TCTACCTGCTGCACAACCTGCTGACGCACCACGACCCGAACACCATCCTCGGTCAGGGCGCGACCTTCGACCTGGTGAAC
ATGTCGCTGCTCAACGACAAGGACTATCTCGCCACGCGCGTCTCCCATCAGTTCAACCTGCGCGGACCGAGCGTCACGGT
GCAGACGGCGTGCTCGTCGAGCATGGTCGCCATCCACACGGCCTGCCAGAGCCTGCTCAACGGGGAATCCGACATCGTGC
TCGCCGGCGGGGTGTCGCTGCGCGTGCCGCATCACGTCGGCTACTTCCACGAACCCGGATCCATGGTGTCCGGCGTCGGG
CATTGCCGGCCGTTCGATTCGCGGGCCGACGGCACGGTGTTCGGCAGTGGCGTCGCGGTGGTGGTGCTCAAACCACTGGC
CACCGCACTCGAGGACGGTGACCGCATCCACGCCGTCATCCGGGGATCGGCCATCAACAACGACGGTTCGATGAAGATGA
CCTACGCGGCCCCCAACGGCGCGGCTCAGGCCGATGTCATCGCCGAGGCGCACGCGGTCGCCGACGTCGACCCCGCGACG
ATCAACTATGTCGAGGCGCACGGGACGGGAACGCCACTGGGCGACCCGATCGAGATCGACGGGCTCCGAAGGGCTTTCGG
GGTCTCCGACACCCCGCGGCCCGGCCCGTGCGCGGTCGGTTCGGTCAAATCCAACATCGGTCACCTCGCCGAGGTCTCCG
GCATCGCGGGCCTGATCAAGACCATCCTGAGCCTCCAGCACAAGGCGATCCCGGCGACGCTGCACTACACCGAACCCAAC
CCGGCGCTCGACCTCGATCGCGGGCCGTTCGTCATCCAGAGTGAGTACACCCCGTGGGAGTGGGACGGGATCCGTCGGGC
CGGGGTGAGTTCGTTCGGCGTCGGCGGCACCAACGTCCACCTGGTCGTCGAGGAGGCGCCCACCCGCCCGGTGACCGCCC
CGCTCGACGGTCCCAAGGTTCTGCGGCTGTCCGCCCGCACCGAGGAGTCGTTGAGCGCACTGCGTACCGCACTGGCCGAT
GAACTCGCCGACAACGACGCCCTCGATCTCGACGATGTGGCGTTCACGCTGGCCGGCCGCCGCACCGACCAGGTGCGGAT
GGCGGCAGTCGTCCACGACCGGGCCGACGCCGCCGCGGTCCTCCGATCACCGGACAGCGACGACGTCTTCGTCGGCGAAG
GCGTCGACGCCCGAGACGAATCCGACCGCGTGGTGTTCCTGTTCCCCGGTCAGGGCGCGCAGCACGCCGACATGGCCCGC
GGCCTCTACGACCGGGAACCCGTGTTCGCGGCGGCGTTCGACGAGTGCGCGGCGGGATTCGACGCAGAACTCGGCATCGA
CCTGAAGGCATCGGTTTTCGGTCCGACGACACCCGAGCTCGAGCGCACGGATCTGGCGCAGTCCTCCCTGTTCACCGTCG
AATACGCGCTCGGTCGGCTGATCGAGTCCTATGGCGTGACCGCCGGCGCCTACGCCGGGCACTCGATCGGGGAGTACGCC
GCGGCCGCCCTGGCCGGCGTGTTCGATCTGCCCACCGCCGTCAAGGTGGTCGCGCAGCGCGCCCGGCTCATGCACGCGTC
ACCGTCGGGCGCCATGGTCGCGGTGGGCGCCGGCCTCGAGGACATCGGCGATCTGCTCACCGCCGATCTCGACGTCGCCG
CGATCAACGAACTGGGTGGCTGCGTCATCTCGGGCTCACAGGAGGACGTCAAGACGCTCCAGAACGAACTTCGCCGACGG
CGCATCCTGGCCCGCCGCGTCAGGACCTCGCATGCGTTCCACTCCCGCCTGATGGACGCGGTGGTCCCGCAGTTCGCCGA
ATTCCTGTCCGGTGTGAAGCTGAACGCCCCACGAATCCCGTTGCTGTCCAACGTTACCGGAACCTGGATGACCGATGCGG
AGGCGACCGACCCGCAGTTCTGGGCGCGACAGATCCGCGCCACCGTGCGCTTCGCCGACGAACTCAGCACCGTCCTCGCG
ACACCCCATCGCGTCCTGGTCGAGGTGGGGCCGGGCGGCACGCTGACCGGAGCCGCGGTTCGCCACCCCCGGTGGTCCGA
GGATCACCGGGCGGTCCGGCTCATGCGCCACCAGGTGCAGACCCGCGACGACCACGACACGTTCCTGCTGGCGCTCGGTC
AGATGTGGGCTGCCGGTGTCGATCTCGACTGGTCGCGCCTGTCGAAGGACAAGCCCGGGCTGATCACCCTGCCGGGCTTC
CAATTCGCCCGCCACCGGCACTGGGTCGAGCCCAACCGGAATCTCGAATGGTCGCAGGGAGTCCCGTCGACCGACGCATC
CCGGCCTGTGTCGGAGCCGGCCGCCGCGGTCGCGGCATCCACGAGCGGCCAGTCGATCGAGCAGCGGCTGCAGCAGATCT
GGTGTGAATGCCTCGGCGTCGCGTCGATCGATCCGGCGGAGAACTTCTTCGAGATCGGCGGCGACTCACTGATCGCGATC
GGGGTCGCGATGAACGCCACGAACAAGGGTCTGGACCTGACTCCACAGGATCTGTACGAATACCCGACGGTGTCCGCGCT
CGCCGGGGCCCTCGGTGCGCGCTTCTCCACGGGGGGCCTGGCGGAGATGCCCGCCGCGGACGCCATCAACCCGCCGGTAC
CGCCGGCCGTCGCGCACTTCCTCGAATACGGCATCCAGGACGCGGGACGCTGGCGGGTACCGCTGCTCTTGGCGATCCGG
CCCGAGGTCGGCGTGGACGACGTCCGGGCCGTACTCACCGCAGTGACGAATCACCATGACGCACTGCGGGTTCGGATCGA
CGCGCGCGCCGGCAGCTGGGAACAGCGCATCACGCCTGCGGTGGAGGCGGTGGACCCGGAGATCCTCACGCTGCCCGCAG
GCACCGGGCACGGCACCGCCCGCGAACGCGAAGCGGTCCTCGACCTCATCGCCGACCACCTGTCGGCCGATGATCTGTCG
GTGTCGCCGCTGCGCGCGGCCTACATCCTCGACGCGGACGGAACGGCGCGTTTCCTCGCGCTCTCGGTGCACGAGATGGT
GGTCGACAGCACTTCACGCGAGATCCTGCTGACCGACATCATCACCGCGTTCGGTCAACGACTCGCCGGGCAGGAGGTCA
GCCTGCCGCCGGCCACCACGTCCTGGCAGGCCTGGTCGCAACGCTGCGCCGAGCTGACCACCCACCCTGCGGTGCTGGCC
GGGCGCGAGTACTGGGTGGAGACCGCCACCAAGACGACGATGCACATCGCGGACCGCCACGTCGCCGACCCGCCACGCAG
CGAACACCTCGTCCGGATGGGGACGACGTTGCCCGCCGGACAGACCGAGGAGGTCGACCGCGCGCGGCGGATGTACCAGT
ACACGCTCGACGAGCTGCTGCTGGCCGCACTCAGCAGGACGGTGGGAGACACGCTCGGTGACGGGGTGCTGGCAGTCGGC
GTCTGCGGTGACGCGCGGCCGGTGCTGAAACCGGAATTGGACCCTCGACGGACCGTGGGCGCGTTCGCCACGCTCTATCC
GCTGGCACTGGCGTGCGCCGGGACCCAGGCAACACCCGCGGTCGAGGTGCTGAACGCCGTGCACAACACGTTGGACGGCG
TGCCGCACCACGGGATCGGCTACGGTCTGCTGCGTTTTCTGTACGGACCGACGGCGCGCACGCTCAGCCCCGTCCCGCCG
CCGGACATCCTGCTGTGCAACGAGGGCGTCGTGCCCGAGGTCGACCTGGGGGACAGCCCGATCCAGCTGGACGCCGACGT
GGCATCGTCGCTGCGCGACAAGATCCCGGGGCTGGGTCACCCGATCGAACTGCGCGTGTTCCGTTCCTCCGGCGAACTGC
ACCTCGACTGGTGGTACGACACCCGGCGCGTGCCACAGGAGACGGTCGAGGTCTTCGCCGCGCGGTTCCCCGCCGCCCTG
AACGACCTCGTCGCCGAGTCGTCCGCGTCGGCCGGTGCGAACGCCGAACTCGCGGACGCCATCGAGGAACTCGCACTCGT
GGACCTGTCCGCGGAATGA

Upstream 100 bases:

>100_bases
AACCGGGAACGACCGCCGTCGACGGCGTGCGTGAAAGAGCCAATCAGCGCGCCGCCGCACGTCGTGGTGCCGCAGTGCGG
CGGAAGAAAGGACAATTGCT

Downstream 100 bases:

>100_bases
GTCAGGTCTCCCGAACCCATCAGCCGACGAAGCACCAATCGACGAAGAGGAATGCGATGCAAGACAGCCGAACGGCGAAC
TCCGACAAGAGCGTCGTCGT

Product: beta-ketoacyl synthase

Products: [acyl carrier protein]; acetoacetyl-ACP; CO2; [acyl carrier protein]; beta-ketoacyl-ACP [C]

Alternate protein names: Polyketide synthase pks2 [H]

Number of amino acids: Translated: 1472; Mature: 1472

Protein sequence:

>1472_residues
MNAPATPGDVPPNAVAVIGMAARLPGANSVSAFWDNLRRGEESIVTLSEEELLAAGISEQTLANPFYIRRAPIVDGIDEF
DNDFFGFPPQMARMMDPQHRLFLQTAWHAMEDAGCDPAGFDGSIGVYATSGSSIYLLHNLLTHHDPNTILGQGATFDLVN
MSLLNDKDYLATRVSHQFNLRGPSVTVQTACSSSMVAIHTACQSLLNGESDIVLAGGVSLRVPHHVGYFHEPGSMVSGVG
HCRPFDSRADGTVFGSGVAVVVLKPLATALEDGDRIHAVIRGSAINNDGSMKMTYAAPNGAAQADVIAEAHAVADVDPAT
INYVEAHGTGTPLGDPIEIDGLRRAFGVSDTPRPGPCAVGSVKSNIGHLAEVSGIAGLIKTILSLQHKAIPATLHYTEPN
PALDLDRGPFVIQSEYTPWEWDGIRRAGVSSFGVGGTNVHLVVEEAPTRPVTAPLDGPKVLRLSARTEESLSALRTALAD
ELADNDALDLDDVAFTLAGRRTDQVRMAAVVHDRADAAAVLRSPDSDDVFVGEGVDARDESDRVVFLFPGQGAQHADMAR
GLYDREPVFAAAFDECAAGFDAELGIDLKASVFGPTTPELERTDLAQSSLFTVEYALGRLIESYGVTAGAYAGHSIGEYA
AAALAGVFDLPTAVKVVAQRARLMHASPSGAMVAVGAGLEDIGDLLTADLDVAAINELGGCVISGSQEDVKTLQNELRRR
RILARRVRTSHAFHSRLMDAVVPQFAEFLSGVKLNAPRIPLLSNVTGTWMTDAEATDPQFWARQIRATVRFADELSTVLA
TPHRVLVEVGPGGTLTGAAVRHPRWSEDHRAVRLMRHQVQTRDDHDTFLLALGQMWAAGVDLDWSRLSKDKPGLITLPGF
QFARHRHWVEPNRNLEWSQGVPSTDASRPVSEPAAAVAASTSGQSIEQRLQQIWCECLGVASIDPAENFFEIGGDSLIAI
GVAMNATNKGLDLTPQDLYEYPTVSALAGALGARFSTGGLAEMPAADAINPPVPPAVAHFLEYGIQDAGRWRVPLLLAIR
PEVGVDDVRAVLTAVTNHHDALRVRIDARAGSWEQRITPAVEAVDPEILTLPAGTGHGTAREREAVLDLIADHLSADDLS
VSPLRAAYILDADGTARFLALSVHEMVVDSTSREILLTDIITAFGQRLAGQEVSLPPATTSWQAWSQRCAELTTHPAVLA
GREYWVETATKTTMHIADRHVADPPRSEHLVRMGTTLPAGQTEEVDRARRMYQYTLDELLLAALSRTVGDTLGDGVLAVG
VCGDARPVLKPELDPRRTVGAFATLYPLALACAGTQATPAVEVLNAVHNTLDGVPHHGIGYGLLRFLYGPTARTLSPVPP
PDILLCNEGVVPEVDLGDSPIQLDADVASSLRDKIPGLGHPIELRVFRSSGELHLDWWYDTRRVPQETVEVFAARFPAAL
NDLVAESSASAGANAELADAIEELALVDLSAE

Sequences:

>Translated_1472_residues
MNAPATPGDVPPNAVAVIGMAARLPGANSVSAFWDNLRRGEESIVTLSEEELLAAGISEQTLANPFYIRRAPIVDGIDEF
DNDFFGFPPQMARMMDPQHRLFLQTAWHAMEDAGCDPAGFDGSIGVYATSGSSIYLLHNLLTHHDPNTILGQGATFDLVN
MSLLNDKDYLATRVSHQFNLRGPSVTVQTACSSSMVAIHTACQSLLNGESDIVLAGGVSLRVPHHVGYFHEPGSMVSGVG
HCRPFDSRADGTVFGSGVAVVVLKPLATALEDGDRIHAVIRGSAINNDGSMKMTYAAPNGAAQADVIAEAHAVADVDPAT
INYVEAHGTGTPLGDPIEIDGLRRAFGVSDTPRPGPCAVGSVKSNIGHLAEVSGIAGLIKTILSLQHKAIPATLHYTEPN
PALDLDRGPFVIQSEYTPWEWDGIRRAGVSSFGVGGTNVHLVVEEAPTRPVTAPLDGPKVLRLSARTEESLSALRTALAD
ELADNDALDLDDVAFTLAGRRTDQVRMAAVVHDRADAAAVLRSPDSDDVFVGEGVDARDESDRVVFLFPGQGAQHADMAR
GLYDREPVFAAAFDECAAGFDAELGIDLKASVFGPTTPELERTDLAQSSLFTVEYALGRLIESYGVTAGAYAGHSIGEYA
AAALAGVFDLPTAVKVVAQRARLMHASPSGAMVAVGAGLEDIGDLLTADLDVAAINELGGCVISGSQEDVKTLQNELRRR
RILARRVRTSHAFHSRLMDAVVPQFAEFLSGVKLNAPRIPLLSNVTGTWMTDAEATDPQFWARQIRATVRFADELSTVLA
TPHRVLVEVGPGGTLTGAAVRHPRWSEDHRAVRLMRHQVQTRDDHDTFLLALGQMWAAGVDLDWSRLSKDKPGLITLPGF
QFARHRHWVEPNRNLEWSQGVPSTDASRPVSEPAAAVAASTSGQSIEQRLQQIWCECLGVASIDPAENFFEIGGDSLIAI
GVAMNATNKGLDLTPQDLYEYPTVSALAGALGARFSTGGLAEMPAADAINPPVPPAVAHFLEYGIQDAGRWRVPLLLAIR
PEVGVDDVRAVLTAVTNHHDALRVRIDARAGSWEQRITPAVEAVDPEILTLPAGTGHGTAREREAVLDLIADHLSADDLS
VSPLRAAYILDADGTARFLALSVHEMVVDSTSREILLTDIITAFGQRLAGQEVSLPPATTSWQAWSQRCAELTTHPAVLA
GREYWVETATKTTMHIADRHVADPPRSEHLVRMGTTLPAGQTEEVDRARRMYQYTLDELLLAALSRTVGDTLGDGVLAVG
VCGDARPVLKPELDPRRTVGAFATLYPLALACAGTQATPAVEVLNAVHNTLDGVPHHGIGYGLLRFLYGPTARTLSPVPP
PDILLCNEGVVPEVDLGDSPIQLDADVASSLRDKIPGLGHPIELRVFRSSGELHLDWWYDTRRVPQETVEVFAARFPAAL
NDLVAESSASAGANAELADAIEELALVDLSAE
>Mature_1472_residues
MNAPATPGDVPPNAVAVIGMAARLPGANSVSAFWDNLRRGEESIVTLSEEELLAAGISEQTLANPFYIRRAPIVDGIDEF
DNDFFGFPPQMARMMDPQHRLFLQTAWHAMEDAGCDPAGFDGSIGVYATSGSSIYLLHNLLTHHDPNTILGQGATFDLVN
MSLLNDKDYLATRVSHQFNLRGPSVTVQTACSSSMVAIHTACQSLLNGESDIVLAGGVSLRVPHHVGYFHEPGSMVSGVG
HCRPFDSRADGTVFGSGVAVVVLKPLATALEDGDRIHAVIRGSAINNDGSMKMTYAAPNGAAQADVIAEAHAVADVDPAT
INYVEAHGTGTPLGDPIEIDGLRRAFGVSDTPRPGPCAVGSVKSNIGHLAEVSGIAGLIKTILSLQHKAIPATLHYTEPN
PALDLDRGPFVIQSEYTPWEWDGIRRAGVSSFGVGGTNVHLVVEEAPTRPVTAPLDGPKVLRLSARTEESLSALRTALAD
ELADNDALDLDDVAFTLAGRRTDQVRMAAVVHDRADAAAVLRSPDSDDVFVGEGVDARDESDRVVFLFPGQGAQHADMAR
GLYDREPVFAAAFDECAAGFDAELGIDLKASVFGPTTPELERTDLAQSSLFTVEYALGRLIESYGVTAGAYAGHSIGEYA
AAALAGVFDLPTAVKVVAQRARLMHASPSGAMVAVGAGLEDIGDLLTADLDVAAINELGGCVISGSQEDVKTLQNELRRR
RILARRVRTSHAFHSRLMDAVVPQFAEFLSGVKLNAPRIPLLSNVTGTWMTDAEATDPQFWARQIRATVRFADELSTVLA
TPHRVLVEVGPGGTLTGAAVRHPRWSEDHRAVRLMRHQVQTRDDHDTFLLALGQMWAAGVDLDWSRLSKDKPGLITLPGF
QFARHRHWVEPNRNLEWSQGVPSTDASRPVSEPAAAVAASTSGQSIEQRLQQIWCECLGVASIDPAENFFEIGGDSLIAI
GVAMNATNKGLDLTPQDLYEYPTVSALAGALGARFSTGGLAEMPAADAINPPVPPAVAHFLEYGIQDAGRWRVPLLLAIR
PEVGVDDVRAVLTAVTNHHDALRVRIDARAGSWEQRITPAVEAVDPEILTLPAGTGHGTAREREAVLDLIADHLSADDLS
VSPLRAAYILDADGTARFLALSVHEMVVDSTSREILLTDIITAFGQRLAGQEVSLPPATTSWQAWSQRCAELTTHPAVLA
GREYWVETATKTTMHIADRHVADPPRSEHLVRMGTTLPAGQTEEVDRARRMYQYTLDELLLAALSRTVGDTLGDGVLAVG
VCGDARPVLKPELDPRRTVGAFATLYPLALACAGTQATPAVEVLNAVHNTLDGVPHHGIGYGLLRFLYGPTARTLSPVPP
PDILLCNEGVVPEVDLGDSPIQLDADVASSLRDKIPGLGHPIELRVFRSSGELHLDWWYDTRRVPQETVEVFAARFPAAL
NDLVAESSASAGANAELADAIEELALVDLSAE

Specific function: Catalyzes the synthesis of methyl phthioceranic acids and/or hydroxyphthioceranic acids that are the major acyl constituents of cell wall lipids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 acyl carrier domain [H]

Homologues:

Organism=Homo sapiens, GI41872631, Length=871, Percent_Identity=29.2766934557979, Blast_Score=272, Evalue=2e-72,
Organism=Homo sapiens, GI8923559, Length=442, Percent_Identity=28.0542986425339, Blast_Score=121, Evalue=5e-27,
Organism=Homo sapiens, GI51243059, Length=248, Percent_Identity=33.0645161290323, Blast_Score=76, Evalue=3e-13,
Organism=Escherichia coli, GI1787337, Length=283, Percent_Identity=31.4487632508834, Blast_Score=113, Evalue=1e-25,
Organism=Escherichia coli, GI1787334, Length=291, Percent_Identity=30.9278350515464, Blast_Score=97, Evalue=6e-21,
Organism=Escherichia coli, GI1788663, Length=273, Percent_Identity=29.6703296703297, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17550940, Length=911, Percent_Identity=26.6739846322722, Blast_Score=293, Evalue=4e-79,
Organism=Caenorhabditis elegans, GI212642053, Length=870, Percent_Identity=27.816091954023, Blast_Score=278, Evalue=2e-74,
Organism=Caenorhabditis elegans, GI71983541, Length=282, Percent_Identity=29.4326241134752, Blast_Score=97, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI71983535, Length=273, Percent_Identity=29.6703296703297, Blast_Score=93, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71984332, Length=307, Percent_Identity=29.3159609120521, Blast_Score=83, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320904, Length=462, Percent_Identity=27.0562770562771, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI221330659, Length=872, Percent_Identity=27.8669724770642, Blast_Score=276, Evalue=1e-73,
Organism=Drosophila melanogaster, GI19920632, Length=872, Percent_Identity=27.8669724770642, Blast_Score=275, Evalue=2e-73,
Organism=Drosophila melanogaster, GI24581345, Length=867, Percent_Identity=28.1430219146482, Blast_Score=243, Evalue=5e-64,
Organism=Drosophila melanogaster, GI24644341, Length=277, Percent_Identity=31.4079422382672, Blast_Score=105, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001227
- InterPro:   IPR009081
- InterPro:   IPR014043
- InterPro:   IPR016035
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR000794
- InterPro:   IPR002198
- InterPro:   IPR011032
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016036
- InterPro:   IPR016040
- InterPro:   IPR006163
- InterPro:   IPR020842
- InterPro:   IPR020801
- InterPro:   IPR020807
- InterPro:   IPR020843
- InterPro:   IPR006162
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00698 Acyl_transf_1; PF08240 ADH_N; PF00106 adh_short; PF00107 ADH_zinc_N; PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C; PF00550 PP-binding [H]

EC number: 2.3.1.41 [C]

Molecular weight: Translated: 157274; Mature: 157274

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS50075 ACP_DOMAIN ; PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAPATPGDVPPNAVAVIGMAARLPGANSVSAFWDNLRRGEESIVTLSEEELLAAGISEQ
CCCCCCCCCCCCCCEEEEEHHHCCCCCCHHHHHHHHHHCCCHHEEEECHHHHHHCCCCHH
TLANPFYIRRAPIVDGIDEFDNDFFGFPPQMARMMDPQHRLFLQTAWHAMEDAGCDPAGF
HHCCCEEEEECCCCCCHHHHCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCC
DGSIGVYATSGSSIYLLHNLLTHHDPNTILGQGATFDLVNMSLLNDKDYLATRVSHQFNL
CCCEEEEEECCCEEEHHHHHHHCCCCCCEECCCCEEEEEEHHHHCCCHHHHHHHCCEEEC
RGPSVTVQTACSSSMVAIHTACQSLLNGESDIVLAGGVSLRVPHHVGYFHEPGSMVSGVG
CCCCEEEEECCCCCHHHHHHHHHHHHCCCCCEEEECCEEEECCHHCCCEECCCHHHCCCC
HCRPFDSRADGTVFGSGVAVVVLKPLATALEDGDRIHAVIRGSAINNDGSMKMTYAAPNG
CCCCCCCCCCCCEECCCEEEEEHHHHHHHHCCCCEEEEEEECCEECCCCCEEEEEECCCC
AAQADVIAEAHAVADVDPATINYVEAHGTGTPLGDPIEIDGLRRAFGVSDTPRPGPCAVG
CCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCEECCCHHHHHCCCCCCCCCCCCCC
SVKSNIGHLAEVSGIAGLIKTILSLQHKAIPATLHYTEPNPALDLDRGPFVIQSEYTPWE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCEEEECCCCCCC
WDGIRRAGVSSFGVGGTNVHLVVEEAPTRPVTAPLDGPKVLRLSARTEESLSALRTALAD
CCCHHHCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHH
ELADNDALDLDDVAFTLAGRRTDQVRMAAVVHDRADAAAVLRSPDSDDVFVGEGVDARDE
HHCCCCCCCHHHHHHHHCCCCCCHHEEHHHHHCCCHHHHHHCCCCCCCEEEECCCCCCCC
SDRVVFLFPGQGAQHADMARGLYDREPVFAAAFDECAAGFDAELGIDLKASVFGPTTPEL
CCCEEEEECCCCCCHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCC
ERTDLAQSSLFTVEYALGRLIESYGVTAGAYAGHSIGEYAAAALAGVFDLPTAVKVVAQR
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHH
ARLMHASPSGAMVAVGAGLEDIGDLLTADLDVAAINELGGCVISGSQEDVKTLQNELRRR
HHHHCCCCCCCEEEECCCHHHHHHHHHCCCCHHHHHHCCCEEEECCHHHHHHHHHHHHHH
RILARRVRTSHAFHSRLMDAVVPQFAEFLSGVKLNAPRIPLLSNVTGTWMTDAEATDPQF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEECCCCCCCHHH
WARQIRATVRFADELSTVLATPHRVLVEVGPGGTLTGAAVRHPRWSEDHRAVRLMRHQVQ
HHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHCCCCCCCHHHHHHHHHHHHH
TRDDHDTFLLALGQMWAAGVDLDWSRLSKDKPGLITLPGFQFARHRHWVEPNRNLEWSQG
CCCCCHHHHHHHHHHHHCCCCCCHHHHCCCCCCEEECCCHHHHHHCCCCCCCCCCCCCCC
VPSTDASRPVSEPAAAVAASTSGQSIEQRLQQIWCECLGVASIDPAENFFEIGGDSLIAI
CCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCEEEE
GVAMNATNKGLDLTPQDLYEYPTVSALAGALGARFSTGGLAEMPAADAINPPVPPAVAHF
EEEECCCCCCCCCCHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHH
LEYGIQDAGRWRVPLLLAIRPEVGVDDVRAVLTAVTNHHDALRVRIDARAGSWEQRITPA
HHHCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHCCCH
VEAVDPEILTLPAGTGHGTAREREAVLDLIADHLSADDLSVSPLRAAYILDADGTARFLA
HHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCEEHH
LSVHEMVVDSTSREILLTDIITAFGQRLAGQEVSLPPATTSWQAWSQRCAELTTHPAVLA
HHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHC
GREYWVETATKTTMHIADRHVADPPRSEHLVRMGTTLPAGQTEEVDRARRMYQYTLDELL
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHH
LAALSRTVGDTLGDGVLAVGVCGDARPVLKPELDPRRTVGAFATLYPLALACAGTQATPA
HHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHH
VEVLNAVHNTLDGVPHHGIGYGLLRFLYGPTARTLSPVPPPDILLCNEGVVPEVDLGDSP
HHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCC
IQLDADVASSLRDKIPGLGHPIELRVFRSSGELHLDWWYDTRRVPQETVEVFAARFPAAL
EEECHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHCCHHH
NDLVAESSASAGANAELADAIEELALVDLSAE
HHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNAPATPGDVPPNAVAVIGMAARLPGANSVSAFWDNLRRGEESIVTLSEEELLAAGISEQ
CCCCCCCCCCCCCCEEEEEHHHCCCCCCHHHHHHHHHHCCCHHEEEECHHHHHHCCCCHH
TLANPFYIRRAPIVDGIDEFDNDFFGFPPQMARMMDPQHRLFLQTAWHAMEDAGCDPAGF
HHCCCEEEEECCCCCCHHHHCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCC
DGSIGVYATSGSSIYLLHNLLTHHDPNTILGQGATFDLVNMSLLNDKDYLATRVSHQFNL
CCCEEEEEECCCEEEHHHHHHHCCCCCCEECCCCEEEEEEHHHHCCCHHHHHHHCCEEEC
RGPSVTVQTACSSSMVAIHTACQSLLNGESDIVLAGGVSLRVPHHVGYFHEPGSMVSGVG
CCCCEEEEECCCCCHHHHHHHHHHHHCCCCCEEEECCEEEECCHHCCCEECCCHHHCCCC
HCRPFDSRADGTVFGSGVAVVVLKPLATALEDGDRIHAVIRGSAINNDGSMKMTYAAPNG
CCCCCCCCCCCCEECCCEEEEEHHHHHHHHCCCCEEEEEEECCEECCCCCEEEEEECCCC
AAQADVIAEAHAVADVDPATINYVEAHGTGTPLGDPIEIDGLRRAFGVSDTPRPGPCAVG
CCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCEECCCHHHHHCCCCCCCCCCCCCC
SVKSNIGHLAEVSGIAGLIKTILSLQHKAIPATLHYTEPNPALDLDRGPFVIQSEYTPWE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCEEEECCCCCCC
WDGIRRAGVSSFGVGGTNVHLVVEEAPTRPVTAPLDGPKVLRLSARTEESLSALRTALAD
CCCHHHCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHH
ELADNDALDLDDVAFTLAGRRTDQVRMAAVVHDRADAAAVLRSPDSDDVFVGEGVDARDE
HHCCCCCCCHHHHHHHHCCCCCCHHEEHHHHHCCCHHHHHHCCCCCCCEEEECCCCCCCC
SDRVVFLFPGQGAQHADMARGLYDREPVFAAAFDECAAGFDAELGIDLKASVFGPTTPEL
CCCEEEEECCCCCCHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCC
ERTDLAQSSLFTVEYALGRLIESYGVTAGAYAGHSIGEYAAAALAGVFDLPTAVKVVAQR
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHH
ARLMHASPSGAMVAVGAGLEDIGDLLTADLDVAAINELGGCVISGSQEDVKTLQNELRRR
HHHHCCCCCCCEEEECCCHHHHHHHHHCCCCHHHHHHCCCEEEECCHHHHHHHHHHHHHH
RILARRVRTSHAFHSRLMDAVVPQFAEFLSGVKLNAPRIPLLSNVTGTWMTDAEATDPQF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEECCCCCCCHHH
WARQIRATVRFADELSTVLATPHRVLVEVGPGGTLTGAAVRHPRWSEDHRAVRLMRHQVQ
HHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHCCCCCCCHHHHHHHHHHHHH
TRDDHDTFLLALGQMWAAGVDLDWSRLSKDKPGLITLPGFQFARHRHWVEPNRNLEWSQG
CCCCCHHHHHHHHHHHHCCCCCCHHHHCCCCCCEEECCCHHHHHHCCCCCCCCCCCCCCC
VPSTDASRPVSEPAAAVAASTSGQSIEQRLQQIWCECLGVASIDPAENFFEIGGDSLIAI
CCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCEEEE
GVAMNATNKGLDLTPQDLYEYPTVSALAGALGARFSTGGLAEMPAADAINPPVPPAVAHF
EEEECCCCCCCCCCHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHH
LEYGIQDAGRWRVPLLLAIRPEVGVDDVRAVLTAVTNHHDALRVRIDARAGSWEQRITPA
HHHCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHCCCH
VEAVDPEILTLPAGTGHGTAREREAVLDLIADHLSADDLSVSPLRAAYILDADGTARFLA
HHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCEEHH
LSVHEMVVDSTSREILLTDIITAFGQRLAGQEVSLPPATTSWQAWSQRCAELTTHPAVLA
HHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHC
GREYWVETATKTTMHIADRHVADPPRSEHLVRMGTTLPAGQTEEVDRARRMYQYTLDELL
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHH
LAALSRTVGDTLGDGVLAVGVCGDARPVLKPELDPRRTVGAFATLYPLALACAGTQATPA
HHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHH
VEVLNAVHNTLDGVPHHGIGYGLLRFLYGPTARTLSPVPPPDILLCNEGVVPEVDLGDSP
HHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCC
IQLDADVASSLRDKIPGLGHPIELRVFRSSGELHLDWWYDTRRVPQETVEVFAARFPAAL
EEECHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHCCHHH
NDLVAESSASAGANAELADAIEELALVDLSAE
HHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: None [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.04 {acetyl-ACP}} 0.031 {acetyl-ACP}} 0.138 {cis-9-hexadecenoyl-ACP}} 0.017 {cis-9-hexadecenoyl-ACP}} 0.012 {cis-3-decenoyl-ACP}} [C]

Substrates: acetyl-ACP; malonyl-ACP; acyl-ACP [C]

Specific reaction: acetyl-ACP + malonyl-ACP = [acyl carrier protein] + acetoacetyl-ACP + CO2 acyl-ACP + malonyl-ACP = [acyl carrier protein] + beta-ketoacyl-ACP + CO2 [C]

General reaction: Acyl group transfer [C]

Inhibitor: Acetyl-CoA; Acyl-CoA; Iodoacetamide; N-Ethyl maleimide acyl -ACP-derivatives protect, malonyl-ACP-decarboxylation, Cerulenin [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]