| Definition | Mycobacterium sp. MCS chromosome, complete genome. |
|---|---|
| Accession | NC_008146 |
| Length | 5,705,448 |
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The map label for this gene is purK [H]
Identifier: 108798269
GI number: 108798269
Start: 1402796
End: 1403986
Strand: Direct
Name: purK [H]
Synonym: Mmcs_1298
Alternate gene names: 108798269
Gene position: 1402796-1403986 (Clockwise)
Preceding gene: 108798267
Following gene: 108798270
Centisome position: 24.59
GC content: 71.62
Gene sequence:
>1191_bases GTGGTGGCCATGATCGGCGGGGGTCAACTCGCCCGGATGACCCACCAGGCGGCGATCGCGCTGGGCCAGACTCTGCGGGT GCTCGCCACCGGCCCGCAGGAGCCGGCCGCCCAGGTGACCCCCGACGTGGTGATCGGATCGCATACCGACCTCGACGCGC TCCGGCGCGCGGCCGCCGGTGCGACCGTACTGACCTTCGACCACGAACACGTCCCCACCGAAGCACTCGAGACGCTGGTG GCCGAGGGGGTCAACGTGGCGCCGCCGCCGGCCGCGCTGGTGCACGCGCAGGACAAGCTGGTGATGCGCAGGCGACTCGA AGCGATGGGTGCGCCGATCCCGCGCTACACCGCCGTCGACACCGTCGACGACGTCGTGGCCTTCTCGTCCGAGGTCGATG GCCCGGTCGTGCTCAAGACGGTCCGCGGGGGATACGACGGCCGCGGCGTGGTGCTGACCGCCGACGCCGAGGAGGCGCGC GACGTGGCCGCCCGCTACCTCGCCGACGGTGTGCCGATCCTGGCCGAGGAGCGTGTCGACATGCGCCGCGAGCTCGCGGC CCTGGTGGCCCGGTCACCGTTCGGGCAGGGTGCGGCGTGGCCGGTGGTCGAGACCGTGCAGCGCGACGGCATCTGCGTCG TGGTGCTGGCCCCGGCGCCGGAGTTGTCCGACGACCTGGGCTCGAGCGCCCAGCAGCTGGGGTTGAAGCTGGCCGCCGAA CTCGGCGTGGTCGGGGTGCTCGCCGTCGAACTCTTCGAAACGGTCGACGGCCGGCTGCTGGTCAACGAATTGGCGATGCG GCCGCACAACTCCGGGCACTGGAGCATGGACGGCGCGGTCACCGGCCAGTTCGAACAGCACGTCCGCGCGGTGCTGGACT ATCCGCTCGGCGACACCTCGCTGCTCGCCCCGGCCACCGTGATGGCCAATGTCCTCGGGGCGCCGCAGACTCCGGCGATG ACGATGGACGAACGGGTGCACCACCTGTTCGCCCGCATGCCGGACGCCAAGGTGCACCTGTACGGCAAGGGGGAGCGGCC CGGCCGCAAGATCGGCCACGTCAACCTCACCGGTGACGATCCGGCGGTGTTGCGTGAGCGGGCCGAGCGGGCCGCGCACT GGTTGTCCCACGCCGAGTGGACCGACGGATGGGATCCGCACGCCGAAGTCAGGGAAGGAATCTCGAGGTGA
Upstream 100 bases:
>100_bases CGCTGCTTCGTTCCTGGTCAATGCGCCCCACCCGGGCCATGACACGATAGGCGGCGTGCCGAGCCATACTCCTTCCACCT CTTCGGCCTCTTCGCCACCG
Downstream 100 bases:
>100_bases ACGCACCCGCCCCGCGCGTCGGGGTCATCATGGGCAGCGACAGCGACTGGTCGGTGATGGCCGACGCCGCCGAAGCGCTC GCCGAGTTCGAGGTGGCCTT
Product: phosphoribosylaminoimidazole carboxylase ATPase subunit
Products: NA
Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]
Number of amino acids: Translated: 396; Mature: 396
Protein sequence:
>396_residues MVAMIGGGQLARMTHQAAIALGQTLRVLATGPQEPAAQVTPDVVIGSHTDLDALRRAAAGATVLTFDHEHVPTEALETLV AEGVNVAPPPAALVHAQDKLVMRRRLEAMGAPIPRYTAVDTVDDVVAFSSEVDGPVVLKTVRGGYDGRGVVLTADAEEAR DVAARYLADGVPILAEERVDMRRELAALVARSPFGQGAAWPVVETVQRDGICVVVLAPAPELSDDLGSSAQQLGLKLAAE LGVVGVLAVELFETVDGRLLVNELAMRPHNSGHWSMDGAVTGQFEQHVRAVLDYPLGDTSLLAPATVMANVLGAPQTPAM TMDERVHHLFARMPDAKVHLYGKGERPGRKIGHVNLTGDDPAVLRERAERAAHWLSHAEWTDGWDPHAEVREGISR
Sequences:
>Translated_396_residues MVAMIGGGQLARMTHQAAIALGQTLRVLATGPQEPAAQVTPDVVIGSHTDLDALRRAAAGATVLTFDHEHVPTEALETLV AEGVNVAPPPAALVHAQDKLVMRRRLEAMGAPIPRYTAVDTVDDVVAFSSEVDGPVVLKTVRGGYDGRGVVLTADAEEAR DVAARYLADGVPILAEERVDMRRELAALVARSPFGQGAAWPVVETVQRDGICVVVLAPAPELSDDLGSSAQQLGLKLAAE LGVVGVLAVELFETVDGRLLVNELAMRPHNSGHWSMDGAVTGQFEQHVRAVLDYPLGDTSLLAPATVMANVLGAPQTPAM TMDERVHHLFARMPDAKVHLYGKGERPGRKIGHVNLTGDDPAVLRERAERAAHWLSHAEWTDGWDPHAEVREGISR >Mature_396_residues MVAMIGGGQLARMTHQAAIALGQTLRVLATGPQEPAAQVTPDVVIGSHTDLDALRRAAAGATVLTFDHEHVPTEALETLV AEGVNVAPPPAALVHAQDKLVMRRRLEAMGAPIPRYTAVDTVDDVVAFSSEVDGPVVLKTVRGGYDGRGVVLTADAEEAR DVAARYLADGVPILAEERVDMRRELAALVARSPFGQGAAWPVVETVQRDGICVVVLAPAPELSDDLGSSAQQLGLKLAAE LGVVGVLAVELFETVDGRLLVNELAMRPHNSGHWSMDGAVTGQFEQHVRAVLDYPLGDTSLLAPATVMANVLGAPQTPAM TMDERVHHLFARMPDAKVHLYGKGERPGRKIGHVNLTGDDPAVLRERAERAAHWLSHAEWTDGWDPHAEVREGISR
Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]
COG id: COG0026
COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 ATP-grasp domain [H]
Homologues:
Organism=Escherichia coli, GI1786733, Length=372, Percent_Identity=29.5698924731183, Blast_Score=124, Evalue=1e-29, Organism=Escherichia coli, GI1788155, Length=386, Percent_Identity=25.6476683937824, Blast_Score=65, Evalue=1e-11, Organism=Saccharomyces cerevisiae, GI6324702, Length=381, Percent_Identity=33.0708661417323, Blast_Score=184, Evalue=1e-47,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR005875 - InterPro: IPR011761 - InterPro: IPR003135 - InterPro: IPR013815 - InterPro: IPR013816 - InterPro: IPR013817 - InterPro: IPR016185 - InterPro: IPR011054 [H]
Pfam domain/function: PF02222 ATP-grasp [H]
EC number: =6.3.4.18 [H]
Molecular weight: Translated: 42221; Mature: 42221
Theoretical pI: Translated: 5.14; Mature: 5.14
Prosite motif: PS50975 ATP_GRASP
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.3 %Cys (Translated Protein) 3.0 %Met (Translated Protein) 3.3 %Cys+Met (Translated Protein) 0.3 %Cys (Mature Protein) 3.0 %Met (Mature Protein) 3.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MVAMIGGGQLARMTHQAAIALGQTLRVLATGPQEPAAQVTPDVVIGSHTDLDALRRAAAG CEEEECCCHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCEEECCCCCHHHHHHHHCC ATVLTFDHEHVPTEALETLVAEGVNVAPPPAALVHAQDKLVMRRRLEAMGAPIPRYTAVD CEEEEECCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH TVDDVVAFSSEVDGPVVLKTVRGGYDGRGVVLTADAEEARDVAARYLADGVPILAEERVD HHHHHHHHHCCCCCCEEEEEECCCCCCCEEEEEECHHHHHHHHHHHHHCCCCCHHHHHHH MRRELAALVARSPFGQGAAWPVVETVQRDGICVVVLAPAPELSDDLGSSAQQLGLKLAAE HHHHHHHHHHCCCCCCCCCCHHHHHHCCCCEEEEEECCCCCCCHHHCCHHHHHHHHHHHH LGVVGVLAVELFETVDGRLLVNELAMRPHNSGHWSMDGAVTGQFEQHVRAVLDYPLGDTS HHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCEECCCCCCCHHHHHHHHHHCCCCCCCH LLAPATVMANVLGAPQTPAMTMDERVHHLFARMPDAKVHLYGKGERPGRKIGHVNLTGDD HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCEECEEEECCCC PAVLRERAERAAHWLSHAEWTDGWDPHAEVREGISR HHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCC >Mature Secondary Structure MVAMIGGGQLARMTHQAAIALGQTLRVLATGPQEPAAQVTPDVVIGSHTDLDALRRAAAG CEEEECCCHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCEEECCCCCHHHHHHHHCC ATVLTFDHEHVPTEALETLVAEGVNVAPPPAALVHAQDKLVMRRRLEAMGAPIPRYTAVD CEEEEECCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH TVDDVVAFSSEVDGPVVLKTVRGGYDGRGVVLTADAEEARDVAARYLADGVPILAEERVD HHHHHHHHHCCCCCCEEEEEECCCCCCCEEEEEECHHHHHHHHHHHHHCCCCCHHHHHHH MRRELAALVARSPFGQGAAWPVVETVQRDGICVVVLAPAPELSDDLGSSAQQLGLKLAAE HHHHHHHHHHCCCCCCCCCCHHHHHHCCCCEEEEEECCCCCCCHHHCCHHHHHHHHHHHH LGVVGVLAVELFETVDGRLLVNELAMRPHNSGHWSMDGAVTGQFEQHVRAVLDYPLGDTS HHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCEECCCCCCCHHHHHHHHHHCCCCCCCH LLAPATVMANVLGAPQTPAMTMDERVHHLFARMPDAKVHLYGKGERPGRKIGHVNLTGDD HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCEECEEEECCCC PAVLRERAERAAHWLSHAEWTDGWDPHAEVREGISR HHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 12788972 [H]