Click here to switch to the map view.

The map label for this gene is deoA [H]

Identifier: 108798203

GI number: 108798203

Start: 1330080

End: 1331426

Strand: Direct

Name: deoA [H]

Synonym: Mmcs_1232

Alternate gene names: 108798203

Gene position: 1330080-1331426 (Clockwise)

Preceding gene: 108798202

Following gene: 108798204

Centisome position: 23.31

GC content: 71.42

Gene sequence:

>1347_bases
GTGACGGACTTCACTTTCGACGCGCCCCGGCCGATGTCGCATCTCGATGCTCCGACCGTCATCCGGGTCAAACGCGACGG
CGGCGACCTGCCCGACGAGGCGATCGACTGGGTGATCGACGCGTACACCCGCGGGCAGGTGGCCGACGAGCAGATGTCGG
CCCTGCTGATGGCGATCTTCCTGCGCGGGATGACCGGCCCCGAGATCGCGCGCTGGACAGCGGCGATGGTGGCATCGGGG
CAGCGGTTCGACTTCACCGATCTGCGACGCGGCGGCCGTCCGCTGGCGCTGGTCGACAAACACTCCACCGGCGGGGTCGG
CGACAAGATCACCATCCCGCTGGTGCCTGTCGTGATGGCCTGCGGCGGCGCGGTGCCCCAGGCCGCCGGACGCGGGCTCG
GCCACACCGGCGGCACCCTCGACAAACTCGAAGCCATCCCCGGATTCACCGCCGAACTGACCAAAAGCCAGATCCGCCAA
CAACTCAGCGAGATCGGTGCGGCGATCTTCGCCGCGGGTGAGCTGGCCCCGGCCGACCGCAAGATCTATGCGCTGCGCGA
CGTCACCGCCACCACCGAATCGCTGCCGCTGATCGCCAGCTCGGTGATGAGCAAGAAGATCGCCGAGGGCGCCCGCGCGC
TGGTGCTCGACACGAAGGTCGGTTCGGGCGCCTTCCTGCCCACCGAGGCCGAGGCCCGCGAACTGGCCCGCACGATGGTC
GAGTTGGGTCACGCGCACGGTCTGGTGACGCGCGCCCTGCTGACCGACATGTCGGTGCCGCTGGGCCGCGCCGTCGGCAA
CGCGGTCGAGGTCGTCGAATCGCTGGAGGTGCTCGCCGGCGGCGGGCCCGACGACGTGGTGGAACTGACGCTGGCGTTGG
CGGCCGAGATGCTCGACGCCGCCGGGATCGACGGGACCGACCCCGCCGAGACGCTGCGCGACGGTACCGCCATGGACTGT
TTCCGCGCGCTCGTCGCGGCCCAGGGCGGCGACACCTCCCGATTGGCCGCCGACGCGTTGCCCATCGGTGTCCACACCGA
CACCGTCACGGCACCGCGCGGTGGCACCATGGGTGACATCGACGCGATGGCGGTGGGTCTGGCGGTGTGGCGGCTCGGAG
CGGGCCGCTCGGCGCCCGGTGAGCAGGTGCAGTTCGGCGCCGGTCTCCGCATCCACCGCCGTCCCGGTGAGCCGGTGAGT
GCGGGCGAGCCGCTGTTCACCCTCTACACCGACACCCCCGACCGGCTCGGGCCGGCCCGAGCCGAACTCGAGGGTGCCTG
GACGGTGGGGGACAGTGCCCCGCCGGCGCGTCCGCTGATCATCGACCGGATCACCGCGACAGGCTGA

Upstream 100 bases:

>100_bases
TGCTGATCGACCATCCGCACGGTCCGCGGCCGCTCGGGGAACTCCTGCCCGACGCGTTCGGACCCGACGATCTGGCGCGG
CGGGCGGCGGGGGAGAAGCC

Downstream 100 bases:

>100_bases
GAGGGTCCGGAGAGGGACCGTGAGGAGCATGTGCCGATGACGACACCGCTGACGCTGGAGAACATCAGCCAGGCGCCCAA
GGCGCTGCTGCACGATCACC

Product: thymidine phosphorylase

Products: NA

Alternate protein names: TdRPase [H]

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MTDFTFDAPRPMSHLDAPTVIRVKRDGGDLPDEAIDWVIDAYTRGQVADEQMSALLMAIFLRGMTGPEIARWTAAMVASG
QRFDFTDLRRGGRPLALVDKHSTGGVGDKITIPLVPVVMACGGAVPQAAGRGLGHTGGTLDKLEAIPGFTAELTKSQIRQ
QLSEIGAAIFAAGELAPADRKIYALRDVTATTESLPLIASSVMSKKIAEGARALVLDTKVGSGAFLPTEAEARELARTMV
ELGHAHGLVTRALLTDMSVPLGRAVGNAVEVVESLEVLAGGGPDDVVELTLALAAEMLDAAGIDGTDPAETLRDGTAMDC
FRALVAAQGGDTSRLAADALPIGVHTDTVTAPRGGTMGDIDAMAVGLAVWRLGAGRSAPGEQVQFGAGLRIHRRPGEPVS
AGEPLFTLYTDTPDRLGPARAELEGAWTVGDSAPPARPLIIDRITATG

Sequences:

>Translated_448_residues
MTDFTFDAPRPMSHLDAPTVIRVKRDGGDLPDEAIDWVIDAYTRGQVADEQMSALLMAIFLRGMTGPEIARWTAAMVASG
QRFDFTDLRRGGRPLALVDKHSTGGVGDKITIPLVPVVMACGGAVPQAAGRGLGHTGGTLDKLEAIPGFTAELTKSQIRQ
QLSEIGAAIFAAGELAPADRKIYALRDVTATTESLPLIASSVMSKKIAEGARALVLDTKVGSGAFLPTEAEARELARTMV
ELGHAHGLVTRALLTDMSVPLGRAVGNAVEVVESLEVLAGGGPDDVVELTLALAAEMLDAAGIDGTDPAETLRDGTAMDC
FRALVAAQGGDTSRLAADALPIGVHTDTVTAPRGGTMGDIDAMAVGLAVWRLGAGRSAPGEQVQFGAGLRIHRRPGEPVS
AGEPLFTLYTDTPDRLGPARAELEGAWTVGDSAPPARPLIIDRITATG
>Mature_447_residues
TDFTFDAPRPMSHLDAPTVIRVKRDGGDLPDEAIDWVIDAYTRGQVADEQMSALLMAIFLRGMTGPEIARWTAAMVASGQ
RFDFTDLRRGGRPLALVDKHSTGGVGDKITIPLVPVVMACGGAVPQAAGRGLGHTGGTLDKLEAIPGFTAELTKSQIRQQ
LSEIGAAIFAAGELAPADRKIYALRDVTATTESLPLIASSVMSKKIAEGARALVLDTKVGSGAFLPTEAEARELARTMVE
LGHAHGLVTRALLTDMSVPLGRAVGNAVEVVESLEVLAGGGPDDVVELTLALAAEMLDAAGIDGTDPAETLRDGTAMDCF
RALVAAQGGDTSRLAADALPIGVHTDTVTAPRGGTMGDIDAMAVGLAVWRLGAGRSAPGEQVQFGAGLRIHRRPGEPVSA
GEPLFTLYTDTPDRLGPARAELEGAWTVGDSAPPARPLIIDRITATG

Specific function: The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis [H]

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=438, Percent_Identity=41.7808219178082, Blast_Score=284, Evalue=1e-76,
Organism=Homo sapiens, GI4503445, Length=438, Percent_Identity=41.7808219178082, Blast_Score=284, Evalue=1e-76,
Organism=Homo sapiens, GI166158922, Length=438, Percent_Identity=41.7808219178082, Blast_Score=284, Evalue=1e-76,
Organism=Escherichia coli, GI1790842, Length=440, Percent_Identity=40.2272727272727, Blast_Score=281, Evalue=8e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.4 [H]

Molecular weight: Translated: 46574; Mature: 46442

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDFTFDAPRPMSHLDAPTVIRVKRDGGDLPDEAIDWVIDAYTRGQVADEQMSALLMAIF
CCCCCCCCCCCHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
LRGMTGPEIARWTAAMVASGQRFDFTDLRRGGRPLALVDKHSTGGVGDKITIPLVPVVMA
HHCCCCCHHHHHHHHHHHCCCCCCHHHHHCCCCCEEEEECCCCCCCCCEEEHHHHHHHHH
CGGAVPQAAGRGLGHTGGTLDKLEAIPGFTAELTKSQIRQQLSEIGAAIFAAGELAPADR
CCCCCCHHHCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
KIYALRDVTATTESLPLIASSVMSKKIAEGARALVLDTKVGSGAFLPTEAEARELARTMV
EEEEEECCHHCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHH
ELGHAHGLVTRALLTDMSVPLGRAVGNAVEVVESLEVLAGGGPDDVVELTLALAAEMLDA
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
AGIDGTDPAETLRDGTAMDCFRALVAAQGGDTSRLAADALPIGVHTDTVTAPRGGTMGDI
CCCCCCCHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHCCEECCCCCCEECCCCCCCCCH
DAMAVGLAVWRLGAGRSAPGEQVQFGAGLRIHRRPGEPVSAGEPLFTLYTDTPDRLGPAR
HHHHHHHHHHHHCCCCCCCCCCEEECCCEEEECCCCCCCCCCCCEEEEECCCCHHCCCHH
AELEGAWTVGDSAPPARPLIIDRITATG
HHCCCCEECCCCCCCCCCEEEEEEECCC
>Mature Secondary Structure 
TDFTFDAPRPMSHLDAPTVIRVKRDGGDLPDEAIDWVIDAYTRGQVADEQMSALLMAIF
CCCCCCCCCCHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
LRGMTGPEIARWTAAMVASGQRFDFTDLRRGGRPLALVDKHSTGGVGDKITIPLVPVVMA
HHCCCCCHHHHHHHHHHHCCCCCCHHHHHCCCCCEEEEECCCCCCCCCEEEHHHHHHHHH
CGGAVPQAAGRGLGHTGGTLDKLEAIPGFTAELTKSQIRQQLSEIGAAIFAAGELAPADR
CCCCCCHHHCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
KIYALRDVTATTESLPLIASSVMSKKIAEGARALVLDTKVGSGAFLPTEAEARELARTMV
EEEEEECCHHCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHH
ELGHAHGLVTRALLTDMSVPLGRAVGNAVEVVESLEVLAGGGPDDVVELTLALAAEMLDA
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
AGIDGTDPAETLRDGTAMDCFRALVAAQGGDTSRLAADALPIGVHTDTVTAPRGGTMGDI
CCCCCCCHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHCCEECCCCCCEECCCCCCCCCH
DAMAVGLAVWRLGAGRSAPGEQVQFGAGLRIHRRPGEPVSAGEPLFTLYTDTPDRLGPAR
HHHHHHHHHHHHCCCCCCCCCCEEECCCEEEECCCCCCCCCCCCEEEEECCCCHHCCCHH
AELEGAWTVGDSAPPARPLIIDRITATG
HHCCCCEECCCCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]