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The map label for this gene is guaB [C]

Identifier: 108798139

GI number: 108798139

Start: 1263799

End: 1264935

Strand: Direct

Name: guaB [C]

Synonym: Mmcs_1168

Alternate gene names: 108798139

Gene position: 1263799-1264935 (Clockwise)

Preceding gene: 108798138

Following gene: 108798141

Centisome position: 22.15

GC content: 71.15

Gene sequence:

>1137_bases
GTGCGAGACATGGTCGAAATCGGTATGGGCCGCACCGCCCGCCGCACCTACGAACTCCACGACATCAACATCGTGCCGTC
GCGCCGTACGCGCTCGTCGAAGGACGTGTCGACGGCGTGGCAGCTCGACGCCTACCGGTTCGAGATCCCGGTGGTGTCGC
ATCCGACCGACGCGCTGGTGTCGGTGGAGTTCGCGATCGAGCTCGGTCGCCTCGGCGGGCTCGGCGTGCTCAACGGCGAA
GGCCTGATCGGCAGGCACGCCGACGTCGAGGAGAAGATTCGGCAGGTCGTCGAGGCCGCCGACAAGGAGCCCGATCCGGC
GGCCGCGATCCGGCTGCTCCAACAACTGCACTCCGCACCGCTGGACCCGGACCTGCTCGGGGCGGCCGTGGCCCGCATCC
GGGAGGCGGGCGTGACGACGGCGGTGCGGGTGAGCCCGCAGAACGCCCAGGCGCTGACCCCTACGCTGGTGCAGGCGGGT
ATCGACCTGCTCGTCATCCAGGGCACGATCGTGTCCGCGGAGCGCGTCGCGAACGACGGCGAACCGCTCAACCTCAAGAC
GTTCATCTCCGAACTCGACATCCCCGTCGTCGCGGGCGGCGTGCTCGACCACCGCACCGCCCTGCACCTGATGCGCACCG
GCGCGGCCGGCGTGATCGTCGGCTACGGGTCGACCTCCGGTGTCACCACAAGCGACGAGGTGCTGGGCATCAGCGTGCCG
ATGGCCACCGCGATCGCCGACGCCGCCGCCGCGCGCCGCGAATACCTCGACGAGACCGGCGGGCGGTACGTGCACGTCCT
CGCCGACGGCGACATCCACACCTCGGGCGACCTGGCCAAGGCCATCGCCTGCGGCGCCGACGCGGTGGTGCTCGGCACAC
CGCTGGCGAGTGCGGCCGAGGCGTTGGGCGGTGGGTGGTTCTGGCCGGCCGCCGCCGCGCATCCGTCGCTGCCGCGCGGC
GCGCTGCTGCAGGTGGCGCTGGGGGAGCGGCCGTCACTCGAACAGGTGCTCACCGGGCCGTCGGACGATCCGTTCGGCTC
GCTCAATCTCGTTGGCGGCCTTAGGCGTTCGATGGCCAAGGCCGGCTACTGCGACCCCAAGGAATTCCAGAAGGTCGGCC
TGACGGTCGGCGCCTGA

Upstream 100 bases:

>100_bases
ATCACCGCGGCGGGGCTGAAGGAAAGCCACCCGCACGACATCACGATGACCGTCGAAGCGCCCAACTACTACGCCCGCTG
ACGGACTGGGATACAGCACT

Downstream 100 bases:

>100_bases
GGTTTCTCCGCGAGCAGACGCAGAATCGCGTTCCGCAGTGCCGTGGAACGCGATTCTGTGTCTACTCAGCCGGCCAGTCG
GGGCTGTGACAAGTGGTGTG

Product: inosine 5-monophosphate dehydrogenase

Products: xanthosine 5'-phosphate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 378; Mature: 378

Protein sequence:

>378_residues
MRDMVEIGMGRTARRTYELHDINIVPSRRTRSSKDVSTAWQLDAYRFEIPVVSHPTDALVSVEFAIELGRLGGLGVLNGE
GLIGRHADVEEKIRQVVEAADKEPDPAAAIRLLQQLHSAPLDPDLLGAAVARIREAGVTTAVRVSPQNAQALTPTLVQAG
IDLLVIQGTIVSAERVANDGEPLNLKTFISELDIPVVAGGVLDHRTALHLMRTGAAGVIVGYGSTSGVTTSDEVLGISVP
MATAIADAAAARREYLDETGGRYVHVLADGDIHTSGDLAKAIACGADAVVLGTPLASAAEALGGGWFWPAAAAHPSLPRG
ALLQVALGERPSLEQVLTGPSDDPFGSLNLVGGLRRSMAKAGYCDPKEFQKVGLTVGA

Sequences:

>Translated_378_residues
MRDMVEIGMGRTARRTYELHDINIVPSRRTRSSKDVSTAWQLDAYRFEIPVVSHPTDALVSVEFAIELGRLGGLGVLNGE
GLIGRHADVEEKIRQVVEAADKEPDPAAAIRLLQQLHSAPLDPDLLGAAVARIREAGVTTAVRVSPQNAQALTPTLVQAG
IDLLVIQGTIVSAERVANDGEPLNLKTFISELDIPVVAGGVLDHRTALHLMRTGAAGVIVGYGSTSGVTTSDEVLGISVP
MATAIADAAAARREYLDETGGRYVHVLADGDIHTSGDLAKAIACGADAVVLGTPLASAAEALGGGWFWPAAAAHPSLPRG
ALLQVALGERPSLEQVLTGPSDDPFGSLNLVGGLRRSMAKAGYCDPKEFQKVGLTVGA
>Mature_378_residues
MRDMVEIGMGRTARRTYELHDINIVPSRRTRSSKDVSTAWQLDAYRFEIPVVSHPTDALVSVEFAIELGRLGGLGVLNGE
GLIGRHADVEEKIRQVVEAADKEPDPAAAIRLLQQLHSAPLDPDLLGAAVARIREAGVTTAVRVSPQNAQALTPTLVQAG
IDLLVIQGTIVSAERVANDGEPLNLKTFISELDIPVVAGGVLDHRTALHLMRTGAAGVIVGYGSTSGVTTSDEVLGISVP
MATAIADAAAARREYLDETGGRYVHVLADGDIHTSGDLAKAIACGADAVVLGTPLASAAEALGGGWFWPAAAAHPSLPRG
ALLQVALGERPSLEQVLTGPSDDPFGSLNLVGGLRRSMAKAGYCDPKEFQKVGLTVGA

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IMPDH/GMPR family [H]

Homologues:

Organism=Caenorhabditis elegans, GI71994385, Length=219, Percent_Identity=28.7671232876712, Blast_Score=64, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24641071, Length=154, Percent_Identity=31.1688311688312, Blast_Score=65, Evalue=1e-10,
Organism=Drosophila melanogaster, GI24641073, Length=154, Percent_Identity=31.1688311688312, Blast_Score=65, Evalue=1e-10,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR001093
- InterPro:   IPR005992 [H]

Pfam domain/function: PF00478 IMPDH [H]

EC number: 1.1.1.205

Molecular weight: Translated: 39496; Mature: 39496

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDMVEIGMGRTARRTYELHDINIVPSRRTRSSKDVSTAWQLDAYRFEIPVVSHPTDALV
CCCHHHHCCCCCHHEEEEEEEEEECCCCCCCCCCCCCHHEEECEEEEEECEECCCCCHHE
SVEFAIELGRLGGLGVLNGEGLIGRHADVEEKIRQVVEAADKEPDPAAAIRLLQQLHSAP
EEEEEEEECCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCC
LDPDLLGAAVARIREAGVTTAVRVSPQNAQALTPTLVQAGIDLLVIQGTIVSAERVANDG
CCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHCCCCEEEEECEEEEHHHHCCCC
EPLNLKTFISELDIPVVAGGVLDHRTALHLMRTGAAGVIVGYGSTSGVTTSDEVLGISVP
CCCCHHHHHHHCCCCEEECCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEEEECH
MATAIADAAAARREYLDETGGRYVHVLADGDIHTSGDLAKAIACGADAVVLGTPLASAAE
HHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHCCCCEEEEECCHHHHHH
ALGGGWFWPAAAAHPSLPRGALLQVALGERPSLEQVLTGPSDDPFGSLNLVGGLRRSMAK
HHCCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHH
AGYCDPKEFQKVGLTVGA
CCCCCHHHHHHHCCEECC
>Mature Secondary Structure
MRDMVEIGMGRTARRTYELHDINIVPSRRTRSSKDVSTAWQLDAYRFEIPVVSHPTDALV
CCCHHHHCCCCCHHEEEEEEEEEECCCCCCCCCCCCCHHEEECEEEEEECEECCCCCHHE
SVEFAIELGRLGGLGVLNGEGLIGRHADVEEKIRQVVEAADKEPDPAAAIRLLQQLHSAP
EEEEEEEECCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCC
LDPDLLGAAVARIREAGVTTAVRVSPQNAQALTPTLVQAGIDLLVIQGTIVSAERVANDG
CCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHCCCCEEEEECEEEEHHHHCCCC
EPLNLKTFISELDIPVVAGGVLDHRTALHLMRTGAAGVIVGYGSTSGVTTSDEVLGISVP
CCCCHHHHHHHCCCCEEECCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEEEECH
MATAIADAAAARREYLDETGGRYVHVLADGDIHTSGDLAKAIACGADAVVLGTPLASAAE
HHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHCCCCEEEEECCHHHHHH
ALGGGWFWPAAAAHPSLPRGALLQVALGERPSLEQVLTGPSDDPFGSLNLVGGLRRSMAK
HHCCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHH
AGYCDPKEFQKVGLTVGA
CCCCCHHHHHHHCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NAD+ [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: inosine 5'-phosphate; NAD+; H2O

Specific reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA