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The map label for this gene is guaB [H]

Identifier: 108798138

GI number: 108798138

Start: 1262226

End: 1263779

Strand: Direct

Name: guaB [H]

Synonym: Mmcs_1167

Alternate gene names: 108798138

Gene position: 1262226-1263779 (Clockwise)

Preceding gene: 108798136

Following gene: 108798139

Centisome position: 22.12

GC content: 69.69

Gene sequence:

>1554_bases
ATGTCGATCGCTGAACGCAGCGTTCCCATCGCCGTACCGGTGCCGACCGGCGGCGACGATCCGACGAAGGTGGCCATGCT
CGGGCTGACCTTCGACGACGTCCTGCTGCTGCCCGCCGCCTCCGACGTCATACCCGCGACGGCCGACACCTCGAGCCAGC
TGACCAAGCGCATCCGGCTGCGGGTGCCGCTGGTCAGCTCGGCGATGGACACGGTCACCGAATCCCGGATGGCCATCGCG
ATGGCCCGGGCCGGCGGCATGGGTGTGCTGCACCGCAACCTGCCCGTGGCCGAACAGGCCGGTCAGGTCGAAACCGTCAA
ACGGTCCGAGGCCGGGATGGTCACCGACCCGGTGACCTGCTCACCGGACAACACGCTGGCCGAAGTCGACGCGATGTGCG
CGCGGTTCCGCATCTCCGGGCTGCCGGTCGTGGATGAGCGCGGCTCCCTCGTCGGCATCATCACCAACCGCGACATGCGC
TTCGAGGTCGACCAGTCCAAACCGGTCTCCGAGGTGATGACCAAGGCGCCCTTGATCACGGCGCAGGAAGGTGTGTCGGC
CGAGGCCGCGCTCGGCCTGCTGCGCCGGCACAAGATCGAGAAGCTGCCGATCGTCGACGGGCACGGCAAGCTCACCGGGC
TGATCACCGTCAAGGACTTCGTCAAGACCGAACAGTTCCCGCTGGCGACCAAGGATTCCGACGGCAGGCTGCTCGTCGGC
GCCGCGGTCGGCGTCGGCGACGACGCGTGGAACCGCGCGATGACGCTGGCCGACGCCGGCGTCGACGTGCTGATCGTCGA
CACCGCCCACGCCCACAACCGGTCGGTGCTCGAGATGGTGCACCGCATCAAGACCGTGCTCGGTGACCGCGTCGAGGTCG
TCGGCGGCAACGTCGCCACCCGCGCCGGGGCCGCCGCACTCGTCGAAGCCGGCGCGGACGCGGTGAAGGTCGGTGTCGGC
CCGGGGTCGATCTGCACCACGCGGGTCGTCGCGGGCGTCGGGGCGCCACAGATCACCGCGATCCTCGAATCGGTCGCCGC
GTGCGCCCCGGCCGGTGTGCCGGTGATCGCCGACGGCGGCCTGCAGTACTCGGGGGACATCGCCAAGGCGCTGGCCGCGG
GCGCGTCGACGGCCATGCTGGGTTCGCTGCTCGCGGGCACCGCAGAGGCGCCGGGCGAGCTGATCTTCGTCAACGGCAAG
CAGTTCAAGAGCTACCGCGGCATGGGATCGCTCGGTGCGATGCAGGGCCGCGGCGCGACAGGCAACCTCCGGGGCTCCTT
CTCGAAGGACCGCTACTTCCAGGACGACGTGCTCTCCGAGGACAAGCTGGTACCCGAGGGCATCGAGGGCCGGGTGCCGT
TCCGCGGTCCGCTGGCGCAGGTGATCCACCAGCTCACCGGCGGTCTGCGCGCGGCCATGGGTTACACCGGTTCACCCTCC
ATCGAGGCGTTGCAGCAGGCGCAATTCGTGCAGATCACCGCGGCGGGGCTGAAGGAAAGCCACCCGCACGACATCACGAT
GACCGTCGAAGCGCCCAACTACTACGCCCGCTGA

Upstream 100 bases:

>100_bases
AGCCGTCGCCGGTGTGGCGACGTGGTGTGCGGGGCCGAGCGACCACGGCCGCAACCGATAGGATTGTGTATCCGCCCAAG
TACCTATGGAGGGCCCGCCC

Downstream 100 bases:

>100_bases
CGGACTGGGATACAGCACTGTGCGAGACATGGTCGAAATCGGTATGGGCCGCACCGCCCGCCGCACCTACGAACTCCACG
ACATCAACATCGTGCCGTCG

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 517; Mature: 516

Protein sequence:

>517_residues
MSIAERSVPIAVPVPTGGDDPTKVAMLGLTFDDVLLLPAASDVIPATADTSSQLTKRIRLRVPLVSSAMDTVTESRMAIA
MARAGGMGVLHRNLPVAEQAGQVETVKRSEAGMVTDPVTCSPDNTLAEVDAMCARFRISGLPVVDERGSLVGIITNRDMR
FEVDQSKPVSEVMTKAPLITAQEGVSAEAALGLLRRHKIEKLPIVDGHGKLTGLITVKDFVKTEQFPLATKDSDGRLLVG
AAVGVGDDAWNRAMTLADAGVDVLIVDTAHAHNRSVLEMVHRIKTVLGDRVEVVGGNVATRAGAAALVEAGADAVKVGVG
PGSICTTRVVAGVGAPQITAILESVAACAPAGVPVIADGGLQYSGDIAKALAAGASTAMLGSLLAGTAEAPGELIFVNGK
QFKSYRGMGSLGAMQGRGATGNLRGSFSKDRYFQDDVLSEDKLVPEGIEGRVPFRGPLAQVIHQLTGGLRAAMGYTGSPS
IEALQQAQFVQITAAGLKESHPHDITMTVEAPNYYAR

Sequences:

>Translated_517_residues
MSIAERSVPIAVPVPTGGDDPTKVAMLGLTFDDVLLLPAASDVIPATADTSSQLTKRIRLRVPLVSSAMDTVTESRMAIA
MARAGGMGVLHRNLPVAEQAGQVETVKRSEAGMVTDPVTCSPDNTLAEVDAMCARFRISGLPVVDERGSLVGIITNRDMR
FEVDQSKPVSEVMTKAPLITAQEGVSAEAALGLLRRHKIEKLPIVDGHGKLTGLITVKDFVKTEQFPLATKDSDGRLLVG
AAVGVGDDAWNRAMTLADAGVDVLIVDTAHAHNRSVLEMVHRIKTVLGDRVEVVGGNVATRAGAAALVEAGADAVKVGVG
PGSICTTRVVAGVGAPQITAILESVAACAPAGVPVIADGGLQYSGDIAKALAAGASTAMLGSLLAGTAEAPGELIFVNGK
QFKSYRGMGSLGAMQGRGATGNLRGSFSKDRYFQDDVLSEDKLVPEGIEGRVPFRGPLAQVIHQLTGGLRAAMGYTGSPS
IEALQQAQFVQITAAGLKESHPHDITMTVEAPNYYAR
>Mature_516_residues
SIAERSVPIAVPVPTGGDDPTKVAMLGLTFDDVLLLPAASDVIPATADTSSQLTKRIRLRVPLVSSAMDTVTESRMAIAM
ARAGGMGVLHRNLPVAEQAGQVETVKRSEAGMVTDPVTCSPDNTLAEVDAMCARFRISGLPVVDERGSLVGIITNRDMRF
EVDQSKPVSEVMTKAPLITAQEGVSAEAALGLLRRHKIEKLPIVDGHGKLTGLITVKDFVKTEQFPLATKDSDGRLLVGA
AVGVGDDAWNRAMTLADAGVDVLIVDTAHAHNRSVLEMVHRIKTVLGDRVEVVGGNVATRAGAAALVEAGADAVKVGVGP
GSICTTRVVAGVGAPQITAILESVAACAPAGVPVIADGGLQYSGDIAKALAAGASTAMLGSLLAGTAEAPGELIFVNGKQ
FKSYRGMGSLGAMQGRGATGNLRGSFSKDRYFQDDVLSEDKLVPEGIEGRVPFRGPLAQVIHQLTGGLRAAMGYTGSPSI
EALQQAQFVQITAAGLKESHPHDITMTVEAPNYYAR

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=470, Percent_Identity=42.3404255319149, Blast_Score=336, Evalue=2e-92,
Organism=Homo sapiens, GI156616279, Length=470, Percent_Identity=42.3404255319149, Blast_Score=335, Evalue=7e-92,
Organism=Homo sapiens, GI34328930, Length=470, Percent_Identity=42.3404255319149, Blast_Score=335, Evalue=7e-92,
Organism=Homo sapiens, GI34328928, Length=470, Percent_Identity=42.3404255319149, Blast_Score=335, Evalue=8e-92,
Organism=Homo sapiens, GI66933016, Length=461, Percent_Identity=42.9501084598698, Blast_Score=329, Evalue=3e-90,
Organism=Homo sapiens, GI217035152, Length=465, Percent_Identity=42.1505376344086, Blast_Score=327, Evalue=2e-89,
Organism=Homo sapiens, GI217035148, Length=470, Percent_Identity=41.7021276595745, Blast_Score=325, Evalue=4e-89,
Organism=Homo sapiens, GI217035150, Length=470, Percent_Identity=40.2127659574468, Blast_Score=305, Evalue=1e-82,
Organism=Homo sapiens, GI50541956, Length=278, Percent_Identity=32.0143884892086, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI50541954, Length=277, Percent_Identity=32.129963898917, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI50541952, Length=277, Percent_Identity=32.129963898917, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI50541948, Length=277, Percent_Identity=32.129963898917, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI156104880, Length=270, Percent_Identity=31.1111111111111, Blast_Score=132, Evalue=8e-31,
Organism=Escherichia coli, GI1788855, Length=494, Percent_Identity=53.8461538461538, Blast_Score=464, Evalue=1e-132,
Organism=Escherichia coli, GI1786293, Length=285, Percent_Identity=29.8245614035088, Blast_Score=132, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI71994385, Length=482, Percent_Identity=35.0622406639004, Blast_Score=268, Evalue=7e-72,
Organism=Caenorhabditis elegans, GI71994389, Length=434, Percent_Identity=36.6359447004608, Blast_Score=261, Evalue=6e-70,
Organism=Caenorhabditis elegans, GI17560440, Length=269, Percent_Identity=33.8289962825279, Blast_Score=149, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6323585, Length=463, Percent_Identity=41.9006479481641, Blast_Score=342, Evalue=7e-95,
Organism=Saccharomyces cerevisiae, GI6323464, Length=463, Percent_Identity=41.2526997840173, Blast_Score=329, Evalue=7e-91,
Organism=Saccharomyces cerevisiae, GI6322012, Length=488, Percent_Identity=38.7295081967213, Blast_Score=326, Evalue=5e-90,
Organism=Saccharomyces cerevisiae, GI6319352, Length=339, Percent_Identity=38.3480825958702, Blast_Score=238, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6319353, Length=120, Percent_Identity=42.5, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24641071, Length=487, Percent_Identity=40.6570841889117, Blast_Score=330, Evalue=1e-90,
Organism=Drosophila melanogaster, GI24641073, Length=487, Percent_Identity=40.6570841889117, Blast_Score=330, Evalue=1e-90,
Organism=Drosophila melanogaster, GI28571163, Length=448, Percent_Identity=39.5089285714286, Blast_Score=290, Evalue=1e-78,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 53707; Mature: 53576

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIAERSVPIAVPVPTGGDDPTKVAMLGLTFDDVLLLPAASDVIPATADTSSQLTKRIRL
CCCCCCCCCEEEECCCCCCCCCEEEEEECCHHHEEEECCCCCCCCCCCCCHHHHHHHHEE
RVPLVSSAMDTVTESRMAIAMARAGGMGVLHRNLPVAEQAGQVETVKRSEAGMVTDPVTC
ECCHHHHHHHHHHHHHHHEEECCCCCCEEEECCCCCHHHCCCHHHHHHCCCCCEECCEEC
SPDNTLAEVDAMCARFRISGLPVVDERGSLVGIITNRDMRFEVDQSKPVSEVMTKAPLIT
CCCCHHHHHHHHHHHHEECCCCEECCCCCEEEEEECCCEEEEECCCCCHHHHHHHCCCEE
AQEGVSAEAALGLLRRHKIEKLPIVDGHGKLTGLITVKDFVKTEQFPLATKDSDGRLLVG
ECCCCCHHHHHHHHHHHHHCCCCEECCCCCEEEEEEEHHHHCCCCCCCEECCCCCCEEEE
AAVGVGDDAWNRAMTLADAGVDVLIVDTAHAHNRSVLEMVHRIKTVLGDRVEVVGGNVAT
EEECCCCHHHHHEEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEECCCHHH
RAGAAALVEAGADAVKVGVGPGSICTTRVVAGVGAPQITAILESVAACAPAGVPVIADGG
HHCHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEECCC
LQYSGDIAKALAAGASTAMLGSLLAGTAEAPGELIFVNGKQFKSYRGMGSLGAMQGRGAT
CEECCHHHHHHHCCCHHHHHHHHHHCCCCCCCCEEEEECHHHHHHCCCCCCCCCCCCCCC
GNLRGSFSKDRYFQDDVLSEDKLVPEGIEGRVPFRGPLAQVIHQLTGGLRAAMGYTGSPS
CCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHCCCCCCCH
IEALQQAQFVQITAAGLKESHPHDITMTVEAPNYYAR
HHHHHHHHEEEEEECCCCCCCCCCEEEEEECCCCCCC
>Mature Secondary Structure 
SIAERSVPIAVPVPTGGDDPTKVAMLGLTFDDVLLLPAASDVIPATADTSSQLTKRIRL
CCCCCCCCEEEECCCCCCCCCEEEEEECCHHHEEEECCCCCCCCCCCCCHHHHHHHHEE
RVPLVSSAMDTVTESRMAIAMARAGGMGVLHRNLPVAEQAGQVETVKRSEAGMVTDPVTC
ECCHHHHHHHHHHHHHHHEEECCCCCCEEEECCCCCHHHCCCHHHHHHCCCCCEECCEEC
SPDNTLAEVDAMCARFRISGLPVVDERGSLVGIITNRDMRFEVDQSKPVSEVMTKAPLIT
CCCCHHHHHHHHHHHHEECCCCEECCCCCEEEEEECCCEEEEECCCCCHHHHHHHCCCEE
AQEGVSAEAALGLLRRHKIEKLPIVDGHGKLTGLITVKDFVKTEQFPLATKDSDGRLLVG
ECCCCCHHHHHHHHHHHHHCCCCEECCCCCEEEEEEEHHHHCCCCCCCEECCCCCCEEEE
AAVGVGDDAWNRAMTLADAGVDVLIVDTAHAHNRSVLEMVHRIKTVLGDRVEVVGGNVAT
EEECCCCHHHHHEEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEECCCHHH
RAGAAALVEAGADAVKVGVGPGSICTTRVVAGVGAPQITAILESVAACAPAGVPVIADGG
HHCHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEECCC
LQYSGDIAKALAAGASTAMLGSLLAGTAEAPGELIFVNGKQFKSYRGMGSLGAMQGRGAT
CEECCHHHHHHHCCCHHHHHHHHHHCCCCCCCCEEEEECHHHHHHCCCCCCCCCCCCCCC
GNLRGSFSKDRYFQDDVLSEDKLVPEGIEGRVPFRGPLAQVIHQLTGGLRAAMGYTGSPS
CCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHCCCCCCCH
IEALQQAQFVQITAAGLKESHPHDITMTVEAPNYYAR
HHHHHHHHEEEEEECCCCCCCCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]