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The map label for this gene is xapA [C]

Identifier: 108797683

GI number: 108797683

Start: 754663

End: 755439

Strand: Direct

Name: xapA [C]

Synonym: Mmcs_0703

Alternate gene names: 108797683

Gene position: 754663-755439 (Clockwise)

Preceding gene: 108797681

Following gene: 108797684

Centisome position: 13.23

GC content: 68.34

Gene sequence:

>777_bases
ATGCTGGGAGTCATCGGCGGCAGCGGTTTCTACTCGTTCTTCGGACCCGATGCGCGCAGCGTCAGGCTCGACACCCCCTT
CGGCGCCCCGAGCGCGGCGATCACGGTCGGCACCGTCGGTGACCACGAGGTCGCGTTCCTGCCCCGGCACGGCGTCGACC
ACGAGTTCTCCCCGCACACCGTGCCGTACCGGGCCAACATGTGGGCGCTGCGCGCGCTCGGCGTGCGGCGGATCTTCGGG
CCGTGCGCGGTCGGCAGCCTCACCCCCGACCTGGGCCCGGGCTCGATGGTGGTGCCCGACCAACTCGTCGACCGCACCAG
CGGACGCGACGACACCTATTTCGACTCCGGCGGCATCCACGTCGACTTCGCCGATCCGTACTGCCCGACGCTGCGCGCGG
CGGCCGCCGGCCTGCCCGGGGTCGTCGACGGGGGCACCATGGTGGTGATCCAGGGACCGCGGTTCTCCACCCGCGCGGAG
AGCAAATGGTTCGCGAGCCAGGGTTTCTCGCTGGTCAACATGACCGGGTATCCCGAGGCGGTGCTGGCGAGGGAACTCGA
GATGTGTTATGCCGCAATAGCTTTGGTGACCGACCTGGACGCGGGCATCGACAGCGAAACGGCGGTCCGGGCTGTCAACG
TGTTCGCCGAGTTCCAGCGAAACCTCGTACCGTTCAAGAAGGTGGTGCACGAGGCGATCGATCAGGTCGCCGTCGAGCGG
ACGTGTGACCACTGCCTACCGCACGACGGTGTGACGCTGCCGATCGAGTTGCCGTGA

Upstream 100 bases:

>100_bases
GTTGCCACGACCGCAATCGTCGCACGGCCGGTCCGTCCGCCCTGCGCGGTGCGCGATGGTCGAGAATGGTCCCATGCCCG
CGCACGTGAGGAGCATCTGA

Downstream 100 bases:

>100_bases
GGGTGCTGCTGACCGGGGCCGCCGGATTCATCGGCTCGCGGGTGCGCGCGGCGCTGGAATCGGCGGGCCACGAGGTCGTC
GCCGTCGACGTGATGCTGCC

Product: 5'-methylthioadenosine phosphorylase

Products: ribose-1-phosphate; xanthine [C]

Alternate protein names: NA

Number of amino acids: Translated: 258; Mature: 258

Protein sequence:

>258_residues
MLGVIGGSGFYSFFGPDARSVRLDTPFGAPSAAITVGTVGDHEVAFLPRHGVDHEFSPHTVPYRANMWALRALGVRRIFG
PCAVGSLTPDLGPGSMVVPDQLVDRTSGRDDTYFDSGGIHVDFADPYCPTLRAAAAGLPGVVDGGTMVVIQGPRFSTRAE
SKWFASQGFSLVNMTGYPEAVLARELEMCYAAIALVTDLDAGIDSETAVRAVNVFAEFQRNLVPFKKVVHEAIDQVAVER
TCDHCLPHDGVTLPIELP

Sequences:

>Translated_258_residues
MLGVIGGSGFYSFFGPDARSVRLDTPFGAPSAAITVGTVGDHEVAFLPRHGVDHEFSPHTVPYRANMWALRALGVRRIFG
PCAVGSLTPDLGPGSMVVPDQLVDRTSGRDDTYFDSGGIHVDFADPYCPTLRAAAAGLPGVVDGGTMVVIQGPRFSTRAE
SKWFASQGFSLVNMTGYPEAVLARELEMCYAAIALVTDLDAGIDSETAVRAVNVFAEFQRNLVPFKKVVHEAIDQVAVER
TCDHCLPHDGVTLPIELP
>Mature_258_residues
MLGVIGGSGFYSFFGPDARSVRLDTPFGAPSAAITVGTVGDHEVAFLPRHGVDHEFSPHTVPYRANMWALRALGVRRIFG
PCAVGSLTPDLGPGSMVVPDQLVDRTSGRDDTYFDSGGIHVDFADPYCPTLRAAAAGLPGVVDGGTMVVIQGPRFSTRAE
SKWFASQGFSLVNMTGYPEAVLARELEMCYAAIALVTDLDAGIDSETAVRAVNVFAEFQRNLVPFKKVVHEAIDQVAVER
TCDHCLPHDGVTLPIELP

Specific function: The Nucleoside Phosphorylases Catalyze The Phosphorolytic Breakdown Of The N-Glycosidic Bond In The Nucleoside Molecule, With The Formation Of The Corresponding Free Bases And Pentose-1-Phosphate. This Protein Can Degrade All Purine Nucleosides Except Ade

COG id: COG0005

COG function: function code F; Purine nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/MTAP phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI47132622, Length=248, Percent_Identity=37.9032258064516, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI71980569, Length=247, Percent_Identity=39.6761133603239, Blast_Score=155, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6323045, Length=243, Percent_Identity=37.037037037037, Blast_Score=149, Evalue=3e-37,
Organism=Drosophila melanogaster, GI20130079, Length=250, Percent_Identity=36.4, Blast_Score=154, Evalue=6e-38,
Organism=Drosophila melanogaster, GI221459247, Length=251, Percent_Identity=31.4741035856574, Blast_Score=130, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010044
- InterPro:   IPR000845
- InterPro:   IPR001369
- InterPro:   IPR018099 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: 2.4.2.- [C]

Molecular weight: Translated: 27592; Mature: 27592

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGVIGGSGFYSFFGPDARSVRLDTPFGAPSAAITVGTVGDHEVAFLPRHGVDHEFSPHT
CEEEECCCCCCCEECCCCCEEEEECCCCCCCCEEEEECCCCCEEEEECCCCCCCCCCCCC
VPYRANMWALRALGVRRIFGPCAVGSLTPDLGPGSMVVPDQLVDRTSGRDDTYFDSGGIH
CCEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEECCHHHHHHCCCCCCCEECCCCEE
VDFADPYCPTLRAAAAGLPGVVDGGTMVVIQGPRFSTRAESKWFASQGFSLVNMTGYPEA
EEECCCCCHHHHHHHCCCCCEECCCEEEEEECCCCCCCCCCHHHHHCCCEEEEECCCCHH
VLARELEMCYAAIALVTDLDAGIDSETAVRAVNVFAEFQRNLVPFKKVVHEAIDQVAVER
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
TCDHCLPHDGVTLPIELP
HHHHCCCCCCEEEEEECC
>Mature Secondary Structure
MLGVIGGSGFYSFFGPDARSVRLDTPFGAPSAAITVGTVGDHEVAFLPRHGVDHEFSPHT
CEEEECCCCCCCEECCCCCEEEEECCCCCCCCEEEEECCCCCEEEEECCCCCCCCCCCCC
VPYRANMWALRALGVRRIFGPCAVGSLTPDLGPGSMVVPDQLVDRTSGRDDTYFDSGGIH
CCEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEECCHHHHHHCCCCCCCEECCCCEE
VDFADPYCPTLRAAAAGLPGVVDGGTMVVIQGPRFSTRAESKWFASQGFSLVNMTGYPEA
EEECCCCCHHHHHHHCCCCCEECCCEEEEEECCCCCCCCCCHHHHHCCCEEEEECCCCHH
VLARELEMCYAAIALVTDLDAGIDSETAVRAVNVFAEFQRNLVPFKKVVHEAIDQVAVER
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
TCDHCLPHDGVTLPIELP
HHHHCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: xanthosine; phosphate [C]

Specific reaction: xanthosine + phosphate = ribose-1-phosphate + xanthine [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]