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The map label for this gene is fgd1 [H]

Identifier: 108797512

GI number: 108797512

Start: 586437

End: 587447

Strand: Direct

Name: fgd1 [H]

Synonym: Mmcs_0532

Alternate gene names: 108797512

Gene position: 586437-587447 (Clockwise)

Preceding gene: 108797510

Following gene: 108797517

Centisome position: 10.28

GC content: 65.97

Gene sequence:

>1011_bases
ATGGCTGAACTCAAACTCGGATACAAGGCGTCGGCGGAGCAGTTCGCGCCGCGGGAACTGGTCGAACTCGCGGTGGCGGC
CGAAGAGCACGGTATGGACAGTGCGACGGTCAGCGACCACTTCCAGCCGTGGCGCCACGAGGGCGGACATGCGCCGTTCT
CGCTGGCGTGGATGACCGCGGTGGGGGAGCGGACCAAGCGGTTGCAGTTGGGCACCTCGGTGCTCACACCGACGTTCCGC
TACAACCCGGCGGTGATCGCGCAGGCGTTCGCGACGATGGCCTGTCTGTATCCGGACCGGATCTTCCTCGGTGTCGGCAC
CGGTGAGGCGCTCAACGAGATCGCGACCGGTTACGAGGGCGACTGGCCGGACTTCAAGGAGCGGTTCGCGCGGCTGCGCG
AGTCGGTGCGGTTGATGCGTGAGTTGTGGCTCGGCGACCGCGTCGACTTCGACGGCGAGTACTACCGCACCAAGGGTGCG
TCGATCTACGACGTCCCCGAAGGCGGCGTCCCGGTGTACATCGCCGCGGGCGGGCCGGTGGTGGCGAAGTACGCCGGGCG
CGCGGGGGACGGTTTCATCTGCACCTCCGGTAAGGGCGAGGAGCTGTACAAGGACAAGCTGCTGCCCGCGGTGGCCGAGG
GCGCCGATGCGGCCGGGAAGAACGTCGACGATGTCGACAAGATGATCGAGATCAAGATCTCCTACGACACGGATCCCGAA
CTGGCGCTGGAGAATACGCGATTCTGGGCGCCGCTGTCGTTGACCGCCGAACAGAAGCACAGCATCGACGACCCGATCGA
GATGGAGAAGGCCGCCGACGAGTTGCCGATCGAGCAGGTCGCCAAACGGTGGATCGTCGCCTCGGATCCGGACGAGGCCG
TCGAGAAGGTCAAGGACTACGTCGGGTGGGGCCTGAACCACCTGGTGTTCCACGCACCCGGCCACGACCAGCGTCGGTTC
CTCGAGCTCTTCAAACGGGATCTGGAGCCACGACTGCGCAAGCTGGGCTGA

Upstream 100 bases:

>100_bases
GGACCCGGTCGGTGACGGCCGTCAGGGCTGCTGCCATGCCGCGAGTGTAGGCAGGTGGAGTAGAAACGAGTCGTGCGCAC
GCGAGGAGCAGGGAGACACC

Downstream 100 bases:

>100_bases
GGCTCACCCCGCCGTCGGCGGCGCAGGCCGGCCGGTCACCCGGTAGACGCGGAAACGTTCGTCGCCGGTCGCGCCGTACA
CCGAGTGCACGAGCGTGCCC

Product: luciferase-like protein

Products: NA

Alternate protein names: F420_G6P_DH [H]

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MAELKLGYKASAEQFAPRELVELAVAAEEHGMDSATVSDHFQPWRHEGGHAPFSLAWMTAVGERTKRLQLGTSVLTPTFR
YNPAVIAQAFATMACLYPDRIFLGVGTGEALNEIATGYEGDWPDFKERFARLRESVRLMRELWLGDRVDFDGEYYRTKGA
SIYDVPEGGVPVYIAAGGPVVAKYAGRAGDGFICTSGKGEELYKDKLLPAVAEGADAAGKNVDDVDKMIEIKISYDTDPE
LALENTRFWAPLSLTAEQKHSIDDPIEMEKAADELPIEQVAKRWIVASDPDEAVEKVKDYVGWGLNHLVFHAPGHDQRRF
LELFKRDLEPRLRKLG

Sequences:

>Translated_336_residues
MAELKLGYKASAEQFAPRELVELAVAAEEHGMDSATVSDHFQPWRHEGGHAPFSLAWMTAVGERTKRLQLGTSVLTPTFR
YNPAVIAQAFATMACLYPDRIFLGVGTGEALNEIATGYEGDWPDFKERFARLRESVRLMRELWLGDRVDFDGEYYRTKGA
SIYDVPEGGVPVYIAAGGPVVAKYAGRAGDGFICTSGKGEELYKDKLLPAVAEGADAAGKNVDDVDKMIEIKISYDTDPE
LALENTRFWAPLSLTAEQKHSIDDPIEMEKAADELPIEQVAKRWIVASDPDEAVEKVKDYVGWGLNHLVFHAPGHDQRRF
LELFKRDLEPRLRKLG
>Mature_335_residues
AELKLGYKASAEQFAPRELVELAVAAEEHGMDSATVSDHFQPWRHEGGHAPFSLAWMTAVGERTKRLQLGTSVLTPTFRY
NPAVIAQAFATMACLYPDRIFLGVGTGEALNEIATGYEGDWPDFKERFARLRESVRLMRELWLGDRVDFDGEYYRTKGAS
IYDVPEGGVPVYIAAGGPVVAKYAGRAGDGFICTSGKGEELYKDKLLPAVAEGADAAGKNVDDVDKMIEIKISYDTDPEL
ALENTRFWAPLSLTAEQKHSIDDPIEMEKAADELPIEQVAKRWIVASDPDEAVEKVKDYVGWGLNHLVFHAPGHDQRRFL
ELFKRDLEPRLRKLG

Specific function: Involved in the bioreductive activation of the prodrug PA-824 (nitroimidazo-oxazine) developed for anti-tuberculosis therapy against both replicating and persistent bacteria. It does not interact directly with PA-824 but, rather, provides reduced F420 to

COG id: COG2141

COG function: function code C; Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the F420-dependent glucose-6-phosphate dehydrogenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019945
- InterPro:   IPR019944
- InterPro:   IPR011251
- InterPro:   IPR016048 [H]

Pfam domain/function: PF00296 Bac_luciferase [H]

EC number: =1.1.99.34 [H]

Molecular weight: Translated: 37406; Mature: 37274

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAELKLGYKASAEQFAPRELVELAVAAEEHGMDSATVSDHFQPWRHEGGHAPFSLAWMTA
CCCCCCCCCCCHHHCCHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHCCCCCCHHHHHHHH
VGERTKRLQLGTSVLTPTFRYNPAVIAQAFATMACLYPDRIFLGVGTGEALNEIATGYEG
HHHHHHHHHHCHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHCCCCC
DWPDFKERFARLRESVRLMRELWLGDRVDFDGEYYRTKGASIYDVPEGGVPVYIAAGGPV
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCEEEECCCCCEEEEEECCCCE
VAKYAGRAGDGFICTSGKGEELYKDKLLPAVAEGADAAGKNVDDVDKMIEIKISYDTDPE
EEHHCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHCEEEEEEECCCCCC
LALENTRFWAPLSLTAEQKHSIDDPIEMEKAADELPIEQVAKRWIVASDPDEAVEKVKDY
EEECCCEEEEEEECCCHHHCCCCCCHHHHHHHHCCCHHHHHHHCEECCCHHHHHHHHHHH
VGWGLNHLVFHAPGHDQRRFLELFKRDLEPRLRKLG
HCCCCHHEEEECCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AELKLGYKASAEQFAPRELVELAVAAEEHGMDSATVSDHFQPWRHEGGHAPFSLAWMTA
CCCCCCCCCCHHHCCHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHCCCCCCHHHHHHHH
VGERTKRLQLGTSVLTPTFRYNPAVIAQAFATMACLYPDRIFLGVGTGEALNEIATGYEG
HHHHHHHHHHCHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHCCCCC
DWPDFKERFARLRESVRLMRELWLGDRVDFDGEYYRTKGASIYDVPEGGVPVYIAAGGPV
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCEEEECCCCCEEEEEECCCCE
VAKYAGRAGDGFICTSGKGEELYKDKLLPAVAEGADAAGKNVDDVDKMIEIKISYDTDPE
EEHHCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHCEEEEEEECCCCCC
LALENTRFWAPLSLTAEQKHSIDDPIEMEKAADELPIEQVAKRWIVASDPDEAVEKVKDY
EEECCCEEEEEEECCCHHHCCCCCCHHHHHHHHCCCHHHHHHHCEECCCHHHHHHHHHHH
VGWGLNHLVFHAPGHDQRRFLELFKRDLEPRLRKLG
HCCCCHHEEEECCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]