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The map label for this gene is puuP [H]

Identifier: 108797493

GI number: 108797493

Start: 569127

End: 570605

Strand: Direct

Name: puuP [H]

Synonym: Mmcs_0513

Alternate gene names: 108797493

Gene position: 569127-570605 (Clockwise)

Preceding gene: 108797492

Following gene: 108797495

Centisome position: 9.98

GC content: 67.28

Gene sequence:

>1479_bases
GTGGCCGATTCCAGCGAGACACGCAGTTACGGCGACGTCGGATCCGCGCCGCACGGCGAGCTCACCCCGGAGCAGGAACG
GGGTCTGCGCCGCGGCGCGATCAACTGGAGACAGGTGGCCGTCCTCTCGGTCGCCGGCTGCGGGCCCGCGTCGGTCATCG
CGCTCAACCTGCAGTTCATGGGCCAGTTCGCCGGTGCCGCACTGGTTCTGGCATTCGTCCTGGTGTGGCCGGGAATCCTG
TTGCTGGTCAACACGTTCGCGGAGTTCTCCAAGAGACTGCCGACCTCCGGCGGGCTCTACACATGGAACTCCAAGGCGTG
GGGGCCCAATGTCGGGTTCGTCTACGGCTGGACGTTCATCGGCGCGTACCTGGTGTTCTCCGCCGCCGGGTTCGCGGTGT
TCGGCGGATGGGTGCAGGAATGGCTGCAGACCCAGTTCGGCATCTCGGTGCCGTGGTGGTTGTTCACCTTCGCGGCGCTG
GCCTACGTATGCGTGCTGGCCTACCTGGGAATCACCCAATCCCTGCATGCCGCACTGGGATTGCTGGCATTCGAGATCAT
CGTGCTGCTGGCCCTGGCGGCGTGGATCTTCATCACCGGGCCGCAGTCCGGCAGCGGATTCGGGGTCGCGCCGTTCCAGG
TGTCCTCGGCCGGGGCGCTCGCCCTCGGCGGTGTCGGGTTGGCGATGACGTACGGCGTGCTGTCACACGTGGGCATCGAG
GAGGGCGCCACCCTGGGCCAGGAGGTCAAGGACCCGAAACGCCAGATCCCGCGGGGGCTCTGGGTGGCGGCCGTCGTGGT
GCCGGTCTTCTACATCGTCGTCGCCTACGCGATGGTCTACGGCTACGGCATCGACGACATGACGGCGTTCGGCGAGGATC
CCGCACCGCTGCAGACGATCGCCCAGACATACTGGGGGCAGGTCGGTCTCACGGTCATCGTGCTGGCCACGCTGAGCAGC
ATCCTGGCGTTCAGCCAGACAGCGTTCCTGGCGGGCGCCCGCGTGCTCTACACGCTCGGCCGGGAGGGCGTGCTGCCCAC
CCGCCTCGGCGCGGTGTCGCGGCGGCAGACGCCGGCGGTGGGGATCGCGGTGATGGGTGTGCTGTCGATGCTGCTCGGGG
TGCCCCTGGCGTTCCTCGTCGGACCGTTCAACGTATGGGGCTACTTCGGGTTCCTCATCTCGATCGCCTTCCTGGTGTCC
TACATCTTCACCAACATCGGCCTGGTGCGGTACATGCTGCGCATCGGGGTGTTCCACTGGTTCCGGCACGGCGTGCTCGG
CGCCCTGGGGTCGCTGGTGTTCCTCTATCCGCTGTACAAGACCGTGTGGCCGCTGCAGACCGGCATCTACGGGGCGCTGC
CGTTCGTGTACCTGGCATGGATCGTGCTGGGCATCGGGTTGCTGATCTACACGCTGCGCCGGCGTCCCGAGGTGATGTCG
CGCATCGGCACCTCGCTGGCCGACGACGACGTCAGCTGA

Upstream 100 bases:

>100_bases
GAAGCGCGCAGAGATCGCGGCCCAGTCGGTGGCGGTCACCGACTGGGAGGTCGCCCGGTACCTCGAGGCGATGTAACCGG
TAACCCAGAAGGGAACTCCC

Downstream 100 bases:

>100_bases
CCCGCAGCCAGCCCTCGGTGTGGCGGTAGAACGTCGACCGTTTCACCTCGCGGGTGCCCTCGACGCCGTCGCGGACCACC
CGCGCACCCGTCGTCCCCAG

Product: amino acid permease-associated protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 492; Mature: 491

Protein sequence:

>492_residues
MADSSETRSYGDVGSAPHGELTPEQERGLRRGAINWRQVAVLSVAGCGPASVIALNLQFMGQFAGAALVLAFVLVWPGIL
LLVNTFAEFSKRLPTSGGLYTWNSKAWGPNVGFVYGWTFIGAYLVFSAAGFAVFGGWVQEWLQTQFGISVPWWLFTFAAL
AYVCVLAYLGITQSLHAALGLLAFEIIVLLALAAWIFITGPQSGSGFGVAPFQVSSAGALALGGVGLAMTYGVLSHVGIE
EGATLGQEVKDPKRQIPRGLWVAAVVVPVFYIVVAYAMVYGYGIDDMTAFGEDPAPLQTIAQTYWGQVGLTVIVLATLSS
ILAFSQTAFLAGARVLYTLGREGVLPTRLGAVSRRQTPAVGIAVMGVLSMLLGVPLAFLVGPFNVWGYFGFLISIAFLVS
YIFTNIGLVRYMLRIGVFHWFRHGVLGALGSLVFLYPLYKTVWPLQTGIYGALPFVYLAWIVLGIGLLIYTLRRRPEVMS
RIGTSLADDDVS

Sequences:

>Translated_492_residues
MADSSETRSYGDVGSAPHGELTPEQERGLRRGAINWRQVAVLSVAGCGPASVIALNLQFMGQFAGAALVLAFVLVWPGIL
LLVNTFAEFSKRLPTSGGLYTWNSKAWGPNVGFVYGWTFIGAYLVFSAAGFAVFGGWVQEWLQTQFGISVPWWLFTFAAL
AYVCVLAYLGITQSLHAALGLLAFEIIVLLALAAWIFITGPQSGSGFGVAPFQVSSAGALALGGVGLAMTYGVLSHVGIE
EGATLGQEVKDPKRQIPRGLWVAAVVVPVFYIVVAYAMVYGYGIDDMTAFGEDPAPLQTIAQTYWGQVGLTVIVLATLSS
ILAFSQTAFLAGARVLYTLGREGVLPTRLGAVSRRQTPAVGIAVMGVLSMLLGVPLAFLVGPFNVWGYFGFLISIAFLVS
YIFTNIGLVRYMLRIGVFHWFRHGVLGALGSLVFLYPLYKTVWPLQTGIYGALPFVYLAWIVLGIGLLIYTLRRRPEVMS
RIGTSLADDDVS
>Mature_491_residues
ADSSETRSYGDVGSAPHGELTPEQERGLRRGAINWRQVAVLSVAGCGPASVIALNLQFMGQFAGAALVLAFVLVWPGILL
LVNTFAEFSKRLPTSGGLYTWNSKAWGPNVGFVYGWTFIGAYLVFSAAGFAVFGGWVQEWLQTQFGISVPWWLFTFAALA
YVCVLAYLGITQSLHAALGLLAFEIIVLLALAAWIFITGPQSGSGFGVAPFQVSSAGALALGGVGLAMTYGVLSHVGIEE
GATLGQEVKDPKRQIPRGLWVAAVVVPVFYIVVAYAMVYGYGIDDMTAFGEDPAPLQTIAQTYWGQVGLTVIVLATLSSI
LAFSQTAFLAGARVLYTLGREGVLPTRLGAVSRRQTPAVGIAVMGVLSMLLGVPLAFLVGPFNVWGYFGFLISIAFLVSY
IFTNIGLVRYMLRIGVFHWFRHGVLGALGSLVFLYPLYKTVWPLQTGIYGALPFVYLAWIVLGIGLLIYTLRRRPEVMSR
IGTSLADDDVS

Specific function: Imports putrescine [H]

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI187423910, Length=338, Percent_Identity=26.3313609467456, Blast_Score=67, Evalue=5e-11,
Organism=Homo sapiens, GI7657591, Length=338, Percent_Identity=26.3313609467456, Blast_Score=67, Evalue=5e-11,
Organism=Homo sapiens, GI258645169, Length=353, Percent_Identity=24.0793201133144, Blast_Score=66, Evalue=7e-11,
Organism=Escherichia coli, GI87081869, Length=355, Percent_Identity=23.6619718309859, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI87082023, Length=361, Percent_Identity=22.4376731301939, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1786789, Length=409, Percent_Identity=23.2273838630807, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1786302, Length=407, Percent_Identity=21.8673218673219, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1789017, Length=404, Percent_Identity=24.5049504950495, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1786602, Length=382, Percent_Identity=22.7748691099476, Blast_Score=63, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24667468, Length=371, Percent_Identity=23.7196765498652, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 52873; Mature: 52741

Theoretical pI: Translated: 8.81; Mature: 8.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADSSETRSYGDVGSAPHGELTPEQERGLRRGAINWRQVAVLSVAGCGPASVIALNLQFM
CCCCCCCCCCCCCCCCCCCCCCCHHHCCHHHCCCCHHHHHHHEECCCCCHHHHHHHHHHH
GQFAGAALVLAFVLVWPGILLLVNTFAEFSKRLPTSGGLYTWNSKAWGPNVGFVYGWTFI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCHHHHHHHH
GAYLVFSAAGFAVFGGWVQEWLQTQFGISVPWWLFTFAALAYVCVLAYLGITQSLHAALG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLAFEIIVLLALAAWIFITGPQSGSGFGVAPFQVSSAGALALGGVGLAMTYGVLSHVGIE
HHHHHHHHHHHHHHHHEEECCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHCCCC
EGATLGQEVKDPKRQIPRGLWVAAVVVPVFYIVVAYAMVYGYGIDDMTAFGEDPAPLQTI
CCCCCCHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCHHHHHH
AQTYWGQVGLTVIVLATLSSILAFSQTAFLAGARVLYTLGREGVLPTRLGAVSRRQTPAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHH
GIAVMGVLSMLLGVPLAFLVGPFNVWGYFGFLISIAFLVSYIFTNIGLVRYMLRIGVFHW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FRHGVLGALGSLVFLYPLYKTVWPLQTGIYGALPFVYLAWIVLGIGLLIYTLRRRPEVMS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
RIGTSLADDDVS
HHCCCCCCCCCC
>Mature Secondary Structure 
ADSSETRSYGDVGSAPHGELTPEQERGLRRGAINWRQVAVLSVAGCGPASVIALNLQFM
CCCCCCCCCCCCCCCCCCCCCCHHHCCHHHCCCCHHHHHHHEECCCCCHHHHHHHHHHH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HHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503 [H]