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The map label for this gene is adhB [H]

Identifier: 108797117

GI number: 108797117

Start: 154315

End: 155439

Strand: Reverse

Name: adhB [H]

Synonym: Mmcs_0137

Alternate gene names: 108797117

Gene position: 155439-154315 (Counterclockwise)

Preceding gene: 108797119

Following gene: 108797115

Centisome position: 2.72

GC content: 65.78

Gene sequence:

>1125_bases
ATGAGGACCAAGGGTGCCCTGCTCTGGGAACTGAACGCGCCGTTCCGTGTCGACGAGATCGAGGTCGGTGACCCCGTCGA
TGACGAGGTGCAGATCCGCGTGCACGCCGCCGGCATGTGCCATTCCGACTACCACCTGACCACCGGGGCCACCCCGATCG
GACTGCCCGCACTCGGCGGCCACGAGGGCGCCGGCGTCGTCACCAAGGTCGGCCGCAACGTCACGGGCATCGAGGAGGGC
GACCACGTCATCCTCGCGTTCATCCCCGCCTGCGGTCAGTGCCAGCCCTGCCTGAAGGGCTATCGCTCGCTGTGCGACCG
CGGTGCGCTGCTGCTCGGCGGCAAGGCCATCGCCGACGGCACGTCGCGGGTGCACGCCGGCAGCACCGAGGTGTCCCCGA
TGAATCTGCTCGGCACCTTCGCGCCCTACATGACCGTCCACAAGGACTCCGTCGTCAAGATCGACCACGACGTCCCGTTC
GAGACCGCCGCGATCATGGGCTGCGCGGTCCCGACCGGGTTCGGCTCGGCCACCAACGTCGCCGAGGTGCAACCGGGCGA
GACGGTGGTGATCGTCGGGGTCGGCGGCATCGGGCTGTCCGCGCTGCAGGGCGCGGTCATCGCCGGCGCCCGCAACGTCG
TCGCCGTCGATCCGGTCGAGTTCAAACGTGACCAGGCGACCAAGTTCGGCGCCACCCACGTCTTCTCGTCGATGGCCGAG
GCGATCGGCCCCGTCCTCGAACTGACCCACGGTTTCATGGCAGAGAAGACGATCATCGCCGTCGGCGAGATGCGCGGTGA
GTACATCGAGGAGGCGATGACGCTGACGGCCAAGACCGGCACCTGCGTCGTCACCGGTATGGGGTCGATGTTCGACGCCG
ACGTCAAGCTCAACCTGTTCCTGTTCACGATGTTGCAGAAGACTCTGAAGGGCAACATCTTCGGCGGTGGCAGCAGCCAC
GTCGAGACACCCCGGCTGGTCGGACTCTACAAATCCGGGTTGCTCAAGGTCGACGAGATGGTCACCAACACCTACCGCCT
CGAGGACATCAACCAGGGTTATCAGGACATGTTGGACGGCAAGAACATTCGCGGCGTCATCACCTTCGACGAATCAGACT
GGTGA

Upstream 100 bases:

>100_bases
ACCTTATTCCGGCGCTTGGTCGACGGTATCTGGGCCATGACTGCCCAGCTCAGGCCGCACCTTCGCCACAGAACTGGAAC
GTGTTCTATGATCGCCACCC

Downstream 100 bases:

>100_bases
GTCGCGGAGGCGTTCGCGCACGGTGTCGATCACGTCGCTGAACGCCTTGCGCCGGGCCGTCGGCATCCCGTCGAAGAGCA
CCCGCCGCACCAGCGCCGCA

Product: zinc-binding alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 374; Mature: 374

Protein sequence:

>374_residues
MRTKGALLWELNAPFRVDEIEVGDPVDDEVQIRVHAAGMCHSDYHLTTGATPIGLPALGGHEGAGVVTKVGRNVTGIEEG
DHVILAFIPACGQCQPCLKGYRSLCDRGALLLGGKAIADGTSRVHAGSTEVSPMNLLGTFAPYMTVHKDSVVKIDHDVPF
ETAAIMGCAVPTGFGSATNVAEVQPGETVVIVGVGGIGLSALQGAVIAGARNVVAVDPVEFKRDQATKFGATHVFSSMAE
AIGPVLELTHGFMAEKTIIAVGEMRGEYIEEAMTLTAKTGTCVVTGMGSMFDADVKLNLFLFTMLQKTLKGNIFGGGSSH
VETPRLVGLYKSGLLKVDEMVTNTYRLEDINQGYQDMLDGKNIRGVITFDESDW

Sequences:

>Translated_374_residues
MRTKGALLWELNAPFRVDEIEVGDPVDDEVQIRVHAAGMCHSDYHLTTGATPIGLPALGGHEGAGVVTKVGRNVTGIEEG
DHVILAFIPACGQCQPCLKGYRSLCDRGALLLGGKAIADGTSRVHAGSTEVSPMNLLGTFAPYMTVHKDSVVKIDHDVPF
ETAAIMGCAVPTGFGSATNVAEVQPGETVVIVGVGGIGLSALQGAVIAGARNVVAVDPVEFKRDQATKFGATHVFSSMAE
AIGPVLELTHGFMAEKTIIAVGEMRGEYIEEAMTLTAKTGTCVVTGMGSMFDADVKLNLFLFTMLQKTLKGNIFGGGSSH
VETPRLVGLYKSGLLKVDEMVTNTYRLEDINQGYQDMLDGKNIRGVITFDESDW
>Mature_374_residues
MRTKGALLWELNAPFRVDEIEVGDPVDDEVQIRVHAAGMCHSDYHLTTGATPIGLPALGGHEGAGVVTKVGRNVTGIEEG
DHVILAFIPACGQCQPCLKGYRSLCDRGALLLGGKAIADGTSRVHAGSTEVSPMNLLGTFAPYMTVHKDSVVKIDHDVPF
ETAAIMGCAVPTGFGSATNVAEVQPGETVVIVGVGGIGLSALQGAVIAGARNVVAVDPVEFKRDQATKFGATHVFSSMAE
AIGPVLELTHGFMAEKTIIAVGEMRGEYIEEAMTLTAKTGTCVVTGMGSMFDADVKLNLFLFTMLQKTLKGNIFGGGSSH
VETPRLVGLYKSGLLKVDEMVTNTYRLEDINQGYQDMLDGKNIRGVITFDESDW

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=372, Percent_Identity=34.9462365591398, Blast_Score=216, Evalue=2e-56,
Organism=Homo sapiens, GI34577061, Length=372, Percent_Identity=33.8709677419355, Blast_Score=210, Evalue=1e-54,
Organism=Homo sapiens, GI71565154, Length=371, Percent_Identity=33.9622641509434, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI4501929, Length=372, Percent_Identity=33.8709677419355, Blast_Score=208, Evalue=5e-54,
Organism=Homo sapiens, GI262073058, Length=371, Percent_Identity=33.1536388140162, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI71743840, Length=371, Percent_Identity=33.1536388140162, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI156523966, Length=375, Percent_Identity=33.8666666666667, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI4501939, Length=369, Percent_Identity=33.8753387533875, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI71565152, Length=379, Percent_Identity=31.3984168865435, Blast_Score=179, Evalue=3e-45,
Organism=Escherichia coli, GI1786552, Length=374, Percent_Identity=32.0855614973262, Blast_Score=157, Evalue=8e-40,
Organism=Escherichia coli, GI1786825, Length=372, Percent_Identity=26.8817204301075, Blast_Score=95, Evalue=8e-21,
Organism=Escherichia coli, GI1788073, Length=385, Percent_Identity=26.2337662337662, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1787863, Length=355, Percent_Identity=25.6338028169014, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI226510992, Length=373, Percent_Identity=25.4691689008043, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1788075, Length=363, Percent_Identity=25.3443526170799, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788407, Length=222, Percent_Identity=30.1801801801802, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI87082125, Length=382, Percent_Identity=24.0837696335079, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1790045, Length=354, Percent_Identity=25.9887005649718, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1786518, Length=371, Percent_Identity=24.7978436657682, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI87081918, Length=224, Percent_Identity=27.6785714285714, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI25146526, Length=382, Percent_Identity=30.3664921465969, Blast_Score=197, Evalue=6e-51,
Organism=Caenorhabditis elegans, GI71997431, Length=384, Percent_Identity=30.2083333333333, Blast_Score=192, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17565904, Length=342, Percent_Identity=30.9941520467836, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17562582, Length=376, Percent_Identity=30.3191489361702, Blast_Score=114, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI17562584, Length=378, Percent_Identity=29.3650793650794, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71988145, Length=375, Percent_Identity=27.4666666666667, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17562876, Length=356, Percent_Identity=23.876404494382, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17562878, Length=240, Percent_Identity=25.4166666666667, Blast_Score=68, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6320033, Length=381, Percent_Identity=32.2834645669291, Blast_Score=198, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6319621, Length=343, Percent_Identity=28.2798833819242, Blast_Score=99, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6323729, Length=379, Percent_Identity=26.9129287598945, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6324486, Length=377, Percent_Identity=28.1167108753316, Blast_Score=90, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6323961, Length=375, Percent_Identity=26.6666666666667, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6323099, Length=353, Percent_Identity=26.3456090651558, Blast_Score=83, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6319258, Length=369, Percent_Identity=24.1192411924119, Blast_Score=77, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6322619, Length=338, Percent_Identity=27.2189349112426, Blast_Score=73, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6319955, Length=338, Percent_Identity=27.2189349112426, Blast_Score=73, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6319257, Length=243, Percent_Identity=27.1604938271605, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17737895, Length=377, Percent_Identity=33.9522546419098, Blast_Score=197, Evalue=7e-51,
Organism=Drosophila melanogaster, GI17137530, Length=350, Percent_Identity=25.4285714285714, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17737897, Length=350, Percent_Identity=27.4285714285714, Blast_Score=79, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 39572; Mature: 39572

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTKGALLWELNAPFRVDEIEVGDPVDDEVQIRVHAAGMCHSDYHLTTGATPIGLPALGG
CCCCCCEEEECCCCEEECEEECCCCCCCCEEEEEEEEEEECCCCEEECCCCCCCCCCCCC
HEGAGVVTKVGRNVTGIEEGDHVILAFIPACGQCQPCLKGYRSLCDRGALLLGGKAIADG
CCCCCHHHHCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCEEECCEEECCC
TSRVHAGSTEVSPMNLLGTFAPYMTVHKDSVVKIDHDVPFETAAIMGCAVPTGFGSATNV
CCEEECCCCCCCHHHHHHHHHHHEEEECCCEEEEECCCCHHHHHHHHCCCCCCCCCCCCC
AEVQPGETVVIVGVGGIGLSALQGAVIAGARNVVAVDPVEFKRDQATKFGATHVFSSMAE
EEECCCCEEEEEEECCCCHHHHCCHHEECCCCEEEECCHHHCCCHHHHHHHHHHHHHHHH
AIGPVLELTHGFMAEKTIIAVGEMRGEYIEEAMTLTAKTGTCVVTGMGSMFDADVKLNLF
HHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHEEEECCCEEEEEECCCEECCCEEEHHH
LFTMLQKTLKGNIFGGGSSHVETPRLVGLYKSGLLKVDEMVTNTYRLEDINQGYQDMLDG
HHHHHHHHHCCCEECCCCCCCCCCHHHHHHHCCCEEHHHHHHCEEEEHHHCCCHHHHHCC
KNIRGVITFDESDW
CCEEEEEEECCCCC
>Mature Secondary Structure
MRTKGALLWELNAPFRVDEIEVGDPVDDEVQIRVHAAGMCHSDYHLTTGATPIGLPALGG
CCCCCCEEEECCCCEEECEEECCCCCCCCEEEEEEEEEEECCCCEEECCCCCCCCCCCCC
HEGAGVVTKVGRNVTGIEEGDHVILAFIPACGQCQPCLKGYRSLCDRGALLLGGKAIADG
CCCCCHHHHCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCEEECCEEECCC
TSRVHAGSTEVSPMNLLGTFAPYMTVHKDSVVKIDHDVPFETAAIMGCAVPTGFGSATNV
CCEEECCCCCCCHHHHHHHHHHHEEEECCCEEEEECCCCHHHHHHHHCCCCCCCCCCCCC
AEVQPGETVVIVGVGGIGLSALQGAVIAGARNVVAVDPVEFKRDQATKFGATHVFSSMAE
EEECCCCEEEEEEECCCCHHHHCCHHEECCCCEEEECCHHHCCCHHHHHHHHHHHHHHHH
AIGPVLELTHGFMAEKTIIAVGEMRGEYIEEAMTLTAKTGTCVVTGMGSMFDADVKLNLF
HHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHEEEECCCEEEEEECCCEECCCEEEHHH
LFTMLQKTLKGNIFGGGSSHVETPRLVGLYKSGLLKVDEMVTNTYRLEDINQGYQDMLDG
HHHHHHHHHCCCEECCCCCCCCCCHHHHHHHCCCEEHHHHHHCEEEEHHHCCCHHHHHCC
KNIRGVITFDESDW
CCEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]