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The map label for this gene is adhB [H]

Identifier: 108797091

GI number: 108797091

Start: 126004

End: 127116

Strand: Reverse

Name: adhB [H]

Synonym: Mmcs_0111

Alternate gene names: 108797091

Gene position: 127116-126004 (Counterclockwise)

Preceding gene: 108797094

Following gene: 108797088

Centisome position: 2.23

GC content: 70.53

Gene sequence:

>1113_bases
ATGACCATGACGATCCGCGGCGCCGTCCTCGAAGAGATCGGCCGGCCCCGCCCTTTCACCGAGTCCGCGCCGCTGTCCGT
GTCCGAACTCCAGCTCGATCCGCCCGGCCCCGACGAACTGCTGATCCGGATCGAGGCCGCGGGTCTGTGCCACTCGGATC
TCTCGGTCGTCGACGGCAACCGCGTGCGGCCGGTTCCGATGCTGCTCGGCCACGAAGCCGCCGGCATCGTCGAGCAGATC
GGTCCGGGCGGCTCCGACCTCGAGGTGGGTCAGCGGGTTGTGATGACGTTCCTGCCGCGCTGCGGCCACTGCACCGCCTG
TGCCACCGGCGGTCTCACCCCGTGCGAACCGGGCACCGCGGCCAACAGCGCCGGCACCCTCATGCACGGCGACATCCGGC
TGCACCGCGACGGCCAACCGGTGCACCATCACCTCGGGGTGTCCGGTTTCGCCACTTACGCCGTGGTGGACCGGCATTCG
GTGGTCGCCGTCGACGCCGACGTCCCACCGGTCGTCGCGTCGCTGCTCGGTTGCGCGGTCCTCACCGGCGGGGGCGCGGT
GCTCAACGTCGGCAAACCGCAACCCGGCCAGACCGTCGTCGTGGTCGGCCTCGGCGGCGTCGGGATGGCCGCGATGATCA
CCGCCATGGCGCACGACGGCGTGGACGTCGTCGGGATCGACCAGCTGGAGGACAAACTCGACCGAGCCCGCGCGATGGGC
ATCAACGCCGCCTACACCCCGGAGGAGGCCGCTGAACGGGGCCTCAAGGCAGCGGTGGTCATCGAAGCGGTCGGCCACCC
CTCCGCACTCGAGACCGCGATCGCGCACACCGCTCCTGGTGGCCGCACGATCACCGTCGGCCTCCCCCGCCCCGATGCGC
GGATCTCGGTGTCGCCGTTGGGTTTCGTCGCCGAAGGCCGGTCCCTGATCGGCAGTTACCTCGGGTCGGCGGTGCCGGCC
CGCGACATCCCCCGGTTCGTCGAGCTGTGGCGCTCTGGTCGTCTCCCGGTGGAAACCCTGGTGTCCTCGACGATCTCACT
CGACGAGATCAATGCCGGTATGGACCGCCTGGCCGAGGGCAAGGCCGTCCGCCAGGTCATCGAGTTCGACTAG

Upstream 100 bases:

>100_bases
GGTCGACACCGGCCAGTGCACCGGGAAGTCACGGCTGGTGGGCCGGTCCGCGGATTCGGGGGGCATGGTTGCAGTCTCTC
AGTCAGGGCAGTCTGTGAGC

Downstream 100 bases:

>100_bases
AACCAGGAGTCGCGCATCTCCAGCGTGGTCCGGTCCAGGCTGTCGAGCAGGTCGAGCTGGGGTCCGACCTTCGGCAGCTC
GTACCGGTAGAAGAACCGCG

Product: alcohol dehydrogenase GroES-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 370; Mature: 369

Protein sequence:

>370_residues
MTMTIRGAVLEEIGRPRPFTESAPLSVSELQLDPPGPDELLIRIEAAGLCHSDLSVVDGNRVRPVPMLLGHEAAGIVEQI
GPGGSDLEVGQRVVMTFLPRCGHCTACATGGLTPCEPGTAANSAGTLMHGDIRLHRDGQPVHHHLGVSGFATYAVVDRHS
VVAVDADVPPVVASLLGCAVLTGGGAVLNVGKPQPGQTVVVVGLGGVGMAAMITAMAHDGVDVVGIDQLEDKLDRARAMG
INAAYTPEEAAERGLKAAVVIEAVGHPSALETAIAHTAPGGRTITVGLPRPDARISVSPLGFVAEGRSLIGSYLGSAVPA
RDIPRFVELWRSGRLPVETLVSSTISLDEINAGMDRLAEGKAVRQVIEFD

Sequences:

>Translated_370_residues
MTMTIRGAVLEEIGRPRPFTESAPLSVSELQLDPPGPDELLIRIEAAGLCHSDLSVVDGNRVRPVPMLLGHEAAGIVEQI
GPGGSDLEVGQRVVMTFLPRCGHCTACATGGLTPCEPGTAANSAGTLMHGDIRLHRDGQPVHHHLGVSGFATYAVVDRHS
VVAVDADVPPVVASLLGCAVLTGGGAVLNVGKPQPGQTVVVVGLGGVGMAAMITAMAHDGVDVVGIDQLEDKLDRARAMG
INAAYTPEEAAERGLKAAVVIEAVGHPSALETAIAHTAPGGRTITVGLPRPDARISVSPLGFVAEGRSLIGSYLGSAVPA
RDIPRFVELWRSGRLPVETLVSSTISLDEINAGMDRLAEGKAVRQVIEFD
>Mature_369_residues
TMTIRGAVLEEIGRPRPFTESAPLSVSELQLDPPGPDELLIRIEAAGLCHSDLSVVDGNRVRPVPMLLGHEAAGIVEQIG
PGGSDLEVGQRVVMTFLPRCGHCTACATGGLTPCEPGTAANSAGTLMHGDIRLHRDGQPVHHHLGVSGFATYAVVDRHSV
VAVDADVPPVVASLLGCAVLTGGGAVLNVGKPQPGQTVVVVGLGGVGMAAMITAMAHDGVDVVGIDQLEDKLDRARAMGI
NAAYTPEEAAERGLKAAVVIEAVGHPSALETAIAHTAPGGRTITVGLPRPDARISVSPLGFVAEGRSLIGSYLGSAVPAR
DIPRFVELWRSGRLPVETLVSSTISLDEINAGMDRLAEGKAVRQVIEFD

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI34577061, Length=378, Percent_Identity=32.2751322751323, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI4501933, Length=378, Percent_Identity=32.010582010582, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI4501929, Length=378, Percent_Identity=31.2169312169312, Blast_Score=208, Evalue=8e-54,
Organism=Homo sapiens, GI262073058, Length=361, Percent_Identity=31.0249307479224, Blast_Score=205, Evalue=5e-53,
Organism=Homo sapiens, GI71743840, Length=361, Percent_Identity=31.0249307479224, Blast_Score=205, Evalue=6e-53,
Organism=Homo sapiens, GI156523966, Length=358, Percent_Identity=30.1675977653631, Blast_Score=181, Evalue=8e-46,
Organism=Homo sapiens, GI71565154, Length=378, Percent_Identity=28.5714285714286, Blast_Score=178, Evalue=8e-45,
Organism=Homo sapiens, GI71565152, Length=365, Percent_Identity=30.6849315068493, Blast_Score=178, Evalue=9e-45,
Organism=Homo sapiens, GI4501939, Length=352, Percent_Identity=30.3977272727273, Blast_Score=177, Evalue=1e-44,
Organism=Escherichia coli, GI1786552, Length=363, Percent_Identity=31.404958677686, Blast_Score=169, Evalue=4e-43,
Organism=Escherichia coli, GI1787863, Length=336, Percent_Identity=25, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1788407, Length=334, Percent_Identity=24.251497005988, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI87081918, Length=345, Percent_Identity=28.695652173913, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1788075, Length=359, Percent_Identity=24.7910863509749, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI87082125, Length=365, Percent_Identity=23.5616438356164, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1790045, Length=352, Percent_Identity=25.2840909090909, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI87082401, Length=86, Percent_Identity=39.5348837209302, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI226510992, Length=348, Percent_Identity=24.7126436781609, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790718, Length=277, Percent_Identity=27.0758122743682, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1788073, Length=353, Percent_Identity=23.2294617563739, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI25146526, Length=367, Percent_Identity=30.2452316076294, Blast_Score=184, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI71997431, Length=369, Percent_Identity=29.810298102981, Blast_Score=180, Evalue=9e-46,
Organism=Caenorhabditis elegans, GI17565904, Length=344, Percent_Identity=29.9418604651163, Blast_Score=164, Evalue=9e-41,
Organism=Caenorhabditis elegans, GI17562584, Length=374, Percent_Identity=26.2032085561497, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17562582, Length=374, Percent_Identity=25.1336898395722, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71988145, Length=379, Percent_Identity=24.2744063324538, Blast_Score=75, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6320033, Length=367, Percent_Identity=29.4277929155313, Blast_Score=162, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6324486, Length=327, Percent_Identity=28.1345565749235, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323729, Length=325, Percent_Identity=25.2307692307692, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6319621, Length=336, Percent_Identity=26.4880952380952, Blast_Score=73, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6323961, Length=355, Percent_Identity=25.9154929577465, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323980, Length=324, Percent_Identity=26.2345679012346, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17737895, Length=359, Percent_Identity=30.6406685236769, Blast_Score=192, Evalue=4e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 38254; Mature: 38123

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMTIRGAVLEEIGRPRPFTESAPLSVSELQLDPPGPDELLIRIEAAGLCHSDLSVVDGN
CEEEECHHHHHHCCCCCCCCCCCCCCHHEEECCCCCCCCEEEEEEECCCCCCCCEEECCC
RVRPVPMLLGHEAAGIVEQIGPGGSDLEVGQRVVMTFLPRCGHCTACATGGLTPCEPGTA
CCCCCHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCC
ANSAGTLMHGDIRLHRDGQPVHHHLGVSGFATYAVVDRHSVVAVDADVPPVVASLLGCAV
CCCCCCEEECCEEEECCCCCHHHHCCCCHHEEEEEEECCEEEEECCCCHHHHHHHHHHHH
LTGGGAVLNVGKPQPGQTVVVVGLGGVGMAAMITAMAHDGVDVVGIDQLEDKLDRARAMG
CCCCCEEEECCCCCCCCEEEEEEECCHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHC
INAAYTPEEAAERGLKAAVVIEAVGHPSALETAIAHTAPGGRTITVGLPRPDARISVSPL
CCCCCCCHHHHHCCCEEEEEEEECCCCHHHHHHHHHCCCCCEEEEEECCCCCCEEEECCC
GFVAEGRSLIGSYLGSAVPARDIPRFVELWRSGRLPVETLVSSTISLDEINAGMDRLAEG
CHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHCC
KAVRQVIEFD
HHHHHHHCCC
>Mature Secondary Structure 
TMTIRGAVLEEIGRPRPFTESAPLSVSELQLDPPGPDELLIRIEAAGLCHSDLSVVDGN
EEEECHHHHHHCCCCCCCCCCCCCCHHEEECCCCCCCCEEEEEEECCCCCCCCEEECCC
RVRPVPMLLGHEAAGIVEQIGPGGSDLEVGQRVVMTFLPRCGHCTACATGGLTPCEPGTA
CCCCCHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCC
ANSAGTLMHGDIRLHRDGQPVHHHLGVSGFATYAVVDRHSVVAVDADVPPVVASLLGCAV
CCCCCCEEECCEEEECCCCCHHHHCCCCHHEEEEEEECCEEEEECCCCHHHHHHHHHHHH
LTGGGAVLNVGKPQPGQTVVVVGLGGVGMAAMITAMAHDGVDVVGIDQLEDKLDRARAMG
CCCCCEEEECCCCCCCCEEEEEEECCHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHC
INAAYTPEEAAERGLKAAVVIEAVGHPSALETAIAHTAPGGRTITVGLPRPDARISVSPL
CCCCCCCHHHHHCCCEEEEEEEECCCCHHHHHHHHHCCCCCEEEEEECCCCCCEEEECCC
GFVAEGRSLIGSYLGSAVPARDIPRFVELWRSGRLPVETLVSSTISLDEINAGMDRLAEG
CHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHCC
KAVRQVIEFD
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]