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The map label for this gene is dnaA [H]

Identifier: 108796982

GI number: 108796982

Start: 20

End: 1507

Strand: Direct

Name: dnaA [H]

Synonym: Mmcs_0001

Alternate gene names: 108796982

Gene position: 20-1507 (Clockwise)

Preceding gene: NA

Following gene: 108796983

Centisome position: 0.0

GC content: 65.39

Gene sequence:

>1488_bases
TTGACAGCCGACCCCGACCCACCTTTTGTCGCCGTCTGGAACACCGTCGTCGCCGAACTCAACGGTGACCCGGCCGCCAC
CGGACCGCGCAACGGTGACGGTGCGCTGCCGACCCTGACCCCGCAGCAACGAGCCTGGCTGAAACTGGTCAAGCCGCTCG
TGATCACCGAGGGTTTCGCACTGCTGTCGGTTCCGACACCGTTCGTCCAGAACGAGATCGAACGTCACCTCCGCGAACCG
ATCATCACCGCCTTGAGCCGCCACCTCGGTCAACGGGTGGAACTCGGTGTGCGGATCGCCACCCCCTCCCCCGAGGACGA
CGACCCGCCGCCGTCCCCGGTGATCGCCGACATCGACGAGGTCGACGAGGACACCGAAGCCCGGGTCAGCGCCGAAGAGA
CCTGGCCGCGCTACTTCAGCCGCCCGCCCGAGACCCCGGCCGCCGAAGATCCGAACGCCGTCAGCCTCAACCGGCGCTAC
ACGTTCGACACGTTCGTCATCGGCGCCTCCAACCGGTTCGCCCACGCGGCGACGCTGGCCATCGCCGAGGCCCCGGCCCG
GGCGTACAACCCGTTGTTCATCTGGGGTGAGTCCGGTCTGGGCAAGACCCATCTGCTGCATGCGGCCGGTAACTATGCCC
AACGCCTCTTCCCCGGTATGCGCGTGAAGTACGTCTCCACCGAGGAATTCACCAACGACTTCATCAACTCGCTGCGCGAC
GACCGCAAGGCGTCGTTCAAGCGCAGTTACCGCGACATCGACGTGCTGCTGGTCGACGACATCCAGTTCATCGAGGGCAA
GGAAGGTATCCAGGAAGAGTTCTTCCACACCTTCAACACGCTGCACAACGCGAACAAGCAGATCGTCATCTCCTCCGACC
GGCCGCCCAAACAGCTGGCGACACTGGAGGATCGGCTGCGGACGCGGTTCGAATGGGGGCTGATCACCGATGTGCAGCCG
CCCGAACTCGAGACCCGAATCGCGATTCTGCGCAAGAAGGCCCAGATGGACCGGCTCGACGTTCCCGACGACGTCCTCGA
GCTCATCGCCAGCAGCATCGAGCGCAACATCCGCGAGCTCGAAGGGGCGCTGATCCGGGTCACCGCGTTCGCCTCGCTCA
ACAAGACCCCGATCGACAAGTCGCTCGCCGAGATCGTGCTGCGGGATCTCATCTCCGACGCCAGCACCATGCAGATCTCG
ACCGCGGCGATCATGGCCGCCACCGCCGAGTACTTCGAGACCACGATCGAAGAGCTCCGCGGCCCGGGTAAGACCAGGGC
GCTGGCGCAGTCCCGCCAGATCGCGATGTACCTGTGCCGCGAGCTCACCGACTTGTCGCTGCCCAAGATCGGGCAGGCGT
TCGGCCGCGACCACACGACCGTGATGTACGCGGAGAAGAAGATCCGCGGCGAGATGGCCGAACGCCGCGAGGTGTTCGAT
CACGTCAAGGAACTCACCACGCGGATCCGCCAGCGCGCCAAGCGCTGA

Upstream 100 bases:

>100_bases
GACGACTGTCTTACTCCACAGGTTGTGGATAACTTTGTGGACAGTTCTGTCTTCGTTCGATCTGGTCGTCTCTGGACAGA
CCGCAAGGGGGTAGCAGTCG

Downstream 100 bases:

>100_bases
ACGTCGTCCCTTTTTCCAGATTTCAGGCCGCCGGGTCCATCCGGCGGCCTTCTGTCACGTGTCGAAAGCCCGCGGATCCG
AAAAAACTTGGGCACCCGCT

Product: chromosomal replication initiation protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 495; Mature: 494

Protein sequence:

>495_residues
MTADPDPPFVAVWNTVVAELNGDPAATGPRNGDGALPTLTPQQRAWLKLVKPLVITEGFALLSVPTPFVQNEIERHLREP
IITALSRHLGQRVELGVRIATPSPEDDDPPPSPVIADIDEVDEDTEARVSAEETWPRYFSRPPETPAAEDPNAVSLNRRY
TFDTFVIGASNRFAHAATLAIAEAPARAYNPLFIWGESGLGKTHLLHAAGNYAQRLFPGMRVKYVSTEEFTNDFINSLRD
DRKASFKRSYRDIDVLLVDDIQFIEGKEGIQEEFFHTFNTLHNANKQIVISSDRPPKQLATLEDRLRTRFEWGLITDVQP
PELETRIAILRKKAQMDRLDVPDDVLELIASSIERNIRELEGALIRVTAFASLNKTPIDKSLAEIVLRDLISDASTMQIS
TAAIMAATAEYFETTIEELRGPGKTRALAQSRQIAMYLCRELTDLSLPKIGQAFGRDHTTVMYAEKKIRGEMAERREVFD
HVKELTTRIRQRAKR

Sequences:

>Translated_495_residues
MTADPDPPFVAVWNTVVAELNGDPAATGPRNGDGALPTLTPQQRAWLKLVKPLVITEGFALLSVPTPFVQNEIERHLREP
IITALSRHLGQRVELGVRIATPSPEDDDPPPSPVIADIDEVDEDTEARVSAEETWPRYFSRPPETPAAEDPNAVSLNRRY
TFDTFVIGASNRFAHAATLAIAEAPARAYNPLFIWGESGLGKTHLLHAAGNYAQRLFPGMRVKYVSTEEFTNDFINSLRD
DRKASFKRSYRDIDVLLVDDIQFIEGKEGIQEEFFHTFNTLHNANKQIVISSDRPPKQLATLEDRLRTRFEWGLITDVQP
PELETRIAILRKKAQMDRLDVPDDVLELIASSIERNIRELEGALIRVTAFASLNKTPIDKSLAEIVLRDLISDASTMQIS
TAAIMAATAEYFETTIEELRGPGKTRALAQSRQIAMYLCRELTDLSLPKIGQAFGRDHTTVMYAEKKIRGEMAERREVFD
HVKELTTRIRQRAKR
>Mature_494_residues
TADPDPPFVAVWNTVVAELNGDPAATGPRNGDGALPTLTPQQRAWLKLVKPLVITEGFALLSVPTPFVQNEIERHLREPI
ITALSRHLGQRVELGVRIATPSPEDDDPPPSPVIADIDEVDEDTEARVSAEETWPRYFSRPPETPAAEDPNAVSLNRRYT
FDTFVIGASNRFAHAATLAIAEAPARAYNPLFIWGESGLGKTHLLHAAGNYAQRLFPGMRVKYVSTEEFTNDFINSLRDD
RKASFKRSYRDIDVLLVDDIQFIEGKEGIQEEFFHTFNTLHNANKQIVISSDRPPKQLATLEDRLRTRFEWGLITDVQPP
ELETRIAILRKKAQMDRLDVPDDVLELIASSIERNIRELEGALIRVTAFASLNKTPIDKSLAEIVLRDLISDASTMQIST
AAIMAATAEYFETTIEELRGPGKTRALAQSRQIAMYLCRELTDLSLPKIGQAFGRDHTTVMYAEKKIRGEMAERREVFDH
VKELTTRIRQRAKR

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family [H]

Homologues:

Organism=Escherichia coli, GI2367267, Length=343, Percent_Identity=45.4810495626822, Blast_Score=296, Evalue=2e-81,
Organism=Escherichia coli, GI226510964, Length=202, Percent_Identity=28.2178217821782, Blast_Score=77, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921 [H]

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C [H]

EC number: NA

Molecular weight: Translated: 55646; Mature: 55515

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTADPDPPFVAVWNTVVAELNGDPAATGPRNGDGALPTLTPQQRAWLKLVKPLVITEGFA
CCCCCCCCEEHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCE
LLSVPTPFVQNEIERHLREPIITALSRHLGQRVELGVRIATPSPEDDDPPPSPVIADIDE
EEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCCCCHHH
VDEDTEARVSAEETWPRYFSRPPETPAAEDPNAVSLNRRYTFDTFVIGASNRFAHAATLA
CCCCHHHHCCHHHHHHHHHCCCCCCCCCCCCCCEEECCEEEEEEEEEECCCCHHHHHHHH
IAEAPARAYNPLFIWGESGLGKTHLLHAAGNYAQRLFPGMRVKYVSTEEFTNDFINSLRD
HHHCCHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHH
DRKASFKRSYRDIDVLLVDDIQFIEGKEGIQEEFFHTFNTLHNANKQIVISSDRPPKQLA
HHHHHHHHHHCCEEEEEECCHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHH
TLEDRLRTRFEWGLITDVQPPELETRIAILRKKAQMDRLDVPDDVLELIASSIERNIREL
HHHHHHHHHHHCCEECCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
EGALIRVTAFASLNKTPIDKSLAEIVLRDLISDASTMQISTAAIMAATAEYFETTIEELR
CCCEEEEEEHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
GPGKTRALAQSRQIAMYLCRELTDLSLPKIGQAFGRDHTTVMYAEKKIRGEMAERREVFD
CCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHH
HVKELTTRIRQRAKR
HHHHHHHHHHHHHCC
>Mature Secondary Structure 
TADPDPPFVAVWNTVVAELNGDPAATGPRNGDGALPTLTPQQRAWLKLVKPLVITEGFA
CCCCCCCEEHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCE
LLSVPTPFVQNEIERHLREPIITALSRHLGQRVELGVRIATPSPEDDDPPPSPVIADIDE
EEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCCCCHHH
VDEDTEARVSAEETWPRYFSRPPETPAAEDPNAVSLNRRYTFDTFVIGASNRFAHAATLA
CCCCHHHHCCHHHHHHHHHCCCCCCCCCCCCCCEEECCEEEEEEEEEECCCCHHHHHHHH
IAEAPARAYNPLFIWGESGLGKTHLLHAAGNYAQRLFPGMRVKYVSTEEFTNDFINSLRD
HHHCCHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHH
DRKASFKRSYRDIDVLLVDDIQFIEGKEGIQEEFFHTFNTLHNANKQIVISSDRPPKQLA
HHHHHHHHHHCCEEEEEECCHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHH
TLEDRLRTRFEWGLITDVQPPELETRIAILRKKAQMDRLDVPDDVLELIASSIERNIREL
HHHHHHHHHHHCCEECCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
EGALIRVTAFASLNKTPIDKSLAEIVLRDLISDASTMQISTAAIMAATAEYFETTIEELR
CCCEEEEEEHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
GPGKTRALAQSRQIAMYLCRELTDLSLPKIGQAFGRDHTTVMYAEKKIRGEMAERREVFD
CCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHH
HVKELTTRIRQRAKR
HHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7592430 [H]