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The map label for this gene is iscS [H]

Identifier: 108764054

GI number: 108764054

Start: 6252137

End: 6253513

Strand: Direct

Name: iscS [H]

Synonym: MXAN_5001

Alternate gene names: 108764054

Gene position: 6252137-6253513 (Clockwise)

Preceding gene: 108758167

Following gene: 108760385

Centisome position: 68.41

GC content: 66.59

Gene sequence:

>1377_bases
GTGTTGGAAGCAATGGTGAAGCTGCCGATCTACATGGACAACCACGCCACCACCCCGCTGGACCCGCGGGTGCTGGAGGC
GATGCTGCCCTACCTGCGAGAGGACTTCGGTAACGCGGCCAGCCGCAATCACGTGTTCGGCTGGAAGGCCGAGGCGGCGG
TGAACAAGGCCCGGCAGCAGGTGGCCGAGCTCATCGGCGCGGCCGAGCAGGAGATCGTCTTCACCTCGGGCGCCACCGAG
TCCGACAACCTGGCCATCAAGGGCGTCATCGAGTTCTACAAGTCCAAGGGTGACCACATCATCACCCTCAAGACGGAGCA
CAAGGCCATCCTGGACACCTGCAAGCGCCTGGAGCGCGTGCGGCAGGAGCGGTTGGACGAGCTGAAGCTGCTGCGGCTGG
CGCAGTTGGCGGGCCAGGACGTCACCGAGGACAACCAGTCGGAGCTGCTGTCGAAGTACGACGTGGACTCCGACGAGACG
TACCGTAAGTGGGCCGAGCTGCCCACCGGCGGCGCGCGCGTCACCTACCTGGACGTGGAGCCCGACGGCCGGGTGAGCCT
GGAGAAGCTGGCCGCGGCGATGACGCCGAAGACGGTGCTGGTCTCCATCATGTTCGCCAACAACGAGATTGGTGTGGTGC
AGCCCATCGCGGAGATTGGCGCGCTGTGCCGCTCCAAGGGCGTGCTCTTCCACTGCGACGCGGTGCAGGGCATCGGCAAG
GTGCCCTTCGACGTGGAGGCCATGAAGGTGGACCTGGCCTCCATCACCTCGCACAAGATGTACGGCCCCAAGGGCATTGG
CGCGCTGTACGTGCGCCGCCGGCCGCGCGTGCGCATCGCGCCCAGCATCGACGGCGGCGGTCATGAGCGCGGCATGCGCT
CCGGCACGCTGAACGTGGCGGCCATCGTCGGCTTTGGCGTGGCTGCCGAGCTGGCTCGCAAGGAGCTGCCCGAGGAGTCG
GCGCGCCTCCTTCGCTTGCGTGAAAAGCTGCGCAAGGGCCTCACGGACGCGCTGGACATGACCGTCATCAACGGCTCGCT
GGAGCACCGGCTGCCCGGCAACCTCAACATCTCCTTCGCCCACGCGGAGGGAGAGTCCCTGATGATGGGCATCAAGGACG
TGGCGGTGTCCTCCGGCTCGGCGTGTACGTCCGCCTCCCTGGAGCCCTCCTACGTGCTGCGCGCGCTGGGCGTGGACGAG
GAGCTGGCGCACAGCTCCATCCGCTTCGGCCTGGGCCGCTTCACCACGGAAGAGGAAGTCGACTACGTGGTGAACCTCGT
AGTGGACAAGGTCCGCAAGCTGCGCGACATGAGCCCGCTCTACGAGATGGCCAAGGAAGGCATCGACCTCAAGAGCATCG
AGTGGACGGCGCACTAG

Upstream 100 bases:

>100_bases
TTTTATATTTGACCAGTCCGGTCCACATTCAGGTGTGACGGTGTAGGTTCCCCTGCGGCAAAGGCGCTCCGAGGCGCCGG
TCGACGTCCCCTCCAGGAAG

Downstream 100 bases:

>100_bases
CGCCTTCTCAGGTAGACAGGGGGGCGCGAGCCCCCTCGCCCGGAGGGTGTTGCCCGCCGGAACCTTTGGTGAGAAGCATC
CGTTGAAGGAGCAGGCATGG

Product: cysteine desulfurase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MLEAMVKLPIYMDNHATTPLDPRVLEAMLPYLREDFGNAASRNHVFGWKAEAAVNKARQQVAELIGAAEQEIVFTSGATE
SDNLAIKGVIEFYKSKGDHIITLKTEHKAILDTCKRLERVRQERLDELKLLRLAQLAGQDVTEDNQSELLSKYDVDSDET
YRKWAELPTGGARVTYLDVEPDGRVSLEKLAAAMTPKTVLVSIMFANNEIGVVQPIAEIGALCRSKGVLFHCDAVQGIGK
VPFDVEAMKVDLASITSHKMYGPKGIGALYVRRRPRVRIAPSIDGGGHERGMRSGTLNVAAIVGFGVAAELARKELPEES
ARLLRLREKLRKGLTDALDMTVINGSLEHRLPGNLNISFAHAEGESLMMGIKDVAVSSGSACTSASLEPSYVLRALGVDE
ELAHSSIRFGLGRFTTEEEVDYVVNLVVDKVRKLRDMSPLYEMAKEGIDLKSIEWTAH

Sequences:

>Translated_458_residues
MLEAMVKLPIYMDNHATTPLDPRVLEAMLPYLREDFGNAASRNHVFGWKAEAAVNKARQQVAELIGAAEQEIVFTSGATE
SDNLAIKGVIEFYKSKGDHIITLKTEHKAILDTCKRLERVRQERLDELKLLRLAQLAGQDVTEDNQSELLSKYDVDSDET
YRKWAELPTGGARVTYLDVEPDGRVSLEKLAAAMTPKTVLVSIMFANNEIGVVQPIAEIGALCRSKGVLFHCDAVQGIGK
VPFDVEAMKVDLASITSHKMYGPKGIGALYVRRRPRVRIAPSIDGGGHERGMRSGTLNVAAIVGFGVAAELARKELPEES
ARLLRLREKLRKGLTDALDMTVINGSLEHRLPGNLNISFAHAEGESLMMGIKDVAVSSGSACTSASLEPSYVLRALGVDE
ELAHSSIRFGLGRFTTEEEVDYVVNLVVDKVRKLRDMSPLYEMAKEGIDLKSIEWTAH
>Mature_458_residues
MLEAMVKLPIYMDNHATTPLDPRVLEAMLPYLREDFGNAASRNHVFGWKAEAAVNKARQQVAELIGAAEQEIVFTSGATE
SDNLAIKGVIEFYKSKGDHIITLKTEHKAILDTCKRLERVRQERLDELKLLRLAQLAGQDVTEDNQSELLSKYDVDSDET
YRKWAELPTGGARVTYLDVEPDGRVSLEKLAAAMTPKTVLVSIMFANNEIGVVQPIAEIGALCRSKGVLFHCDAVQGIGK
VPFDVEAMKVDLASITSHKMYGPKGIGALYVRRRPRVRIAPSIDGGGHERGMRSGTLNVAAIVGFGVAAELARKELPEES
ARLLRLREKLRKGLTDALDMTVINGSLEHRLPGNLNISFAHAEGESLMMGIKDVAVSSGSACTSASLEPSYVLRALGVDE
ELAHSSIRFGLGRFTTEEEVDYVVNLVVDKVRKLRDMSPLYEMAKEGIDLKSIEWTAH

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=450, Percent_Identity=54.2222222222222, Blast_Score=501, Evalue=1e-142,
Organism=Homo sapiens, GI156713448, Length=465, Percent_Identity=32.258064516129, Blast_Score=195, Evalue=8e-50,
Organism=Escherichia coli, GI48994898, Length=455, Percent_Identity=55.1648351648352, Blast_Score=496, Evalue=1e-141,
Organism=Escherichia coli, GI1787970, Length=446, Percent_Identity=23.542600896861, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1789175, Length=443, Percent_Identity=24.1534988713318, Blast_Score=86, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI25143064, Length=451, Percent_Identity=53.6585365853659, Blast_Score=490, Evalue=1e-139,
Organism=Caenorhabditis elegans, GI17533177, Length=367, Percent_Identity=31.8801089918256, Blast_Score=149, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6319831, Length=450, Percent_Identity=50.8888888888889, Blast_Score=461, Evalue=1e-130,
Organism=Drosophila melanogaster, GI20129463, Length=450, Percent_Identity=52.4444444444444, Blast_Score=476, Evalue=1e-134,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 50368; Mature: 50368

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEAMVKLPIYMDNHATTPLDPRVLEAMLPYLREDFGNAASRNHVFGWKAEAAVNKARQQ
CCCCEEECCEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHH
VAELIGAAEQEIVFTSGATESDNLAIKGVIEFYKSKGDHIITLKTEHKAILDTCKRLERV
HHHHHCCCCCEEEEECCCCCCCCEEHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHH
RQERLDELKLLRLAQLAGQDVTEDNQSELLSKYDVDSDETYRKWAELPTGGARVTYLDVE
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCHHHHHHHCCCCCCCEEEEEEEC
PDGRVSLEKLAAAMTPKTVLVSIMFANNEIGVVQPIAEIGALCRSKGVLFHCDAVQGIGK
CCCCCCHHHHHHHCCCCHHEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEHHHCCCCC
VPFDVEAMKVDLASITSHKMYGPKGIGALYVRRRPRVRIAPSIDGGGHERGMRSGTLNVA
CCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCEEECCCCCCCCHHCCCCCCCCEEH
AIVGFGVAAELARKELPEESARLLRLREKLRKGLTDALDMTVINGSLEHRLPGNLNISFA
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHEEECCCCCCCCCCCCEEEEE
HAEGESLMMGIKDVAVSSGSACTSASLEPSYVLRALGVDEELAHSSIRFGLGRFTTEEEV
ECCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHH
DYVVNLVVDKVRKLRDMSPLYEMAKEGIDLKSIEWTAH
HHHHHHHHHHHHHHHCCCHHHHHHHCCCCEECEEEECC
>Mature Secondary Structure
MLEAMVKLPIYMDNHATTPLDPRVLEAMLPYLREDFGNAASRNHVFGWKAEAAVNKARQQ
CCCCEEECCEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHH
VAELIGAAEQEIVFTSGATESDNLAIKGVIEFYKSKGDHIITLKTEHKAILDTCKRLERV
HHHHHCCCCCEEEEECCCCCCCCEEHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHH
RQERLDELKLLRLAQLAGQDVTEDNQSELLSKYDVDSDETYRKWAELPTGGARVTYLDVE
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCHHHHHHHCCCCCCCEEEEEEEC
PDGRVSLEKLAAAMTPKTVLVSIMFANNEIGVVQPIAEIGALCRSKGVLFHCDAVQGIGK
CCCCCCHHHHHHHCCCCHHEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEHHHCCCCC
VPFDVEAMKVDLASITSHKMYGPKGIGALYVRRRPRVRIAPSIDGGGHERGMRSGTLNVA
CCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCEEECCCCCCCCHHCCCCCCCCEEH
AIVGFGVAAELARKELPEESARLLRLREKLRKGLTDALDMTVINGSLEHRLPGNLNISFA
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHEEECCCCCCCCCCCCEEEEE
HAEGESLMMGIKDVAVSSGSACTSASLEPSYVLRALGVDEELAHSSIRFGLGRFTTEEEV
ECCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHH
DYVVNLVVDKVRKLRDMSPLYEMAKEGIDLKSIEWTAH
HHHHHHHHHHHHHHHCCCHHHHHHHCCCCEECEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA