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The map label for this gene is frgB [H]

Identifier: 108763723

GI number: 108763723

Start: 1313908

End: 1315440

Strand: Reverse

Name: frgB [H]

Synonym: MXAN_1129

Alternate gene names: 108763723

Gene position: 1315440-1313908 (Counterclockwise)

Preceding gene: 108759361

Following gene: 108758269

Centisome position: 14.39

GC content: 72.08

Gene sequence:

>1533_bases
ATGACGGGTGGGATGTGGATCAGCCTCCTGGCCTGCGCGGGCCAGCTCGCCTTGGCGGGCCTTGCCCTGGTGCGCGTGGG
CAAGAGTCCGTTGGCGCTGCCGCTGTCGCTGCTGTCCATCGCCCTGTCGACGTGGAACTTCTCCGGCTTCGCGCTGGTGC
GCGCGGACGAGGACGGCTGGCGGCTGGTGGGCTTCACCGCGGGCTTGATGACGGTGCCGTGCGCGCTGCACTTCATCCTG
TCCTTCGTGGGACGGCGACGAAGCCTCGCCTGGGCCATGTACGGGGCCTATGCCCTCTTCGGCGCGTTGGCGCTCGCCAT
GCTGGTGGCGTTGGGCGCCCCCACGCTGGAGGCGCACCTGCTCACGCTGCGCTTCGGGCTGCTCGTCTCCGCGCTGGCCA
TTCCCATCCTCGGTGGAGGCTTCGCGCTCCTGGGATTCCACGTGCTGCACTCGCGACACCCGGACGAGCGCGCCCGCGCG
GGCCTGGTGCTGTTGGGGCTCACGCTGGTGGTGGCCCTGCTGATGACGGAGCTGGCGGCGGAGCTGGGCCTGGAGGTGGT
GCGGCTCGGCCACGTGGGCACGCTCCTGGGCTTGCCGGTGATGGCCACCGCGGCGCTGCGCTTCGGCCTCTTCGGAGACG
ACCCGGGTGCGCCCCGGCTCGCGCTGCACGCGGCGGGCATCGCGGGGCTGGGGGTGCTGGCCTATCTCGCCGTGGTGCGG
CTCTTCGTCGCGCAGGCGGGCACGCTCATCATCTGCACCACGGCGGTGACGTTCGCCCTGGTGGCGGCGACCCGCCGGGG
CGTCACCGCCTACGTCAGCCGAAGCGAGCGACTGGAGCGGCTCGCCACGCTGGGCCGCTTCTCCGCGCAGATGGCGCACG
ACCTCAAGAACCCCATCGCCGCGATGAAGGGCGCCGCGCAGTACCTCAAGGAGGAGCACGCGCGCGGGCGTTCGTGGGAC
GGGCAAGGCGAGTTCCTGGACCTGCTGCTGGAGCAGGTGGAGCGCCTGGACCGGGTGGTGGACACGTATCAGCGGCTGGC
GCGCGTGGAGCCCCTGCCAAAGCCGGTGGACCTGCGCCGGCTGGTGGAGGGCGTGCTGTCGCTCCAGGTCTTCGCCAGCC
CGGGCAAGGTCGTCATCATCCGGGAGCTGGCCGCCGGCCTGCCCCCCTGCGCGGGGGACCAGGACCTGCTGGCCAACGCC
CTGGAGAACCTGGTGCGCAACGCCTGCGAAGCAATGCCGGGAGGTGGCACCCTCACCGTGCGCGCGCTGCGTGACGGTGC
CGACGTGGCCATGGAGGTAGAGGACACCGGCGAGGGCATGGACGCTCGAACACGCGAGCGTGCCTTCGACGACTTCTTCA
CCACCAAGGCCTCGGGCAGCGGCCTGGGGCTGGCCTTCGTCCGGCGCGTGGTGGAAGCGCATGGCGGCGAGGTGCTCCTG
ACAAGCCGGGAGGGGCGCGGTACGGTGGTCCGGATGCGCCTGCCCGTCACGGACGCGAGCCTGGGCGGCGCAGGCGTGGG
AGAAGCCGCGTGA

Upstream 100 bases:

>100_bases
CGAGCGTGAACAGGCGGTGCGCCGCTGGGAGTCCGCGGCGGTGGAGCCGGCCAACGCGCGTCGGCTGGGCATGCTCTAGT
CCCCTGCATCGGAGCGCCCC

Downstream 100 bases:

>100_bases
ACGAATCATTGAGAGGCACGGTGCTGCTGGTCGACGACGACCCCGCCGTGGCCAAGGTGCTGGGCGCCCTGCTGACGCAG
GCGGGCCTGACGACGCATGC

Product: sensor histidine kinase FrgB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 510; Mature: 509

Protein sequence:

>510_residues
MTGGMWISLLACAGQLALAGLALVRVGKSPLALPLSLLSIALSTWNFSGFALVRADEDGWRLVGFTAGLMTVPCALHFIL
SFVGRRRSLAWAMYGAYALFGALALAMLVALGAPTLEAHLLTLRFGLLVSALAIPILGGGFALLGFHVLHSRHPDERARA
GLVLLGLTLVVALLMTELAAELGLEVVRLGHVGTLLGLPVMATAALRFGLFGDDPGAPRLALHAAGIAGLGVLAYLAVVR
LFVAQAGTLIICTTAVTFALVAATRRGVTAYVSRSERLERLATLGRFSAQMAHDLKNPIAAMKGAAQYLKEEHARGRSWD
GQGEFLDLLLEQVERLDRVVDTYQRLARVEPLPKPVDLRRLVEGVLSLQVFASPGKVVIIRELAAGLPPCAGDQDLLANA
LENLVRNACEAMPGGGTLTVRALRDGADVAMEVEDTGEGMDARTRERAFDDFFTTKASGSGLGLAFVRRVVEAHGGEVLL
TSREGRGTVVRMRLPVTDASLGGAGVGEAA

Sequences:

>Translated_510_residues
MTGGMWISLLACAGQLALAGLALVRVGKSPLALPLSLLSIALSTWNFSGFALVRADEDGWRLVGFTAGLMTVPCALHFIL
SFVGRRRSLAWAMYGAYALFGALALAMLVALGAPTLEAHLLTLRFGLLVSALAIPILGGGFALLGFHVLHSRHPDERARA
GLVLLGLTLVVALLMTELAAELGLEVVRLGHVGTLLGLPVMATAALRFGLFGDDPGAPRLALHAAGIAGLGVLAYLAVVR
LFVAQAGTLIICTTAVTFALVAATRRGVTAYVSRSERLERLATLGRFSAQMAHDLKNPIAAMKGAAQYLKEEHARGRSWD
GQGEFLDLLLEQVERLDRVVDTYQRLARVEPLPKPVDLRRLVEGVLSLQVFASPGKVVIIRELAAGLPPCAGDQDLLANA
LENLVRNACEAMPGGGTLTVRALRDGADVAMEVEDTGEGMDARTRERAFDDFFTTKASGSGLGLAFVRRVVEAHGGEVLL
TSREGRGTVVRMRLPVTDASLGGAGVGEAA
>Mature_509_residues
TGGMWISLLACAGQLALAGLALVRVGKSPLALPLSLLSIALSTWNFSGFALVRADEDGWRLVGFTAGLMTVPCALHFILS
FVGRRRSLAWAMYGAYALFGALALAMLVALGAPTLEAHLLTLRFGLLVSALAIPILGGGFALLGFHVLHSRHPDERARAG
LVLLGLTLVVALLMTELAAELGLEVVRLGHVGTLLGLPVMATAALRFGLFGDDPGAPRLALHAAGIAGLGVLAYLAVVRL
FVAQAGTLIICTTAVTFALVAATRRGVTAYVSRSERLERLATLGRFSAQMAHDLKNPIAAMKGAAQYLKEEHARGRSWDG
QGEFLDLLLEQVERLDRVVDTYQRLARVEPLPKPVDLRRLVEGVLSLQVFASPGKVVIIRELAAGLPPCAGDQDLLANAL
ENLVRNACEAMPGGGTLTVRALRDGADVAMEVEDTGEGMDARTRERAFDDFFTTKASGSGLGLAFVRRVVEAHGGEVLLT
SREGRGTVVRMRLPVTDASLGGAGVGEAA

Specific function: Member of the two-component regulatory system zraS/zraR. May function as a membrane-associated protein kinase that phosphorylates zraR in response to high concentrations of zinc or lead in the medium [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=225, Percent_Identity=35.5555555555556, Blast_Score=125, Evalue=6e-30,
Organism=Escherichia coli, GI1788549, Length=227, Percent_Identity=33.4801762114537, Blast_Score=125, Evalue=8e-30,
Organism=Escherichia coli, GI1790300, Length=218, Percent_Identity=29.3577981651376, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1790861, Length=238, Percent_Identity=31.0924369747899, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1786600, Length=220, Percent_Identity=27.7272727272727, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1786783, Length=235, Percent_Identity=31.063829787234, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI87082128, Length=237, Percent_Identity=26.1603375527426, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI87081816, Length=218, Percent_Identity=28.8990825688073, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1788393, Length=240, Percent_Identity=27.5, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 53771; Mature: 53640

Theoretical pI: Translated: 8.24; Mature: 8.24

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGGMWISLLACAGQLALAGLALVRVGKSPLALPLSLLSIALSTWNFSGFALVRADEDGW
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCC
RLVGFTAGLMTVPCALHFILSFVGRRRSLAWAMYGAYALFGALALAMLVALGAPTLEAHL
EEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
LTLRFGLLVSALAIPILGGGFALLGFHVLHSRHPDERARAGLVLLGLTLVVALLMTELAA
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ELGLEVVRLGHVGTLLGLPVMATAALRFGLFGDDPGAPRLALHAAGIAGLGVLAYLAVVR
HHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHH
LFVAQAGTLIICTTAVTFALVAATRRGVTAYVSRSERLERLATLGRFSAQMAHDLKNPIA
HHHHCCCCEEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMKGAAQYLKEEHARGRSWDGQGEFLDLLLEQVERLDRVVDTYQRLARVEPLPKPVDLRR
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
LVEGVLSLQVFASPGKVVIIRELAAGLPPCAGDQDLLANALENLVRNACEAMPGGGTLTV
HHHHHHHHHHEECCCCEEEEEHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEE
RALRDGADVAMEVEDTGEGMDARTRERAFDDFFTTKASGSGLGLAFVRRVVEAHGGEVLL
EEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCEEEE
TSREGRGTVVRMRLPVTDASLGGAGVGEAA
EECCCCCCEEEEEECCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TGGMWISLLACAGQLALAGLALVRVGKSPLALPLSLLSIALSTWNFSGFALVRADEDGW
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCC
RLVGFTAGLMTVPCALHFILSFVGRRRSLAWAMYGAYALFGALALAMLVALGAPTLEAHL
EEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
LTLRFGLLVSALAIPILGGGFALLGFHVLHSRHPDERARAGLVLLGLTLVVALLMTELAA
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ELGLEVVRLGHVGTLLGLPVMATAALRFGLFGDDPGAPRLALHAAGIAGLGVLAYLAVVR
HHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHH
LFVAQAGTLIICTTAVTFALVAATRRGVTAYVSRSERLERLATLGRFSAQMAHDLKNPIA
HHHHCCCCEEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMKGAAQYLKEEHARGRSWDGQGEFLDLLLEQVERLDRVVDTYQRLARVEPLPKPVDLRR
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
LVEGVLSLQVFASPGKVVIIRELAAGLPPCAGDQDLLANALENLVRNACEAMPGGGTLTV
HHHHHHHHHHEECCCCEEEEEHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEE
RALRDGADVAMEVEDTGEGMDARTRERAFDDFFTTKASGSGLGLAFVRRVVEAHGGEVLL
EEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCEEEE
TSREGRGTVVRMRLPVTDASLGGAGVGEAA
EECCCCCCEEEEEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503; 2666400; 11243806 [H]