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The map label for this gene is frgC [H]

Identifier: 108758269

GI number: 108758269

Start: 1312511

End: 1313911

Strand: Reverse

Name: frgC [H]

Synonym: MXAN_1128

Alternate gene names: 108758269

Gene position: 1313911-1312511 (Counterclockwise)

Preceding gene: 108763723

Following gene: 108757996

Centisome position: 14.38

GC content: 71.09

Gene sequence:

>1401_bases
GTGAACGAATCATTGAGAGGCACGGTGCTGCTGGTCGACGACGACCCCGCCGTGGCCAAGGTGCTGGGCGCCCTGCTGAC
GCAGGCGGGCCTGACGACGCATGCGGCGCGCGACGGGCAGGAAGCCCTGGCGCTGCTGGCAAGCAAGCCGGTGGACGTGG
TGGTGAGCGACGTGCGCATGCCGGGCATGGATGGCCTGCAGGTGCTCGCGGAGGTGGCGCGCGGCTGGCCGGACGTGCCC
GTCATCCTCCTCACCGCGCACGGCACGGTGCCGCTGGCGGTGGAGGCGATGAAGGCGGGCGCCGCGGACTTCGTGCTCAA
GCCCTTCGACCGGGAGGAGATTCTCTTCACCGTCCGCAAGGCGCTGCTGCGCGCGCAGGGCGAGGAGGCGCGCCAGCAGG
TGCGGCCCACGGGTGGCTTCATCGGCCGGAGCCGGGCCATGGCGGACGTACAGGCCGTGCTGGCGAAGGCGGCCGCCGGT
ACAGCCACGGTGCTGCTGCGCGGCGAGTCCGGCACGGGCAAGGAGCTGGCAGCCAAGGCCGTTCACGACGCCAGTCCCCG
GCGGGATGGCCCCTTCGTGAAGCTGCACTGCGCGGCGCTGCCGGACACCCTGCTGGAGAGCGAGCTGTTCGGCTACGAGA
AGGGCGCCTTCACGGGCGCCGCCACGCGCAAGCCGGGGCGCGTGGAGCTGGCCCATGGCGGCACGCTGTTCCTCGATGAG
GTGGGCGACATCTCCCCCGCGGTCCAGGTGAAGCTGCTGCGAGTCATCCAGGAGCGCGAACTGGAGCGGCTGGGCGGCAC
GCAGACGGTGAAGGTGGACGTCCGCTTCGTGGCGGCCACGCATCAGCCCTTGGAAGAGCGTGTGAAGGAAGGCCGCTTCC
GCGAGGACCTCTTCTACCGCCTCAACGTGGTGCCCGTGTGGATACCGGCCCTGCGCGAACGCCCGGACGACATCGAGCCG
TTGGCCCTGCACTTCCTGGAGGTCCACGCGAAGACGAACGGGCGCCCGCCCTTCACCCTCATGACCGACGGGCTCGCGGC
GCTGCGGGCCCAGCCGTGGCCCGGCAACGTGCGCCAGCTCCAGAACTTCCTGGAGCGGTTGGTGGTGCTCTCCGACACGC
AGGTGATTGGCGGGCGGGAAGTCCTTCAAGAGCTGGCGCGCCAGCCAGGCCTGGCCCCCGCCCCCTTCGCCGCGACACCT
TCCGTCAGCGCCCTGGAAGCGCCAACGGTGCCTGTCACGGACTCCGCCCGGACACTGGAGTCCCAGCGCAAGGAGATGGA
GCGCCAGGCGATGGCGGATGCGCTCAAGCGCGCGGGCGACAACCGGACGCTGGCGGCGCGGCTGCTCGGCATCAGCCGGC
GCACGCTCTACAACAAGCTGGAGGAGTACGGGCTGCTGTAG

Upstream 100 bases:

>100_bases
AGGTGCTCCTGACAAGCCGGGAGGGGCGCGGTACGGTGGTCCGGATGCGCCTGCCCGTCACGGACGCGAGCCTGGGCGGC
GCAGGCGTGGGAGAAGCCGC

Downstream 100 bases:

>100_bases
TCAGCCCTCAGTCACGCTCCGTCGCGAGCGCATCCAGCTCCTCGTGGAAGGCCTGGATGAGCGCATGCGGGTCGGTCACC
CGGCCCGCGTCCGCCGCCAC

Product: sigma-54 dependent DNA-binding response regulator FrgC

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 466; Mature: 466

Protein sequence:

>466_residues
MNESLRGTVLLVDDDPAVAKVLGALLTQAGLTTHAARDGQEALALLASKPVDVVVSDVRMPGMDGLQVLAEVARGWPDVP
VILLTAHGTVPLAVEAMKAGAADFVLKPFDREEILFTVRKALLRAQGEEARQQVRPTGGFIGRSRAMADVQAVLAKAAAG
TATVLLRGESGTGKELAAKAVHDASPRRDGPFVKLHCAALPDTLLESELFGYEKGAFTGAATRKPGRVELAHGGTLFLDE
VGDISPAVQVKLLRVIQERELERLGGTQTVKVDVRFVAATHQPLEERVKEGRFREDLFYRLNVVPVWIPALRERPDDIEP
LALHFLEVHAKTNGRPPFTLMTDGLAALRAQPWPGNVRQLQNFLERLVVLSDTQVIGGREVLQELARQPGLAPAPFAATP
SVSALEAPTVPVTDSARTLESQRKEMERQAMADALKRAGDNRTLAARLLGISRRTLYNKLEEYGLL

Sequences:

>Translated_466_residues
MNESLRGTVLLVDDDPAVAKVLGALLTQAGLTTHAARDGQEALALLASKPVDVVVSDVRMPGMDGLQVLAEVARGWPDVP
VILLTAHGTVPLAVEAMKAGAADFVLKPFDREEILFTVRKALLRAQGEEARQQVRPTGGFIGRSRAMADVQAVLAKAAAG
TATVLLRGESGTGKELAAKAVHDASPRRDGPFVKLHCAALPDTLLESELFGYEKGAFTGAATRKPGRVELAHGGTLFLDE
VGDISPAVQVKLLRVIQERELERLGGTQTVKVDVRFVAATHQPLEERVKEGRFREDLFYRLNVVPVWIPALRERPDDIEP
LALHFLEVHAKTNGRPPFTLMTDGLAALRAQPWPGNVRQLQNFLERLVVLSDTQVIGGREVLQELARQPGLAPAPFAATP
SVSALEAPTVPVTDSARTLESQRKEMERQAMADALKRAGDNRTLAARLLGISRRTLYNKLEEYGLL
>Mature_466_residues
MNESLRGTVLLVDDDPAVAKVLGALLTQAGLTTHAARDGQEALALLASKPVDVVVSDVRMPGMDGLQVLAEVARGWPDVP
VILLTAHGTVPLAVEAMKAGAADFVLKPFDREEILFTVRKALLRAQGEEARQQVRPTGGFIGRSRAMADVQAVLAKAAAG
TATVLLRGESGTGKELAAKAVHDASPRRDGPFVKLHCAALPDTLLESELFGYEKGAFTGAATRKPGRVELAHGGTLFLDE
VGDISPAVQVKLLRVIQERELERLGGTQTVKVDVRFVAATHQPLEERVKEGRFREDLFYRLNVVPVWIPALRERPDDIEP
LALHFLEVHAKTNGRPPFTLMTDGLAALRAQPWPGNVRQLQNFLERLVVLSDTQVIGGREVLQELARQPGLAPAPFAATP
SVSALEAPTVPVTDSARTLESQRKEMERQAMADALKRAGDNRTLAARLLGISRRTLYNKLEEYGLL

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=464, Percent_Identity=45.0431034482759, Blast_Score=379, Evalue=1e-106,
Organism=Escherichia coli, GI1790299, Length=474, Percent_Identity=45.7805907172996, Blast_Score=357, Evalue=1e-100,
Organism=Escherichia coli, GI1790437, Length=454, Percent_Identity=43.8325991189427, Blast_Score=353, Evalue=1e-98,
Organism=Escherichia coli, GI1788905, Length=462, Percent_Identity=40.2597402597403, Blast_Score=307, Evalue=1e-84,
Organism=Escherichia coli, GI87082117, Length=335, Percent_Identity=45.0746268656716, Blast_Score=259, Evalue=2e-70,
Organism=Escherichia coli, GI1789233, Length=328, Percent_Identity=41.4634146341463, Blast_Score=253, Evalue=3e-68,
Organism=Escherichia coli, GI1789087, Length=239, Percent_Identity=49.3723849372385, Blast_Score=230, Evalue=2e-61,
Organism=Escherichia coli, GI1786524, Length=345, Percent_Identity=40.5797101449275, Blast_Score=225, Evalue=6e-60,
Organism=Escherichia coli, GI87082152, Length=326, Percent_Identity=41.1042944785276, Blast_Score=221, Evalue=7e-59,
Organism=Escherichia coli, GI1787583, Length=338, Percent_Identity=38.7573964497041, Blast_Score=193, Evalue=2e-50,
Organism=Escherichia coli, GI87081872, Length=316, Percent_Identity=39.873417721519, Blast_Score=192, Evalue=4e-50,
Organism=Escherichia coli, GI87081858, Length=313, Percent_Identity=31.629392971246, Blast_Score=132, Evalue=7e-32,
Organism=Escherichia coli, GI1789828, Length=253, Percent_Identity=33.596837944664, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI87082012, Length=114, Percent_Identity=34.2105263157895, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1789402, Length=127, Percent_Identity=30.7086614173228, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1789149, Length=160, Percent_Identity=30, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI1789809, Length=129, Percent_Identity=30.2325581395349, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788394, Length=125, Percent_Identity=27.2, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1786784, Length=117, Percent_Identity=29.9145299145299, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1788222, Length=114, Percent_Identity=35.9649122807018, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50454; Mature: 50454

Theoretical pI: Translated: 7.30; Mature: 7.30

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNESLRGTVLLVDDDPAVAKVLGALLTQAGLTTHAARDGQEALALLASKPVDVVVSDVRM
CCCCCCEEEEEECCCHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHCCCHHHHHHCCCC
PGMDGLQVLAEVARGWPDVPVILLTAHGTVPLAVEAMKAGAADFVLKPFDREEILFTVRK
CCCHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHCCCHHHEECCCCHHHHHHHHHH
ALLRAQGEEARQQVRPTGGFIGRSRAMADVQAVLAKAAAGTATVLLRGESGTGKELAAKA
HHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHH
VHDASPRRDGPFVKLHCAALPDTLLESELFGYEKGAFTGAATRKPGRVELAHGGTLFLDE
HHCCCCCCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCEEEECC
VGDISPAVQVKLLRVIQERELERLGGTQTVKVDVRFVAATHQPLEERVKEGRFREDLFYR
CCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEECCCHHHHHHHCCCHHHHHHHE
LNVVPVWIPALRERPDDIEPLALHFLEVHAKTNGRPPFTLMTDGLAALRAQPWPGNVRQL
EEEHEEEHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCEEEECCCHHHHCCCCCCCCHHHH
QNFLERLVVLSDTQVIGGREVLQELARQPGLAPAPFAATPSVSALEAPTVPVTDSARTLE
HHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
SQRKEMERQAMADALKRAGDNRTLAARLLGISRRTLYNKLEEYGLL
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNESLRGTVLLVDDDPAVAKVLGALLTQAGLTTHAARDGQEALALLASKPVDVVVSDVRM
CCCCCCEEEEEECCCHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHCCCHHHHHHCCCC
PGMDGLQVLAEVARGWPDVPVILLTAHGTVPLAVEAMKAGAADFVLKPFDREEILFTVRK
CCCHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHCCCHHHEECCCCHHHHHHHHHH
ALLRAQGEEARQQVRPTGGFIGRSRAMADVQAVLAKAAAGTATVLLRGESGTGKELAAKA
HHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHH
VHDASPRRDGPFVKLHCAALPDTLLESELFGYEKGAFTGAATRKPGRVELAHGGTLFLDE
HHCCCCCCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCEEEECC
VGDISPAVQVKLLRVIQERELERLGGTQTVKVDVRFVAATHQPLEERVKEGRFREDLFYR
CCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEECCCHHHHHHHCCCHHHHHHHE
LNVVPVWIPALRERPDDIEPLALHFLEVHAKTNGRPPFTLMTDGLAALRAQPWPGNVRQL
EEEHEEEHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCEEEECCCHHHHCCCCCCCCHHHH
QNFLERLVVLSDTQVIGGREVLQELARQPGLAPAPFAATPSVSALEAPTVPVTDSARTLE
HHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
SQRKEMERQAMADALKRAGDNRTLAARLLGISRRTLYNKLEEYGLL
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]