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The map label for this gene is argH [H]

Identifier: 108763718

GI number: 108763718

Start: 6380844

End: 6382193

Strand: Direct

Name: argH [H]

Synonym: MXAN_5107

Alternate gene names: 108763718

Gene position: 6380844-6382193 (Clockwise)

Preceding gene: 108759253

Following gene: 108757976

Centisome position: 69.81

GC content: 72.44

Gene sequence:

>1350_bases
GTGGCTGACACGCTGTGGGGCAAGGGCCTTCCCCTGGACGCGGCCATCCATCGATTCACGGTGGGCAACGACCCGGTGGT
GGACTTGGCGCTGGCGCCGCATGACGCGCTCGGCTCGGCCGCGCACGCGCGGATGCTGGCGCGCGTGGGCCTGCTGAAGG
ACGCGGAGGCCAAGTCCCTGGTGACGGCGCTCAAGGCGCTGCACGACGAGGCCCGCGCGGGCACGTTCGTCATCCGTCCC
GAGCAGGAGGACGGCCACACCGCCCTGGAGGCGGCGCTGGTGGAGCGCGTGGGCGAGCCGGGCAAGCGCATCCACCTGGG
GCGTTCTCGCAACGACCAGGTGCAGTTGGCCCTGCGCCTGCTGCTGCGTGAAGAAGTGCTCACGCTGGGCGCGCGGGCGG
CGGAGCTGGCGGGGGCCTTCCTGGACTTCGCGCAGGCGCACAAGGACGTGGCGCTGCCGGGCTACACGCACCTGCGCCGG
GCCATGCCTTCCACCTTCGGTCTGTGGGGCATGGCGTTCGCGGAAGGGCTGCTGGAGGAACTCGAGGCGCTGCGCGGCGT
GTGGGCTCGGCTGGACCGCTGCCCGCTGGGCGCGGCGGCGGGCTTCGGCGTGCCGCTGCCCATCGACCGGGAGTACGTGG
CGGCGCTGCTGGGTTTCTCGCGCGTGCAGCGCAGCCCCATCGACGTGCAGAACGGACGCGGCCGTCACGAGTCCGCGGTG
CTGGGCTGGGCCTGCTCGGTGGCGGGCACGCTGGAGAAGTGGCTGTGGGACGTGCAGCTCTACAGCATGGACGAGTTCGG
CTTCCTCGGACTGCCGGACGCGTACACCACGGGCTCGTCCATCATGCCGCAGAAGAAGAACCCGGACGTCGTGGAGCTGG
CCCGGGGCCGCTGCCGCGAGCTGCGCGGACTGGCGCATCAGGTGGAGGCCGTCGCGGGCGGACTGCCCTCCAGCTACCAC
CGCGACTTCCAACTGCTGAAGTCCCCCACCCTGACGGCGCTGGGCTCCACGCGGGAGCTGCTGGACGTGCTCACCCGGTT
GGTGCCCGCGCTCCAGGTGAAGGCGGACGCGGCGGCGCGTGCCAGCGACGACACGCTGTACGCGGCGCACCATGCCTATG
CGCTGGTGGCCCAGGGACAGGCCTTCCGTGACGCCTACAAGCAGGTGGGCCGCGAGCTGGTGGAAGGAACGTTCCGTCCA
GACCGCGGCGCCCTGACGGCCACCCACCTGGGTGGCGCCGGCAACCTGGGCCTGCCCCAGGCCCGGGAAGAGCTGGCCGC
CTCGCGCGCCTGGCTCGATGAGACGCACCGCCTGGTGGCCGATGCCGCCGGGCGCGTCTGGACGGTTTGA

Upstream 100 bases:

>100_bases
CGCAGCCACCTGGCGGACGAATTCATCACCCGGGCGGAGCTGGAAGCCGGCGCCGCCTTCTACACGCAACTGGTTCGGGG
TTACTTCGAGGAGGCGGCTC

Downstream 100 bases:

>100_bases
ACCGCATCCCCGCGAGGAGCGAATCATGAGCAACAAGAAGAACGTGGTGCTGGCCTTCTCCGGCGGACTCGATACCGCTT
TCTGTGCCGTCTACCTGCGA

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 449; Mature: 448

Protein sequence:

>449_residues
MADTLWGKGLPLDAAIHRFTVGNDPVVDLALAPHDALGSAAHARMLARVGLLKDAEAKSLVTALKALHDEARAGTFVIRP
EQEDGHTALEAALVERVGEPGKRIHLGRSRNDQVQLALRLLLREEVLTLGARAAELAGAFLDFAQAHKDVALPGYTHLRR
AMPSTFGLWGMAFAEGLLEELEALRGVWARLDRCPLGAAAGFGVPLPIDREYVAALLGFSRVQRSPIDVQNGRGRHESAV
LGWACSVAGTLEKWLWDVQLYSMDEFGFLGLPDAYTTGSSIMPQKKNPDVVELARGRCRELRGLAHQVEAVAGGLPSSYH
RDFQLLKSPTLTALGSTRELLDVLTRLVPALQVKADAAARASDDTLYAAHHAYALVAQGQAFRDAYKQVGRELVEGTFRP
DRGALTATHLGGAGNLGLPQAREELAASRAWLDETHRLVADAAGRVWTV

Sequences:

>Translated_449_residues
MADTLWGKGLPLDAAIHRFTVGNDPVVDLALAPHDALGSAAHARMLARVGLLKDAEAKSLVTALKALHDEARAGTFVIRP
EQEDGHTALEAALVERVGEPGKRIHLGRSRNDQVQLALRLLLREEVLTLGARAAELAGAFLDFAQAHKDVALPGYTHLRR
AMPSTFGLWGMAFAEGLLEELEALRGVWARLDRCPLGAAAGFGVPLPIDREYVAALLGFSRVQRSPIDVQNGRGRHESAV
LGWACSVAGTLEKWLWDVQLYSMDEFGFLGLPDAYTTGSSIMPQKKNPDVVELARGRCRELRGLAHQVEAVAGGLPSSYH
RDFQLLKSPTLTALGSTRELLDVLTRLVPALQVKADAAARASDDTLYAAHHAYALVAQGQAFRDAYKQVGRELVEGTFRP
DRGALTATHLGGAGNLGLPQAREELAASRAWLDETHRLVADAAGRVWTV
>Mature_448_residues
ADTLWGKGLPLDAAIHRFTVGNDPVVDLALAPHDALGSAAHARMLARVGLLKDAEAKSLVTALKALHDEARAGTFVIRPE
QEDGHTALEAALVERVGEPGKRIHLGRSRNDQVQLALRLLLREEVLTLGARAAELAGAFLDFAQAHKDVALPGYTHLRRA
MPSTFGLWGMAFAEGLLEELEALRGVWARLDRCPLGAAAGFGVPLPIDREYVAALLGFSRVQRSPIDVQNGRGRHESAVL
GWACSVAGTLEKWLWDVQLYSMDEFGFLGLPDAYTTGSSIMPQKKNPDVVELARGRCRELRGLAHQVEAVAGGLPSSYHR
DFQLLKSPTLTALGSTRELLDVLTRLVPALQVKADAAARASDDTLYAAHHAYALVAQGQAFRDAYKQVGRELVEGTFRPD
RGALTATHLGGAGNLGLPQAREELAASRAWLDETHRLVADAAGRVWTV

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=383, Percent_Identity=36.0313315926893, Blast_Score=218, Evalue=7e-57,
Organism=Homo sapiens, GI68303542, Length=383, Percent_Identity=36.0313315926893, Blast_Score=218, Evalue=7e-57,
Organism=Homo sapiens, GI68303547, Length=383, Percent_Identity=35.7702349869452, Blast_Score=198, Evalue=1e-50,
Organism=Homo sapiens, GI68303549, Length=383, Percent_Identity=34.2036553524804, Blast_Score=196, Evalue=5e-50,
Organism=Escherichia coli, GI1790398, Length=399, Percent_Identity=37.0927318295739, Blast_Score=220, Evalue=2e-58,
Organism=Saccharomyces cerevisiae, GI6321806, Length=384, Percent_Identity=33.0729166666667, Blast_Score=184, Evalue=2e-47,
Organism=Drosophila melanogaster, GI221473854, Length=386, Percent_Identity=35.2331606217617, Blast_Score=200, Evalue=2e-51,
Organism=Drosophila melanogaster, GI78706858, Length=386, Percent_Identity=35.2331606217617, Blast_Score=200, Evalue=2e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 48467; Mature: 48336

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADTLWGKGLPLDAAIHRFTVGNDPVVDLALAPHDALGSAAHARMLARVGLLKDAEAKSL
CCCCCCCCCCCHHHHHHHEECCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHH
VTALKALHDEARAGTFVIRPEQEDGHTALEAALVERVGEPGKRIHLGRSRNDQVQLALRL
HHHHHHHHHHHHCCEEEECCCCCCCHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHH
LLREEVLTLGARAAELAGAFLDFAQAHKDVALPGYTHLRRAMPSTFGLWGMAFAEGLLEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHH
LEALRGVWARLDRCPLGAAAGFGVPLPIDREYVAALLGFSRVQRSPIDVQNGRGRHESAV
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHH
LGWACSVAGTLEKWLWDVQLYSMDEFGFLGLPDAYTTGSSIMPQKKNPDVVELARGRCRE
HHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
LRGLAHQVEAVAGGLPSSYHRDFQLLKSPTLTALGSTRELLDVLTRLVPALQVKADAAAR
HHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHC
ASDDTLYAAHHAYALVAQGQAFRDAYKQVGRELVEGTFRPDRGALTATHLGGAGNLGLPQ
CCCCCEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCH
AREELAASRAWLDETHRLVADAAGRVWTV
HHHHHHHHHHHHHHHHHHHHHCCCCEECC
>Mature Secondary Structure 
ADTLWGKGLPLDAAIHRFTVGNDPVVDLALAPHDALGSAAHARMLARVGLLKDAEAKSL
CCCCCCCCCCHHHHHHHEECCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHH
VTALKALHDEARAGTFVIRPEQEDGHTALEAALVERVGEPGKRIHLGRSRNDQVQLALRL
HHHHHHHHHHHHCCEEEECCCCCCCHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHH
LLREEVLTLGARAAELAGAFLDFAQAHKDVALPGYTHLRRAMPSTFGLWGMAFAEGLLEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHH
LEALRGVWARLDRCPLGAAAGFGVPLPIDREYVAALLGFSRVQRSPIDVQNGRGRHESAV
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHH
LGWACSVAGTLEKWLWDVQLYSMDEFGFLGLPDAYTTGSSIMPQKKNPDVVELARGRCRE
HHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
LRGLAHQVEAVAGGLPSSYHRDFQLLKSPTLTALGSTRELLDVLTRLVPALQVKADAAAR
HHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHC
ASDDTLYAAHHAYALVAQGQAFRDAYKQVGRELVEGTFRPDRGALTATHLGGAGNLGLPQ
CCCCCEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCH
AREELAASRAWLDETHRLVADAAGRVWTV
HHHHHHHHHHHHHHHHHHHHHCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA