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The map label for this gene is argG [H]

Identifier: 108757976

GI number: 108757976

Start: 6382219

End: 6383409

Strand: Direct

Name: argG [H]

Synonym: MXAN_5108

Alternate gene names: 108757976

Gene position: 6382219-6383409 (Clockwise)

Preceding gene: 108763718

Following gene: 108757124

Centisome position: 69.83

GC content: 69.77

Gene sequence:

>1191_bases
ATGAGCAACAAGAAGAACGTGGTGCTGGCCTTCTCCGGCGGACTCGATACCGCTTTCTGTGCCGTCTACCTGCGAGAGCA
GGGCTACGACGTCACCACCGTCACGGTGGACACCGGCGGCTTCCCGCCCGAGCAGTTGGAGCGCATCGCCGCGCTGTCCA
AGCAGTTGGGCGCGGTGGAGCACGTGACGGTGGACGCGCGCGAGACGCTCTTCCAGGGCTACCTGCGCTACCTCATCGCG
GGCAACGTGCTGCGCGGCCAGGTCTACCCCCTGAGCGTGTCCGCGGAGCGCGCGTGCCAGGCGGCGGAGGTCGTCCGCGT
GGCGCGCGAGAAGGGCACCCAGGCGCTGGCGCACGGCAGCACGGGCGCGGGAAATGACCAGGTGCGCTTCGACGTGGCCT
TCCGCTCGCTGGCGCCGGAGCTGGAGCTGCTCACGCCCATCCGCACGCTGTCCCTGAGCCGGCAGCAGGAGCTGACCTAC
CTGGCCGAGCGCGGCGTCCACATGCCGCCGAAGCTGGGCTCCTACTCCGTCAACGAGGGCATGTGGGGCACCTCCGTGGG
CGGCGCCGAGACGCTGGACTCCTGGAAGGCGCTGCCCGAGGCGGCCTTCCCCGGCGGCGAGCTGTCGCAGGACCTCAAGC
CCCGTCCCCTCACGGTGTCCTTCGAGAAGGGCGTCCCGGTGGCGCTGGACGGCGAGAAGCTGGGCCCCGTGAAGCTGGTG
GAGGCGCTCAACGCGCTGGGGCGCACCTACGGCATCGGCCGGGGCGTGCACCTGGGTGACACGATTCTGGGCATCAAGGG
CCGCGTGGGCTTCGAGGCGCCGGCGGCGCACCTGCTCGTCACCGCGCACCGCGAGCTGGAGAAGCTGGTGCTCTCCGGCA
AGCAGCTCTTCTGGAAGGAGTCGATGGGCAACCTCTACGGCTCGCTGCTGCACGAGGGGCACTTCTTCGACCCGCTGGTG
AAGGACCTGGAGGCGTTCCTCACCTCGTCGCAGGAGCGCGTGACGGGTGACGTGCGGCTGGTGCTGCACCCGCGCACGCA
GGTGGTGGAAGGCGTGCGTTCGCCGCACTCGCTGATGGACGCGAAGGTGGCGACGTACGGAGAGGCCAACGTGTTGTGGA
ACGGCTCGGAAGCCGCGGGCTTCGCCAAGCTGTACGGCGTCGCGCAGATGCTCTCGCATCGCGCGAAGTGA

Upstream 100 bases:

>100_bases
GCCGCCTCGCGCGCCTGGCTCGATGAGACGCACCGCCTGGTGGCCGATGCCGCCGGGCGCGTCTGGACGGTTTGAACCGC
ATCCCCGCGAGGAGCGAATC

Downstream 100 bases:

>100_bases
GGGTGCCATGAAGGTTTTCGTCGACAAGGTAGGCAGTGTCACCCGCAACCTCGGCCTGGGCCGTACCGTCCACCTCGCGT
CCGAGGTGAAGGCCGAGGAG

Product: argininosuccinate synthase

Products: NA

Alternate protein names: Citrulline--aspartate ligase [H]

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MSNKKNVVLAFSGGLDTAFCAVYLREQGYDVTTVTVDTGGFPPEQLERIAALSKQLGAVEHVTVDARETLFQGYLRYLIA
GNVLRGQVYPLSVSAERACQAAEVVRVAREKGTQALAHGSTGAGNDQVRFDVAFRSLAPELELLTPIRTLSLSRQQELTY
LAERGVHMPPKLGSYSVNEGMWGTSVGGAETLDSWKALPEAAFPGGELSQDLKPRPLTVSFEKGVPVALDGEKLGPVKLV
EALNALGRTYGIGRGVHLGDTILGIKGRVGFEAPAAHLLVTAHRELEKLVLSGKQLFWKESMGNLYGSLLHEGHFFDPLV
KDLEAFLTSSQERVTGDVRLVLHPRTQVVEGVRSPHSLMDAKVATYGEANVLWNGSEAAGFAKLYGVAQMLSHRAK

Sequences:

>Translated_396_residues
MSNKKNVVLAFSGGLDTAFCAVYLREQGYDVTTVTVDTGGFPPEQLERIAALSKQLGAVEHVTVDARETLFQGYLRYLIA
GNVLRGQVYPLSVSAERACQAAEVVRVAREKGTQALAHGSTGAGNDQVRFDVAFRSLAPELELLTPIRTLSLSRQQELTY
LAERGVHMPPKLGSYSVNEGMWGTSVGGAETLDSWKALPEAAFPGGELSQDLKPRPLTVSFEKGVPVALDGEKLGPVKLV
EALNALGRTYGIGRGVHLGDTILGIKGRVGFEAPAAHLLVTAHRELEKLVLSGKQLFWKESMGNLYGSLLHEGHFFDPLV
KDLEAFLTSSQERVTGDVRLVLHPRTQVVEGVRSPHSLMDAKVATYGEANVLWNGSEAAGFAKLYGVAQMLSHRAK
>Mature_395_residues
SNKKNVVLAFSGGLDTAFCAVYLREQGYDVTTVTVDTGGFPPEQLERIAALSKQLGAVEHVTVDARETLFQGYLRYLIAG
NVLRGQVYPLSVSAERACQAAEVVRVAREKGTQALAHGSTGAGNDQVRFDVAFRSLAPELELLTPIRTLSLSRQQELTYL
AERGVHMPPKLGSYSVNEGMWGTSVGGAETLDSWKALPEAAFPGGELSQDLKPRPLTVSFEKGVPVALDGEKLGPVKLVE
ALNALGRTYGIGRGVHLGDTILGIKGRVGFEAPAAHLLVTAHRELEKLVLSGKQLFWKESMGNLYGSLLHEGHFFDPLVK
DLEAFLTSSQERVTGDVRLVLHPRTQVVEGVRSPHSLMDAKVATYGEANVLWNGSEAAGFAKLYGVAQMLSHRAK

Specific function: Arginine biosynthesis; seventh step. [C]

COG id: COG0137

COG function: function code E; Argininosuccinate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the argininosuccinate synthase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI53759107, Length=415, Percent_Identity=28.9156626506024, Blast_Score=148, Evalue=9e-36,
Organism=Homo sapiens, GI16950633, Length=415, Percent_Identity=28.9156626506024, Blast_Score=148, Evalue=9e-36,
Organism=Saccharomyces cerevisiae, GI6324514, Length=373, Percent_Identity=28.4182305630027, Blast_Score=142, Evalue=1e-34,
Organism=Drosophila melanogaster, GI21358151, Length=361, Percent_Identity=28.2548476454294, Blast_Score=150, Evalue=1e-36,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001518
- InterPro:   IPR018223
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00764 Arginosuc_synth [H]

EC number: =6.3.4.5 [H]

Molecular weight: Translated: 42774; Mature: 42643

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNKKNVVLAFSGGLDTAFCAVYLREQGYDVTTVTVDTGGFPPEQLERIAALSKQLGAVE
CCCCCCEEEEEECCCCHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHCCHH
HVTVDARETLFQGYLRYLIAGNVLRGQVYPLSVSAERACQAAEVVRVAREKGTQALAHGS
EEEEHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCEECCCC
TGAGNDQVRFDVAFRSLAPELELLTPIRTLSLSRQQELTYLAERGVHMPPKLGSYSVNEG
CCCCCCCEEEEEEHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCEECCCC
MWGTSVGGAETLDSWKALPEAAFPGGELSQDLKPRPLTVSFEKGVPVALDGEKLGPVKLV
CCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCEEECCCCCCHHHHH
EALNALGRTYGIGRGVHLGDTILGIKGRVGFEAPAAHLLVTAHRELEKLVLSGKQLFWKE
HHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHH
SMGNLYGSLLHEGHFFDPLVKDLEAFLTSSQERVTGDVRLVLHPRTQVVEGVRSPHSLMD
HHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHCCCCEEEEECCHHHHHHHHCCCHHHHH
AKVATYGEANVLWNGSEAAGFAKLYGVAQMLSHRAK
HHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SNKKNVVLAFSGGLDTAFCAVYLREQGYDVTTVTVDTGGFPPEQLERIAALSKQLGAVE
CCCCCEEEEEECCCCHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHCCHH
HVTVDARETLFQGYLRYLIAGNVLRGQVYPLSVSAERACQAAEVVRVAREKGTQALAHGS
EEEEHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCEECCCC
TGAGNDQVRFDVAFRSLAPELELLTPIRTLSLSRQQELTYLAERGVHMPPKLGSYSVNEG
CCCCCCCEEEEEEHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCEECCCC
MWGTSVGGAETLDSWKALPEAAFPGGELSQDLKPRPLTVSFEKGVPVALDGEKLGPVKLV
CCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCEEECCCCCCHHHHH
EALNALGRTYGIGRGVHLGDTILGIKGRVGFEAPAAHLLVTAHRELEKLVLSGKQLFWKE
HHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHH
SMGNLYGSLLHEGHFFDPLVKDLEAFLTSSQERVTGDVRLVLHPRTQVVEGVRSPHSLMD
HHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHCCCCEEEEECCHHHHHHHHCCCHHHHH
AKVATYGEANVLWNGSEAAGFAKLYGVAQMLSHRAK
HHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]