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The map label for this gene is zraS [H]

Identifier: 108763685

GI number: 108763685

Start: 5151901

End: 5153190

Strand: Reverse

Name: zraS [H]

Synonym: MXAN_4197

Alternate gene names: 108763685

Gene position: 5153190-5151901 (Counterclockwise)

Preceding gene: 108757011

Following gene: 108761106

Centisome position: 56.38

GC content: 72.17

Gene sequence:

>1290_bases
GTGAGCGGCGCTCCCTGGTGGCGGCCGCTTGGGCCTCGAGCGCCCTGGGTGGCGGCGGTGCTCATGTGCGCGGTGCTGAT
ATCCGCGGCGCTGTTCATCCGGAACACCGCGCTGGAGTCGTCCGCCCTGGTCACCCGGGGCATGGCCAACGTCATCATGG
TCGCCGGCTTCGAGGCCTTCCGCGACACGGAGGGGCTCCCGGACCCGTCCGCGCTGAACGCCTTCCTGGCAGCCCACCGG
GAGGGCGGCCTGCGCTACGTGGCCGTCGTGGATGACGACCAGGTGCTGGCGTCAGCCGGGGAGGTGAAGCTGGGGCGGCT
TCTCTTGCATGAGGGATCGCCGCTGGTGGTCGAAGGCGCGCGCGCGCGCCTGGTCAGCCGCCTCCGCCGGCCCCGTCCCG
CCTTCGGTCCCCTGACACAGGAGGAGGTCCGCGCCATGTCGGCGCAGGGCGATTCCCTGGAGCCGCGCAAGCACCTGCGC
ATTGTCTACGAGTTCGAGCCGCTCACCGCCCTGGCGTTGGAGTCGCGCTCGCAGCGTCTGCTGGGCGTGGCGGTGGCCTC
GTGCGTGGGCATCCTGGTGTTGGCCTTCGCCTTCTCGCGCTCGTTGGCGCAGCGGGAGGCGCTGTCGGAGGAACTGGAGC
GCGGCCGGCGGCTTGCGGCCCTGGGCACCATGTCCGCGGTGCTGGCGCATGAGCTTCGCAATCCCCTGGCCTCGCTCAAG
GGGCATGCGCAACTGCTCGCCGAGCGCGTGGAGCGTGACGCCGTCCTGGCGCCCAAGGCGGACCGGGTGGTGTCGGAGGC
CGTCCGGCTGGAGCAGTTGATGAATGACCTGCTGGGCTTCGTGGCCAGCGGTGAGCTTCGCCGCGTGGAGGCGGACCCCA
ACGACGTGCTCCGCGCGGCGGTGGAGAGCACGGGCGCGGCGCGTGTGGAGGCTCGCTATCTGCCGGACCGCACGCCCTGG
CCTCTGGACGCGGGCCGGTTGCAGCAGGCGCTGGAAAACGTGCTGCGCAATGCCGTCCAGGCCAGCCCCGAAGGCCAGCG
CGTGGAGGCGACCGTGGAGCGGCAGGACTCGTCCCTGGTGTTCACGGTCAAGGACCACGGGCCCGGTATCGCCGCGGGGG
AGGAGGAGCGCATCTTCGAGCCCTTCATCACGGGCCGCATGCGCGGCGTGGGCCTGGGGCTGGCCATCACCCGCCGCATC
GTCGAACTGCACGGCGGCACGGTGAGCGCGCGGAGCCATGCGGGCGGCGGCGCGGAGTTCCGTCTCACCGTTCCCGCGAG
AGGAGCCTGA

Upstream 100 bases:

>100_bases
GCACCGACAGAAGAGAGTGCGGATTCCGCACTCCGCATGCAGAGTTCGCAGCCTGTGGAGGTGTGCGATGGAGTTGGAGT
CCCCACGGCGGAGGTCGGCG

Downstream 100 bases:

>100_bases
GCCATGGCGCGAATCCTGGTGGCGGATGACGAAGAGGGCGTGCGCTCGTTCCTCGCCGAGGCGCTGGAGTACGAAGGTCA
CTCGGTGACCACGGCCGCCG

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 429; Mature: 428

Protein sequence:

>429_residues
MSGAPWWRPLGPRAPWVAAVLMCAVLISAALFIRNTALESSALVTRGMANVIMVAGFEAFRDTEGLPDPSALNAFLAAHR
EGGLRYVAVVDDDQVLASAGEVKLGRLLLHEGSPLVVEGARARLVSRLRRPRPAFGPLTQEEVRAMSAQGDSLEPRKHLR
IVYEFEPLTALALESRSQRLLGVAVASCVGILVLAFAFSRSLAQREALSEELERGRRLAALGTMSAVLAHELRNPLASLK
GHAQLLAERVERDAVLAPKADRVVSEAVRLEQLMNDLLGFVASGELRRVEADPNDVLRAAVESTGAARVEARYLPDRTPW
PLDAGRLQQALENVLRNAVQASPEGQRVEATVERQDSSLVFTVKDHGPGIAAGEEERIFEPFITGRMRGVGLGLAITRRI
VELHGGTVSARSHAGGGAEFRLTVPARGA

Sequences:

>Translated_429_residues
MSGAPWWRPLGPRAPWVAAVLMCAVLISAALFIRNTALESSALVTRGMANVIMVAGFEAFRDTEGLPDPSALNAFLAAHR
EGGLRYVAVVDDDQVLASAGEVKLGRLLLHEGSPLVVEGARARLVSRLRRPRPAFGPLTQEEVRAMSAQGDSLEPRKHLR
IVYEFEPLTALALESRSQRLLGVAVASCVGILVLAFAFSRSLAQREALSEELERGRRLAALGTMSAVLAHELRNPLASLK
GHAQLLAERVERDAVLAPKADRVVSEAVRLEQLMNDLLGFVASGELRRVEADPNDVLRAAVESTGAARVEARYLPDRTPW
PLDAGRLQQALENVLRNAVQASPEGQRVEATVERQDSSLVFTVKDHGPGIAAGEEERIFEPFITGRMRGVGLGLAITRRI
VELHGGTVSARSHAGGGAEFRLTVPARGA
>Mature_428_residues
SGAPWWRPLGPRAPWVAAVLMCAVLISAALFIRNTALESSALVTRGMANVIMVAGFEAFRDTEGLPDPSALNAFLAAHRE
GGLRYVAVVDDDQVLASAGEVKLGRLLLHEGSPLVVEGARARLVSRLRRPRPAFGPLTQEEVRAMSAQGDSLEPRKHLRI
VYEFEPLTALALESRSQRLLGVAVASCVGILVLAFAFSRSLAQREALSEELERGRRLAALGTMSAVLAHELRNPLASLKG
HAQLLAERVERDAVLAPKADRVVSEAVRLEQLMNDLLGFVASGELRRVEADPNDVLRAAVESTGAARVEARYLPDRTPWP
LDAGRLQQALENVLRNAVQASPEGQRVEATVERQDSSLVFTVKDHGPGIAAGEEERIFEPFITGRMRGVGLGLAITRRIV
ELHGGTVSARSHAGGGAEFRLTVPARGA

Specific function: Member of the two-component regulatory system zraS/zraR. May function as a membrane-associated protein kinase that phosphorylates zraR in response to high concentrations of zinc or lead in the medium [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=259, Percent_Identity=33.2046332046332, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI1788549, Length=248, Percent_Identity=31.0483870967742, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1790300, Length=274, Percent_Identity=30.6569343065693, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1786912, Length=216, Percent_Identity=31.9444444444444, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1786600, Length=238, Percent_Identity=30.2521008403361, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI48994928, Length=250, Percent_Identity=28.4, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI145693157, Length=272, Percent_Identity=30.1470588235294, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790346, Length=213, Percent_Identity=30.5164319248826, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI87081816, Length=224, Percent_Identity=32.1428571428571, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1789808, Length=209, Percent_Identity=27.2727272727273, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1790551, Length=191, Percent_Identity=31.413612565445, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788279, Length=243, Percent_Identity=27.5720164609054, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1787894, Length=218, Percent_Identity=31.1926605504587, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1786783, Length=223, Percent_Identity=27.8026905829596, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1788393, Length=235, Percent_Identity=28.0851063829787, Blast_Score=68, Evalue=9e-13,
Organism=Escherichia coli, GI1790861, Length=201, Percent_Identity=28.3582089552239, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI1788713, Length=247, Percent_Identity=25.9109311740891, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 46207; Mature: 46075

Theoretical pI: Translated: 8.28; Mature: 8.28

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGAPWWRPLGPRAPWVAAVLMCAVLISAALFIRNTALESSALVTRGMANVIMVAGFEAF
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHH
RDTEGLPDPSALNAFLAAHREGGLRYVAVVDDDQVLASAGEVKLGRLLLHEGSPLVVEGA
HCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCHHHHCCCCHHHHHHEEECCCCEEECCH
RARLVSRLRRPRPAFGPLTQEEVRAMSAQGDSLEPRKHLRIVYEFEPLTALALESRSQRL
HHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHEEEEEEECCHHHHHHHHHHHHH
LGVAVASCVGILVLAFAFSRSLAQREALSEELERGRRLAALGTMSAVLAHELRNPLASLK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
GHAQLLAERVERDAVLAPKADRVVSEAVRLEQLMNDLLGFVASGELRRVEADPNDVLRAA
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHH
VESTGAARVEARYLPDRTPWPLDAGRLQQALENVLRNAVQASPEGQRVEATVERQDSSLV
HHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEHEEECCCCCEE
FTVKDHGPGIAAGEEERIFEPFITGRMRGVGLGLAITRRIVELHGGTVSARSHAGGGAEF
EEEECCCCCCCCCCHHHHHHHHHHCCHHHCCHHHHHHHHHHHHCCCEEECCCCCCCCCEE
RLTVPARGA
EEECCCCCC
>Mature Secondary Structure 
SGAPWWRPLGPRAPWVAAVLMCAVLISAALFIRNTALESSALVTRGMANVIMVAGFEAF
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHH
RDTEGLPDPSALNAFLAAHREGGLRYVAVVDDDQVLASAGEVKLGRLLLHEGSPLVVEGA
HCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCHHHHCCCCHHHHHHEEECCCCEEECCH
RARLVSRLRRPRPAFGPLTQEEVRAMSAQGDSLEPRKHLRIVYEFEPLTALALESRSQRL
HHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHEEEEEEECCHHHHHHHHHHHHH
LGVAVASCVGILVLAFAFSRSLAQREALSEELERGRRLAALGTMSAVLAHELRNPLASLK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
GHAQLLAERVERDAVLAPKADRVVSEAVRLEQLMNDLLGFVASGELRRVEADPNDVLRAA
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHH
VESTGAARVEARYLPDRTPWPLDAGRLQQALENVLRNAVQASPEGQRVEATVERQDSSLV
HHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEHEEECCCCCEE
FTVKDHGPGIAAGEEERIFEPFITGRMRGVGLGLAITRRIVELHGGTVSARSHAGGGAEF
EEEECCCCCCCCCCHHHHHHHHHHCCHHHCCHHHHHHHHHHHHCCCEEECCCCCCCCCEE
RLTVPARGA
EEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]