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The map label for this gene is atoC [H]

Identifier: 108761106

GI number: 108761106

Start: 5150545

End: 5151897

Strand: Reverse

Name: atoC [H]

Synonym: MXAN_4196

Alternate gene names: 108761106

Gene position: 5151897-5150545 (Counterclockwise)

Preceding gene: 108763685

Following gene: 108761033

Centisome position: 56.37

GC content: 71.84

Gene sequence:

>1353_bases
ATGGCGCGAATCCTGGTGGCGGATGACGAAGAGGGCGTGCGCTCGTTCCTCGCCGAGGCGCTGGAGTACGAAGGTCACTC
GGTGACCACGGCCGCCGACGGTGAGGAGGCCGCGCGGCTGATGGCGAGGCAGGGCGTGGACCTGTTGCTCACGGACCTGC
GGATGCCCGGGATGGACGGGCTGACCTTGCTGCGCAAGGTGCGCGAGGAGCAGCCCGACGTGGAGGTGGTGGTGCTCACC
GCCGTGGGCACGGTGGAGAGCGCCGTGGCGGCGATGAAGGCGGGCGCCTTCGACTTCCTGCTCAAACCGGTGGGCAGCCC
CGCCGAACTGCGCCTGACGGTGGCGCGGGCCCTGGAGCGGCGCGCGCTGCTCAACTGGAAGACCGAGGCGCGGCAGTCGG
CGGGCGAGGTGGAGCTGAGCTGGGGTGCTCCCGCCATGCACCCGGTGGTGGAAGCGCTGCGGAAGGTGTCGCCCACGCAG
GCCACGGTGCTGCTGGTGGGGGAGAGCGGGACCGGCAAGGAGGTGACCGCGCGGGCCCTGCACCAGTGGAGTGAGCGCGC
GGACGGGCCTTTCGTGGCCGTTAACTGCGCGGCGCTGACGGAGACGCTCCTGGAGAGCGAGCTCTTCGGACACGAGAAGG
GCGCGTTCACCGGCGCGGTGGCCCAGCGGCGCGGCCGCATCGAGCTGGCGCAGGGAGGCACCTTCTTCTTGGACGAGGTC
GGCGAGCTGAAGGCCGAGCTCCAGGCCAAGCTGCTGCGCGTCCTCCAAGAACGCCGCTTCGAACGCGTGGGCGGTACGCG
GACCCTGGAAGCCGACGTGCGCTGGGTGGCGGCCACCAACCGCGATCTCAAGGCGATGATGGCGCGCGGTGAGTTCCGCG
AGGACCTCTACCACCGGCTGGCCGTGTTCCCCATCCGGCTGCCGTCCCTGCGCGAGCGGCGCGAGGACCTGCGGCCGTTG
TCGGAGCTGCTGCTGCGCCGCATCGGAGACGAGCTGGGTCGTCCAGGCTTGCGCGTGTCACCGGAGGCCGTGGCGCGGCT
GGAGGCGTTCACCTGGCCGGGCAACGTCCGCGAGCTGCGCAATGCGCTCGAGCGGGCCGCCATCCTCGCGGATGGGCCGG
TGGTGGAGCCTCGGCACCTGTGGCTGGATCCAACGGGCGCGGCGGGGCCCGTGGTGGATGCGCCCGTCTCGGAGGGGGGC
CGGCTTCCCAGCCTGACGCTGGAGGAGCTGGAGCGACGGGCCATTGAGCAGGCCATCGCGGACGAGGCGGGGAACCGCAA
GCGTGCCGCGCAGCGGCTGGGGATTGGTTTGCGGACGCTGTACGACAAGCTGCGGCGCTACGAGTCGCCCTGA

Upstream 100 bases:

>100_bases
CCGCATCGTCGAACTGCACGGCGGCACGGTGAGCGCGCGGAGCCATGCGGGCGGCGGCGCGGAGTTCCGTCTCACCGTTC
CCGCGAGAGGAGCCTGAGCC

Downstream 100 bases:

>100_bases
GCGCATCGAGCGGCGCGGAGAAGCGACTCCGCGCCGCACGCCCCGGCAACCTACACGGGGTTCACGGAGGGCCGTTGCCC
TGCCGCTTCGAGTTCAGCTC

Product: sigma-54 dependent DNA-binding response regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 450; Mature: 449

Protein sequence:

>450_residues
MARILVADDEEGVRSFLAEALEYEGHSVTTAADGEEAARLMARQGVDLLLTDLRMPGMDGLTLLRKVREEQPDVEVVVLT
AVGTVESAVAAMKAGAFDFLLKPVGSPAELRLTVARALERRALLNWKTEARQSAGEVELSWGAPAMHPVVEALRKVSPTQ
ATVLLVGESGTGKEVTARALHQWSERADGPFVAVNCAALTETLLESELFGHEKGAFTGAVAQRRGRIELAQGGTFFLDEV
GELKAELQAKLLRVLQERRFERVGGTRTLEADVRWVAATNRDLKAMMARGEFREDLYHRLAVFPIRLPSLRERREDLRPL
SELLLRRIGDELGRPGLRVSPEAVARLEAFTWPGNVRELRNALERAAILADGPVVEPRHLWLDPTGAAGPVVDAPVSEGG
RLPSLTLEELERRAIEQAIADEAGNRKRAAQRLGIGLRTLYDKLRRYESP

Sequences:

>Translated_450_residues
MARILVADDEEGVRSFLAEALEYEGHSVTTAADGEEAARLMARQGVDLLLTDLRMPGMDGLTLLRKVREEQPDVEVVVLT
AVGTVESAVAAMKAGAFDFLLKPVGSPAELRLTVARALERRALLNWKTEARQSAGEVELSWGAPAMHPVVEALRKVSPTQ
ATVLLVGESGTGKEVTARALHQWSERADGPFVAVNCAALTETLLESELFGHEKGAFTGAVAQRRGRIELAQGGTFFLDEV
GELKAELQAKLLRVLQERRFERVGGTRTLEADVRWVAATNRDLKAMMARGEFREDLYHRLAVFPIRLPSLRERREDLRPL
SELLLRRIGDELGRPGLRVSPEAVARLEAFTWPGNVRELRNALERAAILADGPVVEPRHLWLDPTGAAGPVVDAPVSEGG
RLPSLTLEELERRAIEQAIADEAGNRKRAAQRLGIGLRTLYDKLRRYESP
>Mature_449_residues
ARILVADDEEGVRSFLAEALEYEGHSVTTAADGEEAARLMARQGVDLLLTDLRMPGMDGLTLLRKVREEQPDVEVVVLTA
VGTVESAVAAMKAGAFDFLLKPVGSPAELRLTVARALERRALLNWKTEARQSAGEVELSWGAPAMHPVVEALRKVSPTQA
TVLLVGESGTGKEVTARALHQWSERADGPFVAVNCAALTETLLESELFGHEKGAFTGAVAQRRGRIELAQGGTFFLDEVG
ELKAELQAKLLRVLQERRFERVGGTRTLEADVRWVAATNRDLKAMMARGEFREDLYHRLAVFPIRLPSLRERREDLRPLS
ELLLRRIGDELGRPGLRVSPEAVARLEAFTWPGNVRELRNALERAAILADGPVVEPRHLWLDPTGAAGPVVDAPVSEGGR
LPSLTLEELERRAIEQAIADEAGNRKRAAQRLGIGLRTLYDKLRRYESP

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=457, Percent_Identity=45.0765864332604, Blast_Score=379, Evalue=1e-106,
Organism=Escherichia coli, GI1790437, Length=443, Percent_Identity=41.7607223476298, Blast_Score=329, Evalue=3e-91,
Organism=Escherichia coli, GI1788905, Length=450, Percent_Identity=42, Blast_Score=309, Evalue=3e-85,
Organism=Escherichia coli, GI1790299, Length=467, Percent_Identity=39.8286937901499, Blast_Score=298, Evalue=6e-82,
Organism=Escherichia coli, GI87082117, Length=316, Percent_Identity=43.9873417721519, Blast_Score=251, Evalue=8e-68,
Organism=Escherichia coli, GI1789087, Length=305, Percent_Identity=46.8852459016393, Blast_Score=248, Evalue=7e-67,
Organism=Escherichia coli, GI1789233, Length=310, Percent_Identity=42.5806451612903, Blast_Score=237, Evalue=1e-63,
Organism=Escherichia coli, GI87082152, Length=336, Percent_Identity=40.1785714285714, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI87081872, Length=310, Percent_Identity=40.3225806451613, Blast_Score=212, Evalue=5e-56,
Organism=Escherichia coli, GI1787583, Length=305, Percent_Identity=39.672131147541, Blast_Score=211, Evalue=6e-56,
Organism=Escherichia coli, GI1786524, Length=329, Percent_Identity=39.209726443769, Blast_Score=196, Evalue=3e-51,
Organism=Escherichia coli, GI1789828, Length=241, Percent_Identity=40.6639004149378, Blast_Score=155, Evalue=5e-39,
Organism=Escherichia coli, GI87081858, Length=309, Percent_Identity=33.3333333333333, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1789809, Length=120, Percent_Identity=32.5, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1790863, Length=132, Percent_Identity=31.8181818181818, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787487, Length=202, Percent_Identity=29.2079207920792, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1786911, Length=180, Percent_Identity=31.1111111111111, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI145693157, Length=101, Percent_Identity=33.6633663366337, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1788713, Length=101, Percent_Identity=36.6336633663366, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1786599, Length=154, Percent_Identity=31.8181818181818, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1787375, Length=101, Percent_Identity=33.6633663366337, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 49507; Mature: 49376

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARILVADDEEGVRSFLAEALEYEGHSVTTAADGEEAARLMARQGVDLLLTDLRMPGMDG
CCEEEEECCHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHCCHHHHHHHHCCCCCCH
LTLLRKVREEQPDVEVVVLTAVGTVESAVAAMKAGAFDFLLKPVGSPAELRLTVARALER
HHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHH
RALLNWKTEARQSAGEVELSWGAPAMHPVVEALRKVSPTQATVLLVGESGTGKEVTARAL
HHHHCCHHHHHHCCCCEEEECCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHH
HQWSERADGPFVAVNCAALTETLLESELFGHEKGAFTGAVAQRRGRIELAQGGTFFLDEV
HHHHHHCCCCEEEEEHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCEEEECCCCCHHHHH
GELKAELQAKLLRVLQERRFERVGGTRTLEADVRWVAATNRDLKAMMARGEFREDLYHRL
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCEEEEEECCHHHHHHHHHHHHHHHHHHHH
AVFPIRLPSLRERREDLRPLSELLLRRIGDELGRPGLRVSPEAVARLEAFTWPGNVRELR
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCHHHHH
NALERAAILADGPVVEPRHLWLDPTGAAGPVVDAPVSEGGRLPSLTLEELERRAIEQAIA
HHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
DEAGNRKRAAQRLGIGLRTLYDKLRRYESP
HCCCCHHHHHHHHCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
ARILVADDEEGVRSFLAEALEYEGHSVTTAADGEEAARLMARQGVDLLLTDLRMPGMDG
CEEEEECCHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHCCHHHHHHHHCCCCCCH
LTLLRKVREEQPDVEVVVLTAVGTVESAVAAMKAGAFDFLLKPVGSPAELRLTVARALER
HHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHH
RALLNWKTEARQSAGEVELSWGAPAMHPVVEALRKVSPTQATVLLVGESGTGKEVTARAL
HHHHCCHHHHHHCCCCEEEECCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHH
HQWSERADGPFVAVNCAALTETLLESELFGHEKGAFTGAVAQRRGRIELAQGGTFFLDEV
HHHHHHCCCCEEEEEHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCEEEECCCCCHHHHH
GELKAELQAKLLRVLQERRFERVGGTRTLEADVRWVAATNRDLKAMMARGEFREDLYHRL
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCEEEEEECCHHHHHHHHHHHHHHHHHHHH
AVFPIRLPSLRERREDLRPLSELLLRRIGDELGRPGLRVSPEAVARLEAFTWPGNVRELR
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCHHHHH
NALERAAILADGPVVEPRHLWLDPTGAAGPVVDAPVSEGGRLPSLTLEELERRAIEQAIA
HHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
DEAGNRKRAAQRLGIGLRTLYDKLRRYESP
HCCCCHHHHHHHHCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]