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The map label for this gene is gmk

Identifier: 108763567

GI number: 108763567

Start: 5899453

End: 5900082

Strand: Reverse

Name: gmk

Synonym: MXAN_4705

Alternate gene names: 108763567

Gene position: 5900082-5899453 (Counterclockwise)

Preceding gene: 108757110

Following gene: 108761760

Centisome position: 64.55

GC content: 64.76

Gene sequence:

>630_bases
ATGAACGCGAATACCGTGCTCCCGCCTGGCTTGTTGCTCGTGCTCTCCGCTCCTTCCGGGGCGGGGAAGACCACCCTCGC
GCACCGGCTCCTCAAGGAGACGCCGGATGCGGTGTTCTCCATCAGCGTCACCACCCGAAGGCCTCGGGGGAAGGAGCGCG
AGGGGGTGGATTACAACTTCGTCGACGTCGCGACCTTCCAGTCGAAGATCGAGCGCGGCGAGTTCGTGGAGTGGGCAGAG
GTCTATGGCCACTTCTATGGAAGCCCCCAGTCGGTGGTGGATGAGGCGCGCGCCCGCAAGAGCGCTGCCATCTTCGACAT
CGACGTGCAGGGCGGGCAGGCCATCAAGCGCAAGCACCCGGATGCAGTGACCATCTTCGTGCTGCCACCGTCCATGGAAG
AGTTGGAGCGCCGCCTGAGGGATCGTCAGACGGACTCCGACGAGACCATCCGGCGCCGGATGCTGGCGGCTCGCTCTGAG
ATCGAGCGGGGTATCGCTTCCTACGACTACGTGGTCGTGAATGACGACTTCGAGCGTGCTTTCAGTGACCTGCGCTCGGT
GGTGGTGGCCGAACGTTGCCGGCGCGAACGTGTGGACGTGTCGAAGCTGGGCCTGGGAATCGGCGGCTGA

Upstream 100 bases:

>100_bases
ACACGACCGGCTCCAAGAGCCAGCACGCCGAGATTTCCGTGCGCGTGGTGGCGATGAAGGCCGAGGTCGAGCGCATCCGC
GAACAGGTGCAGAACGTCGA

Downstream 100 bases:

>100_bases
CCACCGCGGCGCAAGTGCTCAGAATCAAACTTCTTGCGCAGTCCGATCTCTTGGTGGATAAGCGGCCACACCTCGCCGCG
TTGCGCGGGCGTCACACAGG

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase

Number of amino acids: Translated: 209; Mature: 209

Protein sequence:

>209_residues
MNANTVLPPGLLLVLSAPSGAGKTTLAHRLLKETPDAVFSISVTTRRPRGKEREGVDYNFVDVATFQSKIERGEFVEWAE
VYGHFYGSPQSVVDEARARKSAAIFDIDVQGGQAIKRKHPDAVTIFVLPPSMEELERRLRDRQTDSDETIRRRMLAARSE
IERGIASYDYVVVNDDFERAFSDLRSVVVAERCRRERVDVSKLGLGIGG

Sequences:

>Translated_209_residues
MNANTVLPPGLLLVLSAPSGAGKTTLAHRLLKETPDAVFSISVTTRRPRGKEREGVDYNFVDVATFQSKIERGEFVEWAE
VYGHFYGSPQSVVDEARARKSAAIFDIDVQGGQAIKRKHPDAVTIFVLPPSMEELERRLRDRQTDSDETIRRRMLAARSE
IERGIASYDYVVVNDDFERAFSDLRSVVVAERCRRERVDVSKLGLGIGG
>Mature_209_residues
MNANTVLPPGLLLVLSAPSGAGKTTLAHRLLKETPDAVFSISVTTRRPRGKEREGVDYNFVDVATFQSKIERGEFVEWAE
VYGHFYGSPQSVVDEARARKSAAIFDIDVQGGQAIKRKHPDAVTIFVLPPSMEELERRLRDRQTDSDETIRRRMLAARSE
IERGIASYDYVVVNDDFERAFSDLRSVVVAERCRRERVDVSKLGLGIGG

Specific function: Essential for recycling GMP and indirectly, cGMP

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain

Homologues:

Organism=Homo sapiens, GI226874831, Length=189, Percent_Identity=38.0952380952381, Blast_Score=132, Evalue=2e-31,
Organism=Homo sapiens, GI226874833, Length=189, Percent_Identity=38.0952380952381, Blast_Score=132, Evalue=2e-31,
Organism=Homo sapiens, GI4504221, Length=189, Percent_Identity=38.0952380952381, Blast_Score=132, Evalue=2e-31,
Organism=Homo sapiens, GI52630447, Length=200, Percent_Identity=27.5, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI21361598, Length=198, Percent_Identity=23.7373737373737, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI38570142, Length=178, Percent_Identity=25.8426966292135, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI14780902, Length=188, Percent_Identity=26.063829787234, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI21389483, Length=178, Percent_Identity=26.9662921348315, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI262118259, Length=174, Percent_Identity=25.2873563218391, Blast_Score=68, Evalue=5e-12,
Organism=Homo sapiens, GI4505237, Length=174, Percent_Identity=25.2873563218391, Blast_Score=68, Evalue=5e-12,
Organism=Homo sapiens, GI262118255, Length=174, Percent_Identity=25.2873563218391, Blast_Score=68, Evalue=5e-12,
Organism=Homo sapiens, GI262118263, Length=174, Percent_Identity=25.2873563218391, Blast_Score=68, Evalue=6e-12,
Organism=Escherichia coli, GI1790080, Length=193, Percent_Identity=45.5958549222798, Blast_Score=167, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI193203132, Length=180, Percent_Identity=38.8888888888889, Blast_Score=130, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17508835, Length=180, Percent_Identity=38.8888888888889, Blast_Score=130, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI17557440, Length=181, Percent_Identity=25.9668508287293, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320662, Length=183, Percent_Identity=41.5300546448087, Blast_Score=155, Evalue=5e-39,
Organism=Drosophila melanogaster, GI21356141, Length=192, Percent_Identity=39.5833333333333, Blast_Score=140, Evalue=8e-34,
Organism=Drosophila melanogaster, GI161077626, Length=173, Percent_Identity=25.4335260115607, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI116007136, Length=173, Percent_Identity=25.4335260115607, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI45554481, Length=173, Percent_Identity=25.4335260115607, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI85724806, Length=173, Percent_Identity=25.4335260115607, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI45554489, Length=173, Percent_Identity=25.4335260115607, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24640542, Length=173, Percent_Identity=25.4335260115607, Blast_Score=70, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KGUA_MYXXD (Q1D3A6)

Other databases:

- EMBL:   CP000113
- RefSeq:   YP_632867.1
- ProteinModelPortal:   Q1D3A6
- SMR:   Q1D3A6
- STRING:   Q1D3A6
- GeneID:   4107326
- GenomeReviews:   CP000113_GR
- KEGG:   mxa:MXAN_4705
- TIGR:   MXAN_4705
- eggNOG:   COG0194
- HOGENOM:   HBG671982
- OMA:   EWAEFAG
- PhylomeDB:   Q1D3A6
- ProtClustDB:   PRK00300
- BioCyc:   MXAN246197:MXAN_4705-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00328
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665
- SMART:   SM00072
- TIGRFAMs:   TIGR03263

Pfam domain/function: PF00625 Guanylate_kin

EC number: =2.7.4.8

Molecular weight: Translated: 23382; Mature: 23382

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: PS00856 GUANYLATE_KINASE_1; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNANTVLPPGLLLVLSAPSGAGKTTLAHRLLKETPDAVFSISVTTRRPRGKEREGVDYNF
CCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCH
VDVATFQSKIERGEFVEWAEVYGHFYGSPQSVVDEARARKSAAIFDIDVQGGQAIKRKHP
HHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEEECCCCHHHHHCCC
DAVTIFVLPPSMEELERRLRDRQTDSDETIRRRMLAARSEIERGIASYDYVVVNDDFERA
CEEEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCHHHHH
FSDLRSVVVAERCRRERVDVSKLGLGIGG
HHHHHHHHHHHHHHHHCCCHHHHCCCCCC
>Mature Secondary Structure
MNANTVLPPGLLLVLSAPSGAGKTTLAHRLLKETPDAVFSISVTTRRPRGKEREGVDYNF
CCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCH
VDVATFQSKIERGEFVEWAEVYGHFYGSPQSVVDEARARKSAAIFDIDVQGGQAIKRKHP
HHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEEECCCCHHHHHCCC
DAVTIFVLPPSMEELERRLRDRQTDSDETIRRRMLAARSEIERGIASYDYVVVNDDFERA
CEEEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCHHHHH
FSDLRSVVVAERCRRERVDVSKLGLGIGG
HHHHHHHHHHHHHHHHCCCHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA