Click here to switch to the map view.

The map label for this gene is folP [H]

Identifier: 108763537

GI number: 108763537

Start: 5358712

End: 5359587

Strand: Reverse

Name: folP [H]

Synonym: MXAN_4353

Alternate gene names: 108763537

Gene position: 5359587-5358712 (Counterclockwise)

Preceding gene: 108762562

Following gene: 108760574

Centisome position: 58.64

GC content: 72.49

Gene sequence:

>876_bases
GTGGCGCCGGCGGCGTTGACGCTGGGCGCCCGGCGCTTCGAGTGGGGCTCCCGCACCTACGTCATGGGCGTGGTGAACGT
GACGCCGGACAGCTTCTCGGATGGCGGGCGCCATGCCGGGACGGACGCCGCCATCGCCCACGGGTTGGCCTTGGCCGAAT
CGGGGGCGGACCTGCTCGACGTGGGCGGCGAGTCCACCCGGCCCGGCTCTCTGCCGGTCAGTGCCGACGAGGAGCTGGCG
CGGGTGATTCCCGTCATCGAGGGCCTCCGGGCCCGGACCGATGTGCCTCTTTCCGTGGACACCACCAAGGCCGCGGTGGC
GCGCGAGGCGTTGAAGGCCGGTGCGCACCTCATCAATGACATCACCGGCTTCAGCTCTGATGCCGGCCTGTCCCGCGTGG
TGGCCGAGGCCGGCGCCGCCTGCTGCCTGATGCACATCCAGGGCACCCCGGCCACGATGCAGCAGGCGCCGCGCTACGAC
GACGTCGTCGAGGACGTGCTGGCTTTCCTGGAGGCCGCTATCCTCCGGGCCGAGTCGGCGGGCATCCCCCGGGGGCGCAT
CCTCCTGGACCCGGGCATCGGCTTCGGGAAGACCTTCGAGCACAACCTCTTCCTGCTGCGCCGCCTCCCGGAGCTGCGCG
TGCTGGGGCTACCGTTGCTGGTGGGTACGAGCCGCAAGGGCTTCCTCGGCCGGTTGGCGGGCGGCAAGCCTGCCTCCGAA
CGGCTGGCGGCGACGTTGGGCTCGGTGGCCTCCATGGCGGCGCTGGGCGGGGCCGACGTGGCCCGCGTCCATGACGTGAC
CGAGGCCCGGGACGCGCTGGCCGTCGCGGACGCCATCCGGCGGTGCGAAGACGGAGGAACGTTCTACGCCCGGTAA

Upstream 100 bases:

>100_bases
GCGCGCAGCGCAGTTCCAGCGGCTGGTGACGGCTGCTCGCACCGACGCCCGGGGCTTGTCCGCGTTGGCATCGGCGGTGG
CGTCCGCGCTGGCCGCGGGC

Downstream 100 bases:

>100_bases
CAAGGTGTGGCCTACAGCCCCCAAGCTGTGGCCGGTACCTTCACCTTCCGCTGGCCGCCCCCCGAGCCGCCGTGTATGGA
CGGCGGCGATTCGGTTGGTA

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 291; Mature: 290

Protein sequence:

>291_residues
MAPAALTLGARRFEWGSRTYVMGVVNVTPDSFSDGGRHAGTDAAIAHGLALAESGADLLDVGGESTRPGSLPVSADEELA
RVIPVIEGLRARTDVPLSVDTTKAAVAREALKAGAHLINDITGFSSDAGLSRVVAEAGAACCLMHIQGTPATMQQAPRYD
DVVEDVLAFLEAAILRAESAGIPRGRILLDPGIGFGKTFEHNLFLLRRLPELRVLGLPLLVGTSRKGFLGRLAGGKPASE
RLAATLGSVASMAALGGADVARVHDVTEARDALAVADAIRRCEDGGTFYAR

Sequences:

>Translated_291_residues
MAPAALTLGARRFEWGSRTYVMGVVNVTPDSFSDGGRHAGTDAAIAHGLALAESGADLLDVGGESTRPGSLPVSADEELA
RVIPVIEGLRARTDVPLSVDTTKAAVAREALKAGAHLINDITGFSSDAGLSRVVAEAGAACCLMHIQGTPATMQQAPRYD
DVVEDVLAFLEAAILRAESAGIPRGRILLDPGIGFGKTFEHNLFLLRRLPELRVLGLPLLVGTSRKGFLGRLAGGKPASE
RLAATLGSVASMAALGGADVARVHDVTEARDALAVADAIRRCEDGGTFYAR
>Mature_290_residues
APAALTLGARRFEWGSRTYVMGVVNVTPDSFSDGGRHAGTDAAIAHGLALAESGADLLDVGGESTRPGSLPVSADEELAR
VIPVIEGLRARTDVPLSVDTTKAAVAREALKAGAHLINDITGFSSDAGLSRVVAEAGAACCLMHIQGTPATMQQAPRYDD
VVEDVLAFLEAAILRAESAGIPRGRILLDPGIGFGKTFEHNLFLLRRLPELRVLGLPLLVGTSRKGFLGRLAGGKPASER
LAATLGSVASMAALGGADVARVHDVTEARDALAVADAIRRCEDGGTFYAR

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=272, Percent_Identity=49.2647058823529, Blast_Score=258, Evalue=3e-70,
Organism=Saccharomyces cerevisiae, GI6324073, Length=321, Percent_Identity=33.0218068535826, Blast_Score=172, Evalue=8e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 30201; Mature: 30070

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPAALTLGARRFEWGSRTYVMGVVNVTPDSFSDGGRHAGTDAAIAHGLALAESGADLLD
CCCCHHHHCCHHCCCCCCEEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHEE
VGGESTRPGSLPVSADEELARVIPVIEGLRARTDVPLSVDTTKAAVAREALKAGAHLIND
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
ITGFSSDAGLSRVVAEAGAACCLMHIQGTPATMQQAPRYDDVVEDVLAFLEAAILRAESA
HCCCCCCCHHHHHHHHCCCEEEEEEECCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHCC
GIPRGRILLDPGIGFGKTFEHNLFLLRRLPELRVLGLPLLVGTSRKGFLGRLAGGKPASE
CCCCCEEEECCCCCCCCCHHHHHHHHHHCCCHHEECCEEEECCCCCCCHHCCCCCCCHHH
RLAATLGSVASMAALGGADVARVHDVTEARDALAVADAIRRCEDGGTFYAR
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECC
>Mature Secondary Structure 
APAALTLGARRFEWGSRTYVMGVVNVTPDSFSDGGRHAGTDAAIAHGLALAESGADLLD
CCCHHHHCCHHCCCCCCEEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHEE
VGGESTRPGSLPVSADEELARVIPVIEGLRARTDVPLSVDTTKAAVAREALKAGAHLIND
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
ITGFSSDAGLSRVVAEAGAACCLMHIQGTPATMQQAPRYDDVVEDVLAFLEAAILRAESA
HCCCCCCCHHHHHHHHCCCEEEEEEECCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHCC
GIPRGRILLDPGIGFGKTFEHNLFLLRRLPELRVLGLPLLVGTSRKGFLGRLAGGKPASE
CCCCCEEEECCCCCCCCCHHHHHHHHHHCCCHHEECCEEEECCCCCCCHHCCCCCCCHHH
RLAATLGSVASMAALGGADVARVHDVTEARDALAVADAIRRCEDGGTFYAR
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]