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The map label for this gene is hemA

Identifier: 108763498

GI number: 108763498

Start: 3097009

End: 3098334

Strand: Direct

Name: hemA

Synonym: MXAN_2655

Alternate gene names: 108763498

Gene position: 3097009-3098334 (Clockwise)

Preceding gene: 108760340

Following gene: 108761567

Centisome position: 33.89

GC content: 71.95

Gene sequence:

>1326_bases
ATGGAGCTCATTTGCATTGGCCTGTCCCACCGGACGGCGCCCCTCACCGTCCGCGAGCGACTGGCCTTGCCGGAGTCGCG
TCAGGTGGACGTGCTCCAGCGGCTGGCCCAGGCGCCCGTGGAGGCCCTCTGGGTGTCCACCTGCAACCGCGTGGAGGTGT
ACCTGTTCGCGCCGGACGCGGCGATGGCGCGGCAGCGCGCCTTGATGGAGCTGCAGGTGCTGGGCGGGGTGGAAGCCCTG
GAGCACCTCTACGAGCACCAGGGCGAGGCGGCGCTGGTGCACCTGTTCCGCGTGGCGTGCAGCCTGGACTCCATGGTGCT
GGGCGAGGCTCAGATTCTGGGCCAGGTGAAGGAAGCCTTCGAGCGGGGCCAGGGCGCGGGCGCGGTGCGTGGTGAGTTGA
TGCGCGCGTGCGCGGCGGCCTTCAGCTGCGCCAAGCGCGTGCGCACGGAGACGGCCATTGGCCGCGCGGCCACGTCCATG
GCGGCGGCGGCGGTGCAACTGGCCAGCAAGGTGTTCGATGGGCTCGCGGGCAAGACGGTGCTGGTGGTGGGCGCGGGGGA
GATGGGCGAGCTGGCGGCGCGCCACTTGAAGCAGGCTGGTGCGTCGAAGCTCTACGTCACCAACCGCACCCTGTCGCGAG
CGGAGGCGCTGGCGGCGGAGGTGGGCGGACAGGCGAGGCCCTTCGAGGAGCTGCTCGGTCTGGTGGCCGCGGCGGACGTG
GTGGTGTGCAGCACGGCGTCGCAGGCGCCGCTCTTCACGCGGGACAACGTGGGCGCCCTGGGGCGCGGACGCCGGGGGCG
GCCGCTGTTCATGGTGGACCTGGCGGTGCCTCGCGACATCGATCCGGCGGTGGGCACGCTGGACTGGGTACATGCATACG
ACGTGGACGACATCCAGAAGTTCGTCGCGGACAACGCCGCGGCGCGCGCGGAAGAGGCGCAGAAGGCGGGCGTGCTCGTC
GCGCAGGAAGTAGCGCGTTTCGTCAAGGAGCGTGCGCTGCGTGAGGGCACGCCGGTGCTGGCGCGACTGCGTCAGCGCGC
GGAAGCCATTGCCCGCTCCGAGGTGGAGCGCACGCTGGGCGCCCTGGGCGACGGACTCAACGAAAAGCAACGCAAGAGCA
TCGAGGCCATGGGCCGAGCCATCGTCAACAAGCTGCTGCATGAGCCCACCGCGCGGCTGCGCGCCGTGGGGCCGGAAGGG
GAGGGCAACCGCCTGGCGGGTGCCGCCGCCGAGCTGTTCGGTCTCCTGGAGGAGGAGGTCGGCACCGCCGCCGCCGCGCC
CTCCGTCATGGCCGCGCCAGTCCAGGTCGCCACGGGGGGCAAGTGA

Upstream 100 bases:

>100_bases
TGGCCTTCCTCACCATGGCGGGGTTCTGCCTGGTCATGGTGTCCTTCCTGTCCTCGTATGACGTGTCGTCGCCCTCGGCG
GCCATGAGGATGCCCTGAGT

Downstream 100 bases:

>100_bases
TGACGCACGTGCGTATCGCCACCCGGCAGAGTCCCCTGGCGCTCTGGCAGGCGCGTCACGTGGGCGCGCTGCTGACCTCG
CGGCATCCCGGTTTGGAAGT

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MELICIGLSHRTAPLTVRERLALPESRQVDVLQRLAQAPVEALWVSTCNRVEVYLFAPDAAMARQRALMELQVLGGVEAL
EHLYEHQGEAALVHLFRVACSLDSMVLGEAQILGQVKEAFERGQGAGAVRGELMRACAAAFSCAKRVRTETAIGRAATSM
AAAAVQLASKVFDGLAGKTVLVVGAGEMGELAARHLKQAGASKLYVTNRTLSRAEALAAEVGGQARPFEELLGLVAAADV
VVCSTASQAPLFTRDNVGALGRGRRGRPLFMVDLAVPRDIDPAVGTLDWVHAYDVDDIQKFVADNAAARAEEAQKAGVLV
AQEVARFVKERALREGTPVLARLRQRAEAIARSEVERTLGALGDGLNEKQRKSIEAMGRAIVNKLLHEPTARLRAVGPEG
EGNRLAGAAAELFGLLEEEVGTAAAAPSVMAAPVQVATGGK

Sequences:

>Translated_441_residues
MELICIGLSHRTAPLTVRERLALPESRQVDVLQRLAQAPVEALWVSTCNRVEVYLFAPDAAMARQRALMELQVLGGVEAL
EHLYEHQGEAALVHLFRVACSLDSMVLGEAQILGQVKEAFERGQGAGAVRGELMRACAAAFSCAKRVRTETAIGRAATSM
AAAAVQLASKVFDGLAGKTVLVVGAGEMGELAARHLKQAGASKLYVTNRTLSRAEALAAEVGGQARPFEELLGLVAAADV
VVCSTASQAPLFTRDNVGALGRGRRGRPLFMVDLAVPRDIDPAVGTLDWVHAYDVDDIQKFVADNAAARAEEAQKAGVLV
AQEVARFVKERALREGTPVLARLRQRAEAIARSEVERTLGALGDGLNEKQRKSIEAMGRAIVNKLLHEPTARLRAVGPEG
EGNRLAGAAAELFGLLEEEVGTAAAAPSVMAAPVQVATGGK
>Mature_441_residues
MELICIGLSHRTAPLTVRERLALPESRQVDVLQRLAQAPVEALWVSTCNRVEVYLFAPDAAMARQRALMELQVLGGVEAL
EHLYEHQGEAALVHLFRVACSLDSMVLGEAQILGQVKEAFERGQGAGAVRGELMRACAAAFSCAKRVRTETAIGRAATSM
AAAAVQLASKVFDGLAGKTVLVVGAGEMGELAARHLKQAGASKLYVTNRTLSRAEALAAEVGGQARPFEELLGLVAAADV
VVCSTASQAPLFTRDNVGALGRGRRGRPLFMVDLAVPRDIDPAVGTLDWVHAYDVDDIQKFVADNAAARAEEAQKAGVLV
AQEVARFVKERALREGTPVLARLRQRAEAIARSEVERTLGALGDGLNEKQRKSIEAMGRAIVNKLLHEPTARLRAVGPEG
EGNRLAGAAAELFGLLEEEVGTAAAAPSVMAAPVQVATGGK

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=410, Percent_Identity=37.3170731707317, Blast_Score=253, Evalue=2e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_MYXXD (Q1D8Z9)

Other databases:

- EMBL:   CP000113
- RefSeq:   YP_630874.1
- ProteinModelPortal:   Q1D8Z9
- SMR:   Q1D8Z9
- STRING:   Q1D8Z9
- GeneID:   4107254
- GenomeReviews:   CP000113_GR
- KEGG:   mxa:MXAN_2655
- TIGR:   MXAN_2655
- eggNOG:   COG0373
- HOGENOM:   HBG732626
- OMA:   GPILNRL
- PhylomeDB:   Q1D8Z9
- ProtClustDB:   PRK00045
- BioCyc:   MXAN246197:MXAN_2655-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 46681; Mature: 46681

Theoretical pI: Translated: 7.16; Mature: 7.16

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 48-48 BINDING 104-104 BINDING 115-115

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELICIGLSHRTAPLTVRERLALPESRQVDVLQRLAQAPVEALWVSTCNRVEVYLFAPDA
CCEEEEECCCCCCCHHHHHHHCCCCCCCHHHHHHHHHCHHHHHHHHCCCCEEEEEECCCH
AMARQRALMELQVLGGVEALEHLYEHQGEAALVHLFRVACSLDSMVLGEAQILGQVKEAF
HHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ERGQGAGAVRGELMRACAAAFSCAKRVRTETAIGRAATSMAAAAVQLASKVFDGLAGKTV
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
LVVGAGEMGELAARHLKQAGASKLYVTNRTLSRAEALAAEVGGQARPFEELLGLVAAADV
EEEECCCHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
VVCSTASQAPLFTRDNVGALGRGRRGRPLFMVDLAVPRDIDPAVGTLDWVHAYDVDDIQK
HEECCCCCCCCEECCCCCCCCCCCCCCCEEEEEECCCCCCCCHHCCHHHHHHCCHHHHHH
FVADNAAARAEEAQKAGVLVAQEVARFVKERALREGTPVLARLRQRAEAIARSEVERTLG
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
ALGDGLNEKQRKSIEAMGRAIVNKLLHEPTARLRAVGPEGEGNRLAGAAAELFGLLEEEV
HHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHEECCCCCCCCCHHHHHHHHHHHHHHHH
GTAAAAPSVMAAPVQVATGGK
CHHHCCCCHHHCCEEECCCCC
>Mature Secondary Structure
MELICIGLSHRTAPLTVRERLALPESRQVDVLQRLAQAPVEALWVSTCNRVEVYLFAPDA
CCEEEEECCCCCCCHHHHHHHCCCCCCCHHHHHHHHHCHHHHHHHHCCCCEEEEEECCCH
AMARQRALMELQVLGGVEALEHLYEHQGEAALVHLFRVACSLDSMVLGEAQILGQVKEAF
HHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ERGQGAGAVRGELMRACAAAFSCAKRVRTETAIGRAATSMAAAAVQLASKVFDGLAGKTV
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
LVVGAGEMGELAARHLKQAGASKLYVTNRTLSRAEALAAEVGGQARPFEELLGLVAAADV
EEEECCCHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
VVCSTASQAPLFTRDNVGALGRGRRGRPLFMVDLAVPRDIDPAVGTLDWVHAYDVDDIQK
HEECCCCCCCCEECCCCCCCCCCCCCCCEEEEEECCCCCCCCHHCCHHHHHHCCHHHHHH
FVADNAAARAEEAQKAGVLVAQEVARFVKERALREGTPVLARLRQRAEAIARSEVERTLG
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
ALGDGLNEKQRKSIEAMGRAIVNKLLHEPTARLRAVGPEGEGNRLAGAAAELFGLLEEEV
HHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHEECCCCCCCCCHHHHHHHHHHHHHHHH
GTAAAAPSVMAAPVQVATGGK
CHHHCCCCHHHCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA