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The map label for this gene is gltT [H]

Identifier: 108763378

GI number: 108763378

Start: 4655649

End: 4656929

Strand: Reverse

Name: gltT [H]

Synonym: MXAN_3877

Alternate gene names: 108763378

Gene position: 4656929-4655649 (Counterclockwise)

Preceding gene: 108762589

Following gene: 108761180

Centisome position: 50.95

GC content: 68.23

Gene sequence:

>1281_bases
GTGAAGAAGCTCGTCTCCGCCTGGTTCCGCATTCCCTTCTGGCAACGTGTCCTGGGGGCGTTCGTGCTCGGGGCCGTGGC
CGGGTGGCTCGTGGGAGAGCCAGCGGGGCCCTGGTTCCAGCCGCTGGGTACGCTCTACGTCAACCTCATCAAGATGATCG
CCACACCGCTGGTGTTCTTCGCGGTCATCAACGCGGTGGCGGCGCTTCACGGGCAGAAGAGCATGGCGGTGCTCGGCGGC
AAGACGTTCCTCTGGTTCGGCGTCACCGCCGCGCTGGCGGTGGGGGTGGGCCTGGGCGTCGCCGCGCTGCTGCGCCCCGG
GGAGGGAGTGGGCCAGCTCATGGCCACCGAAACCTACAAGCCACGGGACGTGCCCGGCCCCATCCAGGTGCTGCTGGATG
TGGTGCCCACCAACCCGTTCGCGGCGCTCGCGAATGGGAAGATCCTCCAGGTCATCTTCTTCGCCGGCCTGCTGGGCTTC
GCGCTGGTGAAGCTCGGCGAGAAGACGGCCCGGCTGCGCGAGCTGGTCCGCGAGGCCAGCGACGCGATGATTCAGGTCAC
CCGCTTCGTGCTGGAGCTCACGCCGCTGGGCACCTTCGGCCTCATCGCCGCACTGGTGGGCACCTACGGCTTCGAGCGCC
TGTTGCCGCTGGGCAAGCTGGTGCTGGCGCTGTACGTGGCGTGCGCGCTGCACATCGTCTTCGTGTACGGCGGCCTCCTG
ATGACACACGGGCTCAATCCGCTGCGCTTCTTCCGGGGCGCCGCGCCCGGCATGCAGGTGGCCTTCGTCAGCTCGTCGAG
CTTCGCGTCCATGCCGGTGGCCCTGCGCGCCGTGACGAACAACCTGGGCGTCAACAAGGACTACGCGGCCTTCGCGGTGC
CGCTGGGGGCCAGCATCAAGATGGATGGGTGTGGTGCCATCTACCCGGCCATCGCGTCGCTCTTCGTCGCGCAGTACTTC
AGCCTGGAGCTGTCCGCGTCGCAGTACTTCATCATCCTGCTGGCTTCGGTGCTGGGCAGCTTCGGTACCGCGGGCGTGCC
CGGGACGGCGGTGGTCATGGCCACGGTGGTGCTCAGCTCCGCGGGCTTGCCGCTGGAGGGGCTGGGCTACCTGCTCGCCA
TCGACCGCATCCTCGACATGATGCGCACGATGACCAACGTCACGGGCCAGATGCTGGTCCCGGTGCTGGTGGCGCGCGAA
GAGGGCCTGCTGGATGCCGCCGTCTACAACGGCGCATCCCCCGCTGTCGCGTTGGAGGAGAACGCGGTGAAGGTGGACTG
A

Upstream 100 bases:

>100_bases
TCCCCGGCGCGGGCATCCCTGGCGCAAATTCTGCGCCTCGCCCTGCGCGGCCTGGGGCCTGGGGTTATCGTCCGCCGCCC
GTTGTCGAGAGGTCTCCCCC

Downstream 100 bases:

>100_bases
GTCTCCTCGGTCCGGGAGGCACGCGCGTGTGGGTTCGCCGACGGGTGTCCTCCCGGACTTGGAGTAACGGACAGGTCGTG
AGGTCCGTCCTATCGCCCTG

Product: sodium:dicarboxylate symporter family protein

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MKKLVSAWFRIPFWQRVLGAFVLGAVAGWLVGEPAGPWFQPLGTLYVNLIKMIATPLVFFAVINAVAALHGQKSMAVLGG
KTFLWFGVTAALAVGVGLGVAALLRPGEGVGQLMATETYKPRDVPGPIQVLLDVVPTNPFAALANGKILQVIFFAGLLGF
ALVKLGEKTARLRELVREASDAMIQVTRFVLELTPLGTFGLIAALVGTYGFERLLPLGKLVLALYVACALHIVFVYGGLL
MTHGLNPLRFFRGAAPGMQVAFVSSSSFASMPVALRAVTNNLGVNKDYAAFAVPLGASIKMDGCGAIYPAIASLFVAQYF
SLELSASQYFIILLASVLGSFGTAGVPGTAVVMATVVLSSAGLPLEGLGYLLAIDRILDMMRTMTNVTGQMLVPVLVARE
EGLLDAAVYNGASPAVALEENAVKVD

Sequences:

>Translated_426_residues
MKKLVSAWFRIPFWQRVLGAFVLGAVAGWLVGEPAGPWFQPLGTLYVNLIKMIATPLVFFAVINAVAALHGQKSMAVLGG
KTFLWFGVTAALAVGVGLGVAALLRPGEGVGQLMATETYKPRDVPGPIQVLLDVVPTNPFAALANGKILQVIFFAGLLGF
ALVKLGEKTARLRELVREASDAMIQVTRFVLELTPLGTFGLIAALVGTYGFERLLPLGKLVLALYVACALHIVFVYGGLL
MTHGLNPLRFFRGAAPGMQVAFVSSSSFASMPVALRAVTNNLGVNKDYAAFAVPLGASIKMDGCGAIYPAIASLFVAQYF
SLELSASQYFIILLASVLGSFGTAGVPGTAVVMATVVLSSAGLPLEGLGYLLAIDRILDMMRTMTNVTGQMLVPVLVARE
EGLLDAAVYNGASPAVALEENAVKVD
>Mature_426_residues
MKKLVSAWFRIPFWQRVLGAFVLGAVAGWLVGEPAGPWFQPLGTLYVNLIKMIATPLVFFAVINAVAALHGQKSMAVLGG
KTFLWFGVTAALAVGVGLGVAALLRPGEGVGQLMATETYKPRDVPGPIQVLLDVVPTNPFAALANGKILQVIFFAGLLGF
ALVKLGEKTARLRELVREASDAMIQVTRFVLELTPLGTFGLIAALVGTYGFERLLPLGKLVLALYVACALHIVFVYGGLL
MTHGLNPLRFFRGAAPGMQVAFVSSSSFASMPVALRAVTNNLGVNKDYAAFAVPLGASIKMDGCGAIYPAIASLFVAQYF
SLELSASQYFIILLASVLGSFGTAGVPGTAVVMATVVLSSAGLPLEGLGYLLAIDRILDMMRTMTNVTGQMLVPVLVARE
EGLLDAAVYNGASPAVALEENAVKVD

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI21314632, Length=398, Percent_Identity=28.894472361809, Blast_Score=132, Evalue=9e-31,
Organism=Homo sapiens, GI66773030, Length=246, Percent_Identity=34.5528455284553, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI169790839, Length=487, Percent_Identity=25.4620123203285, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI4827012, Length=295, Percent_Identity=30.8474576271186, Blast_Score=122, Evalue=8e-28,
Organism=Homo sapiens, GI194239697, Length=249, Percent_Identity=30.1204819277108, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI223468566, Length=285, Percent_Identity=29.8245614035088, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI223468564, Length=250, Percent_Identity=30.8, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI40254478, Length=145, Percent_Identity=37.9310344827586, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI5032093, Length=377, Percent_Identity=27.8514588859416, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI301601644, Length=153, Percent_Identity=35.2941176470588, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI262359914, Length=392, Percent_Identity=23.2142857142857, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1790514, Length=414, Percent_Identity=33.0917874396135, Blast_Score=197, Evalue=1e-51,
Organism=Escherichia coli, GI1789947, Length=422, Percent_Identity=30.0947867298578, Blast_Score=194, Evalue=1e-50,
Organism=Escherichia coli, GI1788024, Length=401, Percent_Identity=33.6658354114713, Blast_Score=165, Evalue=6e-42,
Organism=Escherichia coli, GI1789473, Length=391, Percent_Identity=24.8081841432225, Blast_Score=82, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17537407, Length=445, Percent_Identity=26.7415730337079, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI71983099, Length=458, Percent_Identity=25.5458515283843, Blast_Score=125, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI71983106, Length=441, Percent_Identity=25.8503401360544, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI193206505, Length=399, Percent_Identity=28.3208020050125, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI71996953, Length=449, Percent_Identity=24.0534521158129, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17541374, Length=406, Percent_Identity=27.0935960591133, Blast_Score=104, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI193206654, Length=429, Percent_Identity=26.8065268065268, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24583025, Length=433, Percent_Identity=26.0969976905312, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI17137668, Length=433, Percent_Identity=26.0969976905312, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24583023, Length=433, Percent_Identity=26.0969976905312, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI281360483, Length=439, Percent_Identity=24.8291571753986, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI17137666, Length=439, Percent_Identity=24.8291571753986, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI281360481, Length=439, Percent_Identity=24.8291571753986, Blast_Score=76, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 44821; Mature: 44821

Theoretical pI: Translated: 9.41; Mature: 9.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCEECC
>Mature Secondary Structure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CCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]