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The map label for this gene is mvaS [H]

Identifier: 108763292

GI number: 108763292

Start: 5230137

End: 5231393

Strand: Direct

Name: mvaS [H]

Synonym: MXAN_4267

Alternate gene names: 108763292

Gene position: 5230137-5231393 (Clockwise)

Preceding gene: 108758373

Following gene: 108762480

Centisome position: 57.22

GC content: 71.36

Gene sequence:

>1257_bases
ATGAAGAAGCGCGTGGGAATCGAAGCGTTGGCGGTCGCGGTGCCGTCCCGGTACGTGGACATCGAAGACCTGGCCCGGGC
ACGCGGCGTGGACCCGGCCAAGTACACGGCGGGCCTGGGCGCCAGGGAGATGGCCGTCACCGACCCCGGAGAGGACACCG
TGGCCCTCGCGGCCACCGCGGCGGCCCGCCTCATCCGTCAGCAGGACGTGGACCCGTCCCGCATCGGCATGCTGGTGGTG
GGCACAGAGACGGGCATCGACCACTCGAAACCCGTCGCCTCGCACGTGCAGGGCCTGCTGAAGCTGCCGCGCACCATGCG
GACCTATGACACGCAGCACGCGTGTTACGGCGGCACCGCCGGGCTGATGGCGGCGGTGGAGTGGATTGCGTCCGGCGCGG
GCGCGGGCAAGGTGGCCGTGGTGGTGTGTTCGGACATCGCGCGCTACGGGCTGAACACCGCGGGCGAGCCCACCCAGGGC
GGAGGCGCGGTGGCGCTGCTGGTCTCCGAGCAACCCGACCTGCTCGCCATGGACGTGGGCCTCAACGGCGTGTGCAGCAT
GGACGTGTATGACTTCTGGCGGCCCGTGGGCCGGCGGGAGGCGCTGGTGGACGGGCACTACTCCATCACCTGCTACCTGG
AGGCCCTGTCCGGCGCTTACCGGGGCTGGCGCGAGAAGGCCCTGGCGGCGGGGCTGGTCCGCTGGTCGGACGCGCTGCCC
GGCGAACAGTTGGCGCGCATCGCCTACCACGTGCCCTTCTGCAAGATGGCCCGGAAGGCGCACACCCAACTGCGCCTGTG
CGACCTGGAGGATGCGGCGGACGCGGCGGCTTCGACGCCGGAGTCGCGGGAGGCGCAGGCGAAGTCGGCCGCCAGCTATG
ACGCCCAGGTGGCGACTTCACTGGGACTCAACTCGCGCATCGGAAACGTGTACACCGCGTCCCTCTACCTGGCGCTGGCG
GGCCTGCTGCAACACGAGGCCGGCGCGCTGGCGGGACAGCGCATTGGCCTGCTGTCCTACGGCAGCGGCTGCGCGGCCGA
ATTCTACTCCGGCACGGTGGGCGAGAAGGCCGCCGAGCGGATGGCGAAGGCGGACCTGGAGGCGGTGCTGGCCCGGCGCG
AGCGCGTCTCCATCGAGGAATACGAGCGCCTGATGAAGCTGCCGGCGGATGCGCCCGAGGCCGTGGCCCCGTCGCCCGGA
GCCTTCCGGCTGACGGAGATTCGCGACCACCGCCGCCAGTACGCCGAAGGGAACTGA

Upstream 100 bases:

>100_bases
GAGAACCGCGAAGTGGCGGGCCGGCTGGTGCTGGTGCCCCCCGAGGCGTGAGCAAAGCGGCGGCTGGAATCCAGAGCACG
ACAAGGAATCGAGGAGTCCG

Downstream 100 bases:

>100_bases
CGCAGGGCGCCGGGCGCCCATCCCAGACGCGTGACGAGGCACCGGCAGGCTTCCCGGTGCCTCCCCTTCCGCCGCCATCT
CCCTACCGTGAACCTCGAAA

Product: hydroxymethylglutaryl-CoA synthase

Products: (S)-3-hydroxy-3-methylglutaryl-CoA; CoA

Alternate protein names: HMG synthase [H]

Number of amino acids: Translated: 418; Mature: 418

Protein sequence:

>418_residues
MKKRVGIEALAVAVPSRYVDIEDLARARGVDPAKYTAGLGAREMAVTDPGEDTVALAATAAARLIRQQDVDPSRIGMLVV
GTETGIDHSKPVASHVQGLLKLPRTMRTYDTQHACYGGTAGLMAAVEWIASGAGAGKVAVVVCSDIARYGLNTAGEPTQG
GGAVALLVSEQPDLLAMDVGLNGVCSMDVYDFWRPVGRREALVDGHYSITCYLEALSGAYRGWREKALAAGLVRWSDALP
GEQLARIAYHVPFCKMARKAHTQLRLCDLEDAADAAASTPESREAQAKSAASYDAQVATSLGLNSRIGNVYTASLYLALA
GLLQHEAGALAGQRIGLLSYGSGCAAEFYSGTVGEKAAERMAKADLEAVLARRERVSIEEYERLMKLPADAPEAVAPSPG
AFRLTEIRDHRRQYAEGN

Sequences:

>Translated_418_residues
MKKRVGIEALAVAVPSRYVDIEDLARARGVDPAKYTAGLGAREMAVTDPGEDTVALAATAAARLIRQQDVDPSRIGMLVV
GTETGIDHSKPVASHVQGLLKLPRTMRTYDTQHACYGGTAGLMAAVEWIASGAGAGKVAVVVCSDIARYGLNTAGEPTQG
GGAVALLVSEQPDLLAMDVGLNGVCSMDVYDFWRPVGRREALVDGHYSITCYLEALSGAYRGWREKALAAGLVRWSDALP
GEQLARIAYHVPFCKMARKAHTQLRLCDLEDAADAAASTPESREAQAKSAASYDAQVATSLGLNSRIGNVYTASLYLALA
GLLQHEAGALAGQRIGLLSYGSGCAAEFYSGTVGEKAAERMAKADLEAVLARRERVSIEEYERLMKLPADAPEAVAPSPG
AFRLTEIRDHRRQYAEGN
>Mature_418_residues
MKKRVGIEALAVAVPSRYVDIEDLARARGVDPAKYTAGLGAREMAVTDPGEDTVALAATAAARLIRQQDVDPSRIGMLVV
GTETGIDHSKPVASHVQGLLKLPRTMRTYDTQHACYGGTAGLMAAVEWIASGAGAGKVAVVVCSDIARYGLNTAGEPTQG
GGAVALLVSEQPDLLAMDVGLNGVCSMDVYDFWRPVGRREALVDGHYSITCYLEALSGAYRGWREKALAAGLVRWSDALP
GEQLARIAYHVPFCKMARKAHTQLRLCDLEDAADAAASTPESREAQAKSAASYDAQVATSLGLNSRIGNVYTASLYLALA
GLLQHEAGALAGQRIGLLSYGSGCAAEFYSGTVGEKAAERMAKADLEAVLARRERVSIEEYERLMKLPADAPEAVAPSPG
AFRLTEIRDHRRQYAEGN

Specific function: Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism. It catalyzes the aldol condensation between the acetyl group attached to the acyl-carrier-protein AcpK (Ac- AcpK) and

COG id: COG3425

COG function: function code I; 3-hydroxy-3-methylglutaryl CoA synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA synthase family [H]

Homologues:

Organism=Homo sapiens, GI5031751, Length=459, Percent_Identity=36.8191721132898, Blast_Score=229, Evalue=2e-60,
Organism=Homo sapiens, GI148298764, Length=455, Percent_Identity=34.5054945054945, Blast_Score=204, Evalue=2e-52,
Organism=Homo sapiens, GI148298677, Length=455, Percent_Identity=34.5054945054945, Blast_Score=204, Evalue=2e-52,
Organism=Homo sapiens, GI260656028, Length=459, Percent_Identity=32.4618736383442, Blast_Score=184, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17560126, Length=442, Percent_Identity=29.185520361991, Blast_Score=157, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6323509, Length=444, Percent_Identity=34.009009009009, Blast_Score=223, Evalue=6e-59,
Organism=Drosophila melanogaster, GI24654139, Length=450, Percent_Identity=35.1111111111111, Blast_Score=219, Evalue=3e-57,
Organism=Drosophila melanogaster, GI24654137, Length=450, Percent_Identity=35.1111111111111, Blast_Score=219, Evalue=3e-57,
Organism=Drosophila melanogaster, GI24654133, Length=450, Percent_Identity=35.1111111111111, Blast_Score=219, Evalue=3e-57,
Organism=Drosophila melanogaster, GI24654135, Length=450, Percent_Identity=35.1111111111111, Blast_Score=219, Evalue=3e-57,
Organism=Drosophila melanogaster, GI17933694, Length=450, Percent_Identity=35.1111111111111, Blast_Score=219, Evalue=3e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013746
- InterPro:   IPR013528
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF08540 HMG_CoA_synt_C; PF01154 HMG_CoA_synt_N [H]

EC number: 2.3.3.10

Molecular weight: Translated: 44380; Mature: 44380

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKRVGIEALAVAVPSRYVDIEDLARARGVDPAKYTAGLGAREMAVTDPGEDTVALAATA
CCCCCCHHHHHHHHCCCCCCHHHHHHHCCCCHHHHHHCCCCCCEEECCCCCCHHHHHHHH
AARLIRQQDVDPSRIGMLVVGTETGIDHSKPVASHVQGLLKLPRTMRTYDTQHACYGGTA
HHHHHHHCCCCHHHEEEEEEECCCCCCCCCCHHHHHHHHHHCCHHHHHHCCCCCCCCCHH
GLMAAVEWIASGAGAGKVAVVVCSDIARYGLNTAGEPTQGGGAVALLVSEQPDLLAMDVG
HHHHHHHHHHCCCCCCCEEEEEEHHHHHHCCCCCCCCCCCCCEEEEEEECCCCEEEEECC
LNGVCSMDVYDFWRPVGRREALVDGHYSITCYLEALSGAYRGWREKALAAGLVRWSDALP
CCCEECCCHHHHHCCCCCCHHEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GEQLARIAYHVPFCKMARKAHTQLRLCDLEDAADAAASTPESREAQAKSAASYDAQVATS
HHHHHHHHHHCCHHHHHHHHHHHEEEECCCHHHHHHCCCCCHHHHHHHHHHHCCHHHHHH
LGLNSRIGNVYTASLYLALAGLLQHEAGALAGQRIGLLSYGSGCAAEFYSGTVGEKAAER
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHCCCCHHHHHHH
MAKADLEAVLARRERVSIEEYERLMKLPADAPEAVAPSPGAFRLTEIRDHRRQYAEGN
HHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCEEHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKKRVGIEALAVAVPSRYVDIEDLARARGVDPAKYTAGLGAREMAVTDPGEDTVALAATA
CCCCCCHHHHHHHHCCCCCCHHHHHHHCCCCHHHHHHCCCCCCEEECCCCCCHHHHHHHH
AARLIRQQDVDPSRIGMLVVGTETGIDHSKPVASHVQGLLKLPRTMRTYDTQHACYGGTA
HHHHHHHCCCCHHHEEEEEEECCCCCCCCCCHHHHHHHHHHCCHHHHHHCCCCCCCCCHH
GLMAAVEWIASGAGAGKVAVVVCSDIARYGLNTAGEPTQGGGAVALLVSEQPDLLAMDVG
HHHHHHHHHHCCCCCCCEEEEEEHHHHHHCCCCCCCCCCCCCEEEEEEECCCCEEEEECC
LNGVCSMDVYDFWRPVGRREALVDGHYSITCYLEALSGAYRGWREKALAAGLVRWSDALP
CCCEECCCHHHHHCCCCCCHHEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GEQLARIAYHVPFCKMARKAHTQLRLCDLEDAADAAASTPESREAQAKSAASYDAQVATS
HHHHHHHHHHCCHHHHHHHHHHHEEEECCCHHHHHHCCCCCHHHHHHHHHHHCCHHHHHH
LGLNSRIGNVYTASLYLALAGLLQHEAGALAGQRIGLLSYGSGCAAEFYSGTVGEKAAER
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHCCCCHHHHHHH
MAKADLEAVLARRERVSIEEYERLMKLPADAPEAVAPSPGAFRLTEIRDHRRQYAEGN
HHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCEEHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acetyl-CoA; H2O; acetoacetyl-CoA

Specific reaction: acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7704258; 9384377 [H]