Click here to switch to the map view.

The map label for this gene is adhP [C]

Identifier: 108758373

GI number: 108758373

Start: 5229050

End: 5230087

Strand: Direct

Name: adhP [C]

Synonym: MXAN_4266

Alternate gene names: 108758373

Gene position: 5229050-5230087 (Clockwise)

Preceding gene: 108758212

Following gene: 108763292

Centisome position: 57.21

GC content: 71.48

Gene sequence:

>1038_bases
ATGAAAGCCGTCGTACTGCGCAGCTTTGGTGAAGCGGGCAACCTGAAGATGGAGACCATGCCCATGCCCCGTCCCGGGCG
TGGCGAGGTCCTCCTGCGCGTGCATGCCTGTGGCGTCTGCTACCACGACGTCATCAACCGCCGAGGCAACCTGCCCCGCA
CCAGCGTGCCCGCGATTCTTGGCCACGAGGCCGCGGGTGAAGTCATTGAAGTCGGCCCGGACACGCCAGGCTGGAAGACG
GGAGACCGCGCCGCGACGCTCCAGCGCATGTCGTGCGGCGACTGCGCCCTGTGCCGCAGCGGCCGCAACAGCCTCTGCAA
GACGGACAACCGCTTCTTCGGCGAGGAGCTGCCCGGTGGCTACGCCCAGTTCATGGTGGCCCCCGTCGGCGGACTGGGCC
GGGTGCCCGCGTCGCTGCCCTGGAACGAGGCGGCCACGGTGTGCTGCACCACCGGCACGGCCGTCCACACGGTGCGCACG
CGCGGCAAGGTGCGCGCGGGCGAGACGGTGCTCATCACCGGCGCCAGTGGCGGCGTGGGCCTGTCCTCCGTGCAGCTCGC
GCGGTTGGACGGCGCGCGCGTCATCGCGGTGACGTCCAGCGAGGCGAAGGTGCAGGCGCTGAAGGAGGCGGGCGCGGACG
AGGTCATCGTGTCGCGCGGGCTGGACTTCGCGTCGGACGTCCGCAAGCGCACCCAGGGCGCGGGTGTGGACGTGGCCGTC
GAAATCGTCGGCAGCGCCACGTTCGACCAGACGCTGAAGTCCATGGCGCCCGGAGGCCGCGTGGTGGTGGTGGGCAACCT
GGAGTCGGGGATGGTGCAGCTCAACCCGGGGCTCGTCATCGTCAAGGAGCTGGAGATCCTGGGGGCCTACGCCACCACGC
AGGCGGAGCTGGACGAGGCCCTGCGCCTGACGGCCACCGGCGGCGTGCGGCAGTTCGTGACGGACGCGGTGCCCCTGGCC
GAGGCCGCGAAGGCCCACTTCCGGCTGGAGAACCGCGAAGTGGCGGGCCGGCTGGTGCTGGTGCCCCCCGAGGCGTGA

Upstream 100 bases:

>100_bases
CCATTCGCGCCATCGATCCGCACGGCTACCGCGACGCGCTCGTCGGCGCCTGAGCAGGGCCGTTCCCCTTCCACGAATTC
AGATGCACGGAGGCACCCAG

Downstream 100 bases:

>100_bases
GCAAAGCGGCGGCTGGAATCCAGAGCACGACAAGGAATCGAGGAGTCCGATGAAGAAGCGCGTGGGAATCGAAGCGTTGG
CGGTCGCGGTGCCGTCCCGG

Product: zinc-binding dehydrogenase family oxidoreductase

Products: NA

Alternate protein names: Acryloyl-CoA reductase [H]

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MKAVVLRSFGEAGNLKMETMPMPRPGRGEVLLRVHACGVCYHDVINRRGNLPRTSVPAILGHEAAGEVIEVGPDTPGWKT
GDRAATLQRMSCGDCALCRSGRNSLCKTDNRFFGEELPGGYAQFMVAPVGGLGRVPASLPWNEAATVCCTTGTAVHTVRT
RGKVRAGETVLITGASGGVGLSSVQLARLDGARVIAVTSSEAKVQALKEAGADEVIVSRGLDFASDVRKRTQGAGVDVAV
EIVGSATFDQTLKSMAPGGRVVVVGNLESGMVQLNPGLVIVKELEILGAYATTQAELDEALRLTATGGVRQFVTDAVPLA
EAAKAHFRLENREVAGRLVLVPPEA

Sequences:

>Translated_345_residues
MKAVVLRSFGEAGNLKMETMPMPRPGRGEVLLRVHACGVCYHDVINRRGNLPRTSVPAILGHEAAGEVIEVGPDTPGWKT
GDRAATLQRMSCGDCALCRSGRNSLCKTDNRFFGEELPGGYAQFMVAPVGGLGRVPASLPWNEAATVCCTTGTAVHTVRT
RGKVRAGETVLITGASGGVGLSSVQLARLDGARVIAVTSSEAKVQALKEAGADEVIVSRGLDFASDVRKRTQGAGVDVAV
EIVGSATFDQTLKSMAPGGRVVVVGNLESGMVQLNPGLVIVKELEILGAYATTQAELDEALRLTATGGVRQFVTDAVPLA
EAAKAHFRLENREVAGRLVLVPPEA
>Mature_345_residues
MKAVVLRSFGEAGNLKMETMPMPRPGRGEVLLRVHACGVCYHDVINRRGNLPRTSVPAILGHEAAGEVIEVGPDTPGWKT
GDRAATLQRMSCGDCALCRSGRNSLCKTDNRFFGEELPGGYAQFMVAPVGGLGRVPASLPWNEAATVCCTTGTAVHTVRT
RGKVRAGETVLITGASGGVGLSSVQLARLDGARVIAVTSSEAKVQALKEAGADEVIVSRGLDFASDVRKRTQGAGVDVAV
EIVGSATFDQTLKSMAPGGRVVVVGNLESGMVQLNPGLVIVKELEILGAYATTQAELDEALRLTATGGVRQFVTDAVPLA
EAAKAHFRLENREVAGRLVLVPPEA

Specific function: Plays a role in autotrophic carbon fixation via the 3- hydroxypropionate/4-hydroxybutyrate cycle. Catalyzes the acryloyl- CoA dependent NADPH oxidation and formation of propionyl-CoA. Inactive towards 3-hydroxypropionyl-CoA, NADH and crotonyl-CoA [H]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI194239674, Length=334, Percent_Identity=28.7425149700599, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI13236495, Length=334, Percent_Identity=28.7425149700599, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI22538446, Length=364, Percent_Identity=29.3956043956044, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI22538444, Length=364, Percent_Identity=29.3956043956044, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI156627571, Length=326, Percent_Identity=29.1411042944785, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI194239676, Length=350, Percent_Identity=25.4285714285714, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI197927207, Length=169, Percent_Identity=31.9526627218935, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI18379349, Length=372, Percent_Identity=25.8064516129032, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI4501933, Length=348, Percent_Identity=27.5862068965517, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI34577061, Length=295, Percent_Identity=28.8135593220339, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI4501929, Length=348, Percent_Identity=27.5862068965517, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI28557745, Length=272, Percent_Identity=29.4117647058824, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI71565154, Length=260, Percent_Identity=26.9230769230769, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI71743840, Length=290, Percent_Identity=25.5172413793103, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI4501939, Length=254, Percent_Identity=26.7716535433071, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI156523966, Length=254, Percent_Identity=26.7716535433071, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI262073058, Length=303, Percent_Identity=25.7425742574257, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI41872631, Length=141, Percent_Identity=30.4964539007092, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI87081918, Length=316, Percent_Identity=31.9620253164557, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1790045, Length=287, Percent_Identity=28.9198606271777, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI226510992, Length=318, Percent_Identity=28.3018867924528, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1790485, Length=329, Percent_Identity=27.9635258358663, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1786825, Length=392, Percent_Identity=26.2755102040816, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI87082125, Length=359, Percent_Identity=25.9052924791086, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788075, Length=336, Percent_Identity=27.0833333333333, Blast_Score=88, Evalue=8e-19,
Organism=Escherichia coli, GI1788073, Length=263, Percent_Identity=29.277566539924, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1787863, Length=218, Percent_Identity=27.9816513761468, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1786552, Length=289, Percent_Identity=28.3737024221453, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI1786518, Length=217, Percent_Identity=29.4930875576037, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788407, Length=287, Percent_Identity=26.1324041811847, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71988145, Length=341, Percent_Identity=25.5131964809384, Blast_Score=118, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17562584, Length=341, Percent_Identity=26.6862170087977, Blast_Score=114, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI17562582, Length=344, Percent_Identity=26.1627906976744, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17562876, Length=331, Percent_Identity=27.7945619335347, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17562878, Length=209, Percent_Identity=30.622009569378, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI25146526, Length=278, Percent_Identity=25.8992805755396, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71997431, Length=280, Percent_Identity=25.7142857142857, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17565904, Length=254, Percent_Identity=25.9842519685039, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323729, Length=335, Percent_Identity=29.5522388059701, Blast_Score=140, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6323961, Length=342, Percent_Identity=28.3625730994152, Blast_Score=128, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6319621, Length=343, Percent_Identity=28.2798833819242, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6324486, Length=335, Percent_Identity=27.7611940298507, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6319520, Length=352, Percent_Identity=28.125, Blast_Score=109, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6322619, Length=338, Percent_Identity=29.2899408284024, Blast_Score=95, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6319955, Length=338, Percent_Identity=28.9940828402367, Blast_Score=93, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6320033, Length=273, Percent_Identity=26.7399267399267, Blast_Score=86, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6323980, Length=357, Percent_Identity=25.7703081232493, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6319949, Length=340, Percent_Identity=26.7647058823529, Blast_Score=77, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6319258, Length=384, Percent_Identity=23.4375, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6319257, Length=380, Percent_Identity=21.8421052631579, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17137530, Length=322, Percent_Identity=26.3975155279503, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17737897, Length=324, Percent_Identity=28.3950617283951, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI17737895, Length=352, Percent_Identity=23.2954545454545, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.3.1.84 [H]

Molecular weight: Translated: 36107; Mature: 36107

Theoretical pI: Translated: 8.00; Mature: 8.00

Prosite motif: PS01162 QOR_ZETA_CRYSTAL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVVLRSFGEAGNLKMETMPMPRPGRGEVLLRVHACGVCYHDVINRRGNLPRTSVPAIL
CCEEEEECCCCCCCEEEEECCCCCCCCCCEEEEEEECCHHHHHHHHCCCCCCCCCCCHHH
GHEAAGEVIEVGPDTPGWKTGDRAATLQRMSCGDCALCRSGRNSLCKTDNRFFGEELPGG
CCCCCCCEEECCCCCCCCCCCCHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCH
YAQFMVAPVGGLGRVPASLPWNEAATVCCTTGTAVHTVRTRGKVRAGETVLITGASGGVG
HEEEEEECCCCCCCCCCCCCCCCCCEEEEECCCEEEEEECCCCEECCCEEEEECCCCCCC
LSSVQLARLDGARVIAVTSSEAKVQALKEAGADEVIVSRGLDFASDVRKRTQGAGVDVAV
CCEEEEEECCCCEEEEEECCHHHHHHHHHCCCCCEEHHCCCCHHHHHHHHHCCCCCEEEE
EIVGSATFDQTLKSMAPGGRVVVVGNLESGMVQLNPGLVIVKELEILGAYATTQAELDEA
EEECCCHHHHHHHHHCCCCEEEEEECCCCCEEEECCCEEEEEEEEEHHHHHHHHHHHHHH
LRLTATGGVRQFVTDAVPLAEAAKAHFRLENREVAGRLVLVPPEA
EEEEECCCHHHHHHHHCCHHHHHHHHEEECCCCCCCEEEEECCCC
>Mature Secondary Structure
MKAVVLRSFGEAGNLKMETMPMPRPGRGEVLLRVHACGVCYHDVINRRGNLPRTSVPAIL
CCEEEEECCCCCCCEEEEECCCCCCCCCCEEEEEEECCHHHHHHHHCCCCCCCCCCCHHH
GHEAAGEVIEVGPDTPGWKTGDRAATLQRMSCGDCALCRSGRNSLCKTDNRFFGEELPGG
CCCCCCCEEECCCCCCCCCCCCHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCH
YAQFMVAPVGGLGRVPASLPWNEAATVCCTTGTAVHTVRTRGKVRAGETVLITGASGGVG
HEEEEEECCCCCCCCCCCCCCCCCCEEEEECCCEEEEEECCCCEECCCEEEEECCCCCCC
LSSVQLARLDGARVIAVTSSEAKVQALKEAGADEVIVSRGLDFASDVRKRTQGAGVDVAV
CCEEEEEECCCCEEEEEECCHHHHHHHHHCCCCCEEHHCCCCHHHHHHHHHCCCCCEEEE
EIVGSATFDQTLKSMAPGGRVVVVGNLESGMVQLNPGLVIVKELEILGAYATTQAELDEA
EEECCCHHHHHHHHHCCCCEEEEEECCCCCEEEECCCEEEEEEEEEHHHHHHHHHHHHHH
LRLTATGGVRQFVTDAVPLAEAAKAHFRLENREVAGRLVLVPPEA
EEEEECCCHHHHHHHHCCHHHHHHHHEEECCCCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479 [H]