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The map label for this gene is zraS [H]

Identifier: 108762754

GI number: 108762754

Start: 3885347

End: 3887590

Strand: Reverse

Name: zraS [H]

Synonym: MXAN_3343

Alternate gene names: 108762754

Gene position: 3887590-3885347 (Counterclockwise)

Preceding gene: 108762301

Following gene: 108763255

Centisome position: 42.53

GC content: 68.0

Gene sequence:

>2244_bases
ATGGACATCCGGACACAGAGCGCGCTGCTGGCATCCATCATCGGGCTCGCCCTGGGCGTGTCCATGTTGCTGCGGCCCGG
CAGGCCCAGGGTACTGACGCTGTACTCCGTCTTCGCGCTGACGGTGGCCGGCTACTACCTTTCGCTCTTCTTTCACAGCG
TCTTCCCGGCCGGCGACTACCCGTGGACATCCCGCATCTTCGTGGGCGCCACCATCCTGGTGGGTTCCCTGGTGCCGGGC
GCGGCCGTAGCCTTCTTCCTGGAGTTCCTGGGGGTCAGCAAGGGGACGAACCTGGTGGGCCGCCGGCTCGCCCTGCTGTC
CGCCGTCCTGGGGCTGACCGTGGCTGTCACCCCCCTGGCCGACAAGCTCTGGGCCCGGGTGGGCATGGGCGTGTGGGTGC
TGGGCACGCTGCTGACCTACGGTTCATTGCTGCTCCACCGGGTCCGCACCACGGAGTCGCGCATCGAGAAGTTCCGGCTG
GCGTATCTGGCCAGTGGCGCGGGCGCGGCCATCCTCTTCTCCGCGCTGGATTTCCTGGTCAGCTTCGGCATCCCCTTCCC
CACGCTGGGGTCGGTCTTCTCCACGCTGTACCTGTTCTTCCTGGCCCACACGCTGCTGCGCCTGCGGCTGATGGACCTGC
ACGAGCTGCTGGGCAAGATTGCCTCGCAGACGGTGCTGGCCAGCATCCTGGCCGCCGTCTTCACGGTGCTGACGGCGTGG
GGCAAGGAGAACACCGGCCTCTTCCTCTTCAACACGGTGGTGGCTGCGTTCGTCATCCTCATCCTGCTGGAGCCGCTGAA
GGTGAAGGTGGAGGAGATGGTGGTGCGCATCTTCTTCCGCGAGCGCTTCGCCCTCCTGGACTCGCTGGGCGCGCTGCGCG
TGCGCATCGCGAATGTCATCGAGATTTCCGAGCTGGCCCGGCTGGTGCTGGACACGCTCCACGAGACGGGCCGCGTCACG
CACGCCTCCGTGTACCTGCTGGCGGAGGACCGGCCCGGGTACCGGCTGCTGGACTCACGCGGCCCGCTGCCGGTGGCCTT
CCTGGACACGGCGGTGGCACGCGGCCTCCTCTTCGCGGCGGCCAGCGGACAGAAGGCGGTGCTGCGAGAGAACGTGGAGC
GCCGCATGGCCACCATGCGGCTGCAGGCGGTGGAGGGCAAGCGCTACCGGGACGAGCTCAAGCGGCTCAACGACACGCGC
ACGGCGCTGGTGCAGGTGAAGGCTGGCATCGCCGTGCCGCTGATGGGCAATGACCGCGTCATCGGGTTCCTCAACCTGTG
GGACGAACGGGTGCCGGAGGCCTTCGCGTCCGACGAAATCGCCATCATCCTGGAGGTGGCGGAGCGGCTGGCGACGGTGC
TGGAGAACTCCAAGCTCTACGAGAAGATTCGCGAGCGGGACCGCCTGGCCGCGCTGGGTGAGATGGCGGCGGGTCTCGCG
CATGAGATTCGCAATCCGCTGGGCGCCATCAAGGGCGCGGCGCAGTGCCTGGACCCGGTGCACTACCAGGGCGAAGACGC
CGAGTTCCTCGAAGTCATCGTCGAGGAGGTCAACCGGCTCAACGGCGTGGTGACGGCGTTCCTCGACTACGCGCGCCCGC
TGAAGCAGAGCTTTGGCACCACCGACCTCAACGAGGTGGTCACGCGCACCATGCGGCTCATCCAGAACGACGTGCCATCC
AACCTCCACCTGGCCGTGGAGTTGGACTTGATGCTGCCGCGCGTGGACGGCGACGCGGAGCAGCTCAAGCAGGTGCTCAT
CAACCTGGTGCAGAACGCCGTGCAGGCGCTCGAGACGCGCGAGGGCCGCATCAGCGTGCGCACGGAGAAGCCGGAGCGCT
TCGGTGAGCTGCGCAGCGCCGGCGCCGAGTTCGTAGAGGTGCGGGTGTCCGACAACGGGCCCGGCATTCCTTCGGACCAG
CACCCGCACATCTTCGTGCCGTTCTACACGACGAAGCAGAAAGGCACCGGCCTGGGGCTGGCCATCTGCCAACGCATCGT
GAAGAACCACGGCGGCAGCATCTCCGTGCAAAGCAAGATGGGCGAGGGCACCACGTTCGTCATCCGCCTCCCCGCCCTCC
CCACCGAGCAGCCACCCGCGGAGGCCAGCTCCGTGGACGGCCTGCCCGCCGGGAAGCGGCCGTCGCAGTCATTGCCCGTG
TCCGACGAACTGCGTGATGCGGGCAAGCCATCGCATGTGGACGGCCGCGCCAAGCGGGAGCGCCGCAAGCGGCTCCGCGC
GTAG

Upstream 100 bases:

>100_bases
GGCTGGGTCCCAGGGAGATGCGCGCGGGCTCGCCCCAGGACAACCGGCAGGTCATGGAAAATTTCCGGAGGCTGACACAG
GTTAGACTGTCCGCCTCCTC

Downstream 100 bases:

>100_bases
CGACACCGGGCGGTGCACCTGGGGAACGCACCTTCCAGACATTGCTGCTTTCGCCCCTGGGGGAGAGCGCCTATAGGTCA
TCCCCATGAGCGCATGCCCC

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 747; Mature: 747

Protein sequence:

>747_residues
MDIRTQSALLASIIGLALGVSMLLRPGRPRVLTLYSVFALTVAGYYLSLFFHSVFPAGDYPWTSRIFVGATILVGSLVPG
AAVAFFLEFLGVSKGTNLVGRRLALLSAVLGLTVAVTPLADKLWARVGMGVWVLGTLLTYGSLLLHRVRTTESRIEKFRL
AYLASGAGAAILFSALDFLVSFGIPFPTLGSVFSTLYLFFLAHTLLRLRLMDLHELLGKIASQTVLASILAAVFTVLTAW
GKENTGLFLFNTVVAAFVILILLEPLKVKVEEMVVRIFFRERFALLDSLGALRVRIANVIEISELARLVLDTLHETGRVT
HASVYLLAEDRPGYRLLDSRGPLPVAFLDTAVARGLLFAAASGQKAVLRENVERRMATMRLQAVEGKRYRDELKRLNDTR
TALVQVKAGIAVPLMGNDRVIGFLNLWDERVPEAFASDEIAIILEVAERLATVLENSKLYEKIRERDRLAALGEMAAGLA
HEIRNPLGAIKGAAQCLDPVHYQGEDAEFLEVIVEEVNRLNGVVTAFLDYARPLKQSFGTTDLNEVVTRTMRLIQNDVPS
NLHLAVELDLMLPRVDGDAEQLKQVLINLVQNAVQALETREGRISVRTEKPERFGELRSAGAEFVEVRVSDNGPGIPSDQ
HPHIFVPFYTTKQKGTGLGLAICQRIVKNHGGSISVQSKMGEGTTFVIRLPALPTEQPPAEASSVDGLPAGKRPSQSLPV
SDELRDAGKPSHVDGRAKRERRKRLRA

Sequences:

>Translated_747_residues
MDIRTQSALLASIIGLALGVSMLLRPGRPRVLTLYSVFALTVAGYYLSLFFHSVFPAGDYPWTSRIFVGATILVGSLVPG
AAVAFFLEFLGVSKGTNLVGRRLALLSAVLGLTVAVTPLADKLWARVGMGVWVLGTLLTYGSLLLHRVRTTESRIEKFRL
AYLASGAGAAILFSALDFLVSFGIPFPTLGSVFSTLYLFFLAHTLLRLRLMDLHELLGKIASQTVLASILAAVFTVLTAW
GKENTGLFLFNTVVAAFVILILLEPLKVKVEEMVVRIFFRERFALLDSLGALRVRIANVIEISELARLVLDTLHETGRVT
HASVYLLAEDRPGYRLLDSRGPLPVAFLDTAVARGLLFAAASGQKAVLRENVERRMATMRLQAVEGKRYRDELKRLNDTR
TALVQVKAGIAVPLMGNDRVIGFLNLWDERVPEAFASDEIAIILEVAERLATVLENSKLYEKIRERDRLAALGEMAAGLA
HEIRNPLGAIKGAAQCLDPVHYQGEDAEFLEVIVEEVNRLNGVVTAFLDYARPLKQSFGTTDLNEVVTRTMRLIQNDVPS
NLHLAVELDLMLPRVDGDAEQLKQVLINLVQNAVQALETREGRISVRTEKPERFGELRSAGAEFVEVRVSDNGPGIPSDQ
HPHIFVPFYTTKQKGTGLGLAICQRIVKNHGGSISVQSKMGEGTTFVIRLPALPTEQPPAEASSVDGLPAGKRPSQSLPV
SDELRDAGKPSHVDGRAKRERRKRLRA
>Mature_747_residues
MDIRTQSALLASIIGLALGVSMLLRPGRPRVLTLYSVFALTVAGYYLSLFFHSVFPAGDYPWTSRIFVGATILVGSLVPG
AAVAFFLEFLGVSKGTNLVGRRLALLSAVLGLTVAVTPLADKLWARVGMGVWVLGTLLTYGSLLLHRVRTTESRIEKFRL
AYLASGAGAAILFSALDFLVSFGIPFPTLGSVFSTLYLFFLAHTLLRLRLMDLHELLGKIASQTVLASILAAVFTVLTAW
GKENTGLFLFNTVVAAFVILILLEPLKVKVEEMVVRIFFRERFALLDSLGALRVRIANVIEISELARLVLDTLHETGRVT
HASVYLLAEDRPGYRLLDSRGPLPVAFLDTAVARGLLFAAASGQKAVLRENVERRMATMRLQAVEGKRYRDELKRLNDTR
TALVQVKAGIAVPLMGNDRVIGFLNLWDERVPEAFASDEIAIILEVAERLATVLENSKLYEKIRERDRLAALGEMAAGLA
HEIRNPLGAIKGAAQCLDPVHYQGEDAEFLEVIVEEVNRLNGVVTAFLDYARPLKQSFGTTDLNEVVTRTMRLIQNDVPS
NLHLAVELDLMLPRVDGDAEQLKQVLINLVQNAVQALETREGRISVRTEKPERFGELRSAGAEFVEVRVSDNGPGIPSDQ
HPHIFVPFYTTKQKGTGLGLAICQRIVKNHGGSISVQSKMGEGTTFVIRLPALPTEQPPAEASSVDGLPAGKRPSQSLPV
SDELRDAGKPSHVDGRAKRERRKRLRA

Specific function: Member of the two-component regulatory system zraS/zraR. May function as a membrane-associated protein kinase that phosphorylates zraR in response to high concentrations of zinc or lead in the medium [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=243, Percent_Identity=38.2716049382716, Blast_Score=167, Evalue=2e-42,
Organism=Escherichia coli, GI1788549, Length=239, Percent_Identity=39.7489539748954, Blast_Score=161, Evalue=1e-40,
Organism=Escherichia coli, GI1790300, Length=274, Percent_Identity=32.8467153284672, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI48994928, Length=246, Percent_Identity=28.0487804878049, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI145693157, Length=296, Percent_Identity=25.3378378378378, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1786912, Length=258, Percent_Identity=32.5581395348837, Blast_Score=83, Evalue=6e-17,
Organism=Escherichia coli, GI1786600, Length=229, Percent_Identity=30.5676855895196, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI87081816, Length=262, Percent_Identity=30.9160305343511, Blast_Score=80, Evalue=6e-16,
Organism=Escherichia coli, GI1789149, Length=244, Percent_Identity=28.2786885245902, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI1788713, Length=251, Percent_Identity=27.4900398406374, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1789808, Length=225, Percent_Identity=28.8888888888889, Blast_Score=74, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 81899; Mature: 81899

Theoretical pI: Translated: 9.72; Mature: 9.72

Prosite motif: PS00105 AA_TRANSFER_CLASS_1 ; PS50109 HIS_KIN ; PS00120 LIPASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CHHHHCCCCCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure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CHHHHCCCCCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]