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The map label for this gene is adk [H]

Identifier: 108762648

GI number: 108762648

Start: 3865865

End: 3866512

Strand: Direct

Name: adk [H]

Synonym: MXAN_3320

Alternate gene names: 108762648

Gene position: 3865865-3866512 (Clockwise)

Preceding gene: 108757580

Following gene: 108762768

Centisome position: 42.3

GC content: 67.75

Gene sequence:

>648_bases
ATGAACCTGATCCTGTTGGGGCCGCCGAACGCGGGGAAGGGCACGCAGGCGAAGCGACTGTTCGCCGACTTCCAGATCCC
CCAGATCTCCACCGGAGACATCCTCCGCAAGGCAGTCGCGGAGGGCACGGAGCTGGGCAGGGTGGCCGGCCCGCTGATGG
CCGCCGGGCAGTACGTCCCGGACGACGTCGTGATTGGCATCGTCGAGGAGCGCCTCAAGGAGGCGGACGTGGCCAAGGGC
TTCGTCCTGGACGGCTTTCCGCGCACGCCGGGCCAGGCGGACGCGTTGGACAAGATGCTGGGGCGCCTGGGCAAGCAGCT
GAGCGCCGTCATCTCGCTCGAGGTGCCGCACGCGAAGCTGGTGGAGCGCGGCTCCGGCCGGCGGGTCTGCCCGGTGGACG
GCAGCGTCTACCACGTCTACCAGAGCCCGCCGAAGCGGGCGGGGTACTGTGACAAGTGCAATACCGGGCTTGTCCAGCGC
CCGGATGATATGCCCGAGGTCATCGAGAAGCGCCTTCAGAAGTACGACTCGGAGACGGCGCCGCTGAAGGCCTTCTATGA
GAAGAAGGGTCTGCTCAAGAGCGTGGACGGCGTGGGCACGCCCGAGGGCATCTACGAGGAGATCAAGGCCGCTGCGGGCA
AGGCCTGA

Upstream 100 bases:

>100_bases
GGCTAGGTGTTGTTCAAGGATATTCGCTGGTGCACACGGAGCGCGCTCGGGGGTTTGAGTCCTACGACTTCCGTGCCTTC
CTTCGGAGCAAAGAGGACAC

Downstream 100 bases:

>100_bases
TCCATCTGGCGGGTGGGGTGCCGGCCTGGCTGGTACCTCCTCGCCGGTTCGTCGCTTCAGCAACGGAGCTTGCTTCGTGT
GGACAGGGGGAGCTCTGGCC

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 215; Mature: 215

Protein sequence:

>215_residues
MNLILLGPPNAGKGTQAKRLFADFQIPQISTGDILRKAVAEGTELGRVAGPLMAAGQYVPDDVVIGIVEERLKEADVAKG
FVLDGFPRTPGQADALDKMLGRLGKQLSAVISLEVPHAKLVERGSGRRVCPVDGSVYHVYQSPPKRAGYCDKCNTGLVQR
PDDMPEVIEKRLQKYDSETAPLKAFYEKKGLLKSVDGVGTPEGIYEEIKAAAGKA

Sequences:

>Translated_215_residues
MNLILLGPPNAGKGTQAKRLFADFQIPQISTGDILRKAVAEGTELGRVAGPLMAAGQYVPDDVVIGIVEERLKEADVAKG
FVLDGFPRTPGQADALDKMLGRLGKQLSAVISLEVPHAKLVERGSGRRVCPVDGSVYHVYQSPPKRAGYCDKCNTGLVQR
PDDMPEVIEKRLQKYDSETAPLKAFYEKKGLLKSVDGVGTPEGIYEEIKAAAGKA
>Mature_215_residues
MNLILLGPPNAGKGTQAKRLFADFQIPQISTGDILRKAVAEGTELGRVAGPLMAAGQYVPDDVVIGIVEERLKEADVAKG
FVLDGFPRTPGQADALDKMLGRLGKQLSAVISLEVPHAKLVERGSGRRVCPVDGSVYHVYQSPPKRAGYCDKCNTGLVQR
PDDMPEVIEKRLQKYDSETAPLKAFYEKKGLLKSVDGVGTPEGIYEEIKAAAGKA

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI7524346, Length=212, Percent_Identity=40.0943396226415, Blast_Score=167, Evalue=5e-42,
Organism=Homo sapiens, GI4502013, Length=212, Percent_Identity=40.0943396226415, Blast_Score=167, Evalue=6e-42,
Organism=Homo sapiens, GI19923437, Length=197, Percent_Identity=37.5634517766497, Blast_Score=147, Evalue=8e-36,
Organism=Homo sapiens, GI310110345, Length=197, Percent_Identity=36.0406091370558, Blast_Score=127, Evalue=9e-30,
Organism=Homo sapiens, GI53832003, Length=197, Percent_Identity=36.0406091370558, Blast_Score=127, Evalue=9e-30,
Organism=Homo sapiens, GI8051579, Length=197, Percent_Identity=36.0406091370558, Blast_Score=127, Evalue=9e-30,
Organism=Homo sapiens, GI53832001, Length=197, Percent_Identity=36.0406091370558, Blast_Score=127, Evalue=9e-30,
Organism=Homo sapiens, GI22749187, Length=209, Percent_Identity=30.622009569378, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI4502011, Length=207, Percent_Identity=27.0531400966184, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI28144899, Length=214, Percent_Identity=28.5046728971963, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI28144897, Length=214, Percent_Identity=28.5046728971963, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI7706497, Length=212, Percent_Identity=25.4716981132075, Blast_Score=70, Evalue=1e-12,
Organism=Escherichia coli, GI1786680, Length=189, Percent_Identity=47.0899470899471, Blast_Score=163, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI17552384, Length=194, Percent_Identity=39.1752577319588, Blast_Score=140, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI17537943, Length=210, Percent_Identity=30, Blast_Score=94, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17567503, Length=215, Percent_Identity=27.906976744186, Blast_Score=87, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17550688, Length=208, Percent_Identity=25.4807692307692, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17533833, Length=209, Percent_Identity=27.2727272727273, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6320432, Length=215, Percent_Identity=40, Blast_Score=159, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6321018, Length=197, Percent_Identity=40.6091370558376, Blast_Score=140, Evalue=1e-34,
Organism=Drosophila melanogaster, GI22026816, Length=210, Percent_Identity=38.0952380952381, Blast_Score=150, Evalue=8e-37,
Organism=Drosophila melanogaster, GI17737899, Length=199, Percent_Identity=38.6934673366834, Blast_Score=138, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24645822, Length=199, Percent_Identity=38.6934673366834, Blast_Score=138, Evalue=3e-33,
Organism=Drosophila melanogaster, GI221459597, Length=208, Percent_Identity=25.9615384615385, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI21356893, Length=208, Percent_Identity=25.9615384615385, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI17647141, Length=190, Percent_Identity=26.8421052631579, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24663208, Length=190, Percent_Identity=26.8421052631579, Blast_Score=75, Evalue=2e-14,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- InterPro:   IPR001878 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 23102; Mature: 23102

Theoretical pI: Translated: 8.44; Mature: 8.44

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLILLGPPNAGKGTQAKRLFADFQIPQISTGDILRKAVAEGTELGRVAGPLMAAGQYVP
CCEEEECCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCC
DDVVIGIVEERLKEADVAKGFVLDGFPRTPGQADALDKMLGRLGKQLSAVISLEVPHAKL
HHHHHHHHHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHEECCCHHHH
VERGSGRRVCPVDGSVYHVYQSPPKRAGYCDKCNTGLVQRPDDMPEVIEKRLQKYDSETA
HHCCCCCEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCC
PLKAFYEKKGLLKSVDGVGTPEGIYEEIKAAAGKA
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MNLILLGPPNAGKGTQAKRLFADFQIPQISTGDILRKAVAEGTELGRVAGPLMAAGQYVP
CCEEEECCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCC
DDVVIGIVEERLKEADVAKGFVLDGFPRTPGQADALDKMLGRLGKQLSAVISLEVPHAKL
HHHHHHHHHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHEECCCHHHH
VERGSGRRVCPVDGSVYHVYQSPPKRAGYCDKCNTGLVQRPDDMPEVIEKRLQKYDSETA
HHCCCCCEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCC
PLKAFYEKKGLLKSVDGVGTPEGIYEEIKAAAGKA
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA