Click here to switch to the map view.

The map label for this gene is yngG [H]

Identifier: 108762626

GI number: 108762626

Start: 4470126

End: 4471103

Strand: Direct

Name: yngG [H]

Synonym: MXAN_3753

Alternate gene names: 108762626

Gene position: 4470126-4471103 (Clockwise)

Preceding gene: 108763184

Following gene: 108758139

Centisome position: 48.91

GC content: 69.53

Gene sequence:

>978_bases
ATGGCTGAGATGCAGGAACACTCCAGGGCGAGGTTGGGCTGGCTGGGCCAGTTGCCCAAGCAGGTCGACGTCTACGAAGT
CGGTCCCCGGGACGGCTTGCAGAACGAGCTGCGCACGCTGCCCACGCGGGACAAGGCGCGCCTCATCAACGCACTGGTGG
CCGCGGGGGAGAAGCGCATCGAGGTGACGTCGTTCGTGTCACCCAAGTGGATTCCCCAGCTCGCGGACGCCGAGGAGCTG
CTGCGGCTGGTGGGCCGTCGCGACGGCGTCGTGTTCTCCGCGCTGGTGCCCAACCTCAAGGGCCTGGAGCGCGCGAAGGA
GGCGGGCCTGGAGGAGGCCGCCGTCTTCATCTCCGCCTCCGAGGCGCACTCGAAGAAGAACATCAACAAGAGCATCGCCG
AGGCCGTGGTGGGCGCGCGCGAGGTGACGGCCTCCGCGCTCCAGGCGGGCATGCGCGTGCGCGGCTACCTGTCCACCGTG
TGGGGCTGCCCCTACGAGGGTGACGTTCCGGTGGAGCGCGTGGTGGACATCTGCCGGCAGCTCGTGGACGCGGGCATCTA
CCAGCTCAGCCTGGGAGACACGATTGGCATCGGCACGCCGCGCCAGACCGAGGTCATCCTCGAGGCGCTGCTGAAGCACA
TCCCCGTGGAGAAGCTGGCGCTGCACCTGCACGACACACGCGGCACCGCGCTGGCGAACGCGCTCGTGGGCCTGTCCGCG
GGGGTGACGACCTTCGACGCCAGCATTGGCGGCCTGGGTGGGTGCCCCTACGCCCCGGGAGCGGCGGGGAACCTGGCCAC
CGAGGACGCCGTCTTCATGCTCCACGGCATGGGCGTGGACACAGGCATCAACCTGGACCGGCTGGTGGAGGCCGGGGAGA
TTGCCCAGGAGCTGATTGGCCGGAAGCTGGCGGGCAAGTACCTCCAGGCCGCGCTGGGCGAGCGTGAGAAGAAAGCCGCC
CGCCGGGCTCAGACGTGA

Upstream 100 bases:

>100_bases
GAAAGCACGGGATTTTCCGTCGTCTGGGTGCACGGTGGCCTGGCGGGTGGTCCGCTGGACGCGCAGTCAACCGACCTGAT
CGTGGGAGCGGAGCGGCGCC

Downstream 100 bases:

>100_bases
GCGGGCCCTACCCAGTGTCGAGGTCATGAAATACCCGGCAGTCCTAAAATCCGGGCATCATCGAAAAATTCTGTTCGGAC
TTACGTTTCGAGGTGGTGAG

Product: hydroxymethylglutaryl-CoA lyase

Products: NA

Alternate protein names: HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase [H]

Number of amino acids: Translated: 325; Mature: 324

Protein sequence:

>325_residues
MAEMQEHSRARLGWLGQLPKQVDVYEVGPRDGLQNELRTLPTRDKARLINALVAAGEKRIEVTSFVSPKWIPQLADAEEL
LRLVGRRDGVVFSALVPNLKGLERAKEAGLEEAAVFISASEAHSKKNINKSIAEAVVGAREVTASALQAGMRVRGYLSTV
WGCPYEGDVPVERVVDICRQLVDAGIYQLSLGDTIGIGTPRQTEVILEALLKHIPVEKLALHLHDTRGTALANALVGLSA
GVTTFDASIGGLGGCPYAPGAAGNLATEDAVFMLHGMGVDTGINLDRLVEAGEIAQELIGRKLAGKYLQAALGEREKKAA
RRAQT

Sequences:

>Translated_325_residues
MAEMQEHSRARLGWLGQLPKQVDVYEVGPRDGLQNELRTLPTRDKARLINALVAAGEKRIEVTSFVSPKWIPQLADAEEL
LRLVGRRDGVVFSALVPNLKGLERAKEAGLEEAAVFISASEAHSKKNINKSIAEAVVGAREVTASALQAGMRVRGYLSTV
WGCPYEGDVPVERVVDICRQLVDAGIYQLSLGDTIGIGTPRQTEVILEALLKHIPVEKLALHLHDTRGTALANALVGLSA
GVTTFDASIGGLGGCPYAPGAAGNLATEDAVFMLHGMGVDTGINLDRLVEAGEIAQELIGRKLAGKYLQAALGEREKKAA
RRAQT
>Mature_324_residues
AEMQEHSRARLGWLGQLPKQVDVYEVGPRDGLQNELRTLPTRDKARLINALVAAGEKRIEVTSFVSPKWIPQLADAEELL
RLVGRRDGVVFSALVPNLKGLERAKEAGLEEAAVFISASEAHSKKNINKSIAEAVVGAREVTASALQAGMRVRGYLSTVW
GCPYEGDVPVERVVDICRQLVDAGIYQLSLGDTIGIGTPRQTEVILEALLKHIPVEKLALHLHDTRGTALANALVGLSAG
VTTFDASIGGLGGCPYAPGAAGNLATEDAVFMLHGMGVDTGINLDRLVEAGEIAQELIGRKLAGKYLQAALGEREKKAAR
RAQT

Specific function: Involved in the catabolism of branched amino acids such as leucine (Probable) [H]

COG id: COG0119

COG function: function code E; Isopropylmalate/homocitrate/citramalate synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA lyase family [H]

Homologues:

Organism=Homo sapiens, GI62198232, Length=296, Percent_Identity=48.3108108108108, Blast_Score=298, Evalue=5e-81,
Organism=Homo sapiens, GI109150422, Length=298, Percent_Identity=46.6442953020134, Blast_Score=287, Evalue=8e-78,
Organism=Homo sapiens, GI109150427, Length=298, Percent_Identity=46.6442953020134, Blast_Score=287, Evalue=1e-77,
Organism=Homo sapiens, GI260654708, Length=134, Percent_Identity=50, Blast_Score=148, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI17510563, Length=298, Percent_Identity=46.9798657718121, Blast_Score=278, Evalue=3e-75,
Organism=Drosophila melanogaster, GI24582381, Length=298, Percent_Identity=50, Blast_Score=296, Evalue=2e-80,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000891 [H]

Pfam domain/function: PF00682 HMGL-like [H]

EC number: =4.1.3.4 [H]

Molecular weight: Translated: 34752; Mature: 34621

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS50991 PYR_CT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEMQEHSRARLGWLGQLPKQVDVYEVGPRDGLQNELRTLPTRDKARLINALVAAGEKRI
CCCHHHHHHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCCE
EVTSFVSPKWIPQLADAEELLRLVGRRDGVVFSALVPNLKGLERAKEAGLEEAAVFISAS
EHHHCCCCCCCCCCCCHHHHHHHHCCCCCEEHHHHCCCHHHHHHHHHCCHHHHHHEEECH
EAHSKKNINKSIAEAVVGAREVTASALQAGMRVRGYLSTVWGCPYEGDVPVERVVDICRQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
LVDAGIYQLSLGDTIGIGTPRQTEVILEALLKHIPVEKLALHLHDTRGTALANALVGLSA
HHHCCEEEEECCCEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHC
GVTTFDASIGGLGGCPYAPGAAGNLATEDAVFMLHGMGVDTGINLDRLVEAGEIAQELIG
CCHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHEEECCCCCCCCCHHHHHHHHHHHHHHHH
RKLAGKYLQAALGEREKKAARRAQT
HHHHHHHHHHHHCHHHHHHHHHCCC
>Mature Secondary Structure 
AEMQEHSRARLGWLGQLPKQVDVYEVGPRDGLQNELRTLPTRDKARLINALVAAGEKRI
CCHHHHHHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCCE
EVTSFVSPKWIPQLADAEELLRLVGRRDGVVFSALVPNLKGLERAKEAGLEEAAVFISAS
EHHHCCCCCCCCCCCCHHHHHHHHCCCCCEEHHHHCCCHHHHHHHHHCCHHHHHHEEECH
EAHSKKNINKSIAEAVVGAREVTASALQAGMRVRGYLSTVWGCPYEGDVPVERVVDICRQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
LVDAGIYQLSLGDTIGIGTPRQTEVILEALLKHIPVEKLALHLHDTRGTALANALVGLSA
HHHCCEEEEECCCEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHC
GVTTFDASIGGLGGCPYAPGAAGNLATEDAVFMLHGMGVDTGINLDRLVEAGEIAQELIG
CCHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHEEECCCCCCCCCHHHHHHHHHHHHHHHH
RKLAGKYLQAALGEREKKAARRAQT
HHHHHHHHHHHHCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]