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The map label for this gene is glyA

Identifier: 108762445

GI number: 108762445

Start: 5966856

End: 5968112

Strand: Reverse

Name: glyA

Synonym: MXAN_4766

Alternate gene names: 108762445

Gene position: 5968112-5966856 (Counterclockwise)

Preceding gene: 108758725

Following gene: 108760844

Centisome position: 65.3

GC content: 68.26

Gene sequence:

>1257_bases
ATGGAGAACATCCGTACGCTGGCCGAAGTGGACCCGGAGATTGCCCGCGTCCTCCGCGAGGAGACCCAGCGCCAGGAGGA
AGGGCTGGAGCTCATCGCTTCGGAGAACTTCGTCTCTCCGGCGGTGATGGAGGCGGTGGGCTCGGTGCTCACCAACAAGT
ACGCGGAAGGCTACCCCGGCAAGCGCTACTACGGCGGCTGCGAGGTGGTGGACGTCGCGGAGAACCTGGCCATCGCCCGC
GCCAAGGACCTGTTCGGCGCGGACGCGGTCAACGTGCAGGCGCACTCCGGCAGCCAGGCCAACATGGGCGCCTTCATGGC
GCTGATGAAGCCGGGCGACACCATGCTGTCGCTGGACCTCAACTCCGGCGGCCACCTCACCCACGGCGCCACGTTCAACT
TCTCCGGCAAGCTCTACAAGGTCGTCCACTACGGCCTGACGCGTGACACGGAGACCATCGACTTCGCGCAGGTGGAGTCG
CTGGCCAAGGAGCACAAGCCGAAGGTCATCGTCGTGGGCGCCAGTGCGTACCCGCGCACGCTGGACTTCGCGAAGTTCCG
CGAGATCGCCGACGCGGTGGGCGCGGCGATGCTGGTGGACATGGCGCACATCGCCGGCCTGGTGGCGGCGGGCGTGCACC
CTTCGCCGGTGCCGGTGGCGGACATCGTCACCAGCACCACGCACAAGACGCTGCGCGGTCCGCGTGGCGGCCTGGTGCTG
AGCCGCGAGCCCTACGCCAAGGCCATCAACAGTCAGATCTTCCCCGGCATCCAGGGCGGCCCGCTGATGCACGTCATCGC
CGGCAAGGCGGTGGCCTTCAAGGAGGCGCTGTCGCCGGAGTTCAAGGCGTACCAGCGGCAGATTGTCGCCAACGCGAAGG
CGCTGGCGGAGGCGCTCCAGCGCGCGGGCCTGCGGCTGACGTCCGGCGGCACGGACAACCACCTGATGCTGGTGGACCTG
CGCCCCAAGAAGCTCACGGGCAAGGTGGCCGAAGAGGTGCTGGACAAGGCCGGAATCACCGTGAACAAGAACATGATTCC
GTTTGACCCGGAGAAGCCGATGACCACGTCCGGTGTCCGGGTGGGCACGCCGGCCATCACCACGCGCGGCATGCGCGAGG
CGGAGATGGCGGTGGTGGGGCGGCTCATCGGCGAGGCGCTGGACGCCGCGCAGGACGACGCCGCGCTGGCCCGCATCAAG
GGGCAGGTGAAGGAGCTTTCGCAGGGGTTCCCGCTCTACGCCTCGCGGTTGAAGTAG

Upstream 100 bases:

>100_bases
TTTCGAAGGCGGCCGCCACGAGCGGCGCGTCCAGATGATTCGCGAGGCCGAGTCCCAGGGCTAACGGCCCCGCCGTACCC
GTCGTTCGAGGGAGTCCGCC

Downstream 100 bases:

>100_bases
ATTGGCGAGCCGTACCCTTCCATGCGCTGCCCCTTCTGTCAGGACGCCGAGAACAAGGTCATCGACTCCCGTGAGTCACA
CGAGGGCTCCGTCATCCGGC

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase

Number of amino acids: Translated: 418; Mature: 418

Protein sequence:

>418_residues
MENIRTLAEVDPEIARVLREETQRQEEGLELIASENFVSPAVMEAVGSVLTNKYAEGYPGKRYYGGCEVVDVAENLAIAR
AKDLFGADAVNVQAHSGSQANMGAFMALMKPGDTMLSLDLNSGGHLTHGATFNFSGKLYKVVHYGLTRDTETIDFAQVES
LAKEHKPKVIVVGASAYPRTLDFAKFREIADAVGAAMLVDMAHIAGLVAAGVHPSPVPVADIVTSTTHKTLRGPRGGLVL
SREPYAKAINSQIFPGIQGGPLMHVIAGKAVAFKEALSPEFKAYQRQIVANAKALAEALQRAGLRLTSGGTDNHLMLVDL
RPKKLTGKVAEEVLDKAGITVNKNMIPFDPEKPMTTSGVRVGTPAITTRGMREAEMAVVGRLIGEALDAAQDDAALARIK
GQVKELSQGFPLYASRLK

Sequences:

>Translated_418_residues
MENIRTLAEVDPEIARVLREETQRQEEGLELIASENFVSPAVMEAVGSVLTNKYAEGYPGKRYYGGCEVVDVAENLAIAR
AKDLFGADAVNVQAHSGSQANMGAFMALMKPGDTMLSLDLNSGGHLTHGATFNFSGKLYKVVHYGLTRDTETIDFAQVES
LAKEHKPKVIVVGASAYPRTLDFAKFREIADAVGAAMLVDMAHIAGLVAAGVHPSPVPVADIVTSTTHKTLRGPRGGLVL
SREPYAKAINSQIFPGIQGGPLMHVIAGKAVAFKEALSPEFKAYQRQIVANAKALAEALQRAGLRLTSGGTDNHLMLVDL
RPKKLTGKVAEEVLDKAGITVNKNMIPFDPEKPMTTSGVRVGTPAITTRGMREAEMAVVGRLIGEALDAAQDDAALARIK
GQVKELSQGFPLYASRLK
>Mature_418_residues
MENIRTLAEVDPEIARVLREETQRQEEGLELIASENFVSPAVMEAVGSVLTNKYAEGYPGKRYYGGCEVVDVAENLAIAR
AKDLFGADAVNVQAHSGSQANMGAFMALMKPGDTMLSLDLNSGGHLTHGATFNFSGKLYKVVHYGLTRDTETIDFAQVES
LAKEHKPKVIVVGASAYPRTLDFAKFREIADAVGAAMLVDMAHIAGLVAAGVHPSPVPVADIVTSTTHKTLRGPRGGLVL
SREPYAKAINSQIFPGIQGGPLMHVIAGKAVAFKEALSPEFKAYQRQIVANAKALAEALQRAGLRLTSGGTDNHLMLVDL
RPKKLTGKVAEEVLDKAGITVNKNMIPFDPEKPMTTSGVRVGTPAITTRGMREAEMAVVGRLIGEALDAAQDDAALARIK
GQVKELSQGFPLYASRLK

Specific function: Interconversion of serine and glycine

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family

Homologues:

Organism=Homo sapiens, GI19923315, Length=452, Percent_Identity=44.6902654867257, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI261862352, Length=452, Percent_Identity=44.6902654867257, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI261862350, Length=452, Percent_Identity=44.6902654867257, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI261862348, Length=452, Percent_Identity=44.6902654867257, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI261862346, Length=452, Percent_Identity=43.8053097345133, Blast_Score=351, Evalue=8e-97,
Organism=Homo sapiens, GI22547186, Length=426, Percent_Identity=44.131455399061, Blast_Score=338, Evalue=4e-93,
Organism=Homo sapiens, GI22547189, Length=411, Percent_Identity=42.5790754257908, Blast_Score=309, Evalue=4e-84,
Organism=Escherichia coli, GI1788902, Length=412, Percent_Identity=59.7087378640777, Blast_Score=488, Evalue=1e-139,
Organism=Caenorhabditis elegans, GI25144732, Length=415, Percent_Identity=45.7831325301205, Blast_Score=355, Evalue=2e-98,
Organism=Caenorhabditis elegans, GI25144729, Length=415, Percent_Identity=45.7831325301205, Blast_Score=355, Evalue=2e-98,
Organism=Saccharomyces cerevisiae, GI6319739, Length=412, Percent_Identity=45.873786407767, Blast_Score=367, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6323087, Length=436, Percent_Identity=43.5779816513761, Blast_Score=345, Evalue=7e-96,
Organism=Drosophila melanogaster, GI24640005, Length=414, Percent_Identity=47.3429951690821, Blast_Score=380, Evalue=1e-106,
Organism=Drosophila melanogaster, GI221329721, Length=414, Percent_Identity=47.3429951690821, Blast_Score=379, Evalue=1e-105,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): GLYA_MYXXD (Q1D345)

Other databases:

- EMBL:   CP000113
- RefSeq:   YP_632928.1
- ProteinModelPortal:   Q1D345
- SMR:   Q1D345
- STRING:   Q1D345
- GeneID:   4106195
- GenomeReviews:   CP000113_GR
- KEGG:   mxa:MXAN_4766
- TIGR:   MXAN_4766
- eggNOG:   COG0112
- HOGENOM:   HBG301263
- OMA:   DYEETER
- PhylomeDB:   Q1D345
- ProtClustDB:   PRK00011
- BioCyc:   MXAN246197:MXAN_4766-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00051_B
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11680
- PIRSF:   PIRSF000412

Pfam domain/function: PF00464 SHMT; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.1.2.1

Molecular weight: Translated: 44655; Mature: 44655

Theoretical pI: Translated: 7.86; Mature: 7.86

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENIRTLAEVDPEIARVLREETQRQEEGLELIASENFVSPAVMEAVGSVLTNKYAEGYPG
CCCHHHHHHCCHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHCCCCC
KRYYGGCEVVDVAENLAIARAKDLFGADAVNVQAHSGSQANMGAFMALMKPGDTMLSLDL
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHEEECCCCEEEEEEE
NSGGHLTHGATFNFSGKLYKVVHYGLTRDTETIDFAQVESLAKEHKPKVIVVGASAYPRT
CCCCCEECCEEECCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCH
LDFAKFREIADAVGAAMLVDMAHIAGLVAAGVHPSPVPVADIVTSTTHKTLRGPRGGLVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEE
SREPYAKAINSQIFPGIQGGPLMHVIAGKAVAFKEALSPEFKAYQRQIVANAKALAEALQ
CCCHHHHHHHHHCCCCCCCCCEEEEHHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
RAGLRLTSGGTDNHLMLVDLRPKKLTGKVAEEVLDKAGITVNKNMIPFDPEKPMTTSGVR
HCCCEEECCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCEE
VGTPAITTRGMREAEMAVVGRLIGEALDAAQDDAALARIKGQVKELSQGFPLYASRLK
ECCCHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHCCC
>Mature Secondary Structure
MENIRTLAEVDPEIARVLREETQRQEEGLELIASENFVSPAVMEAVGSVLTNKYAEGYPG
CCCHHHHHHCCHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHCCCCC
KRYYGGCEVVDVAENLAIARAKDLFGADAVNVQAHSGSQANMGAFMALMKPGDTMLSLDL
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHEEECCCCEEEEEEE
NSGGHLTHGATFNFSGKLYKVVHYGLTRDTETIDFAQVESLAKEHKPKVIVVGASAYPRT
CCCCCEECCEEECCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCH
LDFAKFREIADAVGAAMLVDMAHIAGLVAAGVHPSPVPVADIVTSTTHKTLRGPRGGLVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEE
SREPYAKAINSQIFPGIQGGPLMHVIAGKAVAFKEALSPEFKAYQRQIVANAKALAEALQ
CCCHHHHHHHHHCCCCCCCCCEEEEHHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
RAGLRLTSGGTDNHLMLVDLRPKKLTGKVAEEVLDKAGITVNKNMIPFDPEKPMTTSGVR
HCCCEEECCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCEE
VGTPAITTRGMREAEMAVVGRLIGEALDAAQDDAALARIKGQVKELSQGFPLYASRLK
ECCCHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA