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The map label for this gene is xth [H]

Identifier: 108762443

GI number: 108762443

Start: 4833522

End: 4834304

Strand: Reverse

Name: xth [H]

Synonym: MXAN_3970

Alternate gene names: 108762443

Gene position: 4834304-4833522 (Counterclockwise)

Preceding gene: 108759282

Following gene: 108757493

Centisome position: 52.89

GC content: 67.05

Gene sequence:

>783_bases
GTGCGAGTCGTTTCGTGGAACGTGAACGGACTTCGCTCGGTGCACCGCAAGGGCTTCCTGCCCTGGCTCGCGGGGTGCCG
GGCGCAAGTCGTTGGTCTGCAGGAGGTCCGCGCGCGCGCCGACCAGCTTCCCGACGATGTGCGCTCACCGTCCCGGTGGA
AGACGCACTTCGTGGCGGCGGAGCGGCCGGGCTACAGCGGCGTCGGACTGTACAGCCGCCTGGAGCCCGATGAAGTCGTG
ACGGTGCTCGGCGTGGGGGAGCTGGACGTCGAAGGGCGCCTGCAGATTGCCCGCTTCGGCAAGCTCACCGTGGTGAACGG
CTACTTTCCCAACGGCAACGGGAAGGACCGGGACCTGAGCCGCATCCCCTACAAGCTGACCTTCTACCGGCGCCTCTTCG
AGCGGCTGGAGAAGCCCCTGCGCGATGGTGGCCGGGTGCTGGTGATGGGGGACTTCAACACAGCGCATCAAGAAATCGAC
CTGGCGCGGCCCAAGGAGAACCGGGAGACGAGCGGCTTCCGGCCCGAGGAGCGCGAGGAGTTCGACCGGTGGATTCGTGC
CGGCTGGGTGGACACCTTCCGCCACTTCAACAAGGGTGGGGGGAACTATTCGTGGTGGAGTCAGCGGGCCGGCGTTCGGG
AGAAGAATATCGGCTGGAGAATCGACTATGTCCTGGCCTCGCCAGCGGCCATGGCCTACGTGCGCAAGGCTGGCATCCAC
CCGGACGTGCTCGGCTCGGACCACTGTCCGGTGAGCGTGGACCTGGACCCCGCGGTTCGCTGA

Upstream 100 bases:

>100_bases
GAGCGCCACGGAGCCGTAGCCAGCTGCCTGTTCGCCCCTACCGCCTGTGTGTGCGGTAGGGGCTGGTAATGCCGCACGGG
GCGGGCCATAAGCCTTCCCC

Downstream 100 bases:

>100_bases
CGCTTGTTCGAGGCTCTCATGAACGCACTGCTCTCCATCTGGACGTGGATCGAGATTGGCCTGGTGGCGCTGGTCGGCTT
CTGTGTGCAGCTGTCGCTGG

Product: exodeoxyribonuclease III

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 260; Mature: 260

Protein sequence:

>260_residues
MRVVSWNVNGLRSVHRKGFLPWLAGCRAQVVGLQEVRARADQLPDDVRSPSRWKTHFVAAERPGYSGVGLYSRLEPDEVV
TVLGVGELDVEGRLQIARFGKLTVVNGYFPNGNGKDRDLSRIPYKLTFYRRLFERLEKPLRDGGRVLVMGDFNTAHQEID
LARPKENRETSGFRPEEREEFDRWIRAGWVDTFRHFNKGGGNYSWWSQRAGVREKNIGWRIDYVLASPAAMAYVRKAGIH
PDVLGSDHCPVSVDLDPAVR

Sequences:

>Translated_260_residues
MRVVSWNVNGLRSVHRKGFLPWLAGCRAQVVGLQEVRARADQLPDDVRSPSRWKTHFVAAERPGYSGVGLYSRLEPDEVV
TVLGVGELDVEGRLQIARFGKLTVVNGYFPNGNGKDRDLSRIPYKLTFYRRLFERLEKPLRDGGRVLVMGDFNTAHQEID
LARPKENRETSGFRPEEREEFDRWIRAGWVDTFRHFNKGGGNYSWWSQRAGVREKNIGWRIDYVLASPAAMAYVRKAGIH
PDVLGSDHCPVSVDLDPAVR
>Mature_260_residues
MRVVSWNVNGLRSVHRKGFLPWLAGCRAQVVGLQEVRARADQLPDDVRSPSRWKTHFVAAERPGYSGVGLYSRLEPDEVV
TVLGVGELDVEGRLQIARFGKLTVVNGYFPNGNGKDRDLSRIPYKLTFYRRLFERLEKPLRDGGRVLVMGDFNTAHQEID
LARPKENRETSGFRPEEREEFDRWIRAGWVDTFRHFNKGGGNYSWWSQRAGVREKNIGWRIDYVLASPAAMAYVRKAGIH
PDVLGSDHCPVSVDLDPAVR

Specific function: Major Apurinic-Apyrimidinic Endonuclease Of E.Coli. It Removes The Damaged DNA At Cytosines And Guanines By Cleaving On The 3' Side Of The Ap Site By A Beta-Elimination Reaction. It Exhibits 3'-5'-Exonuclease, 3'-Phosphomonoesterase, 3'-Repair Diesterase

COG id: COG0708

COG function: function code L; Exonuclease III

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA repair enzymes AP/ExoA family [H]

Homologues:

Organism=Homo sapiens, GI18375505, Length=259, Percent_Identity=34.7490347490347, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI18375503, Length=259, Percent_Identity=34.7490347490347, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI18375501, Length=259, Percent_Identity=34.7490347490347, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI18375507, Length=319, Percent_Identity=27.2727272727273, Blast_Score=96, Evalue=3e-20,
Organism=Escherichia coli, GI1788046, Length=266, Percent_Identity=31.9548872180451, Blast_Score=120, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI71989536, Length=259, Percent_Identity=35.1351351351351, Blast_Score=147, Evalue=4e-36,
Organism=Drosophila melanogaster, GI221330655, Length=254, Percent_Identity=34.251968503937, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI17136678, Length=254, Percent_Identity=34.251968503937, Blast_Score=149, Evalue=1e-36,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000097
- InterPro:   IPR020847
- InterPro:   IPR020848
- InterPro:   IPR005135
- InterPro:   IPR004808 [H]

Pfam domain/function: PF03372 Exo_endo_phos [H]

EC number: =3.1.11.2 [H]

Molecular weight: Translated: 29647; Mature: 29647

Theoretical pI: Translated: 10.01; Mature: 10.01

Prosite motif: PS00727 AP_NUCLEASE_F1_2 ; PS00728 AP_NUCLEASE_F1_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVVSWNVNGLRSVHRKGFLPWLAGCRAQVVGLQEVRARADQLPDDVRSPSRWKTHFVAA
CEEEEECCHHHHHHHHCCCCHHHHCCHHHHCCHHHHHHHHHCCCHHHCCCCCHHEEEEEE
ERPGYSGVGLYSRLEPDEVVTVLGVGELDVEGRLQIARFGKLTVVNGYFPNGNGKDRDLS
CCCCCCCCCHHHCCCCCCEEEEEECCEECCCCCEEEEECCEEEEEEEECCCCCCCCCCHH
RIPYKLTFYRRLFERLEKPLRDGGRVLVMGDFNTAHQEIDLARPKENRETSGFRPEEREE
HCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHCCCCCCCCCCCCCCCCHHHHH
FDRWIRAGWVDTFRHFNKGGGNYSWWSQRAGVREKNIGWRIDYVLASPAAMAYVRKAGIH
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCEEEEEEECCHHHHHHHHHCCCC
PDVLGSDHCPVSVDLDPAVR
CCCCCCCCCCEEECCCCCCC
>Mature Secondary Structure
MRVVSWNVNGLRSVHRKGFLPWLAGCRAQVVGLQEVRARADQLPDDVRSPSRWKTHFVAA
CEEEEECCHHHHHHHHCCCCHHHHCCHHHHCCHHHHHHHHHCCCHHHCCCCCHHEEEEEE
ERPGYSGVGLYSRLEPDEVVTVLGVGELDVEGRLQIARFGKLTVVNGYFPNGNGKDRDLS
CCCCCCCCCHHHCCCCCCEEEEEECCEECCCCCEEEEECCEEEEEEEECCCCCCCCCCHH
RIPYKLTFYRRLFERLEKPLRDGGRVLVMGDFNTAHQEIDLARPKENRETSGFRPEEREE
HCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHCCCCCCCCCCCCCCCCHHHHH
FDRWIRAGWVDTFRHFNKGGGNYSWWSQRAGVREKNIGWRIDYVLASPAAMAYVRKAGIH
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCEEEEEEECCHHHHHHHHHCCCC
PDVLGSDHCPVSVDLDPAVR
CCCCCCCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377 [H]