Click here to switch to the map view.

The map label for this gene is cumA [H]

Identifier: 108762119

GI number: 108762119

Start: 3974556

End: 3976001

Strand: Reverse

Name: cumA [H]

Synonym: MXAN_3420

Alternate gene names: 108762119

Gene position: 3976001-3974556 (Counterclockwise)

Preceding gene: 108763711

Following gene: 108763457

Centisome position: 43.5

GC content: 66.87

Gene sequence:

>1446_bases
ATGCATCGCAATCGCTGGTTCATCGCGGCAGCTCTCGTTGCCCTCCTCGCAATGCTCGCGGCACTCGGCCTCGGCCAGGA
GGATGATGCCGCCATGGCGACGCTCCGGCAGCCGCGCGTGGCACCGCCCTACCCTGAAGACACCCCGTCCACGGGCCGCG
TGCGCGAGTTCGAGCTCGTCGCGGCCCCGACAGCCCTCCCGCTCCTGGATGGCCGGAGTCTGGAGGTCTGGGCCTACAAC
GGCCAGGTACCCGGCCCCACCCTTCGCGCCACCCATGGCGACACGGTCCGCGTGCGATTCACCAACAAGCTGCCGCAGCC
GACGACCATTCACTGGCACGGCATCCGTCTTCCGAACGGAATGGACGGCGTGCCCGGGGTGACCCAGCCTCCCATCCCAC
CTGGGGGAACCTTCCTCTATGAGTTCAAAGTGAAGGACGCAGGAACCTACTGGTTTCACCCGCACCTGCGCGGGAGCGAG
CAAGTCGAGCGAGGGCTGTTCGGCGTGCTCATCGTGGAGGACCAGAAGCCCGGTCCTTTCTCACGCGAGCTCGTCTGGGT
GCTCGACGACTGGCGACTCGACGCGAGTGGCCAGATTGACGGCCGATTCAACACGCGCCACGACCTCGCGCACGACGGCC
GCTGGGGGCAGGTCTCCACGGTGAACGGGGCTGTCCAGCCAGAAGTCCCGCTGCAGCCCGGCGAGCGGGTGCGACTGCGG
ATGGTCAACGTTGCAAACGGGCGCGTGTTCGCGCCTTCCTTCGAAGGGCTGGGCGCATCTGTCATCGCGATCGACGGGCT
GGCCACGGACCGGCCGCAGCCGGCCTCCCGCTTGGAGCTCGCTCCAGGGAACCGCGTCGACCTGGACTTCACCGTTCCCG
AGGCGCTGAGCAACCAGCGCATGGAGGTGATGGACCACTTCACCCGCAGGCCGTTCCCTCTCGCAACGCTGGTGGTGTCT
GGAGAGGTCGTGCGGCCACCCGAAGTGGCAGCAGTTGCCCCGCCCCCGAGTCCTGACCTCTCTCCAGCGCGTGCACTGCA
ACCCGCGGAGACCTTTCGGCTGAATGCGAGGCGAGGAGGCCCCTTCGGCATCGAGTGGACCATCAATGACGAGGCGTTCC
ACCACGAGGGGGAGCATGCCTCCGCGCACCACAAGGTCTACCGGCTCCCTGCCCACCAATGGGCCACGCTGCGTTTCGTC
AACGAGTCCTCCCGCCTGCACCCCATGCACGTGCATGGCCAGTTCTTCCGGGTGGTGGCACGCAATGGTGCATCGGTGGA
CGAGGGACACTGGCGCGACACCGTGCTGATTCGTCCAAGAGAGACGGTGGATGTGGCGATGTTCCCGCAGGACGTGGGGG
CCTGGATGCTCCACTGCCACATCCAAGAGCACGCCGAGGCTGGGATGATGACGCTCGTGGACGTCCATGCGGAGGGTTCC
CAGTAA

Upstream 100 bases:

>100_bases
GCTGCGCACCGAGGTCACGCGCCTCGGGGCCGGGCCACGCCACCACGGCGGCCTGGTCCCCTCCTCGCCCGCAGCTTCCA
TCCATTCGTGAAGAGGCTTC

Downstream 100 bases:

>100_bases
GCGAGCCGCGCCATTCCGACAGCGCCGCGTTCGCCAGACCTGAAGTCGAGCCCCCGGCCCATTACAGTGTGACCAGCCTG
GTCACACCCGGCCCTTTTCT

Product: multicopper oxidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MHRNRWFIAAALVALLAMLAALGLGQEDDAAMATLRQPRVAPPYPEDTPSTGRVREFELVAAPTALPLLDGRSLEVWAYN
GQVPGPTLRATHGDTVRVRFTNKLPQPTTIHWHGIRLPNGMDGVPGVTQPPIPPGGTFLYEFKVKDAGTYWFHPHLRGSE
QVERGLFGVLIVEDQKPGPFSRELVWVLDDWRLDASGQIDGRFNTRHDLAHDGRWGQVSTVNGAVQPEVPLQPGERVRLR
MVNVANGRVFAPSFEGLGASVIAIDGLATDRPQPASRLELAPGNRVDLDFTVPEALSNQRMEVMDHFTRRPFPLATLVVS
GEVVRPPEVAAVAPPPSPDLSPARALQPAETFRLNARRGGPFGIEWTINDEAFHHEGEHASAHHKVYRLPAHQWATLRFV
NESSRLHPMHVHGQFFRVVARNGASVDEGHWRDTVLIRPRETVDVAMFPQDVGAWMLHCHIQEHAEAGMMTLVDVHAEGS
Q

Sequences:

>Translated_481_residues
MHRNRWFIAAALVALLAMLAALGLGQEDDAAMATLRQPRVAPPYPEDTPSTGRVREFELVAAPTALPLLDGRSLEVWAYN
GQVPGPTLRATHGDTVRVRFTNKLPQPTTIHWHGIRLPNGMDGVPGVTQPPIPPGGTFLYEFKVKDAGTYWFHPHLRGSE
QVERGLFGVLIVEDQKPGPFSRELVWVLDDWRLDASGQIDGRFNTRHDLAHDGRWGQVSTVNGAVQPEVPLQPGERVRLR
MVNVANGRVFAPSFEGLGASVIAIDGLATDRPQPASRLELAPGNRVDLDFTVPEALSNQRMEVMDHFTRRPFPLATLVVS
GEVVRPPEVAAVAPPPSPDLSPARALQPAETFRLNARRGGPFGIEWTINDEAFHHEGEHASAHHKVYRLPAHQWATLRFV
NESSRLHPMHVHGQFFRVVARNGASVDEGHWRDTVLIRPRETVDVAMFPQDVGAWMLHCHIQEHAEAGMMTLVDVHAEGS
Q
>Mature_481_residues
MHRNRWFIAAALVALLAMLAALGLGQEDDAAMATLRQPRVAPPYPEDTPSTGRVREFELVAAPTALPLLDGRSLEVWAYN
GQVPGPTLRATHGDTVRVRFTNKLPQPTTIHWHGIRLPNGMDGVPGVTQPPIPPGGTFLYEFKVKDAGTYWFHPHLRGSE
QVERGLFGVLIVEDQKPGPFSRELVWVLDDWRLDASGQIDGRFNTRHDLAHDGRWGQVSTVNGAVQPEVPLQPGERVRLR
MVNVANGRVFAPSFEGLGASVIAIDGLATDRPQPASRLELAPGNRVDLDFTVPEALSNQRMEVMDHFTRRPFPLATLVVS
GEVVRPPEVAAVAPPPSPDLSPARALQPAETFRLNARRGGPFGIEWTINDEAFHHEGEHASAHHKVYRLPAHQWATLRFV
NESSRLHPMHVHGQFFRVVARNGASVDEGHWRDTVLIRPRETVDVAMFPQDVGAWMLHCHIQEHAEAGMMTLVDVHAEGS
Q

Specific function: May be involved in copper homeostasis and oxidative stress response [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=262, Percent_Identity=33.969465648855, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1789394, Length=450, Percent_Identity=24.6666666666667, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6323703, Length=460, Percent_Identity=25.6521739130435, Blast_Score=122, Evalue=9e-29,
Organism=Saccharomyces cerevisiae, GI6321067, Length=244, Percent_Identity=27.4590163934426, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6320714, Length=540, Percent_Identity=22.037037037037, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI18859919, Length=261, Percent_Identity=31.4176245210728, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI221330000, Length=222, Percent_Identity=33.3333333333333, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24650186, Length=120, Percent_Identity=39.1666666666667, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24585842, Length=222, Percent_Identity=33.3333333333333, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI281360167, Length=222, Percent_Identity=33.3333333333333, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI221329998, Length=222, Percent_Identity=33.3333333333333, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI28574104, Length=141, Percent_Identity=34.7517730496454, Blast_Score=76, Evalue=5e-14,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR002355
- InterPro:   IPR008972 [H]

Pfam domain/function: PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 53254; Mature: 53254

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS00079 MULTICOPPER_OXIDASE1 ; PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHRNRWFIAAALVALLAMLAALGLGQEDDAAMATLRQPRVAPPYPEDTPSTGRVREFELV
CCCCEEEHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEE
AAPTALPLLDGRSLEVWAYNGQVPGPTLRATHGDTVRVRFTNKLPQPTTIHWHGIRLPNG
ECCCEEEEECCCEEEEEEECCCCCCCEEEECCCCEEEEEECCCCCCCCEEEEEEEECCCC
MDGVPGVTQPPIPPGGTFLYEFKVKDAGTYWFHPHLRGSEQVERGLFGVLIVEDQKPGPF
CCCCCCCCCCCCCCCCCEEEEEEEECCCEEEECCCCCCHHHHHCCEEEEEEEECCCCCCC
SRELVWVLDDWRLDASGQIDGRFNTRHDLAHDGRWGQVSTVNGAVQPEVPLQPGERVRLR
CCEEEEEEECEEECCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCEEEEE
MVNVANGRVFAPSFEGLGASVIAIDGLATDRPQPASRLELAPGNRVDLDFTVPEALSNQR
EEEECCCEEECCCCCCCCEEEEEEECCCCCCCCCHHEEEECCCCEEEEEEECHHHHCCCH
MEVMDHFTRRPFPLATLVVSGEVVRPPEVAAVAPPPSPDLSPARALQPAETFRLNARRGG
HHHHHHHHCCCCCEEEEEEECCEECCCCCEEECCCCCCCCCHHHHCCCCHHEEEECCCCC
PFGIEWTINDEAFHHEGEHASAHHKVYRLPAHQWATLRFVNESSRLHPMHVHGQFFRVVA
CEEEEEEECCHHHCCCCCCCCCCCEEEECCCCCEEEEEEECCCCCCCEEEECCCEEEEEE
RNGASVDEGHWRDTVLIRPRETVDVAMFPQDVGAWMLHCHIQEHAEAGMMTLVDVHAEGS
CCCCCCCCCCCCCEEEECCCCCEEEEECCHHHCEEEEEEEEHHHCCCCEEEEEEEECCCC
Q
C
>Mature Secondary Structure
MHRNRWFIAAALVALLAMLAALGLGQEDDAAMATLRQPRVAPPYPEDTPSTGRVREFELV
CCCCEEEHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEE
AAPTALPLLDGRSLEVWAYNGQVPGPTLRATHGDTVRVRFTNKLPQPTTIHWHGIRLPNG
ECCCEEEEECCCEEEEEEECCCCCCCEEEECCCCEEEEEECCCCCCCCEEEEEEEECCCC
MDGVPGVTQPPIPPGGTFLYEFKVKDAGTYWFHPHLRGSEQVERGLFGVLIVEDQKPGPF
CCCCCCCCCCCCCCCCCEEEEEEEECCCEEEECCCCCCHHHHHCCEEEEEEEECCCCCCC
SRELVWVLDDWRLDASGQIDGRFNTRHDLAHDGRWGQVSTVNGAVQPEVPLQPGERVRLR
CCEEEEEEECEEECCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCEEEEE
MVNVANGRVFAPSFEGLGASVIAIDGLATDRPQPASRLELAPGNRVDLDFTVPEALSNQR
EEEECCCEEECCCCCCCCEEEEEEECCCCCCCCCHHEEEECCCCEEEEEEECHHHHCCCH
MEVMDHFTRRPFPLATLVVSGEVVRPPEVAAVAPPPSPDLSPARALQPAETFRLNARRGG
HHHHHHHHCCCCCEEEEEEECCEECCCCCEEECCCCCCCCCHHHHCCCCHHEEEECCCCC
PFGIEWTINDEAFHHEGEHASAHHKVYRLPAHQWATLRFVNESSRLHPMHVHGQFFRVVA
CEEEEEEECCHHHCCCCCCCCCCCEEEECCCCCEEEEEEECCCCCCCEEEECCCEEEEEE
RNGASVDEGHWRDTVLIRPRETVDVAMFPQDVGAWMLHCHIQEHAEAGMMTLVDVHAEGS
CCCCCCCCCCCCCEEEECCCCCEEEEECCHHHCEEEEEEEEHHHCCCCEEEEEEEECCCC
Q
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA