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The map label for this gene is ptpA [H]

Identifier: 108762069

GI number: 108762069

Start: 1989816

End: 1992095

Strand: Reverse

Name: ptpA [H]

Synonym: MXAN_1682

Alternate gene names: 108762069

Gene position: 1992095-1989816 (Counterclockwise)

Preceding gene: 108762139

Following gene: 108758424

Centisome position: 21.8

GC content: 69.43

Gene sequence:

>2280_bases
TTGGTCGTGAAGGATGCCGCTTCCTACCATCGGCGCATGCGATTCCCCTTCGTTCCCCTCGGCCTGATGCTCACGGCGCT
GACGGGAGCCCCCGGCCTGGCGCTGGATGACGCTCCCCCCCCCCTCGCCCCCTCCGGAACCACGCCGGATGCGCAGGTCC
AGGCGAAGCTGGACCTGGCGGACCGGTTCGTCCGCCGGGCGGAACTCCTGCGGGACAGCCTGGTTCCCCCCAGGTGGCTG
CGTGAGGGCGACCGGTTGGTCTTCTGGTCCCGTGAGGGCAAGGACGGCGGGACGTGGGTGCTGGCGCACGCGAAGACCGG
GGAGCTGAAGCCACTCCTTTCCGGTGAGCAACTGAGGCAGCAGCTCTCGACGCTGCTGGGCAAGCCCATCACCGCGCCCC
GCTTCTTCGACGTCGCGCTCGCTCCGGATGAGCGGGGCATCGTGTTCCGCCTGGAGGGGAAGACCTTTGGCCTGGGCCTG
TCAGGTGGCCATGTCACCTTGCTGTCGCCGGAGGACCGGGCCGCGCTGACGCTGTCGCCCCAGCACTTCCTCGCGCCGAA
AGGCGGCGCGCTCGCCGTGCAACGCCAGGGCGGCTTCGCGGTGCTGAACGCGGAAGGCGCCACCGTGGTCGAGCGCACGG
GGGAAGCGAACCTCGACTGGCGGATTCCGGAGCGTCCCTGGTCACCGGATGGCCGCTTCCTGGTGGTGTGGCGGGACGAC
CTCCGCGCCGTTCACCAGGTGCCCGTCGTGGACTACTCCTCCGCGCTGGAGAAGGTGACGACGGTGCCGTACACGAAGTC
CGGGACGCCACTGCCGCGCGCGGAGCTCCATGTCGTGGAAGTGGCGACGGGCCGCGTGACGCGCGTTCCGCCCGTCGAGG
GCGAGACATATGACTGGTTCGCCGGCTGGAATCCCGAGGGCACCGAGGCGCTGTGTCTCCACCTCTCGCGTGACGCCAAG
CGGCTGGACCTGAGCGTCGTGGAACCCGCGTCGGGCCAGCGTCGGCACGTCCTGCGCGAGGAGCGCCCGGAGACCTTCGT
CACCGGCCTGGACTTCGCGGTGGGCGGCTGGGCGAAGCAGGTGACGGCGCTGCCAGGAGGGCGCGGCTACCTCTGGATGT
CCGAGCGTGATGGCTGGCGCCACGTGTATGCGTATGACCGCTCGGGGAAGCGCGTGAGGCAGCTCACGCGAGGCGCCTTT
CCCGTGCACGAAGTGGTGGGAGTCGCCCCCACGGGAGATGCCCTCTACGTGCTGGCCTCCGCCGACAGCGGCGCGCCATA
CGAGCACCTCTTCTACCGGGGAAGCCTGAAGGGAGGCGCGTTGAAGCGGCTGTCCTCTGCCTCGGGGATGCACCGCATCA
CGCCGTCCCCCTCCGGCCAGTACTACGTGGACACATGGTCCTCGCGGACACAGCCCCGGTTGAGGGAGCTGGTGTCCGTG
GAGGGTGGCAAGCGCGTGCGGCTCACCACGTCGGACGCGAGTGAGTTCGAGTCGCTCGGCGACACGCGGCCGGAGGCGCT
GCTCGTCAAGGCGGCCGATGGCGTCACGCCCCTGCACGGCGTGCTCTACAAGCCACGCGACTTCGACGCCTCGAAGCGCT
ACCCCGTGCTCGCCTCCATCTACGCGGGTCCGTTCACCACCGTTGTCCCCTGGAGCTTCCTGGGGACTTCGGATTCGCTG
ACCGCCAGCGGCCTGGCGCAACTGGGCTTCATCGTGGTGTTGCTGGACCCCCGGGGTGGCCCCGGACGGAGCAAGTCCTT
CCAGGACGCGAACTACGGCCGCGTGGGCCAGACGGAGATTCCCGACTACGTCGCGGGGCTGAAGCAGGCCGCGTCCACGC
GCCCCTGGATGGACCTGGAGCGGGTCGGCATCCACGGCGGTTCGTGGGGCGGCTATTTCACGCTGCGCGGCATGCTGACG
GCGCCGGACTTCTTCAAGGCGGGCTACGCCGGAGCCCCCGGAGCGCTGGAGGAAGAGGCCATCATCAACGAGCCCTATCT
CAACCTCCCAAGCGTCAATCCCCAGGGGTACGCGGCGGGCGACAACCTCGCGATTGCAGACAGGCTGAGGGGCCACCTGA
AGCTGATGCACGGCACGAGCGACGTGAATGCCACGCTCTCCGTGACGATGCGGATGGCGGACGCGCTCATCCGCGCGGGC
AAGCGCTTCGAATTGCTCATCATGCCCGGCCAGCCGCACTCCCCTCGGGGTGCCGCCAGCCGCTACTACCGGGACGATGT
GGGCCTGTTCTTCCTCCGGACCCTGGGCGGTCCACGGTAA

Upstream 100 bases:

>100_bases
GCGTCCGAAGTGCAACTCCTCCGCCACGGCGACGAAGAGCTGGAGCTGACGGAATTCCATATCGAGACGATATCCATCTC
AATGCGCATCAAAAGATATA

Downstream 100 bases:

>100_bases
GGGCTCCTCATGGATCCTTGCGGCCAGGCGCTCGGCGGTCCGCATGGAGCCAGCGGCGCACCTCCTCCAGGTACTCCCGA
GGGAGGACATGCCCGCTGTC

Product: S9B family peptidase

Products: NA

Alternate protein names: PTP; Prolyl tripeptidyl peptidase A [H]

Number of amino acids: Translated: 759; Mature: 759

Protein sequence:

>759_residues
MVVKDAASYHRRMRFPFVPLGLMLTALTGAPGLALDDAPPPLAPSGTTPDAQVQAKLDLADRFVRRAELLRDSLVPPRWL
REGDRLVFWSREGKDGGTWVLAHAKTGELKPLLSGEQLRQQLSTLLGKPITAPRFFDVALAPDERGIVFRLEGKTFGLGL
SGGHVTLLSPEDRAALTLSPQHFLAPKGGALAVQRQGGFAVLNAEGATVVERTGEANLDWRIPERPWSPDGRFLVVWRDD
LRAVHQVPVVDYSSALEKVTTVPYTKSGTPLPRAELHVVEVATGRVTRVPPVEGETYDWFAGWNPEGTEALCLHLSRDAK
RLDLSVVEPASGQRRHVLREERPETFVTGLDFAVGGWAKQVTALPGGRGYLWMSERDGWRHVYAYDRSGKRVRQLTRGAF
PVHEVVGVAPTGDALYVLASADSGAPYEHLFYRGSLKGGALKRLSSASGMHRITPSPSGQYYVDTWSSRTQPRLRELVSV
EGGKRVRLTTSDASEFESLGDTRPEALLVKAADGVTPLHGVLYKPRDFDASKRYPVLASIYAGPFTTVVPWSFLGTSDSL
TASGLAQLGFIVVLLDPRGGPGRSKSFQDANYGRVGQTEIPDYVAGLKQAASTRPWMDLERVGIHGGSWGGYFTLRGMLT
APDFFKAGYAGAPGALEEEAIINEPYLNLPSVNPQGYAAGDNLAIADRLRGHLKLMHGTSDVNATLSVTMRMADALIRAG
KRFELLIMPGQPHSPRGAASRYYRDDVGLFFLRTLGGPR

Sequences:

>Translated_759_residues
MVVKDAASYHRRMRFPFVPLGLMLTALTGAPGLALDDAPPPLAPSGTTPDAQVQAKLDLADRFVRRAELLRDSLVPPRWL
REGDRLVFWSREGKDGGTWVLAHAKTGELKPLLSGEQLRQQLSTLLGKPITAPRFFDVALAPDERGIVFRLEGKTFGLGL
SGGHVTLLSPEDRAALTLSPQHFLAPKGGALAVQRQGGFAVLNAEGATVVERTGEANLDWRIPERPWSPDGRFLVVWRDD
LRAVHQVPVVDYSSALEKVTTVPYTKSGTPLPRAELHVVEVATGRVTRVPPVEGETYDWFAGWNPEGTEALCLHLSRDAK
RLDLSVVEPASGQRRHVLREERPETFVTGLDFAVGGWAKQVTALPGGRGYLWMSERDGWRHVYAYDRSGKRVRQLTRGAF
PVHEVVGVAPTGDALYVLASADSGAPYEHLFYRGSLKGGALKRLSSASGMHRITPSPSGQYYVDTWSSRTQPRLRELVSV
EGGKRVRLTTSDASEFESLGDTRPEALLVKAADGVTPLHGVLYKPRDFDASKRYPVLASIYAGPFTTVVPWSFLGTSDSL
TASGLAQLGFIVVLLDPRGGPGRSKSFQDANYGRVGQTEIPDYVAGLKQAASTRPWMDLERVGIHGGSWGGYFTLRGMLT
APDFFKAGYAGAPGALEEEAIINEPYLNLPSVNPQGYAAGDNLAIADRLRGHLKLMHGTSDVNATLSVTMRMADALIRAG
KRFELLIMPGQPHSPRGAASRYYRDDVGLFFLRTLGGPR
>Mature_759_residues
MVVKDAASYHRRMRFPFVPLGLMLTALTGAPGLALDDAPPPLAPSGTTPDAQVQAKLDLADRFVRRAELLRDSLVPPRWL
REGDRLVFWSREGKDGGTWVLAHAKTGELKPLLSGEQLRQQLSTLLGKPITAPRFFDVALAPDERGIVFRLEGKTFGLGL
SGGHVTLLSPEDRAALTLSPQHFLAPKGGALAVQRQGGFAVLNAEGATVVERTGEANLDWRIPERPWSPDGRFLVVWRDD
LRAVHQVPVVDYSSALEKVTTVPYTKSGTPLPRAELHVVEVATGRVTRVPPVEGETYDWFAGWNPEGTEALCLHLSRDAK
RLDLSVVEPASGQRRHVLREERPETFVTGLDFAVGGWAKQVTALPGGRGYLWMSERDGWRHVYAYDRSGKRVRQLTRGAF
PVHEVVGVAPTGDALYVLASADSGAPYEHLFYRGSLKGGALKRLSSASGMHRITPSPSGQYYVDTWSSRTQPRLRELVSV
EGGKRVRLTTSDASEFESLGDTRPEALLVKAADGVTPLHGVLYKPRDFDASKRYPVLASIYAGPFTTVVPWSFLGTSDSL
TASGLAQLGFIVVLLDPRGGPGRSKSFQDANYGRVGQTEIPDYVAGLKQAASTRPWMDLERVGIHGGSWGGYFTLRGMLT
APDFFKAGYAGAPGALEEEAIINEPYLNLPSVNPQGYAAGDNLAIADRLRGHLKLMHGTSDVNATLSVTMRMADALIRAG
KRFELLIMPGQPHSPRGAASRYYRDDVGLFFLRTLGGPR

Specific function: Serine proteinase. Releases tripeptides from the free amino terminus of proteins. Has a requirement for Pro in the P1 position, but is inactivated by Pro in the P1' position [H]

COG id: COG1506

COG function: function code E; Dipeptidyl aminopeptidases/acylaminoacyl-peptidases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9B family [H]

Homologues:

Organism=Homo sapiens, GI37577089, Length=617, Percent_Identity=27.5526742301459, Blast_Score=172, Evalue=2e-42,
Organism=Homo sapiens, GI18450280, Length=617, Percent_Identity=27.5526742301459, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI194394146, Length=351, Percent_Identity=30.7692307692308, Blast_Score=148, Evalue=2e-35,
Organism=Homo sapiens, GI18765694, Length=540, Percent_Identity=24.8148148148148, Blast_Score=106, Evalue=1e-22,
Organism=Homo sapiens, GI37577091, Length=616, Percent_Identity=24.1883116883117, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI16933540, Length=552, Percent_Identity=22.6449275362319, Blast_Score=103, Evalue=6e-22,
Organism=Homo sapiens, GI85787627, Length=564, Percent_Identity=22.8723404255319, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI295842403, Length=564, Percent_Identity=22.8723404255319, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI295842359, Length=564, Percent_Identity=22.8723404255319, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI52426756, Length=565, Percent_Identity=23.1858407079646, Blast_Score=86, Evalue=2e-16,
Organism=Homo sapiens, GI295849272, Length=564, Percent_Identity=22.8723404255319, Blast_Score=85, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17508017, Length=256, Percent_Identity=28.515625, Blast_Score=114, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17508019, Length=256, Percent_Identity=28.515625, Blast_Score=114, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17564634, Length=219, Percent_Identity=26.9406392694064, Blast_Score=72, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17564632, Length=219, Percent_Identity=26.9406392694064, Blast_Score=72, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17550672, Length=580, Percent_Identity=22.0689655172414, Blast_Score=71, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324793, Length=559, Percent_Identity=25.0447227191413, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6321817, Length=567, Percent_Identity=22.5749559082892, Blast_Score=80, Evalue=9e-16,
Organism=Drosophila melanogaster, GI45550825, Length=243, Percent_Identity=33.3333333333333, Blast_Score=139, Evalue=6e-33,
Organism=Drosophila melanogaster, GI45553511, Length=243, Percent_Identity=33.3333333333333, Blast_Score=139, Evalue=6e-33,
Organism=Drosophila melanogaster, GI45551969, Length=243, Percent_Identity=33.3333333333333, Blast_Score=139, Evalue=6e-33,
Organism=Drosophila melanogaster, GI24582032, Length=502, Percent_Identity=24.5019920318725, Blast_Score=86, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24582257, Length=229, Percent_Identity=27.9475982532751, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI17933704, Length=647, Percent_Identity=23.338485316847, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI221331178, Length=242, Percent_Identity=28.5123966942149, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI161083744, Length=647, Percent_Identity=23.338485316847, Blast_Score=74, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001375
- InterPro:   IPR002469 [H]

Pfam domain/function: PF00930 DPPIV_N; PF00326 Peptidase_S9 [H]

EC number: =3.4.14.12 [H]

Molecular weight: Translated: 82734; Mature: 82734

Theoretical pI: Translated: 9.61; Mature: 9.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVKDAASYHRRMRFPFVPLGLMLTALTGAPGLALDDAPPPLAPSGTTPDAQVQAKLDLA
CCCCCCHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHH
DRFVRRAELLRDSLVPPRWLREGDRLVFWSREGKDGGTWVLAHAKTGELKPLLSGEQLRQ
HHHHHHHHHHHHHCCCCHHHCCCCEEEEEECCCCCCCEEEEEECCCCCCCCCCCHHHHHH
QLSTLLGKPITAPRFFDVALAPDERGIVFRLEGKTFGLGLSGGHVTLLSPEDRAALTLSP
HHHHHHCCCCCCCCEEEEEECCCCCCEEEEECCCEEEEECCCCEEEEECCCCCEEEEECC
QHFLAPKGGALAVQRQGGFAVLNAEGATVVERTGEANLDWRIPERPWSPDGRFLVVWRDD
HHHCCCCCCEEEEEECCCEEEEECCCCEEEEECCCCCCEEECCCCCCCCCCCEEEEECHH
LRAVHQVPVVDYSSALEKVTTVPYTKSGTPLPRAELHVVEVATGRVTRVPPVEGETYDWF
HHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEECCCEEECCCCCCCCEEEE
AGWNPEGTEALCLHLSRDAKRLDLSVVEPASGQRRHVLREERPETFVTGLDFAVGGWAKQ
CCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCHHHHHHHCCCCEEEECCCHHHCCHHHH
VTALPGGRGYLWMSERDGWRHVYAYDRSGKRVRQLTRGAFPVHEVVGVAPTGDALYVLAS
EEECCCCCEEEEEECCCCCEEEEEECCCCHHHHHHHHCCCCHHHHEECCCCCCEEEEEEE
ADSGAPYEHLFYRGSLKGGALKRLSSASGMHRITPSPSGQYYVDTWSSRTQPRLRELVSV
CCCCCCHHHEEEECCCCCHHHHHHHHCCCCEEECCCCCCCEEEECCCCCCCHHHHHHHHC
EGGKRVRLTTSDASEFESLGDTRPEALLVKAADGVTPLHGVLYKPRDFDASKRYPVLASI
CCCCEEEEECCCHHHHHHHCCCCCCEEEEEECCCCCCHHHEEECCCCCCCCCCCCEEEEE
YAGPFTTVVPWSFLGTSDSLTASGLAQLGFIVVLLDPRGGPGRSKSFQDANYGRVGQTEI
CCCCCCCCCCEEECCCCCCCCHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCC
PDYVAGLKQAASTRPWMDLERVGIHGGSWGGYFTLRGMLTAPDFFKAGYAGAPGALEEEA
CHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCEEEEEEEECCCHHHHCCCCCCCCCCCCCH
IINEPYLNLPSVNPQGYAAGDNLAIADRLRGHLKLMHGTSDVNATLSVTMRMADALIRAG
HCCCCCCCCCCCCCCCEECCCCEEHHHHHCCEEEEEECCCCCCEEEEHHHHHHHHHHHCC
KRFELLIMPGQPHSPRGAASRYYRDDVGLFFLRTLGGPR
CCEEEEEECCCCCCCCCHHHHHHHHCHHHHHHHHCCCCC
>Mature Secondary Structure
MVVKDAASYHRRMRFPFVPLGLMLTALTGAPGLALDDAPPPLAPSGTTPDAQVQAKLDLA
CCCCCCHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHH
DRFVRRAELLRDSLVPPRWLREGDRLVFWSREGKDGGTWVLAHAKTGELKPLLSGEQLRQ
HHHHHHHHHHHHHCCCCHHHCCCCEEEEEECCCCCCCEEEEEECCCCCCCCCCCHHHHHH
QLSTLLGKPITAPRFFDVALAPDERGIVFRLEGKTFGLGLSGGHVTLLSPEDRAALTLSP
HHHHHHCCCCCCCCEEEEEECCCCCCEEEEECCCEEEEECCCCEEEEECCCCCEEEEECC
QHFLAPKGGALAVQRQGGFAVLNAEGATVVERTGEANLDWRIPERPWSPDGRFLVVWRDD
HHHCCCCCCEEEEEECCCEEEEECCCCEEEEECCCCCCEEECCCCCCCCCCCEEEEECHH
LRAVHQVPVVDYSSALEKVTTVPYTKSGTPLPRAELHVVEVATGRVTRVPPVEGETYDWF
HHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEECCCEEECCCCCCCCEEEE
AGWNPEGTEALCLHLSRDAKRLDLSVVEPASGQRRHVLREERPETFVTGLDFAVGGWAKQ
CCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCHHHHHHHCCCCEEEECCCHHHCCHHHH
VTALPGGRGYLWMSERDGWRHVYAYDRSGKRVRQLTRGAFPVHEVVGVAPTGDALYVLAS
EEECCCCCEEEEEECCCCCEEEEEECCCCHHHHHHHHCCCCHHHHEECCCCCCEEEEEEE
ADSGAPYEHLFYRGSLKGGALKRLSSASGMHRITPSPSGQYYVDTWSSRTQPRLRELVSV
CCCCCCHHHEEEECCCCCHHHHHHHHCCCCEEECCCCCCCEEEECCCCCCCHHHHHHHHC
EGGKRVRLTTSDASEFESLGDTRPEALLVKAADGVTPLHGVLYKPRDFDASKRYPVLASI
CCCCEEEEECCCHHHHHHHCCCCCCEEEEEECCCCCCHHHEEECCCCCCCCCCCCEEEEE
YAGPFTTVVPWSFLGTSDSLTASGLAQLGFIVVLLDPRGGPGRSKSFQDANYGRVGQTEI
CCCCCCCCCCEEECCCCCCCCHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCC
PDYVAGLKQAASTRPWMDLERVGIHGGSWGGYFTLRGMLTAPDFFKAGYAGAPGALEEEA
CHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCEEEEEEEECCCHHHHCCCCCCCCCCCCCH
IINEPYLNLPSVNPQGYAAGDNLAIADRLRGHLKLMHGTSDVNATLSVTMRMADALIRAG
HCCCCCCCCCCCCCCCEECCCCEEHHHHHCCEEEEEECCCCCCEEEEHHHHHHHHHHHCC
KRFELLIMPGQPHSPRGAASRYYRDDVGLFFLRTLGGPR
CCEEEEEECCCCCCCCCHHHHHHHHCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA