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The map label for this gene is prs [H]

Identifier: 108761645

GI number: 108761645

Start: 6349494

End: 6350444

Strand: Direct

Name: prs [H]

Synonym: MXAN_5075

Alternate gene names: 108761645

Gene position: 6349494-6350444 (Clockwise)

Preceding gene: 108757875

Following gene: 108763637

Centisome position: 69.47

GC content: 68.24

Gene sequence:

>951_bases
ATGCAGCCGCGTGACTTCAAGGTGTTCGCCGGGAACTCGAATCCCGGCCTGGCGCATCGCATCTGCGAGTACCTCAAGCG
CCCTCTGGGCAAGGCGGAGGTCGGTCGGTTCTCGGACGGGGAGATTCACGTCGAGATCGGCGAGAACGTCCGCGGCCACG
ACGTCTTCATCCTCCAGTCGACCTGCCCGCCTGCGAACGATCACCTGATGGAGTTGCTCATCATGTGTGACGCGCTCAAG
CGGGCGAGCGCCGGCTCCATCACCGCCGTCATTCCGTACTACGGGTACGCCCGTCAGGACCGGAAGGTGGCGCCGCGTAC
GCCCATCACCGCGAAGCTCATCGCGGACCTGCTGGAGTCCGCGGGCGCCGGGCGCGTGGTGTCCATGGACATGCACGCGG
GGCAGATCCAGGGCTTCTTCAACATCCCCTCGGACCACCTCTACGGCTCGCCGGTGTTCCTGGAAGACCTGCGCAAGCGC
TTCCCGGAGTCGCAGGAGCTGGTCATCGTCTCGCCGGACGCCGGCGGTGTGGAGCGCGCCCGCGCGTACTCCAAGCGGCT
GAACACGGGCCTGGCCATCATCGACAAGCGCCGTCCCCGCCCCAACGCGTCGGAGGTGATGAACCTCATCGGCGACGTGA
GCGGCAAGGACGCGGTGCTGGTGGACGACATGGTGGACACCGCCGGCACGCTCGCCCAGGCGGCCGCGGCGCTGAAGGCC
AAGGGCGCACGGCGCGTGGTGGCATACGCGGTCCACCCCATCCTCTCCGGCCCGGCCATCCAGCGCATCCAGGACTCGGT
GCTGGAAGAGGTCGTCTTCACGGACACCGTGCCGCTGTCCCCGGCGGCGCAGGCCTGCTCGAAGATCCGCCTGCTCACCA
CCGAGCGCCTCTTCGGCGAGGCCATTGCCCGCATCCACCGCGCAGACTCGCTCAGCTCGCTGTTCGTCTGA

Upstream 100 bases:

>100_bases
TCCATCAGGCGCAAGCCGGGATGCTCGTCGCAGCGCCAGCGGACCTCGACTAACGACTTCTTTCCTTCTGTCCGCGTCCA
GGTTAGTCAGCGGCCCCACC

Downstream 100 bases:

>100_bases
GCCGGCGCGCGCTTGCCCGCCGGGCGGCTTGACTCCAGGCCCTCCGGCTGGCATGTGCACGACCCTCCATCGGAGGCCTT
CACAGGCGCCGTCTTCGGGG

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MQPRDFKVFAGNSNPGLAHRICEYLKRPLGKAEVGRFSDGEIHVEIGENVRGHDVFILQSTCPPANDHLMELLIMCDALK
RASAGSITAVIPYYGYARQDRKVAPRTPITAKLIADLLESAGAGRVVSMDMHAGQIQGFFNIPSDHLYGSPVFLEDLRKR
FPESQELVIVSPDAGGVERARAYSKRLNTGLAIIDKRRPRPNASEVMNLIGDVSGKDAVLVDDMVDTAGTLAQAAAALKA
KGARRVVAYAVHPILSGPAIQRIQDSVLEEVVFTDTVPLSPAAQACSKIRLLTTERLFGEAIARIHRADSLSSLFV

Sequences:

>Translated_316_residues
MQPRDFKVFAGNSNPGLAHRICEYLKRPLGKAEVGRFSDGEIHVEIGENVRGHDVFILQSTCPPANDHLMELLIMCDALK
RASAGSITAVIPYYGYARQDRKVAPRTPITAKLIADLLESAGAGRVVSMDMHAGQIQGFFNIPSDHLYGSPVFLEDLRKR
FPESQELVIVSPDAGGVERARAYSKRLNTGLAIIDKRRPRPNASEVMNLIGDVSGKDAVLVDDMVDTAGTLAQAAAALKA
KGARRVVAYAVHPILSGPAIQRIQDSVLEEVVFTDTVPLSPAAQACSKIRLLTTERLFGEAIARIHRADSLSSLFV
>Mature_316_residues
MQPRDFKVFAGNSNPGLAHRICEYLKRPLGKAEVGRFSDGEIHVEIGENVRGHDVFILQSTCPPANDHLMELLIMCDALK
RASAGSITAVIPYYGYARQDRKVAPRTPITAKLIADLLESAGAGRVVSMDMHAGQIQGFFNIPSDHLYGSPVFLEDLRKR
FPESQELVIVSPDAGGVERARAYSKRLNTGLAIIDKRRPRPNASEVMNLIGDVSGKDAVLVDDMVDTAGTLAQAAAALKA
KGARRVVAYAVHPILSGPAIQRIQDSVLEEVVFTDTVPLSPAAQACSKIRLLTTERLFGEAIARIHRADSLSSLFV

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=311, Percent_Identity=48.2315112540193, Blast_Score=303, Evalue=2e-82,
Organism=Homo sapiens, GI28557709, Length=311, Percent_Identity=47.588424437299, Blast_Score=298, Evalue=3e-81,
Organism=Homo sapiens, GI4506129, Length=308, Percent_Identity=47.4025974025974, Blast_Score=298, Evalue=3e-81,
Organism=Homo sapiens, GI84875539, Length=311, Percent_Identity=46.9453376205788, Blast_Score=293, Evalue=1e-79,
Organism=Homo sapiens, GI194018537, Length=343, Percent_Identity=37.0262390670554, Blast_Score=202, Evalue=2e-52,
Organism=Homo sapiens, GI4506133, Length=342, Percent_Identity=35.672514619883, Blast_Score=198, Evalue=7e-51,
Organism=Homo sapiens, GI310128524, Length=147, Percent_Identity=31.9727891156463, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI310115209, Length=147, Percent_Identity=31.9727891156463, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI310118259, Length=147, Percent_Identity=31.9727891156463, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI310119946, Length=147, Percent_Identity=31.9727891156463, Blast_Score=83, Evalue=4e-16,
Organism=Escherichia coli, GI1787458, Length=313, Percent_Identity=58.14696485623, Blast_Score=372, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI25149168, Length=311, Percent_Identity=49.1961414790997, Blast_Score=310, Evalue=5e-85,
Organism=Caenorhabditis elegans, GI17554702, Length=311, Percent_Identity=49.1961414790997, Blast_Score=309, Evalue=1e-84,
Organism=Caenorhabditis elegans, GI17554704, Length=308, Percent_Identity=49.3506493506493, Blast_Score=308, Evalue=3e-84,
Organism=Caenorhabditis elegans, GI71989924, Length=311, Percent_Identity=49.1961414790997, Blast_Score=307, Evalue=5e-84,
Organism=Caenorhabditis elegans, GI17570245, Length=335, Percent_Identity=34.6268656716418, Blast_Score=207, Evalue=7e-54,
Organism=Saccharomyces cerevisiae, GI6319403, Length=317, Percent_Identity=45.1104100946372, Blast_Score=265, Evalue=7e-72,
Organism=Saccharomyces cerevisiae, GI6320946, Length=317, Percent_Identity=45.1104100946372, Blast_Score=264, Evalue=2e-71,
Organism=Saccharomyces cerevisiae, GI6321776, Length=316, Percent_Identity=43.0379746835443, Blast_Score=255, Evalue=6e-69,
Organism=Saccharomyces cerevisiae, GI6322667, Length=208, Percent_Identity=40.8653846153846, Blast_Score=162, Evalue=7e-41,
Organism=Saccharomyces cerevisiae, GI6324511, Length=112, Percent_Identity=45.5357142857143, Blast_Score=99, Evalue=6e-22,
Organism=Drosophila melanogaster, GI21355239, Length=311, Percent_Identity=48.8745980707396, Blast_Score=300, Evalue=1e-81,
Organism=Drosophila melanogaster, GI45551540, Length=334, Percent_Identity=45.5089820359281, Blast_Score=287, Evalue=5e-78,
Organism=Drosophila melanogaster, GI24651458, Length=354, Percent_Identity=33.8983050847458, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24651456, Length=354, Percent_Identity=33.8983050847458, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI281362873, Length=354, Percent_Identity=33.8983050847458, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24651454, Length=354, Percent_Identity=33.8983050847458, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24651462, Length=373, Percent_Identity=32.7077747989276, Blast_Score=198, Evalue=4e-51,
Organism=Drosophila melanogaster, GI24651464, Length=373, Percent_Identity=32.7077747989276, Blast_Score=198, Evalue=4e-51,
Organism=Drosophila melanogaster, GI45552010, Length=373, Percent_Identity=32.7077747989276, Blast_Score=197, Evalue=6e-51,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 34278; Mature: 34278

Theoretical pI: Translated: 8.33; Mature: 8.33

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPRDFKVFAGNSNPGLAHRICEYLKRPLGKAEVGRFSDGEIHVEIGENVRGHDVFILQS
CCCCCEEEEECCCCCCHHHHHHHHHHCCCCCHHCCCCCCCEEEEEECCCCCCCEEEEEEC
TCPPANDHLMELLIMCDALKRASAGSITAVIPYYGYARQDRKVAPRTPITAKLIADLLES
CCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHC
AGAGRVVSMDMHAGQIQGFFNIPSDHLYGSPVFLEDLRKRFPESQELVIVSPDAGGVERA
CCCCCEEEEECCCCCCCEEEECCCCCCCCCCHHHHHHHHHCCCCCCEEEECCCCCCHHHH
RAYSKRLNTGLAIIDKRRPRPNASEVMNLIGDVSGKDAVLVDDMVDTAGTLAQAAAALKA
HHHHHHHCCCEEEEECCCCCCCHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHH
KGARRVVAYAVHPILSGPAIQRIQDSVLEEVVFTDTVPLSPAAQACSKIRLLTTERLFGE
CCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
AIARIHRADSLSSLFV
HHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQPRDFKVFAGNSNPGLAHRICEYLKRPLGKAEVGRFSDGEIHVEIGENVRGHDVFILQS
CCCCCEEEEECCCCCCHHHHHHHHHHCCCCCHHCCCCCCCEEEEEECCCCCCCEEEEEEC
TCPPANDHLMELLIMCDALKRASAGSITAVIPYYGYARQDRKVAPRTPITAKLIADLLES
CCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHC
AGAGRVVSMDMHAGQIQGFFNIPSDHLYGSPVFLEDLRKRFPESQELVIVSPDAGGVERA
CCCCCEEEEECCCCCCCEEEECCCCCCCCCCHHHHHHHHHCCCCCCEEEECCCCCCHHHH
RAYSKRLNTGLAIIDKRRPRPNASEVMNLIGDVSGKDAVLVDDMVDTAGTLAQAAAALKA
HHHHHHHCCCEEEEECCCCCCCHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHH
KGARRVVAYAVHPILSGPAIQRIQDSVLEEVVFTDTVPLSPAAQACSKIRLLTTERLFGE
CCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
AIARIHRADSLSSLFV
HHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA