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The map label for this gene is f1pep1 [H]

Identifier: 108761577

GI number: 108761577

Start: 6798501

End: 6800579

Strand: Direct

Name: f1pep1 [H]

Synonym: MXAN_5460

Alternate gene names: 108761577

Gene position: 6798501-6800579 (Clockwise)

Preceding gene: 108763068

Following gene: 108760386

Centisome position: 74.38

GC content: 69.17

Gene sequence:

>2079_bases
ATGACGCCCGTGGACCGGACCTGCAAGTCCCCCTCCGCACGCAGAGACGCGCGGAGCGGCTACACGCTGCACGGACAGCG
CTTCGACGACCCCTACGCGTGGATGGAGCAGCTCGATGCGCCGGAGACGCAGGCGTGGATTTCCGAGCAGGAGGCCCTCA
CGCAATCGGTGCTCCACGCCCTCCCTGGACGCGAGGCACTGCGCGAAGCGGTCACCCGCTCCGCGCGGCACGCACGCAGG
TCCCCGCCCATTGCCGCCGGTCCGGGGGGGCGTGAGTTCCTCTGGCAGGCAGAGGCGCGCGACGACAAGCTCAAGCTCCT
GCTCCGGCGCCACGAAGGGGCGCCGTTGGAGACGTTGCTCGACCCCAACACGTGGGCGAGCAACGAGGTGCTCGTCTTCG
CGGTCCCCTCCCCGGATGGCGCATTCGTCGCGTTCGGCAAGGCCGTGGGAAGCGCCCACGGCGCATTGATTCACGTCCTC
GAGGTCTCGACGGGGAGGCTGCTGCCGGACCGCCCCCGAGGCACCAGCCACGCCTCGGTGGCCTGGCGGCCCGATGCATC
CGGGTTCTTCTACGCCGCGAACCCCGACCCCGGCGAGGTGCCCACGGGCGAAGAGGCTCACTGGAACGCCGTCTACGAGC
ACCGGCTGGGCTCGGGCGCCCCCGCGCGGCGCGTCTTCGGTGATGACCACGAAAAGGAGTACTGGTGCACCGTCAAGGTG
AGCGAGTGCGGCCGCTTCGCCGTGCTCGCGAAGTGGGACTACGTCCACGCCAACGTCATCACCCTGCTGCGCCTCGCGGA
TGATGCGCGCATCCCTGTGGCAACAGCCATGACCTCCCTCAATCAGGTGCAGGTCATCGGGGAGTCCCTGCTCATCCATA
CCGACCTCGACGCACCACGAGGCAGGCTCTGCACCGCGCCGCTGACGGCGCCCACCCAGTGGCGGACGCTCATCCCGGAA
AGCGAGCACACCCTTCAGACTGTCGCAGGCGTCGGCGGCCGGCTCTACGCCGTCTATTCACGCGCGGCGTCGCACCACGT
GCGCATCCACGCCGAGGACGGCACCTGGCTGCGCGACCTGAAGCTCCCAGCCCTGGGCGCCGTAAATCGCAACGAAGGAG
AGGGAATCGTCAGCGGCGTCAGTGGCCCATGGCGGGGCGACGAGGTGTGGGTGAACTTCATGTCGTACGTGCAGGCCCCC
TCTGTCTATCGCTACGACTACGACGCAGACCTGCTGACGCCGTACCACGTCCCTGACGTCGGGCTCGATGCGTCCGAGTA
CGTGACGGAGCAGGTCTGGTATCCGTCGCTCGACGGCACCCGGGTCTCCATGTTCCTCGTCCACCGGAAGGACCTGCCGC
GCGACGGACAGTGGCCCGTGAGGCTGAGTGGCTACGGCGGCTTCAACATCTCCGTGGAGCCGCGCTTCACGTCGCTCCAA
GCCGCCTGGCTGAAGTGGGGCGGCGTGCTGGCCTTCGCCAACGTCCGGGGCGGCGGAGAGTACGGCCGCGCCTGGCACGA
GGCGGCCCTCAAGACACGCCGGCAGAACGCCTTCGACGACTTCATCGCGGCGGCGCGCTGGCTCGTCTCGGAGGGCTACA
CGGTGCCTGCCCGGCTGGCCTCGCGAGGAAACAGCAATGGTGGGCTGCTGGTCGCCGTCACCGCCATGCAGGCCCCCGCG
TCCTTTGGTGCCGTCTTCTGCCGCGCGCCCACGCTCGACATGCTGCGCTTCCCGAGCTTCGGCTACCTGAGCTCGGCCAC
CGTCGAATACGGCTCACCCGAGGACCCGGTTGAGGGTGCCTACCTCGCGGGGTACTCGCCCTACCACAATGTCAGAGCCG
GGCTCCGTTACCCCCGGATGGCCTTCGTCGCCGCGCTGAACGACCGGACCGCCCCACCCCACGACCCGCTGAAGATGGTC
GCCAGACTTCAGGCAGAAGGCACGCAGGGCGGGCCCTTTCTCCTGCTCCCGCTTCGCGACTCCGGGCATGGGGGCGGCAC
CACCCTGACGGCGCTCATCGAGCAGGACGTCGACGAGCTCTGCTTCTACTGTGGGGCGCTCGGCGTCTCACCGGGCTGA

Upstream 100 bases:

>100_bases
GCCGCGCGAAGGTGGCCCCCGCGCGGTTGGGCTACAACCTCGCCGCGCCTTCCTGCATGAACGTCCGCGCCAGGACCGAC
GCCCCGTGGAGGAACATCCG

Downstream 100 bases:

>100_bases
GGCACCTGCGCCGCAGGGCCCGGCCCCCAGAGCCCCCGAGGCCGCTGGAGAATTCGGCGTCCGACGACGTCAAGCGCCCC
ACCACCCCGGGGCTTCTTGA

Product: S9A family peptidase

Products: NA

Alternate protein names: Post-proline cleaving enzyme; Proline-specific endopeptidase; PE; PSE [H]

Number of amino acids: Translated: 692; Mature: 691

Protein sequence:

>692_residues
MTPVDRTCKSPSARRDARSGYTLHGQRFDDPYAWMEQLDAPETQAWISEQEALTQSVLHALPGREALREAVTRSARHARR
SPPIAAGPGGREFLWQAEARDDKLKLLLRRHEGAPLETLLDPNTWASNEVLVFAVPSPDGAFVAFGKAVGSAHGALIHVL
EVSTGRLLPDRPRGTSHASVAWRPDASGFFYAANPDPGEVPTGEEAHWNAVYEHRLGSGAPARRVFGDDHEKEYWCTVKV
SECGRFAVLAKWDYVHANVITLLRLADDARIPVATAMTSLNQVQVIGESLLIHTDLDAPRGRLCTAPLTAPTQWRTLIPE
SEHTLQTVAGVGGRLYAVYSRAASHHVRIHAEDGTWLRDLKLPALGAVNRNEGEGIVSGVSGPWRGDEVWVNFMSYVQAP
SVYRYDYDADLLTPYHVPDVGLDASEYVTEQVWYPSLDGTRVSMFLVHRKDLPRDGQWPVRLSGYGGFNISVEPRFTSLQ
AAWLKWGGVLAFANVRGGGEYGRAWHEAALKTRRQNAFDDFIAAARWLVSEGYTVPARLASRGNSNGGLLVAVTAMQAPA
SFGAVFCRAPTLDMLRFPSFGYLSSATVEYGSPEDPVEGAYLAGYSPYHNVRAGLRYPRMAFVAALNDRTAPPHDPLKMV
ARLQAEGTQGGPFLLLPLRDSGHGGGTTLTALIEQDVDELCFYCGALGVSPG

Sequences:

>Translated_692_residues
MTPVDRTCKSPSARRDARSGYTLHGQRFDDPYAWMEQLDAPETQAWISEQEALTQSVLHALPGREALREAVTRSARHARR
SPPIAAGPGGREFLWQAEARDDKLKLLLRRHEGAPLETLLDPNTWASNEVLVFAVPSPDGAFVAFGKAVGSAHGALIHVL
EVSTGRLLPDRPRGTSHASVAWRPDASGFFYAANPDPGEVPTGEEAHWNAVYEHRLGSGAPARRVFGDDHEKEYWCTVKV
SECGRFAVLAKWDYVHANVITLLRLADDARIPVATAMTSLNQVQVIGESLLIHTDLDAPRGRLCTAPLTAPTQWRTLIPE
SEHTLQTVAGVGGRLYAVYSRAASHHVRIHAEDGTWLRDLKLPALGAVNRNEGEGIVSGVSGPWRGDEVWVNFMSYVQAP
SVYRYDYDADLLTPYHVPDVGLDASEYVTEQVWYPSLDGTRVSMFLVHRKDLPRDGQWPVRLSGYGGFNISVEPRFTSLQ
AAWLKWGGVLAFANVRGGGEYGRAWHEAALKTRRQNAFDDFIAAARWLVSEGYTVPARLASRGNSNGGLLVAVTAMQAPA
SFGAVFCRAPTLDMLRFPSFGYLSSATVEYGSPEDPVEGAYLAGYSPYHNVRAGLRYPRMAFVAALNDRTAPPHDPLKMV
ARLQAEGTQGGPFLLLPLRDSGHGGGTTLTALIEQDVDELCFYCGALGVSPG
>Mature_691_residues
TPVDRTCKSPSARRDARSGYTLHGQRFDDPYAWMEQLDAPETQAWISEQEALTQSVLHALPGREALREAVTRSARHARRS
PPIAAGPGGREFLWQAEARDDKLKLLLRRHEGAPLETLLDPNTWASNEVLVFAVPSPDGAFVAFGKAVGSAHGALIHVLE
VSTGRLLPDRPRGTSHASVAWRPDASGFFYAANPDPGEVPTGEEAHWNAVYEHRLGSGAPARRVFGDDHEKEYWCTVKVS
ECGRFAVLAKWDYVHANVITLLRLADDARIPVATAMTSLNQVQVIGESLLIHTDLDAPRGRLCTAPLTAPTQWRTLIPES
EHTLQTVAGVGGRLYAVYSRAASHHVRIHAEDGTWLRDLKLPALGAVNRNEGEGIVSGVSGPWRGDEVWVNFMSYVQAPS
VYRYDYDADLLTPYHVPDVGLDASEYVTEQVWYPSLDGTRVSMFLVHRKDLPRDGQWPVRLSGYGGFNISVEPRFTSLQA
AWLKWGGVLAFANVRGGGEYGRAWHEAALKTRRQNAFDDFIAAARWLVSEGYTVPARLASRGNSNGGLLVAVTAMQAPAS
FGAVFCRAPTLDMLRFPSFGYLSSATVEYGSPEDPVEGAYLAGYSPYHNVRAGLRYPRMAFVAALNDRTAPPHDPLKMVA
RLQAEGTQGGPFLLLPLRDSGHGGGTTLTALIEQDVDELCFYCGALGVSPG

Specific function: Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long. Has an absolute requirement for an X-Pro bond in the trans configuration immediately preceding the Pro-Y scissible bond [H]

COG id: COG1505

COG function: function code E; Serine proteases of the peptidase family S9A

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9A family [H]

Homologues:

Organism=Homo sapiens, GI41349456, Length=719, Percent_Identity=29.346314325452, Blast_Score=306, Evalue=3e-83,
Organism=Homo sapiens, GI108860686, Length=201, Percent_Identity=28.3582089552239, Blast_Score=83, Evalue=7e-16,
Organism=Homo sapiens, GI284172420, Length=201, Percent_Identity=28.3582089552239, Blast_Score=83, Evalue=8e-16,
Organism=Homo sapiens, GI284172413, Length=201, Percent_Identity=28.3582089552239, Blast_Score=83, Evalue=8e-16,
Organism=Homo sapiens, GI70778815, Length=201, Percent_Identity=28.3582089552239, Blast_Score=83, Evalue=8e-16,
Organism=Homo sapiens, GI284172438, Length=201, Percent_Identity=28.3582089552239, Blast_Score=83, Evalue=9e-16,
Organism=Homo sapiens, GI284172431, Length=201, Percent_Identity=28.3582089552239, Blast_Score=83, Evalue=9e-16,
Organism=Homo sapiens, GI108860692, Length=199, Percent_Identity=28.1407035175879, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1788150, Length=694, Percent_Identity=24.207492795389, Blast_Score=158, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24583414, Length=723, Percent_Identity=29.3222683264177, Blast_Score=295, Evalue=6e-80,
Organism=Drosophila melanogaster, GI221510989, Length=718, Percent_Identity=29.8050139275766, Blast_Score=294, Evalue=1e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002471
- InterPro:   IPR001375
- InterPro:   IPR002470
- InterPro:   IPR004106 [H]

Pfam domain/function: PF00326 Peptidase_S9; PF02897 Peptidase_S9_N [H]

EC number: =3.4.21.26 [H]

Molecular weight: Translated: 75670; Mature: 75539

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS00708 PRO_ENDOPEP_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPVDRTCKSPSARRDARSGYTLHGQRFDDPYAWMEQLDAPETQAWISEQEALTQSVLHA
CCCCCCCCCCCCHHHHCCCCCEEECCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
LPGREALREAVTRSARHARRSPPIAAGPGGREFLWQAEARDDKLKLLLRRHEGAPLETLL
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHCCCCCHHHHC
DPNTWASNEVLVFAVPSPDGAFVAFGKAVGSAHGALIHVLEVSTGRLLPDRPRGTSHASV
CCCCCCCCCEEEEEECCCCCCEEEEHHHHCCCCCEEEEEEEECCCCCCCCCCCCCCCCEE
AWRPDASGFFYAANPDPGEVPTGEEAHWNAVYEHRLGSGAPARRVFGDDHEKEYWCTVKV
EECCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHCCCCCCCEEEEEEEE
SECGRFAVLAKWDYVHANVITLLRLADDARIPVATAMTSLNQVQVIGESLLIHTDLDAPR
CCCCCEEEEEEECCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHEECCEEEEEECCCCCC
GRLCTAPLTAPTQWRTLIPESEHTLQTVAGVGGRLYAVYSRAASHHVRIHAEDGTWLRDL
CCEEECCCCCCCCHHCCCCCCHHHHHHHHCCCCEEEEEEHHCCCCEEEEEECCCCEEEEE
KLPALGAVNRNEGEGIVSGVSGPWRGDEVWVNFMSYVQAPSVYRYDYDADLLTPYHVPDV
CCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCC
GLDASEYVTEQVWYPSLDGTRVSMFLVHRKDLPRDGQWPVRLSGYGGFNISVEPRFTSLQ
CCCHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCCCCCEEEECCCCEEEEECCCHHHHH
AAWLKWGGVLAFANVRGGGEYGRAWHEAALKTRRQNAFDDFIAAARWLVSEGYTVPARLA
HHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
SRGNSNGGLLVAVTAMQAPASFGAVFCRAPTLDMLRFPSFGYLSSATVEYGSPEDPVEGA
HCCCCCCCEEEEEEEECCCCHHCEEEECCCCHHHHHCCCCCCCCCCEEECCCCCCCCCCC
YLAGYSPYHNVRAGLRYPRMAFVAALNDRTAPPHDPLKMVARLQAEGTQGGPFLLLPLRD
EEECCCCHHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEEECC
SGHGGGTTLTALIEQDVDELCFYCGALGVSPG
CCCCCCHHHHHHHHHCHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TPVDRTCKSPSARRDARSGYTLHGQRFDDPYAWMEQLDAPETQAWISEQEALTQSVLHA
CCCCCCCCCCCHHHHCCCCCEEECCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
LPGREALREAVTRSARHARRSPPIAAGPGGREFLWQAEARDDKLKLLLRRHEGAPLETLL
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHCCCCCHHHHC
DPNTWASNEVLVFAVPSPDGAFVAFGKAVGSAHGALIHVLEVSTGRLLPDRPRGTSHASV
CCCCCCCCCEEEEEECCCCCCEEEEHHHHCCCCCEEEEEEEECCCCCCCCCCCCCCCCEE
AWRPDASGFFYAANPDPGEVPTGEEAHWNAVYEHRLGSGAPARRVFGDDHEKEYWCTVKV
EECCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHCCCCCCCEEEEEEEE
SECGRFAVLAKWDYVHANVITLLRLADDARIPVATAMTSLNQVQVIGESLLIHTDLDAPR
CCCCCEEEEEEECCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHEECCEEEEEECCCCCC
GRLCTAPLTAPTQWRTLIPESEHTLQTVAGVGGRLYAVYSRAASHHVRIHAEDGTWLRDL
CCEEECCCCCCCCHHCCCCCCHHHHHHHHCCCCEEEEEEHHCCCCEEEEEECCCCEEEEE
KLPALGAVNRNEGEGIVSGVSGPWRGDEVWVNFMSYVQAPSVYRYDYDADLLTPYHVPDV
CCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCC
GLDASEYVTEQVWYPSLDGTRVSMFLVHRKDLPRDGQWPVRLSGYGGFNISVEPRFTSLQ
CCCHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCCCCCEEEECCCCEEEEECCCHHHHH
AAWLKWGGVLAFANVRGGGEYGRAWHEAALKTRRQNAFDDFIAAARWLVSEGYTVPARLA
HHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
SRGNSNGGLLVAVTAMQAPASFGAVFCRAPTLDMLRFPSFGYLSSATVEYGSPEDPVEGA
HCCCCCCCEEEEEEEECCCCHHCEEEECCCCHHHHHCCCCCCCCCCEEECCCCCCCCCCC
YLAGYSPYHNVRAGLRYPRMAFVAALNDRTAPPHDPLKMVARLQAEGTQGGPFLLLPLRD
EEECCCCHHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEEECC
SGHGGGTTLTALIEQDVDELCFYCGALGVSPG
CCCCCCHHHHHHHHHCHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1840588; 7764331 [H]