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The map label for this gene is degP [H]

Identifier: 108761525

GI number: 108761525

Start: 3516367

End: 3517848

Strand: Direct

Name: degP [H]

Synonym: MXAN_2995

Alternate gene names: 108761525

Gene position: 3516367-3517848 (Clockwise)

Preceding gene: 108758676

Following gene: 108758516

Centisome position: 38.47

GC content: 69.77

Gene sequence:

>1482_bases
ATGAACCGTTCGACCGTCTCGTTCCGGAAGGCGCTCGTCGCCGCGCTCCTGGTCGCGTTGCCCCCCGCTGCTGCTGTCTC
GCAGGCGCCAAAGTCGCCGCCCGCGGCCACCCAGCCGGGCGCCGGGAACGTCCTCCAGCCCGCGACACGGGAGGCCCAGG
CGCTTCCGTCGCTGGCGCCGCTGGTGGAGTCGGTGAAGTCGGCGGTGGTCAACGTGGACGTGCAGGCTCGAGGGGGCGGC
GTTCCGCGTGGGATGGAGGACAACCCGCTCTTCGAGCGCTTCTTCGGTGGAGGCCGCGAGGGCGGCAGGCCGCGCCGCGA
GCCGCTGCGCCAAGGGGCAGGGTCCGGCTTCATCATCGACCCGAAGGGCGTCGTCCTCACCAACAACCACGTGGTGGAGG
ATGCCGTCAGCATCACCATCCGCCTGGATGACGGACGCAGCTTCAGCGGCGAAGTGGTGGGGCGTGATCCGCTCACGGAC
GTGGCGCTCGTGCGGCTCAAGGAGAAGGTGGAGAACCTGCCCACCGTGAAGCTGGGCGACTCGGATGCATTGCGCGTGGG
GGACTGGGTGGTGGCCATTGGCAACCCCTTCGGTCTGGCCTCCAGCGTCAGCCTGGGCATCGTCTCCGCGAGGGCGCGTG
AGATTGGCGCCAGCCAGTACGACGAGTTCCTTCAGACGGACGCGGCCATCAACCCGGGCAACTCGGGCGGCCCGCTCTTC
AACATGAAGGGCGAAGTGGTGGGCATCAACACCGCCATCGTCGGCGGTGGCTCCGGCATCGGCTTCGCGGTGCCCAGCAA
TCTCATCGGTTCACTGCTGCCGCAGTTGGAGAAGGAAGGCTCCGTCACGCGCGCATGGCTGGGCGTGGGCATCCAGGACT
TGACGCGGGACCTGGCCAGCGCGCTCAAGCTCCCCGTGAATCAAGGCGCCATCCTCACGCAGGTGATGCCGTCGTCTCCC
GCGGCGAAGGCGGGCCTGAAGCAGGATGACGTCGTCATCGCCATCGACGGCCGGACCGTCACCTCCAGCGGCGAGCTGAC
GCGCACCGTGGCGCTCAAGCGTCCCGGAAGCACCTCCACGTTGACGCTCTACCGCGACGGCAAGAAGCAGGACGTGAAGG
TGACGCTCGGTACGCGGCCAGACCTGGAGGGCGTGGCCTCGGGGAAGCAGCGGCCGGAGGACCAGCAGGAGAGCTCCCGG
CGCGTGGGCGTCAGCCTCCAGAACCTGGATGCGCGCACCGCGCAGCAGGCCGGCTTCACGGACAGCAGCGGCGCGCTCAT
CACCGACGTGGTGCCCGGCTCGCCAGCGGACCGCGCGCAGTTGGAGCCCGGCATGGTCGTCATCGAGGCCAACCGCAAGA
AGGTGGAGAACGCGGACGCCCTGGCCCGCATCATCAAGGGCGCCGAGTCCGGGAGCACCTTGCTGCTGCGCGTGACGGCG
CCGGGCGGGGCTCGCAACCTGCGCGCCCTGCGGGTGCCGTGA

Upstream 100 bases:

>100_bases
TGAGGCCAGGGGGGAGTAGGGTGGGGTGATGTGTCCTCCTGTCGCCACGTCAGACGGTTTGGCTTGCGGGGCTGGTTTTC
GGCTTTAGCTTGGTCTGCAT

Downstream 100 bases:

>100_bases
GTCCGGCGCGTGGGAGCGGCGGATGAGCGTCAACTACGTCGCGCTTGGAGACAGCACGGCCGTGGGCGTGGGGGCGGCGC
GAGGAGGCGGCTATCCCGAG

Product: S1C family peptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 493; Mature: 493

Protein sequence:

>493_residues
MNRSTVSFRKALVAALLVALPPAAAVSQAPKSPPAATQPGAGNVLQPATREAQALPSLAPLVESVKSAVVNVDVQARGGG
VPRGMEDNPLFERFFGGGREGGRPRREPLRQGAGSGFIIDPKGVVLTNNHVVEDAVSITIRLDDGRSFSGEVVGRDPLTD
VALVRLKEKVENLPTVKLGDSDALRVGDWVVAIGNPFGLASSVSLGIVSARAREIGASQYDEFLQTDAAINPGNSGGPLF
NMKGEVVGINTAIVGGGSGIGFAVPSNLIGSLLPQLEKEGSVTRAWLGVGIQDLTRDLASALKLPVNQGAILTQVMPSSP
AAKAGLKQDDVVIAIDGRTVTSSGELTRTVALKRPGSTSTLTLYRDGKKQDVKVTLGTRPDLEGVASGKQRPEDQQESSR
RVGVSLQNLDARTAQQAGFTDSSGALITDVVPGSPADRAQLEPGMVVIEANRKKVENADALARIIKGAESGSTLLLRVTA
PGGARNLRALRVP

Sequences:

>Translated_493_residues
MNRSTVSFRKALVAALLVALPPAAAVSQAPKSPPAATQPGAGNVLQPATREAQALPSLAPLVESVKSAVVNVDVQARGGG
VPRGMEDNPLFERFFGGGREGGRPRREPLRQGAGSGFIIDPKGVVLTNNHVVEDAVSITIRLDDGRSFSGEVVGRDPLTD
VALVRLKEKVENLPTVKLGDSDALRVGDWVVAIGNPFGLASSVSLGIVSARAREIGASQYDEFLQTDAAINPGNSGGPLF
NMKGEVVGINTAIVGGGSGIGFAVPSNLIGSLLPQLEKEGSVTRAWLGVGIQDLTRDLASALKLPVNQGAILTQVMPSSP
AAKAGLKQDDVVIAIDGRTVTSSGELTRTVALKRPGSTSTLTLYRDGKKQDVKVTLGTRPDLEGVASGKQRPEDQQESSR
RVGVSLQNLDARTAQQAGFTDSSGALITDVVPGSPADRAQLEPGMVVIEANRKKVENADALARIIKGAESGSTLLLRVTA
PGGARNLRALRVP
>Mature_493_residues
MNRSTVSFRKALVAALLVALPPAAAVSQAPKSPPAATQPGAGNVLQPATREAQALPSLAPLVESVKSAVVNVDVQARGGG
VPRGMEDNPLFERFFGGGREGGRPRREPLRQGAGSGFIIDPKGVVLTNNHVVEDAVSITIRLDDGRSFSGEVVGRDPLTD
VALVRLKEKVENLPTVKLGDSDALRVGDWVVAIGNPFGLASSVSLGIVSARAREIGASQYDEFLQTDAAINPGNSGGPLF
NMKGEVVGINTAIVGGGSGIGFAVPSNLIGSLLPQLEKEGSVTRAWLGVGIQDLTRDLASALKLPVNQGAILTQVMPSSP
AAKAGLKQDDVVIAIDGRTVTSSGELTRTVALKRPGSTSTLTLYRDGKKQDVKVTLGTRPDLEGVASGKQRPEDQQESSR
RVGVSLQNLDARTAQQAGFTDSSGALITDVVPGSPADRAQLEPGMVVIEANRKKVENADALARIIKGAESGSTLLLRVTA
PGGARNLRALRVP

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=279, Percent_Identity=37.2759856630824, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI22129776, Length=316, Percent_Identity=33.8607594936709, Blast_Score=159, Evalue=7e-39,
Organism=Homo sapiens, GI7019477, Length=273, Percent_Identity=38.0952380952381, Blast_Score=152, Evalue=5e-37,
Organism=Homo sapiens, GI24308541, Length=253, Percent_Identity=33.9920948616601, Blast_Score=147, Evalue=3e-35,
Organism=Escherichia coli, GI1786356, Length=439, Percent_Identity=40.3189066059225, Blast_Score=282, Evalue=3e-77,
Organism=Escherichia coli, GI1789629, Length=429, Percent_Identity=38.4615384615385, Blast_Score=251, Evalue=7e-68,
Organism=Escherichia coli, GI1789630, Length=274, Percent_Identity=37.5912408759124, Blast_Score=178, Evalue=6e-46,
Organism=Drosophila melanogaster, GI24646839, Length=313, Percent_Identity=33.8658146964856, Blast_Score=159, Evalue=4e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 51179; Mature: 51179

Theoretical pI: Translated: 10.17; Mature: 10.17

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRSTVSFRKALVAALLVALPPAAAVSQAPKSPPAATQPGAGNVLQPATREAQALPSLAP
CCCCHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHCCHHHH
LVESVKSAVVNVDVQARGGGVPRGMEDNPLFERFFGGGREGGRPRREPLRQGAGSGFIID
HHHHHHHHEEEEEEEECCCCCCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHCCCCCEEEC
PKGVVLTNNHVVEDAVSITIRLDDGRSFSGEVVGRDPLTDVALVRLKEKVENLPTVKLGD
CCCEEEECCEEEECEEEEEEEECCCCCCCCCEECCCCCHHHHHHHHHHHHHCCCEEEECC
SDALRVGDWVVAIGNPFGLASSVSLGIVSARAREIGASQYDEFLQTDAAINPGNSGGPLF
CCCEEECCEEEEECCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCEE
NMKGEVVGINTAIVGGGSGIGFAVPSNLIGSLLPQLEKEGSVTRAWLGVGIQDLTRDLAS
ECCCCEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCEEEHHHHCCHHHHHHHHHH
ALKLPVNQGAILTQVMPSSPAAKAGLKQDDVVIAIDGRTVTSSGELTRTVALKRPGSTST
HHCCCCCCCEEEEEECCCCCHHHCCCCCCCEEEEECCEEEECCCCEEEEEEEECCCCCCE
LTLYRDGKKQDVKVTLGTRPDLEGVASGKQRPEDQQESSRRVGVSLQNLDARTAQQAGFT
EEEEECCCCCEEEEEECCCCCHHHHHCCCCCCCHHHHHHHHHCCEEECCCHHHHHHCCCC
DSSGALITDVVPGSPADRAQLEPGMVVIEANRKKVENADALARIIKGAESGSTLLLRVTA
CCCCCEEEEECCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCCEEEEEEEC
PGGARNLRALRVP
CCCCCCCEEEECC
>Mature Secondary Structure
MNRSTVSFRKALVAALLVALPPAAAVSQAPKSPPAATQPGAGNVLQPATREAQALPSLAP
CCCCHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHCCHHHH
LVESVKSAVVNVDVQARGGGVPRGMEDNPLFERFFGGGREGGRPRREPLRQGAGSGFIID
HHHHHHHHEEEEEEEECCCCCCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHCCCCCEEEC
PKGVVLTNNHVVEDAVSITIRLDDGRSFSGEVVGRDPLTDVALVRLKEKVENLPTVKLGD
CCCEEEECCEEEECEEEEEEEECCCCCCCCCEECCCCCHHHHHHHHHHHHHCCCEEEECC
SDALRVGDWVVAIGNPFGLASSVSLGIVSARAREIGASQYDEFLQTDAAINPGNSGGPLF
CCCEEECCEEEEECCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCEE
NMKGEVVGINTAIVGGGSGIGFAVPSNLIGSLLPQLEKEGSVTRAWLGVGIQDLTRDLAS
ECCCCEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCEEEHHHHCCHHHHHHHHHH
ALKLPVNQGAILTQVMPSSPAAKAGLKQDDVVIAIDGRTVTSSGELTRTVALKRPGSTST
HHCCCCCCCEEEEEECCCCCHHHCCCCCCCEEEEECCEEEECCCCEEEEEEEECCCCCCE
LTLYRDGKKQDVKVTLGTRPDLEGVASGKQRPEDQQESSRRVGVSLQNLDARTAQQAGFT
EEEEECCCCCEEEEEECCCCCHHHHHCCCCCCCHHHHHHHHHCCEEECCCHHHHHHCCCC
DSSGALITDVVPGSPADRAQLEPGMVVIEANRKKVENADALARIIKGAESGSTLLLRVTA
CCCCCEEEEECCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCCEEEEEEEC
PGGARNLRALRVP
CCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]