Click here to switch to the map view.

The map label for this gene is argE

Identifier: 108761521

GI number: 108761521

Start: 1177865

End: 1179007

Strand: Direct

Name: argE

Synonym: MXAN_1012

Alternate gene names: 108761521

Gene position: 1177865-1179007 (Clockwise)

Preceding gene: 108757743

Following gene: 108758841

Centisome position: 12.89

GC content: 71.83

Gene sequence:

>1143_bases
ATGAGTGACACGCTGCCCGCGCTGCGGGCCACCCTGACGGAGTTGGTGGCGATGGACACCACGTCCTTCCGCCCCAACGT
TCCGCTCATCGACTACGCGCAGGCGCGCCTGGAGGCCGCGGGCTTCAGCGCGGAGCGCCAGAAGTTCCTGGACGACGCGG
GCGTGGAGAAGGTGAACCTCGTCGCGGTGAAGGGCGGTTCCGGCTCCGGCCGCGCCGCGCTGGCCCTGGTGGGGCACTCC
GACTGCGTGCCGTACGACGCGGCCTGGACGGACGCGCTGCGGCTGACGGAGAAGGACGGGCGGCTCTACGCGCGCGGCGC
GTGTGACACGAAGGGCTTCATCGCCTGCGCGCTGCACGCGGCGTTGAACGCCGAGCAGTTGAAGGCCCCGCTGATGGTGG
TCCTCACCGCGGACGAGGAAGTCGGCCTGACGGGCGCGAAGAAGCTGGTGGAGGCGGGACTGGGCCGCGCGCGGCACGCG
ATTGTCGGCGAGCCCACGCGCCTCATTCCGGTGCGCGCCAACAAGGGCTACTGCCTGGCGGAGGTGGAGGTGCGGGGGAA
GGAAGGGCACAGCGCGTACCCGGACTCGGGCGCGTCGGCCATCTTCCGCGCGGGCCGCTTCCTCCAGCGCCTGGAGCACC
TGGCGCTGACGGTGCTGCGCGAGGACCTCGACGAGGGCTTCCAGCCGCCCTTCACCACCGTGAACGTGGGCGTCATCCAG
GGCGGCAAGGCGAAGAACGTCATCCCCGGCGCCTGCCGCTTCGTCGTGGAGTGGCGGCCCATTCCCGGGCAGCCGCCGGA
GCGCGTGTCTCAGTTGCTGGAGACCATCCGCCAGGAGCTGGTGCGTGACGAGCCCGCCTTCGAGGCGCAGATTCGCGTGG
TGCGCACGGACCGGGGTGTGAATACCCGGGCGGACGCGGAGGTGGTGCGCTTCCTTGCGGAGGCCAGTGGCAACGCGCCG
GAGACGGTGTCCTTCGGGACGGAGGCGCCGCAGATGACGGAGCTGGGCGCGGAGGCGGTGGTGTTCGGCCCCGGCGACAT
CCGCGTGGCGCACCAGACGGGCGAATACGTGCCCGTGGAAGACCTGGTGCGCTGCGAGGCCGTCCTGGCTCGCGCCGTGG
CCCACTTCTGCGGCGGGCGCTGA

Upstream 100 bases:

>100_bases
CGCCCCAGGTGGCGTCCGTTCGCTGAGTAGACATGGGGGAGGGAAGGGCCTTCCGGGGGCTGGCGTGCCGTGGCATGACC
CGTCCCTGGAGGTCTTACCC

Downstream 100 bases:

>100_bases
GCCTGAGTGACTGCGCTTGGGCGGAAGCGCACGGCCTCGGCGGCGGAACGGCCGCCGAGGTCCGCGTCTACGCCTGCGGC
AGTGCGCAGTGGCTCAAATC

Product: acetylornithine deacetylase

Products: NA

Alternate protein names: AO; Acetylornithinase; N-acetylornithinase; NAO

Number of amino acids: Translated: 380; Mature: 379

Protein sequence:

>380_residues
MSDTLPALRATLTELVAMDTTSFRPNVPLIDYAQARLEAAGFSAERQKFLDDAGVEKVNLVAVKGGSGSGRAALALVGHS
DCVPYDAAWTDALRLTEKDGRLYARGACDTKGFIACALHAALNAEQLKAPLMVVLTADEEVGLTGAKKLVEAGLGRARHA
IVGEPTRLIPVRANKGYCLAEVEVRGKEGHSAYPDSGASAIFRAGRFLQRLEHLALTVLREDLDEGFQPPFTTVNVGVIQ
GGKAKNVIPGACRFVVEWRPIPGQPPERVSQLLETIRQELVRDEPAFEAQIRVVRTDRGVNTRADAEVVRFLAEASGNAP
ETVSFGTEAPQMTELGAEAVVFGPGDIRVAHQTGEYVPVEDLVRCEAVLARAVAHFCGGR

Sequences:

>Translated_380_residues
MSDTLPALRATLTELVAMDTTSFRPNVPLIDYAQARLEAAGFSAERQKFLDDAGVEKVNLVAVKGGSGSGRAALALVGHS
DCVPYDAAWTDALRLTEKDGRLYARGACDTKGFIACALHAALNAEQLKAPLMVVLTADEEVGLTGAKKLVEAGLGRARHA
IVGEPTRLIPVRANKGYCLAEVEVRGKEGHSAYPDSGASAIFRAGRFLQRLEHLALTVLREDLDEGFQPPFTTVNVGVIQ
GGKAKNVIPGACRFVVEWRPIPGQPPERVSQLLETIRQELVRDEPAFEAQIRVVRTDRGVNTRADAEVVRFLAEASGNAP
ETVSFGTEAPQMTELGAEAVVFGPGDIRVAHQTGEYVPVEDLVRCEAVLARAVAHFCGGR
>Mature_379_residues
SDTLPALRATLTELVAMDTTSFRPNVPLIDYAQARLEAAGFSAERQKFLDDAGVEKVNLVAVKGGSGSGRAALALVGHSD
CVPYDAAWTDALRLTEKDGRLYARGACDTKGFIACALHAALNAEQLKAPLMVVLTADEEVGLTGAKKLVEAGLGRARHAI
VGEPTRLIPVRANKGYCLAEVEVRGKEGHSAYPDSGASAIFRAGRFLQRLEHLALTVLREDLDEGFQPPFTTVNVGVIQG
GKAKNVIPGACRFVVEWRPIPGQPPERVSQLLETIRQELVRDEPAFEAQIRVVRTDRGVNTRADAEVVRFLAEASGNAPE
TVSFGTEAPQMTELGAEAVVFGPGDIRVAHQTGEYVPVEDLVRCEAVLARAVAHFCGGR

Specific function: Displays A Broad Specificity And Can Also Deacylate Substrates Such As Acetylarginine, Acetylhistidine Or Acetylglutamate Semialdehyde. [C]

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family. ArgE subfamily

Homologues:

Organism=Escherichia coli, GI1790395, Length=387, Percent_Identity=31.5245478036176, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI1788816, Length=350, Percent_Identity=28, Blast_Score=87, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17551016, Length=361, Percent_Identity=25.207756232687, Blast_Score=84, Evalue=9e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARGE_MYXXA (O68873)

Other databases:

- EMBL:   AF055904
- ProteinModelPortal:   O68873
- SMR:   O68873
- MEROPS:   M20.974
- BRENDA:   3.5.1.16
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_01108
- InterPro:   IPR010169
- InterPro:   IPR001261
- InterPro:   IPR002933
- InterPro:   IPR011650
- TIGRFAMs:   TIGR01892

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20; SSF55031 Peptidase_M20_dimer

EC number: =3.5.1.16

Molecular weight: Translated: 40716; Mature: 40585

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS00758 ARGE_DAPE_CPG2_1; PS00759 ARGE_DAPE_CPG2_2; PS00687 ALDEHYDE_DEHYDR_GLU

Important sites: ACT_SITE 81-81 ACT_SITE 139-139

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDTLPALRATLTELVAMDTTSFRPNVPLIDYAQARLEAAGFSAERQKFLDDAGVEKVNL
CCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEE
VAVKGGSGSGRAALALVGHSDCVPYDAAWTDALRLTEKDGRLYARGACDTKGFIACALHA
EEEECCCCCCCEEEEEEECCCCCCCCCHHHHHHEEECCCCCEEECCCCCCCHHHHHHHHH
ALNAEQLKAPLMVVLTADEEVGLTGAKKLVEAGLGRARHAIVGEPTRLIPVRANKGYCLA
HCCHHHHCCCEEEEEECCCCCCCHHHHHHHHHHCCHHHHHHCCCCCEEEEEECCCCEEEE
EVEVRGKEGHSAYPDSGASAIFRAGRFLQRLEHLALTVLREDLDEGFQPPFTTVNVGVIQ
EEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEE
GGKAKNVIPGACRFVVEWRPIPGQPPERVSQLLETIRQELVRDEPAFEAQIRVVRTDRGV
CCCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCC
NTRADAEVVRFLAEASGNAPETVSFGTEAPQMTELGAEAVVFGPGDIRVAHQTGEYVPVE
CCCHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHCCCCEEEECCCCEEEEECCCCCCCHH
DLVRCEAVLARAVAHFCGGR
HHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SDTLPALRATLTELVAMDTTSFRPNVPLIDYAQARLEAAGFSAERQKFLDDAGVEKVNL
CCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEE
VAVKGGSGSGRAALALVGHSDCVPYDAAWTDALRLTEKDGRLYARGACDTKGFIACALHA
EEEECCCCCCCEEEEEEECCCCCCCCCHHHHHHEEECCCCCEEECCCCCCCHHHHHHHHH
ALNAEQLKAPLMVVLTADEEVGLTGAKKLVEAGLGRARHAIVGEPTRLIPVRANKGYCLA
HCCHHHHCCCEEEEEECCCCCCCHHHHHHHHHHCCHHHHHHCCCCCEEEEEECCCCEEEE
EVEVRGKEGHSAYPDSGASAIFRAGRFLQRLEHLALTVLREDLDEGFQPPFTTVNVGVIQ
EEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEE
GGKAKNVIPGACRFVVEWRPIPGQPPERVSQLLETIRQELVRDEPAFEAQIRVVRTDRGV
CCCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCC
NTRADAEVVRFLAEASGNAPETVSFGTEAPQMTELGAEAVVFGPGDIRVAHQTGEYVPVE
CCCHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHCCCCEEEECCCCEEEEECCCCCCCHH
DLVRCEAVLARAVAHFCGGR
HHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9829957