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The map label for this gene is mvaA [H]

Identifier: 108759501

GI number: 108759501

Start: 6274722

End: 6276050

Strand: Reverse

Name: mvaA [H]

Synonym: MXAN_5020

Alternate gene names: 108759501

Gene position: 6276050-6274722 (Counterclockwise)

Preceding gene: 108762094

Following gene: 108761374

Centisome position: 68.67

GC content: 70.43

Gene sequence:

>1329_bases
ATGTCTGACACCGTGACGTCCCGGCTTCCCGGGTTCCACAAGCTGCCGATGGAGGAGCGCCACGCGCACCTCTCCCGCAT
GTTCCGGCTCACGCCCGAGGACCTGCAGCAGCTGCTGGGCTCGGAGGCGCTCCAGCCTGTCCTGGCGAACCAGATGATTG
AGAACGCGGTGGGGACCTTCTCCCTCCCGCTGGGCCTGGGCCTCAACCTCCAGGTCAACGGACGTGACTACCTGGTGCCC
ATGGCGGTGGAGGAGCCGTCCGTCGTGGCGGCGGTGTCCTTCGCGGCGAAGATTGTCCGGGAGGCGGGCGGCTTCATCGG
CGAGGCGGACCCGTCGCTGATGATTGGCCAGGTGCAGGTGTCGCGCTACGGCGACCCGACGGTGGCCACCGAGCGCATCC
TGGAGCACAAGGAGCAGATTCTCGCGCTGGCCAACAGCTTCCACCCGGCCATGGTGGCGCGTGGCGGCGGGGCGAAGGAC
GTCGAGGTTCGCGTGCTGCCGGCCCCGGAAGGGCCGCGCGGCGAGCCGCTGCTCATCGTCCACCTCATCATTGACGCCCA
GGAGGCGATGGGGGCCAACCTCATCAACACCATGGCGGAGGGCGTGGCGCCGCTCATCGAGCAGGTGACGGGCGGCAAGG
TGTACCTGCGCATCCTCTCCAACCTGGCGGACCGCCGGCTGGCGCGCGCCATGTGCCGCATCCCCATCCCGCTGCTGGCG
GACTTCGAGATGCCGGCCGAGGAGATCGCCGAGGGCATCGCCCAGGCCAGCCGCTTCGCGGAGGCGGACCCGTACCGCGC
GGCCACGCACAACAAGGGCGTGATGAACGGCATTGACTCGGTGGCCATCGCCACGGGGCAGGACTGGCGCGCCATTGAAG
CGGGCGCGCACGCGTTCGCCTGCCGCAACGGGCAGTACCGGCCGCTGTCCACCTGGTACCTGGAAGAGGGCCACCTGGTG
GGCCGCATCGAGCTGCCCATGGCGCTGGGGACGGTGGGCGGGCCCATCAAGATCCACCCGGGCGTGCAGATGGCGCTCAA
GCTGATGCAGACCACGTCGGTGCGAGAGCTCGCCATGGTGTTCGCGGCGGTGGGCCTGGCGCAGAACTTCGCGGCGCTCC
GGGCGCTGGGCAGCGTGGGCATCCAGAAGGGCCACATGGCGATGCACGCGCGCTGCGTGGCGGTGACGGCGGGCGCGCGA
GGCGACTGGGTGGAGAAGATCGCCAACCTGCTGGTGAAGGCGGGCCACGTGAAGGTGGAGAAGGCCCGCGAGCTGCTGGC
CAGCCTCCCCGCCGAGGATGCCGCGGCCGCGACCGGCACCACGGTCTGA

Upstream 100 bases:

>100_bases
CGCTGAACTGAGACAGCGGCCCCGGGTGGTCACCGGAGAGTTGAAGGATTGGTTGGCGGCGCTGTAGAGGGTGGCCGCGC
CGAAGTCTGGAAGGAAGAAC

Downstream 100 bases:

>100_bases
CGCCGTGGCTCCTCGTCCTGAATCCTTGTCGGCCTTTGGCGCCGGCAAGGTCATCCTGTTGGGTGAGCACAGCGTCGTGT
ACGGGCACCCGGCCCTGGCC

Product: hydroxymethylglutaryl-CoA reductase

Products: NA

Alternate protein names: HMG-CoA reductase [H]

Number of amino acids: Translated: 442; Mature: 441

Protein sequence:

>442_residues
MSDTVTSRLPGFHKLPMEERHAHLSRMFRLTPEDLQQLLGSEALQPVLANQMIENAVGTFSLPLGLGLNLQVNGRDYLVP
MAVEEPSVVAAVSFAAKIVREAGGFIGEADPSLMIGQVQVSRYGDPTVATERILEHKEQILALANSFHPAMVARGGGAKD
VEVRVLPAPEGPRGEPLLIVHLIIDAQEAMGANLINTMAEGVAPLIEQVTGGKVYLRILSNLADRRLARAMCRIPIPLLA
DFEMPAEEIAEGIAQASRFAEADPYRAATHNKGVMNGIDSVAIATGQDWRAIEAGAHAFACRNGQYRPLSTWYLEEGHLV
GRIELPMALGTVGGPIKIHPGVQMALKLMQTTSVRELAMVFAAVGLAQNFAALRALGSVGIQKGHMAMHARCVAVTAGAR
GDWVEKIANLLVKAGHVKVEKARELLASLPAEDAAAATGTTV

Sequences:

>Translated_442_residues
MSDTVTSRLPGFHKLPMEERHAHLSRMFRLTPEDLQQLLGSEALQPVLANQMIENAVGTFSLPLGLGLNLQVNGRDYLVP
MAVEEPSVVAAVSFAAKIVREAGGFIGEADPSLMIGQVQVSRYGDPTVATERILEHKEQILALANSFHPAMVARGGGAKD
VEVRVLPAPEGPRGEPLLIVHLIIDAQEAMGANLINTMAEGVAPLIEQVTGGKVYLRILSNLADRRLARAMCRIPIPLLA
DFEMPAEEIAEGIAQASRFAEADPYRAATHNKGVMNGIDSVAIATGQDWRAIEAGAHAFACRNGQYRPLSTWYLEEGHLV
GRIELPMALGTVGGPIKIHPGVQMALKLMQTTSVRELAMVFAAVGLAQNFAALRALGSVGIQKGHMAMHARCVAVTAGAR
GDWVEKIANLLVKAGHVKVEKARELLASLPAEDAAAATGTTV
>Mature_441_residues
SDTVTSRLPGFHKLPMEERHAHLSRMFRLTPEDLQQLLGSEALQPVLANQMIENAVGTFSLPLGLGLNLQVNGRDYLVPM
AVEEPSVVAAVSFAAKIVREAGGFIGEADPSLMIGQVQVSRYGDPTVATERILEHKEQILALANSFHPAMVARGGGAKDV
EVRVLPAPEGPRGEPLLIVHLIIDAQEAMGANLINTMAEGVAPLIEQVTGGKVYLRILSNLADRRLARAMCRIPIPLLAD
FEMPAEEIAEGIAQASRFAEADPYRAATHNKGVMNGIDSVAIATGQDWRAIEAGAHAFACRNGQYRPLSTWYLEEGHLVG
RIELPMALGTVGGPIKIHPGVQMALKLMQTTSVRELAMVFAAVGLAQNFAALRALGSVGIQKGHMAMHARCVAVTAGARG
DWVEKIANLLVKAGHVKVEKARELLASLPAEDAAAATGTTV

Specific function: P.mevalonii can use mevalonate as sole carbon source. With this enzyme mevalonate is deacetylated to HMG-CoA [H]

COG id: COG1257

COG function: function code I; Hydroxymethylglutaryl-CoA reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA reductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002202
- InterPro:   IPR004553
- InterPro:   IPR023074
- InterPro:   IPR023076
- InterPro:   IPR009023
- InterPro:   IPR009029 [H]

Pfam domain/function: PF00368 HMG-CoA_red [H]

EC number: =1.1.1.88 [H]

Molecular weight: Translated: 47152; Mature: 47021

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS50065 HMG_COA_REDUCTASE_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDTVTSRLPGFHKLPMEERHAHLSRMFRLTPEDLQQLLGSEALQPVLANQMIENAVGTF
CCCCHHHHCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
SLPLGLGLNLQVNGRDYLVPMAVEEPSVVAAVSFAAKIVREAGGFIGEADPSLMIGQVQV
EECCCCCEEEEECCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEE
SRYGDPTVATERILEHKEQILALANSFHPAMVARGGGAKDVEVRVLPAPEGPRGEPLLIV
ECCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCEEEEEEECCCCCCCCCEEEE
HLIIDAQEAMGANLINTMAEGVAPLIEQVTGGKVYLRILSNLADRRLARAMCRIPIPLLA
EEEEECHHHHCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEE
DFEMPAEEIAEGIAQASRFAEADPYRAATHNKGVMNGIDSVAIATGQDWRAIEAGAHAFA
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHCCCCCEEEECCCCCHHHHHCCCEEE
CRNGQYRPLSTWYLEEGHLVGRIELPMALGTVGGPIKIHPGVQMALKLMQTTSVRELAMV
ECCCCCCCCCEEEEECCCEEEEEECCEEECCCCCCEEECCCHHHHHHHHHHHHHHHHHHH
FAAVGLAQNFAALRALGSVGIQKGHMAMHARCVAVTAGARGDWVEKIANLLVKAGHVKVE
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHEEEEEEECCCCCHHHHHHHHHHHHCCCEEHH
KARELLASLPAEDAAAATGTTV
HHHHHHHHCCCCHHHCCCCCCC
>Mature Secondary Structure 
SDTVTSRLPGFHKLPMEERHAHLSRMFRLTPEDLQQLLGSEALQPVLANQMIENAVGTF
CCCHHHHCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
SLPLGLGLNLQVNGRDYLVPMAVEEPSVVAAVSFAAKIVREAGGFIGEADPSLMIGQVQV
EECCCCCEEEEECCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEE
SRYGDPTVATERILEHKEQILALANSFHPAMVARGGGAKDVEVRVLPAPEGPRGEPLLIV
ECCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCEEEEEEECCCCCCCCCEEEE
HLIIDAQEAMGANLINTMAEGVAPLIEQVTGGKVYLRILSNLADRRLARAMCRIPIPLLA
EEEEECHHHHCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEE
DFEMPAEEIAEGIAQASRFAEADPYRAATHNKGVMNGIDSVAIATGQDWRAIEAGAHAFA
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHCCCCCEEEECCCCCHHHHHCCCEEE
CRNGQYRPLSTWYLEEGHLVGRIELPMALGTVGGPIKIHPGVQMALKLMQTTSVRELAMV
ECCCCCCCCCEEEEECCCEEEEEECCEEECCCCCCEEECCCHHHHHHHHHHHHHHHHHHH
FAAVGLAQNFAALRALGSVGIQKGHMAMHARCVAVTAGARGDWVEKIANLLVKAGHVKVE
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHEEEEEEECCCCCHHHHHHHHHHHHCCCEEHH
KARELLASLPAEDAAAATGTTV
HHHHHHHHCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2656635; 2477360; 2123872; 1634543; 10377386 [H]