Click here to switch to the map view.

The map label for this gene is dctA [H]

Identifier: 108761343

GI number: 108761343

Start: 3480066

End: 3481361

Strand: Reverse

Name: dctA [H]

Synonym: MXAN_2970

Alternate gene names: 108761343

Gene position: 3481361-3480066 (Counterclockwise)

Preceding gene: 108763691

Following gene: 108759563

Centisome position: 38.09

GC content: 66.9

Gene sequence:

>1296_bases
GTGCGGATGCGGTGGTTGAAGAATCTGTACGTCCAGGTGCTGCTGGCCATCGCGGTGGGCGTCATCCTCGGATGGCTGCG
GCCGGACCTGGGGGAGTCCATGAAGCCGCTGGGCGACGGCTTCATCAAACTGGTGAAGATGATCATCGCACCGGTCATCT
TCCTCACCATCGTCGCGGGCATCGCGAAGATGGGCGACCTCAAGCACGTGGGCCGCATCGGCCTCAAGGCGCTCATCTAC
TTCGAAGTCCTGACGACGCTGGCGCTCGTCGTGGGCATGGTGGTGGTGAACACCCTGAAGCCCGGCGCGGGGATGAACAT
CGACCCGGCGCAGATCGACACCTCCGGCATCACCCAGTACCGCGCGTCCGCGTCGCAGCAGGGCACCATCCCCTTCCTCC
TGGACATCATCCCGCATGACTTCCTGTCGGCCTTCACCGAGGGGAAGTTGCTCCAGGTGCTGCTCGTCGCCGTGCTGACG
GGCGTGGCGCTCACCCGCCTGGGGCCCATGGGACAGCGCGTGCTCGACTTGTCGGATGACCTGGCGCAGGTCTTCTTCGG
CATCGTCGGGATGATCATGAAGCTGGCGCCGCTGGGCGCCTTCGGCGCCATGGCCTTCACCGTGGGTAAGTTCGGTGTCG
AATCGCTCAGCTCCCTGGGCCGGCTGCTCATCGCCGTCTACGTCACCTGCGCCCTCTTCGTGTTCCTGGTGCTGGGGCTG
GTGGCGCGGCTGTCCGGCTTCTCGCTGTGGAAGCTGCTGCGCTATATGCGCAGCGAGCTGTTGCTCGTGCTGGGGACGTC
GTCATCGGAGTCCGCGCTGCCCCGGCTGCTCAAGCGGCTGGAGACGCTGGGCTGCGACCGGGGCGCCGTCGGGCTGGTGC
TGCCCACCGGGTACTCCTTCAACCTGGACGGGACGTGCATCTACCTGACGATGGCGGCCATCTTCATCGCCCAGGCGGTG
AACGTGGACCTTTCGCTGGGCGAGGAGCTCACCTTGCTGGGCGTGCTGCTGCTGACGTCGAAGGGCGCGGCGGGCGTGAC
GGGTTCGGGCTTCATCACGCTGATGGCCACGCTGGCGGCGCTCAACGGCAAGGTGCCCGTGGAAGGCGTGGCCCTGCTGC
TGGGCGTGGACCGCTTCATGTCCGAGGCCCGGGCCATCACCAACGTCATCGGCAACACGGTGGCGACGCTGGTGGTGTCC
AAGTGGGAGGGCGTGCGTGACGACACCGTCATGCACGCCGAGCTCGACAGCGGGCCCAAGCCCCTGGAAGGGATGAGCCT
GGGCCACGGCGCCTGA

Upstream 100 bases:

>100_bases
TGACGCAGCCCGCCACCCGAAGCCCCCGAGGTCCGCCGGCGCCTGGCGCCAACGAAGCGCCGAACCGGGGCGCTATAGTC
CGCTGCCTCCCGAGAGAGGG

Downstream 100 bases:

>100_bases
GTGCGCGGCGCTAGAAGCCGTAGATCTTCGAGATGATCTCCTTCATCACCTCGGAGGTGCCGCCGCCGATGGTGATGAGG
CGCACGTCGCGCCACATGCG

Product: sodium:dicarboxylate symporter family protein

Products: orotate [Cytoplasm]; fumarate [Cytoplasm]; malate [Cytoplasm]; Na (I) [Cytoplasm]; succinate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MRMRWLKNLYVQVLLAIAVGVILGWLRPDLGESMKPLGDGFIKLVKMIIAPVIFLTIVAGIAKMGDLKHVGRIGLKALIY
FEVLTTLALVVGMVVVNTLKPGAGMNIDPAQIDTSGITQYRASASQQGTIPFLLDIIPHDFLSAFTEGKLLQVLLVAVLT
GVALTRLGPMGQRVLDLSDDLAQVFFGIVGMIMKLAPLGAFGAMAFTVGKFGVESLSSLGRLLIAVYVTCALFVFLVLGL
VARLSGFSLWKLLRYMRSELLLVLGTSSSESALPRLLKRLETLGCDRGAVGLVLPTGYSFNLDGTCIYLTMAAIFIAQAV
NVDLSLGEELTLLGVLLLTSKGAAGVTGSGFITLMATLAALNGKVPVEGVALLLGVDRFMSEARAITNVIGNTVATLVVS
KWEGVRDDTVMHAELDSGPKPLEGMSLGHGA

Sequences:

>Translated_431_residues
MRMRWLKNLYVQVLLAIAVGVILGWLRPDLGESMKPLGDGFIKLVKMIIAPVIFLTIVAGIAKMGDLKHVGRIGLKALIY
FEVLTTLALVVGMVVVNTLKPGAGMNIDPAQIDTSGITQYRASASQQGTIPFLLDIIPHDFLSAFTEGKLLQVLLVAVLT
GVALTRLGPMGQRVLDLSDDLAQVFFGIVGMIMKLAPLGAFGAMAFTVGKFGVESLSSLGRLLIAVYVTCALFVFLVLGL
VARLSGFSLWKLLRYMRSELLLVLGTSSSESALPRLLKRLETLGCDRGAVGLVLPTGYSFNLDGTCIYLTMAAIFIAQAV
NVDLSLGEELTLLGVLLLTSKGAAGVTGSGFITLMATLAALNGKVPVEGVALLLGVDRFMSEARAITNVIGNTVATLVVS
KWEGVRDDTVMHAELDSGPKPLEGMSLGHGA
>Mature_431_residues
MRMRWLKNLYVQVLLAIAVGVILGWLRPDLGESMKPLGDGFIKLVKMIIAPVIFLTIVAGIAKMGDLKHVGRIGLKALIY
FEVLTTLALVVGMVVVNTLKPGAGMNIDPAQIDTSGITQYRASASQQGTIPFLLDIIPHDFLSAFTEGKLLQVLLVAVLT
GVALTRLGPMGQRVLDLSDDLAQVFFGIVGMIMKLAPLGAFGAMAFTVGKFGVESLSSLGRLLIAVYVTCALFVFLVLGL
VARLSGFSLWKLLRYMRSELLLVLGTSSSESALPRLLKRLETLGCDRGAVGLVLPTGYSFNLDGTCIYLTMAAIFIAQAV
NVDLSLGEELTLLGVLLLTSKGAAGVTGSGFITLMATLAALNGKVPVEGVALLLGVDRFMSEARAITNVIGNTVATLVVS
KWEGVRDDTVMHAELDSGPKPLEGMSLGHGA

Specific function: Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI169790839, Length=450, Percent_Identity=25.3333333333333, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI4827012, Length=389, Percent_Identity=27.5064267352185, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI194239697, Length=452, Percent_Identity=24.7787610619469, Blast_Score=109, Evalue=6e-24,
Organism=Homo sapiens, GI66773030, Length=408, Percent_Identity=26.7156862745098, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI21314632, Length=400, Percent_Identity=26.25, Blast_Score=102, Evalue=8e-22,
Organism=Homo sapiens, GI40254478, Length=260, Percent_Identity=30.3846153846154, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI5032093, Length=403, Percent_Identity=26.7990074441687, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI223468566, Length=252, Percent_Identity=30.1587301587302, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI223468564, Length=252, Percent_Identity=30.1587301587302, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI262359914, Length=415, Percent_Identity=24.3373493975904, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI301601644, Length=161, Percent_Identity=34.7826086956522, Blast_Score=74, Evalue=4e-13,
Organism=Escherichia coli, GI1789947, Length=416, Percent_Identity=59.375, Blast_Score=509, Evalue=1e-145,
Organism=Escherichia coli, GI1790514, Length=414, Percent_Identity=40.0966183574879, Blast_Score=312, Evalue=3e-86,
Organism=Escherichia coli, GI1788024, Length=395, Percent_Identity=25.0632911392405, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1789473, Length=339, Percent_Identity=23.598820058997, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17537407, Length=429, Percent_Identity=27.7389277389277, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI71983106, Length=457, Percent_Identity=25.601750547046, Blast_Score=114, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI71983099, Length=416, Percent_Identity=26.2019230769231, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI71996953, Length=442, Percent_Identity=26.6968325791855, Blast_Score=108, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI193206505, Length=448, Percent_Identity=25.8928571428571, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI193206654, Length=456, Percent_Identity=23.0263157894737, Blast_Score=101, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI17541374, Length=402, Percent_Identity=24.8756218905473, Blast_Score=85, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24583025, Length=420, Percent_Identity=25.2380952380952, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI17137668, Length=420, Percent_Identity=25.2380952380952, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24583023, Length=420, Percent_Identity=25.2380952380952, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI281360481, Length=469, Percent_Identity=26.4392324093817, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI281360483, Length=469, Percent_Identity=26.4392324093817, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17137666, Length=469, Percent_Identity=26.4392324093817, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 45673; Mature: 45673

Theoretical pI: Translated: 8.77; Mature: 8.77

Prosite motif: PS00713 NA_DICARBOXYL_SYMP_1 ; PS00714 NA_DICARBOXYL_SYMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCCCCCC
>Mature Secondary Structure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CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: orotate [Periplasm]; fumarate [Periplasm]; malate [Periplasm]; Na (I) [Periplasm]; succinate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + orotate [Periplasm] = Na (I) [Cytoplasm] + orotate [Cytoplasm] Na (I) [Periplasm] + fumarate [Periplasm] = Na (I) [Cytoplasm] + fumarate [Cytoplasm] Na (I) [Periplasm] + malate [Periplasm] = Na (I) [Cytoplasm] + malate [Cytoplasm] Na

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 14500782 [H]