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The map label for this gene is glmS [H]

Identifier: 108761243

GI number: 108761243

Start: 1627444

End: 1629279

Strand: Direct

Name: glmS [H]

Synonym: MXAN_1386

Alternate gene names: 108761243

Gene position: 1627444-1629279 (Clockwise)

Preceding gene: 108760157

Following gene: 108759733

Centisome position: 17.81

GC content: 67.43

Gene sequence:

>1836_bases
ATGTGCGGGATTGTTGGTTACGTCGGTGACAAGGAATCAGCCCCCATCCTGGTGTCGGGCCTGAAGCGGCTCGAATACCG
TGGCTATGACTCGGCGGGCGTGGCGGTGCTGAATCAGCGCAAGCTCAATGTCGTGCGGGCCACGGGCAAGCTCCGCAACT
TGGAAAACCGGGTGGTGGCGGACCAGCCACCAGGCAACATCGGCATCGGGCACACCCGCTGGGCGACCCACGGGCGTCCC
TCCGACGAGAACGCGCACCCGCACACGTACAAGGACGTGGCGGTGGTGCACAACGGCATCATCGAAAACCACCTGTCGCT
CAAGGAGCAGTTGCGCTCGCGTGGGCACGTCTTCTCCTCGGAGACGGACTCGGAGGTGTTCGCGCACCTCATCTCCGAAG
AGCTGGAGCGCGGGCTGGAGCTGCCGGACGCGGTGCGCGCGGCCATTGCCCAGGTGAAGGGCACCTACGCGCTGGCCGTG
CTGACGGCCAGCGACCCCAGCCGCATCGTCTGCACCAAGGACGCCTCGCCCATGGTGCTGGGCCTGGGCCAGGGGCAGAA
CTTCCTGGCCAGCGACGTGCCGGCGCTGCTCGAGCACACGCGCGACTTCGTCTACATGGAAGAGGGTGACCTGGCCGTCA
TCACCGCGGCGGCCGTGGACATCTTCAACCGCCAGGGCCAGAAGGTGAACCGGCCCACCCGCCGCATCGACTGGACGCCG
ATGATGGCGGAGAAGGGCGGCCACAAGCACTTCATGCACAAGGAAATCTGGGAGCAGCCCCGCGCCGTCGCGGACACGCT
GCGCGGCCGGATGCTCCTGTCGGAAGGCGACGTCCACTTCGAGGGCTGGAACCTGTCGGCGGAGAAGGTCCGCTCGCTGA
CCAAGATCACCATCCTCGCGTGCGGCACGTCGTGGCACTCCGGTGTCGCGGGCAAGCACATGATTGAGTCGCTGGCGCGC
CTGCCGGTCGAGGTGGAGCTGGCGAGCGAGTTCCGCTACCGCGACCCCATCGTCGACGGCACGCACCTGGCCATCGCCAT
CAGCCAGTCGGGCGAGACGGCGGACACGCTGGCGGCCTTCAAGGAGGCCAAGGCCCGCGGCGCCACGGCCATGGCCATCT
GCAACGTCATTGGCAGCGCGATGACGCGCGAGGCCGACTTCTCCGTGCTCACCAACGCGGGCCCGGAGATTGGCGTGGCG
TCCACCAAGGCGTTCACCACGCAGCTGGTGGCCTTGTTCCTGCTGGCCGTCAAGCTGGGCCGCATGCGTGGCACCCTGTC
CGTGCCGGCGGCGCAGGAGCACCTGACGCAGCTCACGAAGGTGCCGAAGATGATTGAGGACGTCCTCAAGTGCGAGCCGG
CCGTGACGCGCGTGTCGCGTGAGTACATGGACTCGCAGGACTTCCTCTTCCTCGGCCGCGGCCCCATGCACCCGGTGGCG
CTGGAGGGCGCGCTCAAGCTGAAGGAAATCTCGTACATCCACGCGGAGGGCTACGCGGGCGGTGAGATGAAGCACGGCCC
CATCGCGCTCATCGACGAGAAGATGCCGGTGGTGGTCATCGCGCCGAAGCAGCCGCACGTCGCGTACGAGAAAATCATCG
GCAACATCGAGGAGGTCCGCGCGCGCGGTGGCAAGGTGATTGCCATCATCGACGAGGACGACGAGCACGTGGCCACGCTG
GCCGACCAGGTCATCCGGATTCCAGCGGCTTGCGCGCTGCTGGCGCCGGTGGTGGCCACCATCCCCCTGCAGCTGCTCGC
CTACCACGTGGCGGACCTGCGCGGGAACGACGTGGACCAGCCGCGCAACCTGGCCAAGAGCGTGACGGTGGAGTAG

Upstream 100 bases:

>100_bases
GGCTCTTGCTTGGGTACCAGGCAGAGCGCGGCCCGGCAGGGATGTAGGGGAATCCCGCGGATTGCTCCGGCGGGCGAGGG
CGTGAGAGAGAGGTGCAACT

Downstream 100 bases:

>100_bases
CCGCCGCGCGTCTTCGGACGTGAAGCGCCAGAAGCCCGGGCTCCCGCGAAGGGGGCTCGGGCTTCGTCGTTTGTGCGTGA
GGGAGCGGCACCTGGTGAAG

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 611; Mature: 611

Protein sequence:

>611_residues
MCGIVGYVGDKESAPILVSGLKRLEYRGYDSAGVAVLNQRKLNVVRATGKLRNLENRVVADQPPGNIGIGHTRWATHGRP
SDENAHPHTYKDVAVVHNGIIENHLSLKEQLRSRGHVFSSETDSEVFAHLISEELERGLELPDAVRAAIAQVKGTYALAV
LTASDPSRIVCTKDASPMVLGLGQGQNFLASDVPALLEHTRDFVYMEEGDLAVITAAAVDIFNRQGQKVNRPTRRIDWTP
MMAEKGGHKHFMHKEIWEQPRAVADTLRGRMLLSEGDVHFEGWNLSAEKVRSLTKITILACGTSWHSGVAGKHMIESLAR
LPVEVELASEFRYRDPIVDGTHLAIAISQSGETADTLAAFKEAKARGATAMAICNVIGSAMTREADFSVLTNAGPEIGVA
STKAFTTQLVALFLLAVKLGRMRGTLSVPAAQEHLTQLTKVPKMIEDVLKCEPAVTRVSREYMDSQDFLFLGRGPMHPVA
LEGALKLKEISYIHAEGYAGGEMKHGPIALIDEKMPVVVIAPKQPHVAYEKIIGNIEEVRARGGKVIAIIDEDDEHVATL
ADQVIRIPAACALLAPVVATIPLQLLAYHVADLRGNDVDQPRNLAKSVTVE

Sequences:

>Translated_611_residues
MCGIVGYVGDKESAPILVSGLKRLEYRGYDSAGVAVLNQRKLNVVRATGKLRNLENRVVADQPPGNIGIGHTRWATHGRP
SDENAHPHTYKDVAVVHNGIIENHLSLKEQLRSRGHVFSSETDSEVFAHLISEELERGLELPDAVRAAIAQVKGTYALAV
LTASDPSRIVCTKDASPMVLGLGQGQNFLASDVPALLEHTRDFVYMEEGDLAVITAAAVDIFNRQGQKVNRPTRRIDWTP
MMAEKGGHKHFMHKEIWEQPRAVADTLRGRMLLSEGDVHFEGWNLSAEKVRSLTKITILACGTSWHSGVAGKHMIESLAR
LPVEVELASEFRYRDPIVDGTHLAIAISQSGETADTLAAFKEAKARGATAMAICNVIGSAMTREADFSVLTNAGPEIGVA
STKAFTTQLVALFLLAVKLGRMRGTLSVPAAQEHLTQLTKVPKMIEDVLKCEPAVTRVSREYMDSQDFLFLGRGPMHPVA
LEGALKLKEISYIHAEGYAGGEMKHGPIALIDEKMPVVVIAPKQPHVAYEKIIGNIEEVRARGGKVIAIIDEDDEHVATL
ADQVIRIPAACALLAPVVATIPLQLLAYHVADLRGNDVDQPRNLAKSVTVE
>Mature_611_residues
MCGIVGYVGDKESAPILVSGLKRLEYRGYDSAGVAVLNQRKLNVVRATGKLRNLENRVVADQPPGNIGIGHTRWATHGRP
SDENAHPHTYKDVAVVHNGIIENHLSLKEQLRSRGHVFSSETDSEVFAHLISEELERGLELPDAVRAAIAQVKGTYALAV
LTASDPSRIVCTKDASPMVLGLGQGQNFLASDVPALLEHTRDFVYMEEGDLAVITAAAVDIFNRQGQKVNRPTRRIDWTP
MMAEKGGHKHFMHKEIWEQPRAVADTLRGRMLLSEGDVHFEGWNLSAEKVRSLTKITILACGTSWHSGVAGKHMIESLAR
LPVEVELASEFRYRDPIVDGTHLAIAISQSGETADTLAAFKEAKARGATAMAICNVIGSAMTREADFSVLTNAGPEIGVA
STKAFTTQLVALFLLAVKLGRMRGTLSVPAAQEHLTQLTKVPKMIEDVLKCEPAVTRVSREYMDSQDFLFLGRGPMHPVA
LEGALKLKEISYIHAEGYAGGEMKHGPIALIDEKMPVVVIAPKQPHVAYEKIIGNIEEVRARGGKVIAIIDEDDEHVATL
ADQVIRIPAACALLAPVVATIPLQLLAYHVADLRGNDVDQPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=685, Percent_Identity=36.2043795620438, Blast_Score=433, Evalue=1e-121,
Organism=Homo sapiens, GI205277386, Length=684, Percent_Identity=35.8187134502924, Blast_Score=424, Evalue=1e-118,
Organism=Escherichia coli, GI1790167, Length=618, Percent_Identity=49.6763754045307, Blast_Score=586, Evalue=1e-168,
Organism=Escherichia coli, GI87082251, Length=318, Percent_Identity=21.3836477987421, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1788651, Length=201, Percent_Identity=28.3582089552239, Blast_Score=70, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17539970, Length=430, Percent_Identity=39.3023255813954, Blast_Score=308, Evalue=6e-84,
Organism=Caenorhabditis elegans, GI17532899, Length=432, Percent_Identity=38.4259259259259, Blast_Score=304, Evalue=1e-82,
Organism=Caenorhabditis elegans, GI17532897, Length=434, Percent_Identity=38.2488479262673, Blast_Score=303, Evalue=2e-82,
Organism=Saccharomyces cerevisiae, GI6322745, Length=453, Percent_Identity=38.6313465783664, Blast_Score=301, Evalue=2e-82,
Organism=Saccharomyces cerevisiae, GI6323731, Length=430, Percent_Identity=30.9302325581395, Blast_Score=203, Evalue=5e-53,
Organism=Saccharomyces cerevisiae, GI6323730, Length=205, Percent_Identity=33.6585365853659, Blast_Score=113, Evalue=9e-26,
Organism=Saccharomyces cerevisiae, GI6323958, Length=145, Percent_Identity=28.9655172413793, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21357745, Length=689, Percent_Identity=37.4455732946299, Blast_Score=437, Evalue=1e-122,
Organism=Drosophila melanogaster, GI28573187, Length=219, Percent_Identity=28.7671232876712, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24659598, Length=201, Percent_Identity=28.3582089552239, Blast_Score=66, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 66459; Mature: 66459

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGYVGDKESAPILVSGLKRLEYRGYDSAGVAVLNQRKLNVVRATGKLRNLENRVVA
CCCEEEECCCCCCCCHHHHHHHHHHCCCCCCCCEEEECCCCEEEEEHHHHHHCCCCCEEC
DQPPGNIGIGHTRWATHGRPSDENAHPHTYKDVAVVHNGIIENHLSLKEQLRSRGHVFSS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
ETDSEVFAHLISEELERGLELPDAVRAAIAQVKGTYALAVLTASDPSRIVCTKDASPMVL
CCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCEEEEECCCCCEEE
GLGQGQNFLASDVPALLEHTRDFVYMEEGDLAVITAAAVDIFNRQGQKVNRPTRRIDWTP
EECCCCCHHHHHHHHHHHCCCCEEEEECCCEEEEHHHHHHHHHCCCCCCCCCCCCCCCCC
MMAEKGGHKHFMHKEIWEQPRAVADTLRGRMLLSEGDVHFEGWNLSAEKVRSLTKITILA
HHHCCCCCCHHHHHHHHHCHHHHHHHHHCCEEEECCCEEEECCCCCHHHHHHHHEEEEEE
CGTSWHSGVAGKHMIESLARLPVEVELASEFRYRDPIVDGTHLAIAISQSGETADTLAAF
ECCCCCCCCCHHHHHHHHHHCCEEEEEHHHHHCCCCCCCCCEEEEEEECCCCHHHHHHHH
KEAKARGATAMAICNVIGSAMTREADFSVLTNAGPEIGVASTKAFTTQLVALFLLAVKLG
HHHHHCCHHHHHHHHHHHHHHCCCCCCHHEECCCCCCCCCCHHHHHHHHHHHHHHHHHHH
RMRGTLSVPAAQEHLTQLTKVPKMIEDVLKCEPAVTRVSREYMDSQDFLFLGRGPMHPVA
HHCCCEECCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCEEEECCCCCCCEE
LEGALKLKEISYIHAEGYAGGEMKHGPIALIDEKMPVVVIAPKQPHVAYEKIIGNIEEVR
CCCCEEEHHEEEEEECCCCCCCCCCCCEEEEECCCCEEEECCCCCCHHHHHHHCCHHHHH
ARGGKVIAIIDEDDEHVATLADQVIRIPAACALLAPVVATIPLQLLAYHVADLRGNDVDQ
HCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
PRNLAKSVTVE
HHHHHHHCCCC
>Mature Secondary Structure
MCGIVGYVGDKESAPILVSGLKRLEYRGYDSAGVAVLNQRKLNVVRATGKLRNLENRVVA
CCCEEEECCCCCCCCHHHHHHHHHHCCCCCCCCEEEECCCCEEEEEHHHHHHCCCCCEEC
DQPPGNIGIGHTRWATHGRPSDENAHPHTYKDVAVVHNGIIENHLSLKEQLRSRGHVFSS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
ETDSEVFAHLISEELERGLELPDAVRAAIAQVKGTYALAVLTASDPSRIVCTKDASPMVL
CCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCEEEEECCCCCEEE
GLGQGQNFLASDVPALLEHTRDFVYMEEGDLAVITAAAVDIFNRQGQKVNRPTRRIDWTP
EECCCCCHHHHHHHHHHHCCCCEEEEECCCEEEEHHHHHHHHHCCCCCCCCCCCCCCCCC
MMAEKGGHKHFMHKEIWEQPRAVADTLRGRMLLSEGDVHFEGWNLSAEKVRSLTKITILA
HHHCCCCCCHHHHHHHHHCHHHHHHHHHCCEEEECCCEEEECCCCCHHHHHHHHEEEEEE
CGTSWHSGVAGKHMIESLARLPVEVELASEFRYRDPIVDGTHLAIAISQSGETADTLAAF
ECCCCCCCCCHHHHHHHHHHCCEEEEEHHHHHCCCCCCCCCEEEEEEECCCCHHHHHHHH
KEAKARGATAMAICNVIGSAMTREADFSVLTNAGPEIGVASTKAFTTQLVALFLLAVKLG
HHHHHCCHHHHHHHHHHHHHHCCCCCCHHEECCCCCCCCCCHHHHHHHHHHHHHHHHHHH
RMRGTLSVPAAQEHLTQLTKVPKMIEDVLKCEPAVTRVSREYMDSQDFLFLGRGPMHPVA
HHCCCEECCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCEEEECCCCCCCEE
LEGALKLKEISYIHAEGYAGGEMKHGPIALIDEKMPVVVIAPKQPHVAYEKIIGNIEEVR
CCCCEEEHHEEEEEECCCCCCCCCCCCEEEEECCCCEEEECCCCCCHHHHHHHCCHHHHH
ARGGKVIAIIDEDDEHVATLADQVIRIPAACALLAPVVATIPLQLLAYHVADLRGNDVDQ
HCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
PRNLAKSVTVE
HHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA