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The map label for this gene is glmU

Identifier: 108760157

GI number: 108760157

Start: 1625936

End: 1627336

Strand: Direct

Name: glmU

Synonym: MXAN_1385

Alternate gene names: 108760157

Gene position: 1625936-1627336 (Clockwise)

Preceding gene: 108762790

Following gene: 108761243

Centisome position: 17.79

GC content: 68.74

Gene sequence:

>1401_bases
ATGAGCGTTCTGGCGGCGGTGGTGCTGTGCGCGGGCAAGGGCACGCGGATGAAGTCGGAGAAGGCGAAGGTCCTTCACCC
CATCCTCGGTCGACCCCTTTGCGCGTATCCCCTCAAGCGGGCCCTTGAACTGGGCGCCACGTCGGTGGTCCCCGTGGTGG
GCCACCAGGCGGAAGCGGTGGAAAAGGCCGTCCGAGGCCTCTTCCCGGATGCCCCCCTGCGCTTCGCGCTCCAGCGCGAG
CAGCGCGGGACGGCGGACGCGGTGCGCTCCGCGGAGGAGGCCCTGAAGGGGTACTCCGGACGGGTCCTCATCCTTTACGG
CGATGTGCCGTTGCTGCGCCGCGAGACGCTGGAGGCGCTGCTGGCCGCCCATGACCAGGCGGGCGGCAAGCTGGCCATGG
TGACCACCACCCTGGAGGACCCCACGGGCTATGGCCGGGTCATCCGCGACGGTGGCAAGGTGACGCGCATCGTGGAGCAC
AAGGACTGCACCCCGGAGCAGCGCGCGGTGCGCGAGTGCAACGCCGGCATCTACTCCGTGGACGCGGACTTCCTCTGGAA
GGCGCTGGCTGAAATCAAACCGCAGAACGCCCAGGGCGAGTACTACCTCACCGACCTGGTGGAGATGGCCGCGAAGCGGG
GCCCGGTGGGCTCGGTGGAGGCGGACGCCACGGAGACGGCCGGCGTGAATGACCGGGTGGAGCTGGCCGCCCGCGCGCGC
GTGCTGCAGCAGCGCATCAACGAGGCGCACATGCGCGCCGGCGTCTCGCTACAGGACCCCGCCACCGCCTACATCGAGGA
AGGCGTCACCGTGGGGCCCGACACCGAAATCGGTCCCTCCGTCACGCTGGCCGCCGGCACCGTGGTGGGCAAGGGCTGCA
CCATTGGCCAGGGCAGCGTGCTGCACGCCTCCACCGTGGCGGACGGCACCGTCATCAAGCCTTACTCCGTGCTGGAAGAG
GCCCGGGTGGGGGAGCGCAACGTCATTGGCCCCTTCTCGCGGCTGCGCCCAGGGACGGAGCTGGCCGAGGACGTGCATCT
GGGCAACTTCGTGGAGACGAAGAAGGCCCGCATCGGAAAAGGTTCGAAGGCCAACCACCTCACTTACCTGGGGGACGCTG
TCATTGGTTCCGGGTGCAACGTGGGGGCGGGCACCATCACCTGTAACTATGACGGGGTGAACAAGCACCTGACTGAGCTG
GGGGATGGTGTGTTCATCGGCTCCGACACCCAGCTCGTCGCGCCCGTGAAGGTCGGCGACGGCTCGTATGTCGGCGCGGG
CACCACGGTGACGAAAAATGTGCCTCCAGGGAGCCTCGCTGTGTCCCGGACGCCACAGGTGACCAAGGAAGGTTGGGTGG
CCACCAAGAAGGCGCGGCAGGCGAAGGCGCGGGCGGGATAG

Upstream 100 bases:

>100_bases
GCGTCTCGGTCAGTGCGAAGGCACGGCCGGTGGACACCGTCACGCCTTCTGATCCGCGCGCGGTTGACGACTCGATTGGC
TGTCCCTAATTCTCCGCCGC

Downstream 100 bases:

>100_bases
TCGGCGCGGCTCTTGCTTGGGTACCAGGCAGAGCGCGGCCCGGCAGGGATGTAGGGGAATCCCGCGGATTGCTCCGGCGG
GCGAGGGCGTGAGAGAGAGG

Product: UDP-N-acetylglucosamine pyrophosphorylase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase

Number of amino acids: Translated: 466; Mature: 465

Protein sequence:

>466_residues
MSVLAAVVLCAGKGTRMKSEKAKVLHPILGRPLCAYPLKRALELGATSVVPVVGHQAEAVEKAVRGLFPDAPLRFALQRE
QRGTADAVRSAEEALKGYSGRVLILYGDVPLLRRETLEALLAAHDQAGGKLAMVTTTLEDPTGYGRVIRDGGKVTRIVEH
KDCTPEQRAVRECNAGIYSVDADFLWKALAEIKPQNAQGEYYLTDLVEMAAKRGPVGSVEADATETAGVNDRVELAARAR
VLQQRINEAHMRAGVSLQDPATAYIEEGVTVGPDTEIGPSVTLAAGTVVGKGCTIGQGSVLHASTVADGTVIKPYSVLEE
ARVGERNVIGPFSRLRPGTELAEDVHLGNFVETKKARIGKGSKANHLTYLGDAVIGSGCNVGAGTITCNYDGVNKHLTEL
GDGVFIGSDTQLVAPVKVGDGSYVGAGTTVTKNVPPGSLAVSRTPQVTKEGWVATKKARQAKARAG

Sequences:

>Translated_466_residues
MSVLAAVVLCAGKGTRMKSEKAKVLHPILGRPLCAYPLKRALELGATSVVPVVGHQAEAVEKAVRGLFPDAPLRFALQRE
QRGTADAVRSAEEALKGYSGRVLILYGDVPLLRRETLEALLAAHDQAGGKLAMVTTTLEDPTGYGRVIRDGGKVTRIVEH
KDCTPEQRAVRECNAGIYSVDADFLWKALAEIKPQNAQGEYYLTDLVEMAAKRGPVGSVEADATETAGVNDRVELAARAR
VLQQRINEAHMRAGVSLQDPATAYIEEGVTVGPDTEIGPSVTLAAGTVVGKGCTIGQGSVLHASTVADGTVIKPYSVLEE
ARVGERNVIGPFSRLRPGTELAEDVHLGNFVETKKARIGKGSKANHLTYLGDAVIGSGCNVGAGTITCNYDGVNKHLTEL
GDGVFIGSDTQLVAPVKVGDGSYVGAGTTVTKNVPPGSLAVSRTPQVTKEGWVATKKARQAKARAG
>Mature_465_residues
SVLAAVVLCAGKGTRMKSEKAKVLHPILGRPLCAYPLKRALELGATSVVPVVGHQAEAVEKAVRGLFPDAPLRFALQREQ
RGTADAVRSAEEALKGYSGRVLILYGDVPLLRRETLEALLAAHDQAGGKLAMVTTTLEDPTGYGRVIRDGGKVTRIVEHK
DCTPEQRAVRECNAGIYSVDADFLWKALAEIKPQNAQGEYYLTDLVEMAAKRGPVGSVEADATETAGVNDRVELAARARV
LQQRINEAHMRAGVSLQDPATAYIEEGVTVGPDTEIGPSVTLAAGTVVGKGCTIGQGSVLHASTVADGTVIKPYSVLEEA
RVGERNVIGPFSRLRPGTELAEDVHLGNFVETKKARIGKGSKANHLTYLGDAVIGSGCNVGAGTITCNYDGVNKHLTELG
DGVFIGSDTQLVAPVKVGDGSYVGAGTTVTKNVPPGSLAVSRTPQVTKEGWVATKKARQAKARAG

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family

Homologues:

Organism=Homo sapiens, GI11761621, Length=356, Percent_Identity=23.5955056179775, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI11761619, Length=349, Percent_Identity=22.9226361031519, Blast_Score=72, Evalue=9e-13,
Organism=Escherichia coli, GI1790168, Length=453, Percent_Identity=47.682119205298, Blast_Score=396, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6320148, Length=357, Percent_Identity=25.7703081232493, Blast_Score=92, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMU_MYXXD (Q1DCI1)

Other databases:

- EMBL:   CP000113
- RefSeq:   YP_629642.1
- ProteinModelPortal:   Q1DCI1
- SMR:   Q1DCI1
- STRING:   Q1DCI1
- GeneID:   4103303
- GenomeReviews:   CP000113_GR
- KEGG:   mxa:MXAN_1385
- TIGR:   MXAN_1385
- eggNOG:   COG1207
- HOGENOM:   HBG688195
- OMA:   GSKVNHL
- PhylomeDB:   Q1DCI1
- ProtClustDB:   CLSK2516865
- BioCyc:   MXAN246197:MXAN_1385-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01631
- InterPro:   IPR005882
- InterPro:   IPR018357
- InterPro:   IPR005835
- InterPro:   IPR011004
- TIGRFAMs:   TIGR01173

Pfam domain/function: PF00483 NTP_transferase; SSF51161 Trimer_LpxA_like

EC number: =2.7.7.23; =2.3.1.157

Molecular weight: Translated: 49030; Mature: 48898

Theoretical pI: Translated: 8.45; Mature: 8.45

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: ACT_SITE 366-366 BINDING 78-78 BINDING 145-145 BINDING 159-159 BINDING 174-174 BINDING 390-390 BINDING 408-408 BINDING 426-426 BINDING 443-443

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVLAAVVLCAGKGTRMKSEKAKVLHPILGRPLCAYPLKRALELGATSVVPVVGHQAEAV
CHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEHHCCCHHHHH
EKAVRGLFPDAPLRFALQREQRGTADAVRSAEEALKGYSGRVLILYGDVPLLRRETLEAL
HHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHH
LAAHDQAGGKLAMVTTTLEDPTGYGRVIRDGGKVTRIVEHKDCTPEQRAVRECNAGIYSV
HHHHCCCCCEEEEEEEECCCCCCCCCEEECCCCEEEEECCCCCCHHHHHHHHHCCCEEEE
DADFLWKALAEIKPQNAQGEYYLTDLVEMAAKRGPVGSVEADATETAGVNDRVELAARAR
CHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHH
VLQQRINEAHMRAGVSLQDPATAYIEEGVTVGPDTEIGPSVTLAAGTVVGKGCTIGQGSV
HHHHHHHHHHHHCCCCCCCCHHHHHHCCCEECCCCCCCCCEEEEECEEEECCCCCCCCCE
LHASTVADGTVIKPYSVLEEARVGERNVIGPFSRLRPGTELAEDVHLGNFVETKKARIGK
EEEHHCCCCCEECHHHHHHHHHCCCCCCCCCHHHCCCCHHHHHHHHCCCHHHHHHHHCCC
GSKANHLTYLGDAVIGSGCNVGAGTITCNYDGVNKHLTELGDGVFIGSDTQLVAPVKVGD
CCCCCCEEEECHHHHCCCCCCCCCEEEEECCCHHHHHHHHCCEEEECCCCEEEEEEEECC
GSYVGAGTTVTKNVPPGSLAVSRTPQVTKEGWVATKKARQAKARAG
CCEECCCCEEECCCCCCCEEECCCCCCCCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure 
SVLAAVVLCAGKGTRMKSEKAKVLHPILGRPLCAYPLKRALELGATSVVPVVGHQAEAV
HHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEHHCCCHHHHH
EKAVRGLFPDAPLRFALQREQRGTADAVRSAEEALKGYSGRVLILYGDVPLLRRETLEAL
HHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHH
LAAHDQAGGKLAMVTTTLEDPTGYGRVIRDGGKVTRIVEHKDCTPEQRAVRECNAGIYSV
HHHHCCCCCEEEEEEEECCCCCCCCCEEECCCCEEEEECCCCCCHHHHHHHHHCCCEEEE
DADFLWKALAEIKPQNAQGEYYLTDLVEMAAKRGPVGSVEADATETAGVNDRVELAARAR
CHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHH
VLQQRINEAHMRAGVSLQDPATAYIEEGVTVGPDTEIGPSVTLAAGTVVGKGCTIGQGSV
HHHHHHHHHHHHCCCCCCCCHHHHHHCCCEECCCCCCCCCEEEEECEEEECCCCCCCCCE
LHASTVADGTVIKPYSVLEEARVGERNVIGPFSRLRPGTELAEDVHLGNFVETKKARIGK
EEEHHCCCCCEECHHHHHHHHHCCCCCCCCCHHHCCCCHHHHHHHHCCCHHHHHHHHCCC
GSKANHLTYLGDAVIGSGCNVGAGTITCNYDGVNKHLTELGDGVFIGSDTQLVAPVKVGD
CCCCCCEEEECHHHHCCCCCCCCCEEEEECCCHHHHHHHHCCEEEECCCCEEEEEEEECC
GSYVGAGTTVTKNVPPGSLAVSRTPQVTKEGWVATKKARQAKARAG
CCEECCCCEEECCCCCCCEEECCCCCCCCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA