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The map label for this gene is taC [H]

Identifier: 108761111

GI number: 108761111

Start: 4807103

End: 4808365

Strand: Reverse

Name: taC [H]

Synonym: MXAN_3948

Alternate gene names: 108761111

Gene position: 4808365-4807103 (Counterclockwise)

Preceding gene: 108761688

Following gene: 108759315

Centisome position: 52.61

GC content: 67.3

Gene sequence:

>1263_bases
ATGGGGCCGGTCGGGATTGAAGCCATGAATGCCTACTGTGGCATCGCCAGGTTGGATGTGTTGCAGCTGGCGACCCACCG
TGGCCTGGACACCTCCCGCTTCGCGAACCTGCTCATGGAGGAGAAGACCGTCCCGCTCCCCTATGAGGACCCTGTCACCT
ACGGCGTGAATGCCGCCCGGCCCATCCTGGACCAGTTGACCGCGGCGGAACGGGACAGCATCGAGCTGCTGGTGGCTTGC
ACGGAGTCCTCGTTCGACTTCGGCAAGGCCATGAGCACCTACCTGCACCAGCACCTGGGGCTGAGCCGCAACTGCCGGCT
CATCGAGCTCAAGAGCGCCTGCTACTCCGGGGTCGCCGGGCTGCAGATGGCCGTCAACTTCATCCTGTCCGGCGTGTCGC
CGGGGGCCAAGGCCCTGGTGGTGGCCTCCGACCTGTCGCGCTTCTCCATCGCCGAAGGGGGAGATGCCTCCACGGAGGAC
TGGTCCTTCGCGGAGCCGAGCTCGGGTGCGGGCGCGGTGGCCATGCTGGTGAGCGACACGCCCCGGGTGTTCCGCGTCGA
CGTGGGGGCGAACGGCTACTACGGCTACGAGGTGATGGATACCTGCCGCCCGGTGGCGGACAGCGAAGCGGGAGACGCGG
ACCTGTCGCTCCTCTCGTACCTGGACTGCTGTGAGAACGCCTTCCGGGAGTACACCCGCCGCGTCCCCGCGGCGAACTAC
GCGGAGAGCTTCGGCTACCTCGCCTTCCACACGCCGTTTGGCGGCATGGTGAAGGGCGCCCACCGCACGATGATGCGCAA
GTTCTCCGGCAAGAACCGCGGGGACATCGAAGCGGACTTCCAGCGGCGAGTGGCCCCCGGGCTGACCTACTGCCAGCGCG
TGGGGAACATCATGGGCGCGACGATGGCGCTCTCGCTCCTCGGGACCATCGACCACGGCGACTTCGCCACCGCGAAGCGG
ATTGGCTGCTTCTCGTATGGCTCGGGGTGCAGCTCGGAGTTCTTCAGCGGCGTGGTGACGGAGGAAGGGCAGCAGCGGCA
GCGCGCCCTGGGGCTGGGAGAAGCGCTGGGGCGCCGGCAGCAGCTCTCCATGCCGGATTACGACGCGCTGCTGAAGGGGA
ACGGCCTGGTGCGCTTCGGGACCCGGAACGCCGAGCTGGATTTCGGTGTCGTCGGCAGCATCCGGCCGGGCGGGTGGGGC
AGGCCCTTGCTCTTCTTGTCGGCGATTCGTGACTTCCATCGCGACTACCAATGGATTTCCTAG

Upstream 100 bases:

>100_bases
GGAGAAGCTGGCGCTCAACATCCCCCGGGTCGAGCTGATTGACGCGAAGACCATTGGCGGGCTGGTGGACGTCCTTCACG
CGAGGCTGTGAGGCGAAGCC

Downstream 100 bases:

>100_bases
CCTCGGGGCTTCGAGCAAAGCCATGTCCAGCGTAGCGACGGCCGTCCCCCTGACGGCCCGTGACAGCGCGGTGAGCCGCC
GGCTGCGAATCACCCCCAGC

Product: polyketide TA biosynthesis protein TaC

Products: (S)-3-hydroxy-3-methylglutaryl-CoA; CoA

Alternate protein names: HMG synthase [H]

Number of amino acids: Translated: 420; Mature: 419

Protein sequence:

>420_residues
MGPVGIEAMNAYCGIARLDVLQLATHRGLDTSRFANLLMEEKTVPLPYEDPVTYGVNAARPILDQLTAAERDSIELLVAC
TESSFDFGKAMSTYLHQHLGLSRNCRLIELKSACYSGVAGLQMAVNFILSGVSPGAKALVVASDLSRFSIAEGGDASTED
WSFAEPSSGAGAVAMLVSDTPRVFRVDVGANGYYGYEVMDTCRPVADSEAGDADLSLLSYLDCCENAFREYTRRVPAANY
AESFGYLAFHTPFGGMVKGAHRTMMRKFSGKNRGDIEADFQRRVAPGLTYCQRVGNIMGATMALSLLGTIDHGDFATAKR
IGCFSYGSGCSSEFFSGVVTEEGQQRQRALGLGEALGRRQQLSMPDYDALLKGNGLVRFGTRNAELDFGVVGSIRPGGWG
RPLLFLSAIRDFHRDYQWIS

Sequences:

>Translated_420_residues
MGPVGIEAMNAYCGIARLDVLQLATHRGLDTSRFANLLMEEKTVPLPYEDPVTYGVNAARPILDQLTAAERDSIELLVAC
TESSFDFGKAMSTYLHQHLGLSRNCRLIELKSACYSGVAGLQMAVNFILSGVSPGAKALVVASDLSRFSIAEGGDASTED
WSFAEPSSGAGAVAMLVSDTPRVFRVDVGANGYYGYEVMDTCRPVADSEAGDADLSLLSYLDCCENAFREYTRRVPAANY
AESFGYLAFHTPFGGMVKGAHRTMMRKFSGKNRGDIEADFQRRVAPGLTYCQRVGNIMGATMALSLLGTIDHGDFATAKR
IGCFSYGSGCSSEFFSGVVTEEGQQRQRALGLGEALGRRQQLSMPDYDALLKGNGLVRFGTRNAELDFGVVGSIRPGGWG
RPLLFLSAIRDFHRDYQWIS
>Mature_419_residues
GPVGIEAMNAYCGIARLDVLQLATHRGLDTSRFANLLMEEKTVPLPYEDPVTYGVNAARPILDQLTAAERDSIELLVACT
ESSFDFGKAMSTYLHQHLGLSRNCRLIELKSACYSGVAGLQMAVNFILSGVSPGAKALVVASDLSRFSIAEGGDASTEDW
SFAEPSSGAGAVAMLVSDTPRVFRVDVGANGYYGYEVMDTCRPVADSEAGDADLSLLSYLDCCENAFREYTRRVPAANYA
ESFGYLAFHTPFGGMVKGAHRTMMRKFSGKNRGDIEADFQRRVAPGLTYCQRVGNIMGATMALSLLGTIDHGDFATAKRI
GCFSYGSGCSSEFFSGVVTEEGQQRQRALGLGEALGRRQQLSMPDYDALLKGNGLVRFGTRNAELDFGVVGSIRPGGWGR
PLLFLSAIRDFHRDYQWIS

Specific function: Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism. It catalyzes the aldol condensation between the acetyl group attached to the acyl-carrier-protein AcpK (Ac- AcpK) and

COG id: COG3425

COG function: function code I; 3-hydroxy-3-methylglutaryl CoA synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA synthase family [H]

Homologues:

Organism=Homo sapiens, GI148298764, Length=392, Percent_Identity=25.765306122449, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI148298677, Length=392, Percent_Identity=25.765306122449, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI5031751, Length=399, Percent_Identity=24.3107769423559, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24654139, Length=390, Percent_Identity=26.9230769230769, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24654137, Length=390, Percent_Identity=26.9230769230769, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24654133, Length=390, Percent_Identity=26.9230769230769, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24654135, Length=390, Percent_Identity=26.9230769230769, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI17933694, Length=390, Percent_Identity=26.9230769230769, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013746
- InterPro:   IPR013528
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF08540 HMG_CoA_synt_C; PF01154 HMG_CoA_synt_N [H]

EC number: 2.3.3.10

Molecular weight: Translated: 45499; Mature: 45368

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGPVGIEAMNAYCGIARLDVLQLATHRGLDTSRFANLLMEEKTVPLPYEDPVTYGVNAAR
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHH
PILDQLTAAERDSIELLVACTESSFDFGKAMSTYLHQHLGLSRNCRLIELKSACYSGVAG
HHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHH
LQMAVNFILSGVSPGAKALVVASDLSRFSIAEGGDASTEDWSFAEPSSGAGAVAMLVSDT
HHHHHHHHHHCCCCCCCEEEEECCCCHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCC
PRVFRVDVGANGYYGYEVMDTCRPVADSEAGDADLSLLSYLDCCENAFREYTRRVPAANY
CCEEEEEECCCCEECHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHH
AESFGYLAFHTPFGGMVKGAHRTMMRKFSGKNRGDIEADFQRRVAPGLTYCQRVGNIMGA
HHHCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHH
TMALSLLGTIDHGDFATAKRIGCFSYGSGCSSEFFSGVVTEEGQQRQRALGLGEALGRRQ
HHHHHHHHCCCCCCCHHHHHCEEECCCCCCCHHHHHCHHCCCHHHHHHHHHHHHHHCCHH
QLSMPDYDALLKGNGLVRFGTRNAELDFGVVGSIRPGGWGRPLLFLSAIRDFHRDYQWIS
CCCCCCHHHHHCCCCEEEECCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
GPVGIEAMNAYCGIARLDVLQLATHRGLDTSRFANLLMEEKTVPLPYEDPVTYGVNAAR
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHH
PILDQLTAAERDSIELLVACTESSFDFGKAMSTYLHQHLGLSRNCRLIELKSACYSGVAG
HHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHH
LQMAVNFILSGVSPGAKALVVASDLSRFSIAEGGDASTEDWSFAEPSSGAGAVAMLVSDT
HHHHHHHHHHCCCCCCCEEEEECCCCHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCC
PRVFRVDVGANGYYGYEVMDTCRPVADSEAGDADLSLLSYLDCCENAFREYTRRVPAANY
CCEEEEEECCCCEECHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHH
AESFGYLAFHTPFGGMVKGAHRTMMRKFSGKNRGDIEADFQRRVAPGLTYCQRVGNIMGA
HHHCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHH
TMALSLLGTIDHGDFATAKRIGCFSYGSGCSSEFFSGVVTEEGQQRQRALGLGEALGRRQ
HHHHHHHHCCCCCCCHHHHHCEEECCCCCCCHHHHHCHHCCCHHHHHHHHHHHHHHCCHH
QLSMPDYDALLKGNGLVRFGTRNAELDFGVVGSIRPGGWGRPLLFLSAIRDFHRDYQWIS
CCCCCCHHHHHCCCCEEEECCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acetyl-CoA; H2O; acetoacetyl-CoA

Specific reaction: acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7704258; 9384377 [H]