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The map label for this gene is purE [H]

Identifier: 108761078

GI number: 108761078

Start: 2949219

End: 2949716

Strand: Reverse

Name: purE [H]

Synonym: MXAN_2535

Alternate gene names: 108761078

Gene position: 2949716-2949219 (Counterclockwise)

Preceding gene: 108759016

Following gene: 108756981

Centisome position: 32.27

GC content: 70.88

Gene sequence:

>498_bases
ATGGCGAGCACGGTCACCCCCTGGGTCGGGGTCATCATGGGCGGTAGGAGCGACCTGGAGCACCTGCAGCCCGCGGTCGA
CATTCTCAAGGAACTGGGCATCCCGCACGAGGTGCGCGTGGTGTCCGCTCACCGCACCCCGGACTGGATGATGGAGTACG
CGTCCACCGCGGAGTCGCGGGGGCTGTCCGTCATCATCGCCGCCGCGGGCGGCGCGGCGCACCTGCCGGGCATGGTGTCG
AGCAAGACGCTGCTGCCCGTCATTGGCGTGCCCATGCCCACCACGCTGCTCAGCGGCCTGGACGCGCTGCTGTCCATCGT
CCAGATGCCCAAGGGCGTGCCGGTGGGAACGCAGGCCATTGGCAAGCCGGGCGCCGCCAACGCGGCCCTGCACGCCGCGG
CCATCCTCTGCCTCAAGTACCCCGAGCTGCGCGAGCGGCTCGCGGCCTGGCGCAAGGCGCGTACGGACGAAGTGCTGGCG
CACCGGGAGCTGTCATGA

Upstream 100 bases:

>100_bases
CGTCACCCGCGCCTTTCCGTGTTGACCCGCGGAATCCCCCCGCCCTATCTCCGCGTTCCTCCTGGTTTCGGCGGGACAGC
GCACGGAGGCGCGCACACCA

Downstream 100 bases:

>100_bases
GCCCCCGCGTGGTGCTGCCCGGCGGCACGATTGGCATGCTCGGCGGTGGCCAGCTGGGGCGGATGATGGCCCTGGCCGCG
CGCACGCTCGGCTTCCAGGT

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 165; Mature: 164

Protein sequence:

>165_residues
MASTVTPWVGVIMGGRSDLEHLQPAVDILKELGIPHEVRVVSAHRTPDWMMEYASTAESRGLSVIIAAAGGAAHLPGMVS
SKTLLPVIGVPMPTTLLSGLDALLSIVQMPKGVPVGTQAIGKPGAANAALHAAAILCLKYPELRERLAAWRKARTDEVLA
HRELS

Sequences:

>Translated_165_residues
MASTVTPWVGVIMGGRSDLEHLQPAVDILKELGIPHEVRVVSAHRTPDWMMEYASTAESRGLSVIIAAAGGAAHLPGMVS
SKTLLPVIGVPMPTTLLSGLDALLSIVQMPKGVPVGTQAIGKPGAANAALHAAAILCLKYPELRERLAAWRKARTDEVLA
HRELS
>Mature_164_residues
ASTVTPWVGVIMGGRSDLEHLQPAVDILKELGIPHEVRVVSAHRTPDWMMEYASTAESRGLSVIIAAAGGAAHLPGMVSS
KTLLPVIGVPMPTTLLSGLDALLSIVQMPKGVPVGTQAIGKPGAANAALHAAAILCLKYPELRERLAAWRKARTDEVLAH
RELS

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=162, Percent_Identity=58.0246913580247, Blast_Score=154, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6324702, Length=159, Percent_Identity=49.0566037735849, Blast_Score=141, Evalue=5e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17394; Mature: 17262

Theoretical pI: Translated: 8.53; Mature: 8.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASTVTPWVGVIMGGRSDLEHLQPAVDILKELGIPHEVRVVSAHRTPDWMMEYASTAESR
CCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHC
GLSVIIAAAGGAAHLPGMVSSKTLLPVIGVPMPTTLLSGLDALLSIVQMPKGVPVGTQAI
CCEEEEEECCCHHHCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHC
GKPGAANAALHAAAILCLKYPELRERLAAWRKARTDEVLAHRELS
CCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHCCCC
>Mature Secondary Structure 
ASTVTPWVGVIMGGRSDLEHLQPAVDILKELGIPHEVRVVSAHRTPDWMMEYASTAESR
CCCCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHC
GLSVIIAAAGGAAHLPGMVSSKTLLPVIGVPMPTTLLSGLDALLSIVQMPKGVPVGTQAI
CCEEEEEECCCHHHCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHC
GKPGAANAALHAAAILCLKYPELRERLAAWRKARTDEVLAHRELS
CCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9311113; 11427726 [H]