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The map label for this gene is purK [H]

Identifier: 108756981

GI number: 108756981

Start: 2948080

End: 2949222

Strand: Reverse

Name: purK [H]

Synonym: MXAN_2534

Alternate gene names: 108756981

Gene position: 2949222-2948080 (Counterclockwise)

Preceding gene: 108761078

Following gene: 108757752

Centisome position: 32.27

GC content: 72.18

Gene sequence:

>1143_bases
ATGAGCCCCCGCGTGGTGCTGCCCGGCGGCACGATTGGCATGCTCGGCGGTGGCCAGCTGGGGCGGATGATGGCCCTGGC
CGCGCGCACGCTCGGCTTCCAGGTTCAGGCGTTGGACCCGGACGCGGACTGCCCGGCCCACTCCGTGGTGGACCTGTGTG
TTACCGCGTCCTTCGGTGACACGGCGGCCGCGGAGACGCTGGCGCGCGCGTGCGACACCGTGACGCTCGAAATCGAGAAG
ATTCCCCTCCCCACGCTGGAAGCGGTGGCGCGGCACACCCCCATGCGCCCGGGTGCGGACGTGCTCCGCGTGATTCAGCA
CCGGGGCCGGCAGAAGGGCTGGCTCGCCAAGGGGGGCTTTCCCCTGGGCCCGTGGCGCGAGGCGCACTCCGCCGCGGAGC
TGGCCGAAGCCATCCAGGCGCTGGGTGGACGCTGCTTCGTGAAGTCCAGTGAGGGCGGCTACGACGGGCGCGGGCAGGTG
GAGGTGACCTCCGCGGACGAGGCCGCCCAGGCGTGGCGCGAGCTGGGTGAGCGCTCCGTGGTGGTGGAGGCCGCGCTGGC
GCTCCAGTCCGAGCTGTCCGTGCTGGTGGCCCGCAGCCCCAATGGAGAAGTGGCGGTGTATCCGCCAGCCTTCAATCACC
ACGAGGAGCGCATCCTCGCGTGGTCGCTGCTGCCGGGGCCGCTGCCGCCCGCGGTGCTGGACACGGCCACGGAGCTGGCG
CGCGGCATCACCGAGTCGCTCCAGGTCGAAGGCCTGCTCGTCATCGAGCTGTTCCTGCTGAAGGACGGCAGCGTGCTCGT
CAACGAGCTGGCGCCGCGCCCGCACAACAGCTTCCACTCCACCGAGGTGGCGTGCCTCACCTCCCAGTTCGAGCAGGCGG
TGCGCGCGGTGTGCAACCTGCCGCTGGGCTCCGTGGAGGTGGTGCGTCCAGCGGCCATCGTCAACCTGCTGGGCGACTTG
TGGCTGAAGGACGGCGGCCCTCGCTTCCAGGAGGTGCTGGCCATGCCCGGCGTCCGCCTGCACCTGTACGGCAAGCGGGA
GGCGCGCAAGGGCCGGAAGATGGGGCACCTGTCCGCGGTGGGCAGCTCGCCCGAGGACGCGCTCGCTCGCGTGCAGGCCG
CCGCCACCGCGCTGGGGATGTGA

Upstream 100 bases:

>100_bases
CCGCGGCCATCCTCTGCCTCAAGTACCCCGAGCTGCGCGAGCGGCTCGCGGCCTGGCGCAAGGCGCGTACGGACGAAGTG
CTGGCGCACCGGGAGCTGTC

Downstream 100 bases:

>100_bases
GGCCGTGAAGACGAACAGCGCCCGACTCCTGGACTCGCTCGGCGTGAAGTACGCGCTGCGCGACTACGACGTGGACCTGG
AGGATTTGTCCGCGGAGTCG

Product: phosphoribosylaminoimidazole carboxylase, ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 380; Mature: 379

Protein sequence:

>380_residues
MSPRVVLPGGTIGMLGGGQLGRMMALAARTLGFQVQALDPDADCPAHSVVDLCVTASFGDTAAAETLARACDTVTLEIEK
IPLPTLEAVARHTPMRPGADVLRVIQHRGRQKGWLAKGGFPLGPWREAHSAAELAEAIQALGGRCFVKSSEGGYDGRGQV
EVTSADEAAQAWRELGERSVVVEAALALQSELSVLVARSPNGEVAVYPPAFNHHEERILAWSLLPGPLPPAVLDTATELA
RGITESLQVEGLLVIELFLLKDGSVLVNELAPRPHNSFHSTEVACLTSQFEQAVRAVCNLPLGSVEVVRPAAIVNLLGDL
WLKDGGPRFQEVLAMPGVRLHLYGKREARKGRKMGHLSAVGSSPEDALARVQAAATALGM

Sequences:

>Translated_380_residues
MSPRVVLPGGTIGMLGGGQLGRMMALAARTLGFQVQALDPDADCPAHSVVDLCVTASFGDTAAAETLARACDTVTLEIEK
IPLPTLEAVARHTPMRPGADVLRVIQHRGRQKGWLAKGGFPLGPWREAHSAAELAEAIQALGGRCFVKSSEGGYDGRGQV
EVTSADEAAQAWRELGERSVVVEAALALQSELSVLVARSPNGEVAVYPPAFNHHEERILAWSLLPGPLPPAVLDTATELA
RGITESLQVEGLLVIELFLLKDGSVLVNELAPRPHNSFHSTEVACLTSQFEQAVRAVCNLPLGSVEVVRPAAIVNLLGDL
WLKDGGPRFQEVLAMPGVRLHLYGKREARKGRKMGHLSAVGSSPEDALARVQAAATALGM
>Mature_379_residues
SPRVVLPGGTIGMLGGGQLGRMMALAARTLGFQVQALDPDADCPAHSVVDLCVTASFGDTAAAETLARACDTVTLEIEKI
PLPTLEAVARHTPMRPGADVLRVIQHRGRQKGWLAKGGFPLGPWREAHSAAELAEAIQALGGRCFVKSSEGGYDGRGQVE
VTSADEAAQAWRELGERSVVVEAALALQSELSVLVARSPNGEVAVYPPAFNHHEERILAWSLLPGPLPPAVLDTATELAR
GITESLQVEGLLVIELFLLKDGSVLVNELAPRPHNSFHSTEVACLTSQFEQAVRAVCNLPLGSVEVVRPAAIVNLLGDLW
LKDGGPRFQEVLAMPGVRLHLYGKREARKGRKMGHLSAVGSSPEDALARVQAAATALGM

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=368, Percent_Identity=33.695652173913, Blast_Score=145, Evalue=5e-36,
Organism=Escherichia coli, GI1788155, Length=380, Percent_Identity=28.9473684210526, Blast_Score=116, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6324702, Length=366, Percent_Identity=35.792349726776, Blast_Score=199, Evalue=6e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006115
- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp; PF03446 NAD_binding_2 [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 40255; Mature: 40124

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPRVVLPGGTIGMLGGGQLGRMMALAARTLGFQVQALDPDADCPAHSVVDLCVTASFGD
CCCCEECCCCCEEECCCCHHHHHHHHHHHHHCEEEEEECCCCCCCHHHHHHHHHCCCCCC
TAAAETLARACDTVTLEIEKIPLPTLEAVARHTPMRPGADVLRVIQHRGRQKGWLAKGGF
HHHHHHHHHHHCEEEEEEECCCCCHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCEECCCC
PLGPWREAHSAAELAEAIQALGGRCFVKSSEGGYDGRGQVEVTSADEAAQAWRELGERSV
CCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEECCHHHHHHHHHHCCCHH
VVEAALALQSELSVLVARSPNGEVAVYPPAFNHHEERILAWSLLPGPLPPAVLDTATELA
HHHHHHHHHHCCEEEEEECCCCCEEEECCCCCCCCHHEEEEEECCCCCCHHHHHHHHHHH
RGITESLQVEGLLVIELFLLKDGSVLVNELAPRPHNSFHSTEVACLTSQFEQAVRAVCNL
HHHHHHHHCCCEEEEEEEECCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCC
PLGSVEVVRPAAIVNLLGDLWLKDGGPRFQEVLAMPGVRLHLYGKREARKGRKMGHLSAV
CCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCEEEEEECCHHHHCCCCCCCHHHC
GSSPEDALARVQAAATALGM
CCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SPRVVLPGGTIGMLGGGQLGRMMALAARTLGFQVQALDPDADCPAHSVVDLCVTASFGD
CCCEECCCCCEEECCCCHHHHHHHHHHHHHCEEEEEECCCCCCCHHHHHHHHHCCCCCC
TAAAETLARACDTVTLEIEKIPLPTLEAVARHTPMRPGADVLRVIQHRGRQKGWLAKGGF
HHHHHHHHHHHCEEEEEEECCCCCHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCEECCCC
PLGPWREAHSAAELAEAIQALGGRCFVKSSEGGYDGRGQVEVTSADEAAQAWRELGERSV
CCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEECCHHHHHHHHHHCCCHH
VVEAALALQSELSVLVARSPNGEVAVYPPAFNHHEERILAWSLLPGPLPPAVLDTATELA
HHHHHHHHHHCCEEEEEECCCCCEEEECCCCCCCCHHEEEEEECCCCCCHHHHHHHHHHH
RGITESLQVEGLLVIELFLLKDGSVLVNELAPRPHNSFHSTEVACLTSQFEQAVRAVCNL
HHHHHHHHCCCEEEEEEEECCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCC
PLGSVEVVRPAAIVNLLGDLWLKDGGPRFQEVLAMPGVRLHLYGKREARKGRKMGHLSAV
CCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCEEEEEECCHHHHCCCCCCCHHHC
GSSPEDALARVQAAATALGM
CCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3036807; 9384377 [H]