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The map label for this gene is topB [H]

Identifier: 108761008

GI number: 108761008

Start: 610214

End: 614896

Strand: Direct

Name: topB [H]

Synonym: MXAN_0535

Alternate gene names: 108761008

Gene position: 610214-614896 (Clockwise)

Preceding gene: 108758760

Following gene: 108763411

Centisome position: 6.68

GC content: 71.86

Gene sequence:

>4683_bases
GTGCTGGCGGAGAAGCCCTCGGTGGCGCGCGACATCGCGCGGGTGCTGGGGGCGAACGAGCGCGGTGAGGGCTGGCTGCG
CGGCAATGGCTACGTGGTGACGTGGGCCATCGGGCACCTGGTGGGCCTGGCGCAGCCCCATGAGATTCGCGCGGACTGGA
AGAAGTGGAGCCGCGCGCTGCTGCCCATGCTCCCGGCGGACTGGCCGCTGGTCGTCTCCAAGGAGACGCGCAGCCAGTTC
GAGGTGGTGAAGCAGGTGCTCAACGCGCCGGAGGTGTCCTCGGTGGTGTGCGCAACGGACGCGGGGCGCGAGGGCGAGCT
TATCTTCCGGTACATCTACGACGCGGCGAAGTGCCGCAAGCCGGTACAGCGGCTGTGGGTGTCGTCGCTGACGGAGCGGG
CCATCCAGGACGGCTTCCGCCGGCTCGCGGACGGCCGTGAATACGAAGCGCTGGCCGCCGCGGCCATGGGGCGCAGCCGG
GCGGACTGGCTGGTGGGGATGAACCTGTCGCGCCTGTACACGCTGGCGCACGGGGGCCATGGAGAGATGCTGAGCGTGGG
CCGGGTGCAGACGCCCACGCTGGCCATGGTGGTGGAGCGCGAGTTGGCCATCCGCGACTTCGTGCCGCGTGACTACCTGG
AGCTCGTGGCCACCTTCGCGCCCAGGGCGAAGGGGGTTCCGCCGGACGCGCTGTACAAGGGCACGTGGTTCCGCTCGGGG
CCGGATGGCAAGCCCGTGGCGCCCCCGGGCTTCGAGGGCGTGCGCGAGGCGCGGCGGCTGGATGCGAACGGCGTGGAGGC
GCAGGCCATCATCGACCGGGTGCGCGCCGGGCGGGCCATCATCGAATCGCTGGAGTCGGAGGAGAAGAGGATGGCGCCTC
CGCTCCTCTACGACTTGACGGAGTTGCAGCGGCACGCCAACCGGCTCCATGGCTTCAGCGCGCAGCGCACGCTGGAGGTG
GCGCAGGCGCTCTACGAGAAGCACAAGCTGTTGAGCTATCCGCGCACCGCCAGCCGGCACCTGTCACGCACCGTGGCGGA
CACGCTGCCGGAGGTGGTGAACGCCATTCGCGGGCCCTACGAGGAGGACCTGGCCGTCGGTACGGGGGCTCGGGCGCTGG
GCAAGCGCTATGTGGATGACGCGAAGGTGACGGACCACCACGCCATCATCCCCACGCCCACGGCGCCGGGCGGGGTGCGG
CTGTCTCCGGACGAGCAGCGCGTCTATGACCTGGTGTGCCGGCGTCTGCTCCAGGCGTGGCACGAGGACCACGTCTGGCG
GGTCACCACGGTCATCACCGCGGTGACGTCGGCAGGGGCGCCGCCCGTGGTGGACCGCTTCCAGAGCACGGGCACCCAGG
TGGAGCAGGTGGGCTGGAAGGTGCTGGACATTGGCGGCGGACAGAAGGCGCCGCGGCTGAAGTCGGAGGGGCGCAAGGGC
GAGGACGCGGAGCGGGAGCCGGAGGACGAGCCCCAGACGCTGCCGTCGGGGTTGGCGCGCGCGCAGCCGCAGTCCGTGGA
GGACGTGGAGGCGGTGAAGAAGCGCACGCGTCCGCCTCCCCGCTTCACGGATGCGACGCTGCTGACGGCCATGGAGTCGG
CGGGGCGGGCGTTGGATGAGAAGGAGCTCGCGGACGCGATGCGCGAGACGGGCCTGGGGACTCCCGCCACCCGCGCGGCC
ATCATCGAGGTGCTGCTGGACCGCGAGTACCTGCGCCGCCGGGGCAAGGTGATGGAGGCCACGGAGAAGGGCATCCATCT
CATCCAGGTGGTGCACCCGGATGTGAAGACGCCGGCCATGACGGGCCAGTGGGAGGCGTGGCTCCAGCGCATCGAGCGCG
GCGAAGGCCAGCTCGATGAGTTCATCCGTGGCATCGAGGCGTATGTCATCGAGGTGGTGGGCCATGGCGCCACCGCGCCG
CAACGGCCTCCGCGCAACGAGGTGTTGGGGGCTCCACCTGGAGCAGGTTGGGGGCAGGGCGGCGCGGCGCAGGTGGCGAG
CGAGGGCGCGGCCGCGGCGCACGGCGCTGGCGCGGGAGCGCGTGGCCCTGGCGGGCAGGGGGCGTTCGCGGAGTCCTCTG
CTGAGCGTTTCGGGGATGCTTCGGCGGGGGGGGCGGGGCGTGGCCGGCAGGGGGCGTTCACGGAGGCTTCTGCCGAGCGC
TTCGCGGATGCCGCGCCGGGTGTGCAGGGACAGGGACGCCCGGGCGCGCTCTCGGAGGCTTCGGAGCCGCTCTTCGGGAC
GCGGCGGAGCAGGACCTCGGGCTCCGTGGGTCGCTCGGAGCCTCATGGCGAGCCGCTGTCCTCCACCATGTCACCGGGCG
GAGGCGCGGCCTCGCGTCTTCCTCGGGCGGACGGCACAGGCTGGAACGCCGGGGCCTGGGAGAACACGGGCGCTGCTCGC
GCTCCAGTGAACCGTGCGAGGACCCCGGCGTCAGCCGCGTCCACCGGGCAGCGGCCGGAGCGCGTGCGGCGCGCACCGAC
GGCGCCCGAGGCGCTGCGTCCGCTGCTGAAGGAGGCGTTCGGCTTCTCGGACTTCCGGCCGTATCAGGAGGCCGTGTGCC
GCGCGGCCACGGCGGGAGAGGACCTGCTGCTCGTGATGCCCACGGGCGCGGGCAAGTCGCTCTGCTATCAGTTGCCGGGT
CTGGCGCGCGCAGGCACCACGCTGGTGGTGAGTCCGCTCATCGCGCTGATGGAGGACCAGGTGGCGCGGCTCCAGTCGCT
CGGCTTCGCGGCGGACCGCATCCACTCCGGAAGAGACCGGGCCATGTCGCGGCAGGTGTGCGCGGACTACCTGGAGGACC
GGCTCGACTTCCTGTTCATCGCGCCCGAGCGGCTCGGCGTTCCGGGCTTCGTGGAGTTCCTGGCGCGCCGCACGCCCGCG
CTCATCGCGGTGGACGAGGCCCACTGCATCTCCCAGTGGGGACACGACTTCCGCCCGGACTATCGACTCCTGGGCGCGCG
TTTGCCCCTGCTGCGCCCCGCGCCCGTGGTGGCGCTCACCGCCACCGCCACGCCGGACGTGCAGCGGGACATCGTTCAGC
AGCTCGGCCTGCAAGGCCCCGGGGGCAAGGCGCGCACCTTCATTCACGGCTTCCGCCGCACCAACATCGCCATCGAGGTG
CGGGAGCTGAACCCCGGCGCGCGCGGCGACGCCATCCAGGGATTGCTCGAGGACGAGGAGAACCGGCCCGCGATTGTCTA
CGCGGCCACGCGCAAGCACGCCGAGCAGCTCGCGGACCAGCTCGCGGGCGAGTTCCCCGCGGCCGCCTATCACGCGGGGC
TCCAGCCTTCGGAGCGAGATCGGGTGCAGGCCGAGTTCCTCCGGGGCTCGCTGGAGGTCATCGTGGCCACCACGGCGTTC
GGCATGGGCATCGACAAGGCGGACGTGCGCACCGTCATCCACGCGGCGCTCCCCGCCAGCCTGGAGGGCTACTACCAGGA
GCTGGGCCGCGCGGGCCGCGATGGGAAGCCGTCGCGCGCGGTGCTGCTGCATTCGTACATCGACCGGCGCACGCACGAGT
TCTTCCACCGGCGCGACTACCCGGAGGCGTACGTGCTGGAGCGGCTGTTCAAGTCCACGGCGCCGCAGCTCGAGCCCAAG
GCCGTGCTCCAGGGCCGCGTGCGAGGAGACCCCGAGGTCTTCGACAAGGCACTGGAGCAGCTCTGGATTCACGGCGGCGT
CGTCATGACGCCTGACGAGACGGTGATGCGCGGGAAGCCGGGCTGGTCCGCGTCGTACTCGGCCCAGCGCGATCGCAAAC
TGCTGCACCTGGAGCAGATGGGGCGCTACGCGGAGGCCCATGGCTGCCGCATGAAGCAGCTCGTGGGGCACTTCGGTGAC
ACCCAGGATTCGGGTGAGCCGTGCGGCCTGTGTGATGTCTGCGCGCCGGAGGACTGCGCCACGCTGCGCTTCGCCGAGCC
GACCTCCGCGGAGCGGCACTGGCTGGAGCGCATCCTGGAGTCGCTCCAGGAGCGGGACGGACAGGCCACCGGAAGGCTCC
ACCGCGAGTTGTTTGGAGAGTCCCTGCCACGGCGCGACTTCGAGCGACTGGTGGGCGGACTGGTTCGCGCCGGGCTGACG
CGCTTGGAGGTGGACTCGTTCGACAAGGACGGGCAGGTCATTTCGTTCCAGCGTCTCGCCCTGACGGACGAGGGCCGGCG
CACGCGCGCGGTGGACCCCCAGCGAGTGGTCCTGCCGTTGCCCCTGGAGAAGGCCGCGAAGCGCAAGCGGGGCAAGGGCG
CGGAGAAGGGCACCGCGAAGCGGGCCACGGCCAAGAAACGCACGGTCCGCGCCAAGGCCGGGGCCGCGACGCGGCGCACG
GCATCCGAATCCGATGAGGAAGACTCGCCGACGCACTGGCGCGCGAACGCTCCCTCGAAGAGCACCGCCGGGGCGCCACG
TGCGTCCCGGAGCACGGGGGCTCCGAGTGGCTCCGCGTCAGGCCGCCGCGCCGCGGCCGAGCCTTCTCCGAAGATGGTGG
AGGCCTTGAAGGCCTGGCGGCTCGCGGAGGCGCGCAAGCGGCGGGTGCCTGCCTTCCGCATCCTCACGGACCGGGTGCTG
GAGGCCATCGCGTCGGCCTGTCCGGAGAATGGCTCGGAGTTGATGGCCATCCACGGGGTGGGGCCCTCCCTCACGGAGCG
CTACGGCGCGCAGATTCTTTCCCTCGTGGCGCGCAGGAGCTGA

Upstream 100 bases:

>100_bases
CATGAGGTGGGAAGAGATGGGCGAGACGCCCCGGGAGGACAGGCGCGGAGGCAGGGACGGCGGTGCGAAGGCGTCCTCCG
GTCGCTCCTCCCTGCTGGCC

Downstream 100 bases:

>100_bases
GCCCGGACGCCTCGCGGAAGGAGGCGTCCTTCCCACGAAGGGAAGGGCGCTTCCCTCCGCGCGCCACGGCGATTCCAGCG
CAAGTCCGGGTGCGGGGCGC

Product: RecQ family DNA topoisomerase III/ATP-dependent DNA helicase

Products: NA

Alternate protein names: DNA topoisomerase III [H]

Number of amino acids: Translated: 1560; Mature: 1560

Protein sequence:

>1560_residues
MLAEKPSVARDIARVLGANERGEGWLRGNGYVVTWAIGHLVGLAQPHEIRADWKKWSRALLPMLPADWPLVVSKETRSQF
EVVKQVLNAPEVSSVVCATDAGREGELIFRYIYDAAKCRKPVQRLWVSSLTERAIQDGFRRLADGREYEALAAAAMGRSR
ADWLVGMNLSRLYTLAHGGHGEMLSVGRVQTPTLAMVVERELAIRDFVPRDYLELVATFAPRAKGVPPDALYKGTWFRSG
PDGKPVAPPGFEGVREARRLDANGVEAQAIIDRVRAGRAIIESLESEEKRMAPPLLYDLTELQRHANRLHGFSAQRTLEV
AQALYEKHKLLSYPRTASRHLSRTVADTLPEVVNAIRGPYEEDLAVGTGARALGKRYVDDAKVTDHHAIIPTPTAPGGVR
LSPDEQRVYDLVCRRLLQAWHEDHVWRVTTVITAVTSAGAPPVVDRFQSTGTQVEQVGWKVLDIGGGQKAPRLKSEGRKG
EDAEREPEDEPQTLPSGLARAQPQSVEDVEAVKKRTRPPPRFTDATLLTAMESAGRALDEKELADAMRETGLGTPATRAA
IIEVLLDREYLRRRGKVMEATEKGIHLIQVVHPDVKTPAMTGQWEAWLQRIERGEGQLDEFIRGIEAYVIEVVGHGATAP
QRPPRNEVLGAPPGAGWGQGGAAQVASEGAAAAHGAGAGARGPGGQGAFAESSAERFGDASAGGAGRGRQGAFTEASAER
FADAAPGVQGQGRPGALSEASEPLFGTRRSRTSGSVGRSEPHGEPLSSTMSPGGGAASRLPRADGTGWNAGAWENTGAAR
APVNRARTPASAASTGQRPERVRRAPTAPEALRPLLKEAFGFSDFRPYQEAVCRAATAGEDLLLVMPTGAGKSLCYQLPG
LARAGTTLVVSPLIALMEDQVARLQSLGFAADRIHSGRDRAMSRQVCADYLEDRLDFLFIAPERLGVPGFVEFLARRTPA
LIAVDEAHCISQWGHDFRPDYRLLGARLPLLRPAPVVALTATATPDVQRDIVQQLGLQGPGGKARTFIHGFRRTNIAIEV
RELNPGARGDAIQGLLEDEENRPAIVYAATRKHAEQLADQLAGEFPAAAYHAGLQPSERDRVQAEFLRGSLEVIVATTAF
GMGIDKADVRTVIHAALPASLEGYYQELGRAGRDGKPSRAVLLHSYIDRRTHEFFHRRDYPEAYVLERLFKSTAPQLEPK
AVLQGRVRGDPEVFDKALEQLWIHGGVVMTPDETVMRGKPGWSASYSAQRDRKLLHLEQMGRYAEAHGCRMKQLVGHFGD
TQDSGEPCGLCDVCAPEDCATLRFAEPTSAERHWLERILESLQERDGQATGRLHRELFGESLPRRDFERLVGGLVRAGLT
RLEVDSFDKDGQVISFQRLALTDEGRRTRAVDPQRVVLPLPLEKAAKRKRGKGAEKGTAKRATAKKRTVRAKAGAATRRT
ASESDEEDSPTHWRANAPSKSTAGAPRASRSTGAPSGSASGRRAAAEPSPKMVEALKAWRLAEARKRRVPAFRILTDRVL
EAIASACPENGSELMAIHGVGPSLTERYGAQILSLVARRS

Sequences:

>Translated_1560_residues
MLAEKPSVARDIARVLGANERGEGWLRGNGYVVTWAIGHLVGLAQPHEIRADWKKWSRALLPMLPADWPLVVSKETRSQF
EVVKQVLNAPEVSSVVCATDAGREGELIFRYIYDAAKCRKPVQRLWVSSLTERAIQDGFRRLADGREYEALAAAAMGRSR
ADWLVGMNLSRLYTLAHGGHGEMLSVGRVQTPTLAMVVERELAIRDFVPRDYLELVATFAPRAKGVPPDALYKGTWFRSG
PDGKPVAPPGFEGVREARRLDANGVEAQAIIDRVRAGRAIIESLESEEKRMAPPLLYDLTELQRHANRLHGFSAQRTLEV
AQALYEKHKLLSYPRTASRHLSRTVADTLPEVVNAIRGPYEEDLAVGTGARALGKRYVDDAKVTDHHAIIPTPTAPGGVR
LSPDEQRVYDLVCRRLLQAWHEDHVWRVTTVITAVTSAGAPPVVDRFQSTGTQVEQVGWKVLDIGGGQKAPRLKSEGRKG
EDAEREPEDEPQTLPSGLARAQPQSVEDVEAVKKRTRPPPRFTDATLLTAMESAGRALDEKELADAMRETGLGTPATRAA
IIEVLLDREYLRRRGKVMEATEKGIHLIQVVHPDVKTPAMTGQWEAWLQRIERGEGQLDEFIRGIEAYVIEVVGHGATAP
QRPPRNEVLGAPPGAGWGQGGAAQVASEGAAAAHGAGAGARGPGGQGAFAESSAERFGDASAGGAGRGRQGAFTEASAER
FADAAPGVQGQGRPGALSEASEPLFGTRRSRTSGSVGRSEPHGEPLSSTMSPGGGAASRLPRADGTGWNAGAWENTGAAR
APVNRARTPASAASTGQRPERVRRAPTAPEALRPLLKEAFGFSDFRPYQEAVCRAATAGEDLLLVMPTGAGKSLCYQLPG
LARAGTTLVVSPLIALMEDQVARLQSLGFAADRIHSGRDRAMSRQVCADYLEDRLDFLFIAPERLGVPGFVEFLARRTPA
LIAVDEAHCISQWGHDFRPDYRLLGARLPLLRPAPVVALTATATPDVQRDIVQQLGLQGPGGKARTFIHGFRRTNIAIEV
RELNPGARGDAIQGLLEDEENRPAIVYAATRKHAEQLADQLAGEFPAAAYHAGLQPSERDRVQAEFLRGSLEVIVATTAF
GMGIDKADVRTVIHAALPASLEGYYQELGRAGRDGKPSRAVLLHSYIDRRTHEFFHRRDYPEAYVLERLFKSTAPQLEPK
AVLQGRVRGDPEVFDKALEQLWIHGGVVMTPDETVMRGKPGWSASYSAQRDRKLLHLEQMGRYAEAHGCRMKQLVGHFGD
TQDSGEPCGLCDVCAPEDCATLRFAEPTSAERHWLERILESLQERDGQATGRLHRELFGESLPRRDFERLVGGLVRAGLT
RLEVDSFDKDGQVISFQRLALTDEGRRTRAVDPQRVVLPLPLEKAAKRKRGKGAEKGTAKRATAKKRTVRAKAGAATRRT
ASESDEEDSPTHWRANAPSKSTAGAPRASRSTGAPSGSASGRRAAAEPSPKMVEALKAWRLAEARKRRVPAFRILTDRVL
EAIASACPENGSELMAIHGVGPSLTERYGAQILSLVARRS
>Mature_1560_residues
MLAEKPSVARDIARVLGANERGEGWLRGNGYVVTWAIGHLVGLAQPHEIRADWKKWSRALLPMLPADWPLVVSKETRSQF
EVVKQVLNAPEVSSVVCATDAGREGELIFRYIYDAAKCRKPVQRLWVSSLTERAIQDGFRRLADGREYEALAAAAMGRSR
ADWLVGMNLSRLYTLAHGGHGEMLSVGRVQTPTLAMVVERELAIRDFVPRDYLELVATFAPRAKGVPPDALYKGTWFRSG
PDGKPVAPPGFEGVREARRLDANGVEAQAIIDRVRAGRAIIESLESEEKRMAPPLLYDLTELQRHANRLHGFSAQRTLEV
AQALYEKHKLLSYPRTASRHLSRTVADTLPEVVNAIRGPYEEDLAVGTGARALGKRYVDDAKVTDHHAIIPTPTAPGGVR
LSPDEQRVYDLVCRRLLQAWHEDHVWRVTTVITAVTSAGAPPVVDRFQSTGTQVEQVGWKVLDIGGGQKAPRLKSEGRKG
EDAEREPEDEPQTLPSGLARAQPQSVEDVEAVKKRTRPPPRFTDATLLTAMESAGRALDEKELADAMRETGLGTPATRAA
IIEVLLDREYLRRRGKVMEATEKGIHLIQVVHPDVKTPAMTGQWEAWLQRIERGEGQLDEFIRGIEAYVIEVVGHGATAP
QRPPRNEVLGAPPGAGWGQGGAAQVASEGAAAAHGAGAGARGPGGQGAFAESSAERFGDASAGGAGRGRQGAFTEASAER
FADAAPGVQGQGRPGALSEASEPLFGTRRSRTSGSVGRSEPHGEPLSSTMSPGGGAASRLPRADGTGWNAGAWENTGAAR
APVNRARTPASAASTGQRPERVRRAPTAPEALRPLLKEAFGFSDFRPYQEAVCRAATAGEDLLLVMPTGAGKSLCYQLPG
LARAGTTLVVSPLIALMEDQVARLQSLGFAADRIHSGRDRAMSRQVCADYLEDRLDFLFIAPERLGVPGFVEFLARRTPA
LIAVDEAHCISQWGHDFRPDYRLLGARLPLLRPAPVVALTATATPDVQRDIVQQLGLQGPGGKARTFIHGFRRTNIAIEV
RELNPGARGDAIQGLLEDEENRPAIVYAATRKHAEQLADQLAGEFPAAAYHAGLQPSERDRVQAEFLRGSLEVIVATTAF
GMGIDKADVRTVIHAALPASLEGYYQELGRAGRDGKPSRAVLLHSYIDRRTHEFFHRRDYPEAYVLERLFKSTAPQLEPK
AVLQGRVRGDPEVFDKALEQLWIHGGVVMTPDETVMRGKPGWSASYSAQRDRKLLHLEQMGRYAEAHGCRMKQLVGHFGD
TQDSGEPCGLCDVCAPEDCATLRFAEPTSAERHWLERILESLQERDGQATGRLHRELFGESLPRRDFERLVGGLVRAGLT
RLEVDSFDKDGQVISFQRLALTDEGRRTRAVDPQRVVLPLPLEKAAKRKRGKGAEKGTAKRATAKKRTVRAKAGAATRRT
ASESDEEDSPTHWRANAPSKSTAGAPRASRSTGAPSGSASGRRAAAEPSPKMVEALKAWRLAEARKRRVPAFRILTDRVL
EAIASACPENGSELMAIHGVGPSLTERYGAQILSLVARRS

Specific function: The reaction catalyzed by topoisomerases leads to the conversion of one topological isomer of DNA to another. TOP3 is a potent decatenase [H]

COG id: COG0550

COG function: function code L; Topoisomerase IA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Toprim domain [H]

Homologues:

Organism=Homo sapiens, GI51242947, Length=373, Percent_Identity=43.9678284182306, Blast_Score=259, Evalue=1e-68,
Organism=Homo sapiens, GI51242943, Length=373, Percent_Identity=43.9678284182306, Blast_Score=259, Evalue=2e-68,
Organism=Homo sapiens, GI148612816, Length=373, Percent_Identity=43.9678284182306, Blast_Score=258, Evalue=5e-68,
Organism=Homo sapiens, GI4557365, Length=381, Percent_Identity=38.8451443569554, Blast_Score=255, Evalue=2e-67,
Organism=Homo sapiens, GI14591902, Length=351, Percent_Identity=39.031339031339, Blast_Score=250, Evalue=6e-66,
Organism=Homo sapiens, GI14591904, Length=351, Percent_Identity=39.031339031339, Blast_Score=250, Evalue=6e-66,
Organism=Homo sapiens, GI169218196, Length=346, Percent_Identity=39.8843930635838, Blast_Score=225, Evalue=3e-58,
Organism=Homo sapiens, GI110735439, Length=346, Percent_Identity=39.8843930635838, Blast_Score=225, Evalue=3e-58,
Organism=Homo sapiens, GI284005309, Length=362, Percent_Identity=38.121546961326, Blast_Score=191, Evalue=4e-48,
Organism=Homo sapiens, GI222352149, Length=350, Percent_Identity=23.4285714285714, Blast_Score=75, Evalue=6e-13,
Organism=Escherichia coli, GI1788061, Length=665, Percent_Identity=33.2330827067669, Blast_Score=320, Evalue=6e-88,
Organism=Escherichia coli, GI48994977, Length=337, Percent_Identity=45.9940652818991, Blast_Score=281, Evalue=2e-76,
Organism=Escherichia coli, GI1787529, Length=668, Percent_Identity=23.2035928143713, Blast_Score=92, Evalue=4e-19,
Organism=Escherichia coli, GI87082221, Length=382, Percent_Identity=23.8219895287958, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71987997, Length=355, Percent_Identity=39.1549295774648, Blast_Score=257, Evalue=4e-68,
Organism=Caenorhabditis elegans, GI71987993, Length=355, Percent_Identity=39.1549295774648, Blast_Score=256, Evalue=5e-68,
Organism=Caenorhabditis elegans, GI25145561, Length=351, Percent_Identity=39.6011396011396, Blast_Score=250, Evalue=4e-66,
Organism=Caenorhabditis elegans, GI32564293, Length=378, Percent_Identity=38.8888888888889, Blast_Score=235, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI17552866, Length=339, Percent_Identity=38.6430678466077, Blast_Score=221, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI32563869, Length=668, Percent_Identity=25.8982035928144, Blast_Score=117, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI17508543, Length=114, Percent_Identity=35.0877192982456, Blast_Score=68, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323844, Length=367, Percent_Identity=39.5095367847411, Blast_Score=256, Evalue=2e-68,
Organism=Drosophila melanogaster, GI24646066, Length=343, Percent_Identity=39.6501457725948, Blast_Score=254, Evalue=3e-67,
Organism=Drosophila melanogaster, GI24664226, Length=488, Percent_Identity=33.8114754098361, Blast_Score=221, Evalue=3e-57,
Organism=Drosophila melanogaster, GI24664230, Length=487, Percent_Identity=33.4702258726899, Blast_Score=212, Evalue=2e-54,
Organism=Drosophila melanogaster, GI62472181, Length=487, Percent_Identity=33.4702258726899, Blast_Score=212, Evalue=2e-54,
Organism=Drosophila melanogaster, GI21358123, Length=377, Percent_Identity=34.4827586206897, Blast_Score=185, Evalue=2e-46,
Organism=Drosophila melanogaster, GI21355075, Length=396, Percent_Identity=22.979797979798, Blast_Score=77, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24584399, Length=361, Percent_Identity=22.9916897506925, Blast_Score=77, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28574962, Length=356, Percent_Identity=23.5955056179775, Blast_Score=68, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24666101, Length=330, Percent_Identity=26.0606060606061, Blast_Score=67, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003601
- InterPro:   IPR013497
- InterPro:   IPR013824
- InterPro:   IPR013825
- InterPro:   IPR000380
- InterPro:   IPR003602
- InterPro:   IPR005738
- InterPro:   IPR006171 [H]

Pfam domain/function: PF01131 Topoisom_bac; PF01751 Toprim [H]

EC number: =5.99.1.2 [H]

Molecular weight: Translated: 169642; Mature: 169642

Theoretical pI: Translated: 9.38; Mature: 9.38

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLAEKPSVARDIARVLGANERGEGWLRGNGYVVTWAIGHLVGLAQPHEIRADWKKWSRAL
CCCCCCHHHHHHHHHHCCCCCCCCEEECCCEEEEEHHHHHHHCCCCHHHHHHHHHHHHHH
LPMLPADWPLVVSKETRSQFEVVKQVLNAPEVSSVVCATDAGREGELIFRYIYDAAKCRK
HHCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHH
PVQRLWVSSLTERAIQDGFRRLADGREYEALAAAAMGRSRADWLVGMNLSRLYTLAHGGH
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHCCCCHHHHHHHHCCCC
GEMLSVGRVQTPTLAMVVERELAIRDFVPRDYLELVATFAPRAKGVPPDALYKGTWFRSG
CCEEECCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCC
PDGKPVAPPGFEGVREARRLDANGVEAQAIIDRVRAGRAIIESLESEEKRMAPPLLYDLT
CCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
ELQRHANRLHGFSAQRTLEVAQALYEKHKLLSYPRTASRHLSRTVADTLPEVVNAIRGPY
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
EEDLAVGTGARALGKRYVDDAKVTDHHAIIPTPTAPGGVRLSPDEQRVYDLVCRRLLQAW
HHHHHHCCCHHHHHHHHHCCCCCCCCCEEECCCCCCCCEEECCHHHHHHHHHHHHHHHHH
HEDHVWRVTTVITAVTSAGAPPVVDRFQSTGTQVEQVGWKVLDIGGGQKAPRLKSEGRKG
CCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHCCCEEEECCCCCCCCCHHHCCCCC
EDAEREPEDEPQTLPSGLARAQPQSVEDVEAVKKRTRPPPRFTDATLLTAMESAGRALDE
CCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCH
KELADAMRETGLGTPATRAAIIEVLLDREYLRRRGKVMEATEKGIHLIQVVHPDVKTPAM
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCEEEEEECCCCCCCCC
TGQWEAWLQRIERGEGQLDEFIRGIEAYVIEVVGHGATAPQRPPRNEVLGAPPGAGWGQG
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
GAAQVASEGAAAAHGAGAGARGPGGQGAFAESSAERFGDASAGGAGRGRQGAFTEASAER
CHHHHHHCCCHHHCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHH
FADAAPGVQGQGRPGALSEASEPLFGTRRSRTSGSVGRSEPHGEPLSSTMSPGGGAASRL
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCHHHCC
PRADGTGWNAGAWENTGAARAPVNRARTPASAASTGQRPERVRRAPTAPEALRPLLKEAF
CCCCCCCCCCCCCCCCCCCCCCHHHCCCCCHHHHCCCCHHHHHCCCCCHHHHHHHHHHHC
GFSDFRPYQEAVCRAATAGEDLLLVMPTGAGKSLCYQLPGLARAGTTLVVSPLIALMEDQ
CCCCCCHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHCCCCHHCCHHHHHHHHHHHHHHH
VARLQSLGFAADRIHSGRDRAMSRQVCADYLEDRLDFLFIAPERLGVPGFVEFLARRTPA
HHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHCEEEECHHHCCCCHHHHHHHHCCCC
LIAVDEAHCISQWGHDFRPDYRLLGARLPLLRPAPVVALTATATPDVQRDIVQQLGLQGP
EEEECHHHHHHHCCCCCCCCHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCC
GGKARTFIHGFRRTNIAIEVRELNPGARGDAIQGLLEDEENRPAIVYAATRKHAEQLADQ
CCHHHHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHH
LAGEFPAAAYHAGLQPSERDRVQAEFLRGSLEVIVATTAFGMGIDKADVRTVIHAALPAS
HHCCCCHHHHHCCCCCCHHHHHHHHHHHCCHHEEEEHHHHHCCCCHHHHHHHHHHHCCHH
LEGYYQELGRAGRDGKPSRAVLLHSYIDRRTHEFFHRRDYPEAYVLERLFKSTAPQLEPK
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCH
AVLQGRVRGDPEVFDKALEQLWIHGGVVMTPDETVMRGKPGWSASYSAQRDRKLLHLEQM
HHHHCCCCCCHHHHHHHHHHHHHCCCEEECCCCHHHCCCCCCCCCCCHHHHHHHHHHHHH
GRYAEAHGCRMKQLVGHFGDTQDSGEPCGLCDVCAPEDCATLRFAEPTSAERHWLERILE
HHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHH
SLQERDGQATGRLHRELFGESLPRRDFERLVGGLVRAGLTRLEVDSFDKDGQVISFQRLA
HHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCHHHHHHCCCCCCCCEEEEEHEE
LTDEGRRTRAVDPQRVVLPLPLEKAAKRKRGKGAEKGTAKRATAKKRTVRAKAGAATRRT
ECCCCCCCCCCCCCCEEEECCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHC
ASESDEEDSPTHWRANAPSKSTAGAPRASRSTGAPSGSASGRRAAAEPSPKMVEALKAWR
CCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
LAEARKRRVPAFRILTDRVLEAIASACPENGSELMAIHGVGPSLTERYGAQILSLVARRS
HHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLAEKPSVARDIARVLGANERGEGWLRGNGYVVTWAIGHLVGLAQPHEIRADWKKWSRAL
CCCCCCHHHHHHHHHHCCCCCCCCEEECCCEEEEEHHHHHHHCCCCHHHHHHHHHHHHHH
LPMLPADWPLVVSKETRSQFEVVKQVLNAPEVSSVVCATDAGREGELIFRYIYDAAKCRK
HHCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHH
PVQRLWVSSLTERAIQDGFRRLADGREYEALAAAAMGRSRADWLVGMNLSRLYTLAHGGH
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHCCCCHHHHHHHHCCCC
GEMLSVGRVQTPTLAMVVERELAIRDFVPRDYLELVATFAPRAKGVPPDALYKGTWFRSG
CCEEECCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCC
PDGKPVAPPGFEGVREARRLDANGVEAQAIIDRVRAGRAIIESLESEEKRMAPPLLYDLT
CCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
ELQRHANRLHGFSAQRTLEVAQALYEKHKLLSYPRTASRHLSRTVADTLPEVVNAIRGPY
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
EEDLAVGTGARALGKRYVDDAKVTDHHAIIPTPTAPGGVRLSPDEQRVYDLVCRRLLQAW
HHHHHHCCCHHHHHHHHHCCCCCCCCCEEECCCCCCCCEEECCHHHHHHHHHHHHHHHHH
HEDHVWRVTTVITAVTSAGAPPVVDRFQSTGTQVEQVGWKVLDIGGGQKAPRLKSEGRKG
CCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHCCCEEEECCCCCCCCCHHHCCCCC
EDAEREPEDEPQTLPSGLARAQPQSVEDVEAVKKRTRPPPRFTDATLLTAMESAGRALDE
CCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCH
KELADAMRETGLGTPATRAAIIEVLLDREYLRRRGKVMEATEKGIHLIQVVHPDVKTPAM
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCEEEEEECCCCCCCCC
TGQWEAWLQRIERGEGQLDEFIRGIEAYVIEVVGHGATAPQRPPRNEVLGAPPGAGWGQG
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
GAAQVASEGAAAAHGAGAGARGPGGQGAFAESSAERFGDASAGGAGRGRQGAFTEASAER
CHHHHHHCCCHHHCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHH
FADAAPGVQGQGRPGALSEASEPLFGTRRSRTSGSVGRSEPHGEPLSSTMSPGGGAASRL
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCHHHCC
PRADGTGWNAGAWENTGAARAPVNRARTPASAASTGQRPERVRRAPTAPEALRPLLKEAF
CCCCCCCCCCCCCCCCCCCCCCHHHCCCCCHHHHCCCCHHHHHCCCCCHHHHHHHHHHHC
GFSDFRPYQEAVCRAATAGEDLLLVMPTGAGKSLCYQLPGLARAGTTLVVSPLIALMEDQ
CCCCCCHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHCCCCHHCCHHHHHHHHHHHHHHH
VARLQSLGFAADRIHSGRDRAMSRQVCADYLEDRLDFLFIAPERLGVPGFVEFLARRTPA
HHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHCEEEECHHHCCCCHHHHHHHHCCCC
LIAVDEAHCISQWGHDFRPDYRLLGARLPLLRPAPVVALTATATPDVQRDIVQQLGLQGP
EEEECHHHHHHHCCCCCCCCHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCC
GGKARTFIHGFRRTNIAIEVRELNPGARGDAIQGLLEDEENRPAIVYAATRKHAEQLADQ
CCHHHHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHH
LAGEFPAAAYHAGLQPSERDRVQAEFLRGSLEVIVATTAFGMGIDKADVRTVIHAALPAS
HHCCCCHHHHHCCCCCCHHHHHHHHHHHCCHHEEEEHHHHHCCCCHHHHHHHHHHHCCHH
LEGYYQELGRAGRDGKPSRAVLLHSYIDRRTHEFFHRRDYPEAYVLERLFKSTAPQLEPK
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCH
AVLQGRVRGDPEVFDKALEQLWIHGGVVMTPDETVMRGKPGWSASYSAQRDRKLLHLEQM
HHHHCCCCCCHHHHHHHHHHHHHCCCEEECCCCHHHCCCCCCCCCCCHHHHHHHHHHHHH
GRYAEAHGCRMKQLVGHFGDTQDSGEPCGLCDVCAPEDCATLRFAEPTSAERHWLERILE
HHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHH
SLQERDGQATGRLHRELFGESLPRRDFERLVGGLVRAGLTRLEVDSFDKDGQVISFQRLA
HHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCHHHHHHCCCCCCCCEEEEEHEE
LTDEGRRTRAVDPQRVVLPLPLEKAAKRKRGKGAEKGTAKRATAKKRTVRAKAGAATRRT
ECCCCCCCCCCCCCCEEEECCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHC
ASESDEEDSPTHWRANAPSKSTAGAPRASRSTGAPSGSASGRRAAAEPSPKMVEALKAWR
CCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
LAEARKRRVPAFRILTDRVLEAIASACPENGSELMAIHGVGPSLTERYGAQILSLVARRS
HHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA